HAD hydrolase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGI1_LEIBR

TriTrypDb:

LbrM.28.1440 , LBRM2903_280020700

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	258	260	PF00675	0.274
CLV_NRD_NRD_1	8	10	PF00675	0.342
CLV_NRD_NRD_1	81	83	PF00675	0.186
CLV_PCSK_FUR_1	6	10	PF00082	0.326
CLV_PCSK_KEX2_1	8	10	PF00082	0.342
CLV_PCSK_KEX2_1	81	83	PF00082	0.186
CLV_PCSK_SKI1_1	134	138	PF00082	0.264
CLV_PCSK_SKI1_1	175	179	PF00082	0.264
CLV_PCSK_SKI1_1	262	266	PF00082	0.414
DEG_APCC_DBOX_1	8	16	PF00400	0.381
DEG_Kelch_Keap1_1	37	42	PF01344	0.396
DEG_MDM2_SWIB_1	136	144	PF02201	0.423
DEG_Nend_UBRbox_3	1	3	PF02207	0.318
DEG_SPOP_SBC_1	15	19	PF00917	0.405
DOC_MAPK_gen_1	206	213	PF00069	0.464
DOC_MAPK_gen_1	240	248	PF00069	0.438
DOC_MAPK_HePTP_8	152	164	PF00069	0.464
DOC_MAPK_MEF2A_6	155	164	PF00069	0.464
DOC_MAPK_MEF2A_6	240	248	PF00069	0.410
DOC_PP1_RVXF_1	132	138	PF00149	0.464
DOC_USP7_MATH_1	226	230	PF00917	0.437
DOC_USP7_MATH_2	194	200	PF00917	0.450
DOC_USP7_UBL2_3	130	134	PF12436	0.386
DOC_USP7_UBL2_3	175	179	PF12436	0.464
DOC_WW_Pin1_4	118	123	PF00397	0.508
DOC_WW_Pin1_4	199	204	PF00397	0.482
DOC_WW_Pin1_4	20	25	PF00397	0.469
LIG_14-3-3_CanoR_1	198	202	PF00244	0.424
LIG_14-3-3_CanoR_1	206	212	PF00244	0.439
LIG_deltaCOP1_diTrp_1	76	84	PF00928	0.458
LIG_FHA_1	113	119	PF00498	0.426
LIG_FHA_1	38	44	PF00498	0.435
LIG_FHA_1	68	74	PF00498	0.401
LIG_FHA_2	171	177	PF00498	0.391
LIG_FHA_2	249	255	PF00498	0.519
LIG_GBD_Chelix_1	53	61	PF00786	0.237
LIG_LIR_Gen_1	184	194	PF02991	0.450
LIG_LIR_Gen_1	56	63	PF02991	0.403
LIG_LIR_Nem_3	56	61	PF02991	0.403
LIG_Pex14_2	136	140	PF04695	0.464
LIG_REV1ctd_RIR_1	2	13	PF16727	0.344
LIG_SH2_CRK	58	62	PF00017	0.379
LIG_SH2_STAP1	187	191	PF00017	0.450
LIG_SH2_STAT3	96	99	PF00017	0.450
LIG_SH2_STAT5	26	29	PF00017	0.437
LIG_SH3_3	116	122	PF00018	0.402
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.386
LIG_SUMO_SIM_par_1	50	56	PF11976	0.375
LIG_TRFH_1	58	62	PF08558	0.403
MOD_CDK_SPxxK_3	199	206	PF00069	0.450
MOD_CK1_1	123	129	PF00069	0.444
MOD_CK1_1	158	164	PF00069	0.429
MOD_CK1_1	199	205	PF00069	0.450
MOD_CK2_1	140	146	PF00069	0.478
MOD_CK2_1	248	254	PF00069	0.519
MOD_GlcNHglycan	109	113	PF01048	0.331
MOD_GlcNHglycan	122	125	PF01048	0.278
MOD_GlcNHglycan	164	167	PF01048	0.277
MOD_GlcNHglycan	224	227	PF01048	0.226
MOD_GlcNHglycan	93	96	PF01048	0.269
MOD_GSK3_1	104	111	PF00069	0.483
MOD_GSK3_1	114	121	PF00069	0.502
MOD_GSK3_1	136	143	PF00069	0.490
MOD_GSK3_1	158	165	PF00069	0.525
MOD_GSK3_1	16	23	PF00069	0.514
MOD_GSK3_1	218	225	PF00069	0.413
MOD_GSK3_1	63	70	PF00069	0.455
MOD_NEK2_1	148	153	PF00069	0.491
MOD_NEK2_1	160	165	PF00069	0.468
MOD_NEK2_1	170	175	PF00069	0.496
MOD_NEK2_1	207	212	PF00069	0.440
MOD_NEK2_1	222	227	PF00069	0.550
MOD_PKA_2	197	203	PF00069	0.391
MOD_Plk_1	140	146	PF00069	0.423
MOD_Plk_1	148	154	PF00069	0.406
MOD_Plk_1	158	164	PF00069	0.431
MOD_Plk_1	218	224	PF00069	0.386
MOD_Plk_4	114	120	PF00069	0.414
MOD_Plk_4	140	146	PF00069	0.423
MOD_Plk_4	218	224	PF00069	0.386
MOD_ProDKin_1	118	124	PF00069	0.508
MOD_ProDKin_1	199	205	PF00069	0.482
MOD_ProDKin_1	20	26	PF00069	0.458
TRG_DiLeu_BaEn_1	39	44	PF01217	0.492
TRG_DiLeu_BaEn_1	56	61	PF01217	0.366
TRG_ENDOCYTIC_2	187	190	PF00928	0.471
TRG_ENDOCYTIC_2	58	61	PF00928	0.379
TRG_ENDOCYTIC_2	98	101	PF00928	0.426
TRG_ER_diArg_1	239	242	PF00400	0.426
TRG_ER_diArg_1	80	82	PF00400	0.386
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	61%	82%
A0A0N0P7W9	Leptomonas seymouri	33%	92%
A0A0N1I1D8	Leptomonas seymouri	41%	81%
A0A0N1I836	Leptomonas seymouri	32%	91%
A0A0N1I9R7	Leptomonas seymouri	24%	94%
A0A0N1ILU0	Leptomonas seymouri	25%	71%
A0A0N1IM34	Leptomonas seymouri	29%	96%
A0A0N1PEM6	Leptomonas seymouri	28%	69%
A0A1X0NRL0	Trypanosomatidae	27%	92%
A0A1X0NYN3	Trypanosomatidae	33%	82%
A0A1X0NYY3	Trypanosomatidae	30%	91%
A0A3Q8IAZ9	Leishmania donovani	29%	93%
A0A3Q8IDX0	Leishmania donovani	39%	80%
A0A3Q8IEU6	Leishmania donovani	27%	67%
A0A3Q8IGR3	Leishmania donovani	79%	80%
