LeishMANIAdb
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DHHC domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DHHC domain-containing protein
Gene product:
Ankyrin repeats (3 copies)/DHHC palmitoyltransferase, putative
Species:
Leishmania braziliensis
UniProt:
A4HGI3_LEIBR
TriTrypDb:
LbrM.28.1460 , LBRM2903_030009600 *
Length:
998

Annotations

LeishMANIAdb annotations

This small but fast-evolving family of Kinetoplastid proteins likely serves either as a transporter or a lipid-related enzyme (e.g. palmitoyltransferase).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HGI3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI3

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0016310 phosphorylation 5 2
GO:0044237 cellular metabolic process 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016409 palmitoyltransferase activity 5 3
GO:0016740 transferase activity 2 6
GO:0016746 acyltransferase activity 3 3
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 3
GO:0016301 kinase activity 4 2
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 281 285 PF00656 0.458
CLV_C14_Caspase3-7 354 358 PF00656 0.749
CLV_C14_Caspase3-7 367 371 PF00656 0.676
CLV_C14_Caspase3-7 527 531 PF00656 0.431
CLV_NRD_NRD_1 105 107 PF00675 0.273
CLV_NRD_NRD_1 54 56 PF00675 0.532
CLV_NRD_NRD_1 72 74 PF00675 0.417
CLV_NRD_NRD_1 742 744 PF00675 0.582
CLV_PCSK_KEX2_1 105 107 PF00082 0.314
CLV_PCSK_KEX2_1 475 477 PF00082 0.416
CLV_PCSK_KEX2_1 54 56 PF00082 0.528
CLV_PCSK_KEX2_1 71 73 PF00082 0.422
CLV_PCSK_KEX2_1 742 744 PF00082 0.582
CLV_PCSK_KEX2_1 975 977 PF00082 0.424
CLV_PCSK_PC1ET2_1 475 477 PF00082 0.390
CLV_PCSK_PC1ET2_1 975 977 PF00082 0.507
CLV_PCSK_SKI1_1 163 167 PF00082 0.247
CLV_PCSK_SKI1_1 373 377 PF00082 0.497
CLV_PCSK_SKI1_1 450 454 PF00082 0.431
CLV_PCSK_SKI1_1 550 554 PF00082 0.659
CLV_PCSK_SKI1_1 589 593 PF00082 0.402
CLV_PCSK_SKI1_1 643 647 PF00082 0.385
CLV_PCSK_SKI1_1 839 843 PF00082 0.630
CLV_PCSK_SKI1_1 884 888 PF00082 0.412
CLV_PCSK_SKI1_1 937 941 PF00082 0.429
DEG_APCC_DBOX_1 329 337 PF00400 0.473
DEG_APCC_DBOX_1 588 596 PF00400 0.402
DEG_Nend_Nbox_1 1 3 PF02207 0.628
DEG_SCF_FBW7_1 989 996 PF00400 0.658
DEG_SCF_FBW7_2 19 26 PF00400 0.637
DEG_SPOP_SBC_1 349 353 PF00917 0.694
DOC_CKS1_1 20 25 PF01111 0.698
DOC_CKS1_1 677 682 PF01111 0.428
DOC_CKS1_1 990 995 PF01111 0.732
DOC_CYCLIN_RxL_1 158 167 PF00134 0.452
DOC_CYCLIN_RxL_1 547 557 PF00134 0.428
DOC_CYCLIN_yClb1_LxF_4 684 690 PF00134 0.530
DOC_CYCLIN_yClb1_LxF_4 963 969 PF00134 0.669
