Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGI2_LEIBR

TriTrypDb:

LbrM.28.1450 , LBRM2903_030009500

Length:

956

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 2
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HGI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.402
CLV_C14_Caspase3-7	267	271	PF00656	0.436
CLV_C14_Caspase3-7	276	280	PF00656	0.370
CLV_C14_Caspase3-7	359	363	PF00656	0.458
CLV_C14_Caspase3-7	516	520	PF00656	0.579
CLV_C14_Caspase3-7	749	753	PF00656	0.627
CLV_C14_Caspase3-7	75	79	PF00656	0.457
CLV_NRD_NRD_1	143	145	PF00675	0.666
CLV_NRD_NRD_1	149	151	PF00675	0.595
CLV_NRD_NRD_1	222	224	PF00675	0.589
CLV_NRD_NRD_1	334	336	PF00675	0.627
CLV_NRD_NRD_1	467	469	PF00675	0.666
CLV_NRD_NRD_1	657	659	PF00675	0.368
CLV_NRD_NRD_1	688	690	PF00675	0.703
CLV_NRD_NRD_1	912	914	PF00675	0.399
CLV_PCSK_FUR_1	899	903	PF00082	0.515
CLV_PCSK_KEX2_1	117	119	PF00082	0.669
CLV_PCSK_KEX2_1	143	145	PF00082	0.666
CLV_PCSK_KEX2_1	149	151	PF00082	0.595
CLV_PCSK_KEX2_1	222	224	PF00082	0.589
CLV_PCSK_KEX2_1	333	335	PF00082	0.646
CLV_PCSK_KEX2_1	466	468	PF00082	0.665
CLV_PCSK_KEX2_1	657	659	PF00082	0.368
CLV_PCSK_KEX2_1	688	690	PF00082	0.703
CLV_PCSK_KEX2_1	901	903	PF00082	0.461
CLV_PCSK_KEX2_1	912	914	PF00082	0.374
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.686
CLV_PCSK_PC1ET2_1	901	903	PF00082	0.511
CLV_PCSK_SKI1_1	117	121	PF00082	0.552
CLV_PCSK_SKI1_1	159	163	PF00082	0.604
CLV_PCSK_SKI1_1	322	326	PF00082	0.614
CLV_PCSK_SKI1_1	346	350	PF00082	0.666
CLV_PCSK_SKI1_1	375	379	PF00082	0.590
CLV_PCSK_SKI1_1	799	803	PF00082	0.349
CLV_PCSK_SKI1_1	912	916	PF00082	0.423
CLV_PCSK_SKI1_1	928	932	PF00082	0.451
DEG_APCC_DBOX_1	374	382	PF00400	0.408
DEG_APCC_DBOX_1	480	488	PF00400	0.378
DEG_APCC_DBOX_1	798	806	PF00400	0.343
DEG_APCC_DBOX_1	911	919	PF00400	0.615
DEG_MDM2_SWIB_1	582	590	PF02201	0.441
DEG_SCF_TRCP1_1	78	83	PF00400	0.463
DEG_SPOP_SBC_1	119	123	PF00917	0.536
DEG_SPOP_SBC_1	239	243	PF00917	0.418
DEG_SPOP_SBC_1	753	757	PF00917	0.596
DOC_CKS1_1	167	172	PF01111	0.449
DOC_CKS1_1	405	410	PF01111	0.434
DOC_CYCLIN_RxL_1	796	804	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	784	787	PF00134	0.396
DOC_MAPK_DCC_7	471	479	PF00069	0.444
DOC_MAPK_DCC_7	868	876	PF00069	0.761
DOC_MAPK_gen_1	333	342	PF00069	0.448