A0A3R7M7Z1	Trypanosoma rangeli	27%	92%
A0A3S7X1G8	Leishmania donovani	28%	94%
A0A422MX56	Trypanosoma rangeli	31%	98%
A0A422N4F0	Trypanosoma rangeli	26%	70%
A1A8B5	Escherichia coli O1:K1 / APEC	30%	99%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	29%	98%
A4HGI5	Leishmania braziliensis	100%	100%
A4HGI6	Leishmania braziliensis	40%	80%
A4HGI8	Leishmania braziliensis	28%	89%
A4HGI9	Leishmania braziliensis	27%	95%
A4HGJ0	Leishmania braziliensis	28%	71%
A4I3L3	Leishmania infantum	76%	100%
A4I3L4	Leishmania infantum	39%	80%
A4I3L5	Leishmania infantum	29%	93%
A4I3L6	Leishmania infantum	28%	94%
A4I3L7	Leishmania infantum	27%	67%
A4TPD3	Yersinia pestis (strain Pestoides F)	29%	98%
A4W7B7	Enterobacter sp. (strain 638)	28%	99%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	27%	99%
A7FLB5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	29%	98%
A7MFJ6	Cronobacter sakazakii (strain ATCC BAA-894)	28%	99%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	30%	99%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	30%	99%
A8AK07	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	27%	99%
A8GAR8	Serratia proteamaculans (strain 568)	25%	98%
A9MM14	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	28%	99%
A9QZP3	Yersinia pestis bv. Antiqua (strain Angola)	29%	98%
B1IZE7	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	30%	100%
B1JHR2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	29%	98%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	30%	99%
B1XFN4	Escherichia coli (strain K12 / DH10B)	30%	99%
B2K6W6	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	29%	98%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	30%	99%
B4SWV0	Salmonella newport (strain SL254)	28%	99%
B5Y0T3	Klebsiella pneumoniae (strain 342)	28%	99%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	30%	99%
B6HZQ3	Escherichia coli (strain SE11)	30%	99%
B7L683	Escherichia coli (strain 55989 / EAEC)	30%	99%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	30%	99%
B7M3T9	Escherichia coli O8 (strain IAI1)	30%	99%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	30%	99%
B7MQG2	Escherichia coli O81 (strain ED1a)	30%	99%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	30%	99%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	30%	99%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	30%	99%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	30%	99%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	86%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%
E9AZV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	80%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	93%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	67%
P27848	Escherichia coli (strain K12)	33%	100%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	99%
P46891	Escherichia coli (strain K12)	30%	99%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	27%	99%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	31%	99%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	30%	99%
Q1C4L7	Yersinia pestis bv. Antiqua (strain Antiqua)	29%	98%
Q1CL56	Yersinia pestis bv. Antiqua (strain Nepal516)	29%	98%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	30%	99%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	30%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	30%	99%
Q4Q8C8	Leishmania major	29%	100%
Q4Q8C9	Leishmania major	28%	100%
Q4Q8D0	Leishmania major	28%	100%
Q4Q8D1	Leishmania major	40%	100%
Q4Q8D2	Leishmania major	75%	100%
Q66DS5	Yersinia pseudotuberculosis serotype I (strain IP32953)	29%	98%
Q7CK25	Yersinia pestis	29%	98%
Q83M49	Shigella flexneri	31%	99%
Q89B25	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	25%	100%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	99%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	98%
Q8X8L6	Escherichia coli O157:H7	33%	100%
Q8XE50	Escherichia coli O157:H7	30%	99%
V5BGL5	Trypanosoma cruzi	30%	85%
V5D8D2	Trypanosoma cruzi	30%	86%