DOC_CYCLIN_yCln2_LP_2 495 501 PF00134 0.632
DOC_MAPK_DCC_7 123 131 PF00069 0.444
DOC_MAPK_gen_1 492 501 PF00069 0.638
DOC_MAPK_gen_1 975 983 PF00069 0.638
DOC_MAPK_MEF2A_6 123 131 PF00069 0.486
DOC_MAPK_MEF2A_6 494 503 PF00069 0.612
DOC_MAPK_MEF2A_6 589 598 PF00069 0.400
DOC_MAPK_MEF2A_6 852 860 PF00069 0.330
DOC_MAPK_NFAT4_5 589 597 PF00069 0.360
DOC_PP1_RVXF_1 448 455 PF00149 0.629
DOC_PP1_RVXF_1 548 555 PF00149 0.428
DOC_PP2B_LxvP_1 505 508 PF13499 0.369
DOC_PP2B_PxIxI_1 507 513 PF00149 0.203
DOC_PP4_FxxP_1 218 221 PF00568 0.676
DOC_SPAK_OSR1_1 130 134 PF12202 0.538
DOC_USP7_MATH_1 170 174 PF00917 0.547
DOC_USP7_MATH_1 186 190 PF00917 0.597
DOC_USP7_MATH_1 343 347 PF00917 0.671
DOC_USP7_MATH_1 437 441 PF00917 0.640
DOC_USP7_MATH_1 461 465 PF00917 0.654
DOC_USP7_MATH_1 514 518 PF00917 0.448
DOC_USP7_MATH_1 610 614 PF00917 0.660
DOC_USP7_MATH_1 837 841 PF00917 0.402
DOC_WW_Pin1_4 19 24 PF00397 0.697
DOC_WW_Pin1_4 262 267 PF00397 0.552
DOC_WW_Pin1_4 286 291 PF00397 0.465
DOC_WW_Pin1_4 554 559 PF00397 0.430
DOC_WW_Pin1_4 567 572 PF00397 0.350
DOC_WW_Pin1_4 623 628 PF00397 0.597
DOC_WW_Pin1_4 676 681 PF00397 0.537
DOC_WW_Pin1_4 748 753 PF00397 0.395
DOC_WW_Pin1_4 989 994 PF00397 0.664
LIG_14-3-3_CanoR_1 385 394 PF00244 0.710
LIG_14-3-3_CanoR_1 409 415 PF00244 0.669
LIG_14-3-3_CanoR_1 460 470 PF00244 0.712
LIG_14-3-3_CanoR_1 54 64 PF00244 0.771
LIG_14-3-3_CanoR_1 550 555 PF00244 0.463
LIG_14-3-3_CanoR_1 589 595 PF00244 0.203
LIG_14-3-3_CanoR_1 616 623 PF00244 0.682
LIG_14-3-3_CanoR_1 742 752 PF00244 0.393
LIG_14-3-3_CanoR_1 832 837 PF00244 0.312
LIG_14-3-3_CanoR_1 852 857 PF00244 0.475
LIG_deltaCOP1_diTrp_1 26 30 PF00928 0.572
LIG_eIF4E_1 424 430 PF01652 0.524
LIG_eIF4E_1 543 549 PF01652 0.414
LIG_eIF4E_1 836 842 PF01652 0.306
LIG_FHA_1 157 163 PF00498 0.481
LIG_FHA_1 235 241 PF00498 0.554
LIG_FHA_1 287 293 PF00498 0.447
LIG_FHA_1 504 510 PF00498 0.347
LIG_FHA_1 591 597 PF00498 0.376
LIG_FHA_1 623 629 PF00498 0.629
LIG_FHA_1 709 715 PF00498 0.324
LIG_FHA_1 853 859 PF00498 0.250
LIG_FHA_1 97 103 PF00498 0.500
LIG_FHA_1 990 996 PF00498 0.730
LIG_FHA_2 56 62 PF00498 0.701
LIG_FHA_2 790 796 PF00498 0.420
LIG_FHA_2 822 828 PF00498 0.341
LIG_FHA_2 885 891 PF00498 0.586
LIG_GBD_Chelix_1 962 970 PF00786 0.443
LIG_IRF3_LxIS_1 592 599 PF10401 0.203
LIG_LIR_Gen_1 181 192 PF02991 0.539
LIG_LIR_Gen_1 297 307 PF02991 0.476
LIG_LIR_Gen_1 318 329 PF02991 0.526
LIG_LIR_Gen_1 36 47 PF02991 0.677
LIG_LIR_Gen_1 390 401 PF02991 0.605
LIG_LIR_Gen_1 412 422 PF02991 0.590