DOC_MAPK_gen_1	471	479	PF00069	0.444
DOC_MAPK_gen_1	481	489	PF00069	0.331
DOC_MAPK_gen_1	657	665	PF00069	0.525
DOC_MAPK_HePTP_8	330	342	PF00069	0.450
DOC_MAPK_MEF2A_6	333	342	PF00069	0.448
DOC_MAPK_MEF2A_6	721	730	PF00069	0.666
DOC_PP1_RVXF_1	391	398	PF00149	0.348
DOC_PP1_RVXF_1	577	583	PF00149	0.322
DOC_PP2B_LxvP_1	784	787	PF13499	0.396
DOC_PP4_FxxP_1	839	842	PF00568	0.761
DOC_PP4_MxPP_1	371	374	PF00568	0.425
DOC_SPAK_OSR1_1	581	585	PF12202	0.290
DOC_USP7_MATH_1	119	123	PF00917	0.438
DOC_USP7_MATH_1	175	179	PF00917	0.559
DOC_USP7_MATH_1	238	242	PF00917	0.547
DOC_USP7_MATH_1	252	256	PF00917	0.465
DOC_USP7_MATH_1	257	261	PF00917	0.531
DOC_USP7_MATH_1	264	268	PF00917	0.476
DOC_USP7_MATH_1	320	324	PF00917	0.508
DOC_USP7_MATH_1	415	419	PF00917	0.611
DOC_USP7_MATH_1	423	427	PF00917	0.463
DOC_USP7_MATH_1	511	515	PF00917	0.441
DOC_USP7_MATH_1	543	547	PF00917	0.373
DOC_USP7_MATH_1	618	622	PF00917	0.403
DOC_USP7_MATH_1	754	758	PF00917	0.620
DOC_USP7_MATH_1	842	846	PF00917	0.595
DOC_USP7_MATH_1	875	879	PF00917	0.722
DOC_USP7_MATH_1	880	884	PF00917	0.697
DOC_USP7_MATH_1	914	918	PF00917	0.551
DOC_WW_Pin1_4	166	171	PF00397	0.437
DOC_WW_Pin1_4	346	351	PF00397	0.398
DOC_WW_Pin1_4	404	409	PF00397	0.427
DOC_WW_Pin1_4	410	415	PF00397	0.430
DOC_WW_Pin1_4	45	50	PF00397	0.514
DOC_WW_Pin1_4	591	596	PF00397	0.300
DOC_WW_Pin1_4	838	843	PF00397	0.596
LIG_14-3-3_CanoR_1	118	126	PF00244	0.444
LIG_14-3-3_CanoR_1	159	164	PF00244	0.478
LIG_14-3-3_CanoR_1	26	31	PF00244	0.492
LIG_14-3-3_CanoR_1	322	331	PF00244	0.337
LIG_14-3-3_CanoR_1	393	398	PF00244	0.359
LIG_14-3-3_CanoR_1	4	14	PF00244	0.603
LIG_14-3-3_CanoR_1	43	49	PF00244	0.532
LIG_14-3-3_CanoR_1	563	572	PF00244	0.499
LIG_14-3-3_CanoR_1	791	796	PF00244	0.394
LIG_14-3-3_CanoR_1	834	842	PF00244	0.633
LIG_14-3-3_CanoR_1	849	857	PF00244	0.681
LIG_Actin_WH2_2	377	395	PF00022	0.326
LIG_Actin_WH2_2	777	793	PF00022	0.605
LIG_Actin_WH2_2	798	814	PF00022	0.480
LIG_BIR_III_4	205	209	PF00653	0.419
LIG_BRCT_BRCA1_1	755	759	PF00533	0.580
LIG_CaM_IQ_9	325	341	PF13499	0.294
LIG_deltaCOP1_diTrp_1	639	647	PF00928	0.340
LIG_FHA_1	160	166	PF00498	0.398
LIG_FHA_1	308	314	PF00498	0.497
LIG_FHA_1	323	329	PF00498	0.343
LIG_FHA_1	423	429	PF00498	0.370
LIG_FHA_1	567	573	PF00498	0.324
LIG_FHA_1	6	12	PF00498	0.560
LIG_FHA_1	638	644	PF00498	0.253
LIG_FHA_1	699	705	PF00498	0.306
LIG_FHA_2	108	114	PF00498	0.501
LIG_FHA_2	193	199	PF00498	0.461
LIG_FHA_2	946	952	PF00498	0.703
LIG_GBD_Chelix_1	32	40	PF00786	0.561
LIG_GBD_Chelix_1	336	344	PF00786	0.493
LIG_GBD_Chelix_1	664	672	PF00786	0.298
LIG_Integrin_RGD_1	268	270	PF01839	0.639
LIG_LIR_Apic_2	837	842	PF02991	0.708
LIG_LIR_Gen_1	325	332	PF02991	0.470
LIG_LIR_Gen_1	639	649	PF02991	0.329
LIG_LIR_Gen_1	756	765	PF02991	0.543
LIG_LIR_Nem_3	178	183	PF02991	0.460
LIG_LIR_Nem_3	325	330	PF02991	0.375
LIG_LIR_Nem_3	396	400	PF02991	0.362
LIG_LIR_Nem_3	639	645	PF02991	0.329
LIG_LIR_Nem_3	756	762	PF02991	0.686
LIG_LIR_Nem_3	793	798	PF02991	0.447
LIG_LIR_Nem_3	887	893	PF02991	0.641
LIG_MYND_1	478	482	PF01753	0.405
LIG_NRBOX	35	41	PF00104	0.432
LIG_NRBOX	675	681	PF00104	0.480
LIG_PCNA_PIPBox_1	661	670	PF02747	0.647
LIG_PCNA_yPIPBox_3	657	669	PF02747	0.550
LIG_Pex14_1	327	331	PF04695	0.369
LIG_Pex14_2	180	184	PF04695	0.445
LIG_Pex14_2	582	586	PF04695	0.443
LIG_Pex14_2	759	763	PF04695	0.433
LIG_RPA_C_Fungi	263	275	PF08784	0.535
LIG_SH2_CRK	227	231	PF00017	0.578
LIG_SH2_CRK	890	894	PF00017	0.545
LIG_SH2_PTP2	870	873	PF00017	0.581
LIG_SH2_STAP1	115	119	PF00017	0.600
LIG_SH2_STAP1	304	308	PF00017	0.429
LIG_SH2_STAP1	929	933	PF00017	0.472
LIG_SH2_STAT5	183	186	PF00017	0.555
LIG_SH2_STAT5	685	688	PF00017	0.480
LIG_SH2_STAT5	729	732	PF00017	0.557
LIG_SH2_STAT5	870	873	PF00017	0.581
LIG_SH3_3	164	170	PF00018	0.514
LIG_SH3_3	392	398	PF00018	0.459
LIG_SH3_3	402	408	PF00018	0.536
LIG_SH3_3	8	14	PF00018	0.545
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.394
LIG_SUMO_SIM_anti_2	609	614	PF11976	0.441
LIG_SUMO_SIM_anti_2	673	679	PF11976	0.445
LIG_SUMO_SIM_par_1	628	634	PF11976	0.504
LIG_SUMO_SIM_par_1	872	878	PF11976	0.705
LIG_TRAF2_1	110	113	PF00917	0.626
LIG_TRAF2_1	950	953	PF00917	0.780
LIG_WW_3	372	376	PF00397	0.509
MOD_CK1_1	12	18	PF00069	0.730
MOD_CK1_1	273	279	PF00069	0.599
MOD_CK1_1	363	369	PF00069	0.554
MOD_CK1_1	413	419	PF00069	0.701
MOD_CK1_1	422	428	PF00069	0.452
MOD_CK1_1	502	508	PF00069	0.608
MOD_CK1_1	637	643	PF00069	0.253
MOD_CK1_1	755	761	PF00069	0.669
MOD_CK1_1	79	85	PF00069	0.735
MOD_CK1_1	837	843	PF00069	0.481
MOD_CK1_1	845	851	PF00069	0.485
MOD_CK1_1	885	891	PF00069	0.684
MOD_CK1_1	947	953	PF00069	0.640