LIG_LIR_Gen_1 694 704 PF02991 0.431
LIG_LIR_Gen_1 786 794 PF02991 0.439
LIG_LIR_Gen_1 925 936 PF02991 0.699
LIG_LIR_Nem_3 181 187 PF02991 0.539
LIG_LIR_Nem_3 26 30 PF02991 0.734
LIG_LIR_Nem_3 297 302 PF02991 0.473
LIG_LIR_Nem_3 318 324 PF02991 0.541
LIG_LIR_Nem_3 36 42 PF02991 0.539
LIG_LIR_Nem_3 390 396 PF02991 0.587
LIG_LIR_Nem_3 438 444 PF02991 0.611
LIG_LIR_Nem_3 626 632 PF02991 0.644
LIG_LIR_Nem_3 634 640 PF02991 0.666
LIG_LIR_Nem_3 694 699 PF02991 0.431
LIG_LIR_Nem_3 726 731 PF02991 0.483
LIG_LIR_Nem_3 786 790 PF02991 0.446
LIG_LIR_Nem_3 925 931 PF02991 0.695
LIG_NRBOX 191 197 PF00104 0.646
LIG_NRBOX 239 245 PF00104 0.389
LIG_NRBOX 547 553 PF00104 0.409
LIG_NRBOX 591 597 PF00104 0.425
LIG_NRBOX 604 610 PF00104 0.409
LIG_NRBOX 697 703 PF00104 0.360
LIG_NRBOX 965 971 PF00104 0.645
LIG_PCNA_PIPBox_1 652 661 PF02747 0.524
LIG_PCNA_yPIPBox_3 649 659 PF02747 0.524
LIG_PDZ_Class_1 993 998 PF00595 0.588
LIG_Pex14_2 180 184 PF04695 0.581
LIG_Pex14_2 444 448 PF04695 0.599
LIG_Pex14_2 75 79 PF04695 0.642
LIG_REV1ctd_RIR_1 446 454 PF16727 0.574
LIG_REV1ctd_RIR_1 643 653 PF16727 0.389
LIG_SH2_CRK 39 43 PF00017 0.668
LIG_SH2_CRK 873 877 PF00017 0.318
LIG_SH2_CRK 928 932 PF00017 0.735
LIG_SH2_GRB2like 27 30 PF00017 0.652
LIG_SH2_GRB2like 816 819 PF00017 0.314
LIG_SH2_PTP2 393 396 PF00017 0.661
LIG_SH2_SRC 18 21 PF00017 0.673
LIG_SH2_SRC 816 819 PF00017 0.314
LIG_SH2_SRC 956 959 PF00017 0.650
LIG_SH2_STAT3 580 583 PF00017 0.435
LIG_SH2_STAT5 164 167 PF00017 0.523
LIG_SH2_STAT5 18 21 PF00017 0.647
LIG_SH2_STAT5 242 245 PF00017 0.530
LIG_SH2_STAT5 271 274 PF00017 0.479
LIG_SH2_STAT5 337 340 PF00017 0.581
LIG_SH2_STAT5 393 396 PF00017 0.635
LIG_SH2_STAT5 424 427 PF00017 0.600
LIG_SH2_STAT5 441 444 PF00017 0.558
LIG_SH2_STAT5 543 546 PF00017 0.466
LIG_SH2_STAT5 659 662 PF00017 0.442
LIG_SH2_STAT5 816 819 PF00017 0.442
LIG_SH2_STAT5 847 850 PF00017 0.368
LIG_SH3_2 20 25 PF14604 0.624
LIG_SH3_3 17 23 PF00018 0.667
LIG_SH3_3 431 437 PF00018 0.709
LIG_SH3_3 455 461 PF00018 0.664
LIG_SH3_3 97 103 PF00018 0.530
LIG_SH3_3 987 993 PF00018 0.728
LIG_SUMO_SIM_anti_2 428 433 PF11976 0.621
LIG_SUMO_SIM_anti_2 593 599 PF11976 0.203
LIG_SUMO_SIM_anti_2 700 705 PF11976 0.400
LIG_SUMO_SIM_par_1 194 201 PF11976 0.526
LIG_SUMO_SIM_par_1 375 380 PF11976 0.590
LIG_SUMO_SIM_par_1 593 599 PF11976 0.413
LIG_SUMO_SIM_par_1 689 694 PF11976 0.424
LIG_SUMO_SIM_par_1 98 104 PF11976 0.511
LIG_TRAF2_1 58 61 PF00917 0.560
LIG_TRAF2_1 617 620 PF00917 0.685
LIG_TRFH_1 242 246 PF08558 0.490
LIG_TRFH_1 846 850 PF08558 0.438
LIG_TYR_ITIM 541 546 PF00017 0.473
LIG_TYR_ITIM 871 876 PF00017 0.318
LIG_WRC_WIRS_1 551 556 PF05994 0.469
LIG_WRC_WIRS_1 784 789 PF05994 0.438
MOD_CDK_SPxK_1 19 25 PF00069 0.622
MOD_CDK_SPxxK_3 623 630 PF00069 0.664
MOD_CDK_SPxxK_3 676 683 PF00069 0.502
MOD_CK1_1 265 271 PF00069 0.530
MOD_CK1_1 345 351 PF00069 0.737
MOD_CK1_1 380 386 PF00069 0.611
MOD_CK1_1 387 393 PF00069 0.597
MOD_CK1_1 45 51 PF00069 0.629
MOD_CK1_1 464 470 PF00069 0.722
MOD_CK1_1 672 678 PF00069 0.455
MOD_CK1_1 744 750 PF00069 0.389
MOD_CK1_1 761 767 PF00069 0.415
MOD_CK1_1 864 870 PF00069 0.279
MOD_CK1_1 96 102 PF00069 0.493
MOD_CK2_1 479 485 PF00069 0.663
MOD_CK2_1 55 61 PF00069 0.726
MOD_CK2_1 74 80 PF00069 0.480
MOD_CK2_1 789 795 PF00069 0.422
MOD_CK2_1 821 827 PF00069 0.338
MOD_CK2_1 884 890 PF00069 0.589
MOD_CK2_1 896 902 PF00069 0.662
MOD_Cter_Amidation 973 976 PF01082 0.422
MOD_GlcNHglycan 112 115 PF01048 0.218
MOD_GlcNHglycan 188 191 PF01048 0.342
MOD_GlcNHglycan 221 224 PF01048 0.414
MOD_GlcNHglycan 370 373 PF01048 0.497
MOD_GlcNHglycan 379 382 PF01048 0.510
MOD_GlcNHglycan 386 389 PF01048 0.436
MOD_GlcNHglycan 466 469 PF01048 0.569
MOD_GlcNHglycan 47 50 PF01048 0.430
MOD_GlcNHglycan 526 529 PF01048 0.702
MOD_GlcNHglycan 766 769 PF01048 0.623
MOD_GlcNHglycan 863 866 PF01048 0.412
MOD_GSK3_1 152 159 PF00069 0.509
MOD_GSK3_1 182 189 PF00069 0.538
MOD_GSK3_1 282 289 PF00069 0.493
MOD_GSK3_1 315 322 PF00069 0.576
MOD_GSK3_1 338 345 PF00069 0.604
MOD_GSK3_1 347 354 PF00069 0.581
MOD_GSK3_1 380 387 PF00069 0.779
MOD_GSK3_1 550 557 PF00069 0.431
MOD_GSK3_1 615 622 PF00069 0.623
MOD_GSK3_1 672 679 PF00069 0.544
MOD_GSK3_1 741 748 PF00069 0.433
MOD_GSK3_1 760 767 PF00069 0.557
MOD_GSK3_1 769 776 PF00069 0.474
MOD_GSK3_1 848 855 PF00069 0.371
MOD_GSK3_1 989 996 PF00069 0.704
MOD_N-GLC_1 363 368 PF02516 0.366
MOD_N-GLC_1 410 415 PF02516 0.389
MOD_N-GLC_1 45 50 PF02516 0.509
MOD_NEK2_1 145 150 PF00069 0.458
MOD_NEK2_1 305 310 PF00069 0.530
MOD_NEK2_1 347 352 PF00069 0.592
MOD_NEK2_1 368 373 PF00069 0.716
MOD_NEK2_1 407 412 PF00069 0.634
MOD_NEK2_1 425 430 PF00069 0.612
MOD_NEK2_1 524 529 PF00069 0.456
MOD_NEK2_1 544 549 PF00069 0.460
MOD_NEK2_1 581 586 PF00069 0.458
MOD_NEK2_1 596 601 PF00069 0.301
MOD_NEK2_1 689 694 PF00069 0.338
MOD_NEK2_1 741 746 PF00069 0.462
MOD_NEK2_1 760 765 PF00069 0.411
MOD_NEK2_1 861 866 PF00069 0.296
MOD_NEK2_1 93 98 PF00069 0.468
MOD_NEK2_1 981 986 PF00069 0.690
MOD_NEK2_2 401 406 PF00069 0.660