MOD_CK2_1	107	113	PF00069	0.585
MOD_CK2_1	149	155	PF00069	0.560
MOD_CK2_1	543	549	PF00069	0.473
MOD_CK2_1	838	844	PF00069	0.628
MOD_CK2_1	947	953	PF00069	0.634
MOD_CMANNOS	650	653	PF00535	0.480
MOD_CMANNOS	824	827	PF00535	0.554
MOD_GlcNHglycan	11	14	PF01048	0.760
MOD_GlcNHglycan	126	129	PF01048	0.541
MOD_GlcNHglycan	139	142	PF01048	0.434
MOD_GlcNHglycan	152	155	PF01048	0.465
MOD_GlcNHglycan	254	257	PF01048	0.777
MOD_GlcNHglycan	279	282	PF01048	0.543
MOD_GlcNHglycan	289	292	PF01048	0.558
MOD_GlcNHglycan	297	301	PF01048	0.622
MOD_GlcNHglycan	362	366	PF01048	0.598
MOD_GlcNHglycan	368	371	PF01048	0.590
MOD_GlcNHglycan	421	424	PF01048	0.521
MOD_GlcNHglycan	49	52	PF01048	0.651
MOD_GlcNHglycan	501	504	PF01048	0.728
MOD_GlcNHglycan	515	518	PF01048	0.735
MOD_GlcNHglycan	523	526	PF01048	0.673
MOD_GlcNHglycan	672	675	PF01048	0.402
MOD_GlcNHglycan	732	735	PF01048	0.627
MOD_GlcNHglycan	745	749	PF01048	0.575
MOD_GlcNHglycan	759	762	PF01048	0.431
MOD_GlcNHglycan	776	779	PF01048	0.283
MOD_GlcNHglycan	78	81	PF01048	0.620
MOD_GlcNHglycan	844	847	PF01048	0.497
MOD_GlcNHglycan	895	898	PF01048	0.631
MOD_GlcNHglycan	92	95	PF01048	0.686
MOD_GSK3_1	120	127	PF00069	0.536
MOD_GSK3_1	133	140	PF00069	0.608
MOD_GSK3_1	155	162	PF00069	0.403
MOD_GSK3_1	269	276	PF00069	0.622
MOD_GSK3_1	409	416	PF00069	0.620
MOD_GSK3_1	419	426	PF00069	0.609
MOD_GSK3_1	5	12	PF00069	0.685
MOD_GSK3_1	521	528	PF00069	0.661
MOD_GSK3_1	543	550	PF00069	0.459
MOD_GSK3_1	586	593	PF00069	0.328
MOD_GSK3_1	59	66	PF00069	0.559
MOD_GSK3_1	72	79	PF00069	0.586
MOD_GSK3_1	753	760	PF00069	0.610
MOD_GSK3_1	834	841	PF00069	0.510
MOD_GSK3_1	875	882	PF00069	0.714
MOD_GSK3_1	96	103	PF00069	0.665
MOD_N-GLC_1	185	190	PF02516	0.567
MOD_N-GLC_1	416	421	PF02516	0.546
MOD_N-GLC_1	63	68	PF02516	0.641
MOD_N-GLC_1	885	890	PF02516	0.474
MOD_NEK2_1	120	125	PF00069	0.468
MOD_NEK2_1	185	190	PF00069	0.582
MOD_NEK2_1	19	24	PF00069	0.473
MOD_NEK2_1	277	282	PF00069	0.610
MOD_NEK2_1	287	292	PF00069	0.497
MOD_NEK2_1	376	381	PF00069	0.628
MOD_NEK2_1	427	432	PF00069	0.596
MOD_NEK2_1	501	506	PF00069	0.632
MOD_NEK2_1	547	552	PF00069	0.653
MOD_NEK2_1	559	564	PF00069	0.460
MOD_NEK2_1	590	595	PF00069	0.345
MOD_NEK2_1	690	695	PF00069	0.661
MOD_NEK2_1	706	711	PF00069	0.234
MOD_NEK2_1	730	735	PF00069	0.556
MOD_NEK2_1	790	795	PF00069	0.566
MOD_NEK2_1	801	806	PF00069	0.348
MOD_NEK2_1	822	827	PF00069	0.608
MOD_NEK2_1	874	879	PF00069	0.726
MOD_NEK2_1	893	898	PF00069	0.631
MOD_NEK2_1	96	101	PF00069	0.648
MOD_NEK2_2	175	180	PF00069	0.476
MOD_NEK2_2	561	566	PF00069	0.646
MOD_NEK2_2	80	85	PF00069	0.572
MOD_PIKK_1	566	572	PF00454	0.385
MOD_PKA_1	149	155	PF00069	0.406
MOD_PKA_2	103	109	PF00069	0.725
MOD_PKA_2	133	139	PF00069	0.594
MOD_PKA_2	149	155	PF00069	0.399
MOD_PKA_2	247	253	PF00069	0.576
MOD_PKA_2	257	263	PF00069	0.637
MOD_PKA_2	366	372	PF00069	0.758
MOD_PKA_2	6	12	PF00069	0.599
MOD_PKA_2	790	796	PF00069	0.461
MOD_Plk_1	269	275	PF00069	0.742
MOD_Plk_1	416	422	PF00069	0.544
MOD_Plk_1	586	592	PF00069	0.545
MOD_Plk_1	63	69	PF00069	0.670
MOD_Plk_1	72	78	PF00069	0.603
MOD_Plk_2-3	634	640	PF00069	0.480
MOD_Plk_4	120	126	PF00069	0.430
MOD_Plk_4	13	19	PF00069	0.516
MOD_Plk_4	175	181	PF00069	0.569
MOD_Plk_4	273	279	PF00069	0.636
MOD_Plk_4	387	393	PF00069	0.442
MOD_Plk_4	423	429	PF00069	0.584
MOD_Plk_4	435	441	PF00069	0.395
MOD_Plk_4	485	491	PF00069	0.658
MOD_Plk_4	547	553	PF00069	0.707
MOD_Plk_4	637	643	PF00069	0.253
MOD_Plk_4	722	728	PF00069	0.427
MOD_Plk_4	791	797	PF00069	0.609
MOD_Plk_4	801	807	PF00069	0.433
MOD_ProDKin_1	166	172	PF00069	0.546
MOD_ProDKin_1	346	352	PF00069	0.491
MOD_ProDKin_1	404	410	PF00069	0.525
MOD_ProDKin_1	45	51	PF00069	0.519
MOD_ProDKin_1	591	597	PF00069	0.343
MOD_ProDKin_1	838	844	PF00069	0.481
TRG_DiLeu_BaEn_4	633	639	PF01217	0.338
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.530
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.659
TRG_ENDOCYTIC_2	227	230	PF00928	0.577
TRG_ENDOCYTIC_2	890	893	PF00928	0.545
TRG_ER_diArg_1	148	150	PF00400	0.411
TRG_ER_diArg_1	222	224	PF00400	0.573
TRG_ER_diArg_1	332	335	PF00400	0.553
TRG_ER_diArg_1	466	468	PF00400	0.578
TRG_ER_diArg_1	471	474	PF00400	0.743
TRG_ER_diArg_1	480	483	PF00400	0.408
TRG_ER_diArg_1	579	582	PF00400	0.362
TRG_ER_diArg_1	657	659	PF00400	0.442
TRG_ER_diArg_1	687	689	PF00400	0.633
TRG_NES_CRM1_1	633	644	PF08389	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE8	Leptomonas seymouri	34%	100%
A0A451EJP9	Leishmania donovani	66%	100%
E9ACJ2	Leishmania major	66%	100%
E9AG36	Leishmania infantum	67%	100%
E9AJT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%