MOD_NEK2_2 837 842 PF00069 0.308
MOD_PIKK_1 279 285 PF00454 0.405
MOD_PIKK_1 459 465 PF00454 0.736
MOD_PIKK_1 7 13 PF00454 0.558
MOD_PIKK_1 767 773 PF00454 0.366
MOD_PIKK_1 93 99 PF00454 0.486
MOD_PKA_2 384 390 PF00069 0.695
MOD_PKA_2 459 465 PF00069 0.707
MOD_PKA_2 487 493 PF00069 0.655
MOD_PKA_2 615 621 PF00069 0.660
MOD_PKA_2 741 747 PF00069 0.391
MOD_PKA_2 851 857 PF00069 0.472
MOD_Plk_1 410 416 PF00069 0.632
MOD_Plk_2-3 274 280 PF00069 0.389
MOD_Plk_2-3 810 816 PF00069 0.386
MOD_Plk_4 252 258 PF00069 0.465
MOD_Plk_4 425 431 PF00069 0.668
MOD_Plk_4 437 443 PF00069 0.585
MOD_Plk_4 469 475 PF00069 0.612
MOD_Plk_4 544 550 PF00069 0.396
MOD_Plk_4 583 589 PF00069 0.349
MOD_Plk_4 590 596 PF00069 0.273
MOD_Plk_4 672 678 PF00069 0.504
MOD_Plk_4 709 715 PF00069 0.343
MOD_Plk_4 773 779 PF00069 0.549
MOD_Plk_4 902 908 PF00069 0.650
MOD_ProDKin_1 19 25 PF00069 0.696
MOD_ProDKin_1 262 268 PF00069 0.552
MOD_ProDKin_1 286 292 PF00069 0.465
MOD_ProDKin_1 554 560 PF00069 0.430
MOD_ProDKin_1 567 573 PF00069 0.345
MOD_ProDKin_1 623 629 PF00069 0.595
MOD_ProDKin_1 676 682 PF00069 0.537
MOD_ProDKin_1 748 754 PF00069 0.397
MOD_ProDKin_1 989 995 PF00069 0.664
TRG_DiLeu_BaEn_1 252 257 PF01217 0.465
TRG_DiLeu_BaEn_1 301 306 PF01217 0.530
TRG_DiLeu_BaLyEn_6 547 552 PF01217 0.362
TRG_DiLeu_LyEn_5 536 541 PF01217 0.353
TRG_ENDOCYTIC_2 241 244 PF00928 0.530
TRG_ENDOCYTIC_2 27 30 PF00928 0.730
TRG_ENDOCYTIC_2 39 42 PF00928 0.690
TRG_ENDOCYTIC_2 393 396 PF00928 0.635
TRG_ENDOCYTIC_2 424 427 PF00928 0.581
TRG_ENDOCYTIC_2 441 444 PF00928 0.544
TRG_ENDOCYTIC_2 543 546 PF00928 0.466
TRG_ENDOCYTIC_2 637 640 PF00928 0.604
TRG_ENDOCYTIC_2 806 809 PF00928 0.454
TRG_ENDOCYTIC_2 873 876 PF00928 0.345
TRG_ENDOCYTIC_2 928 931 PF00928 0.699
TRG_ER_diArg_1 493 496 PF00400 0.620
TRG_ER_diArg_1 70 73 PF00400 0.657
TRG_ER_diArg_1 741 743 PF00400 0.379
TRG_NES_CRM1_1 497 511 PF08389 0.502
TRG_Pf-PMV_PEXEL_1 130 134 PF00026 0.290
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.247
TRG_Pf-PMV_PEXEL_1 313 317 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 481 485 PF00026 0.359

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1V5 Leptomonas seymouri 59% 100%
A0A422NMJ8 Trypanosoma rangeli 33% 100%
A0A451EJQ0 Leishmania donovani 79% 99%
D0A254 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9ACJ3 Leishmania major 78% 99%
E9AG37 Leishmania infantum 79% 99%
E9AJT1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 99%
V5BST1 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS