Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGI0_LEIBR

TriTrypDb:

LbrM.28.1430 , LBRM2903_280020600

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4HGI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.620
CLV_PCSK_KEX2_1	23	25	PF00082	0.563
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.563
CLV_PCSK_SKI1_1	132	136	PF00082	0.473
CLV_PCSK_SKI1_1	310	314	PF00082	0.490
CLV_PCSK_SKI1_1	5	9	PF00082	0.534
CLV_PCSK_SKI1_1	72	76	PF00082	0.575
DEG_APCC_DBOX_1	150	158	PF00400	0.459
DEG_APCC_DBOX_1	167	175	PF00400	0.307
DEG_SPOP_SBC_1	17	21	PF00917	0.543
DOC_CYCLIN_yClb1_LxF_4	130	135	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	66	69	PF00134	0.501
DOC_MAPK_JIP1_4	92	98	PF00069	0.540
DOC_MAPK_MEF2A_6	203	212	PF00069	0.423
DOC_PP1_RVXF_1	130	136	PF00149	0.469
DOC_PP2B_LxvP_1	15	18	PF13499	0.535
DOC_PP2B_LxvP_1	66	69	PF13499	0.501
DOC_USP7_MATH_1	114	118	PF00917	0.700
DOC_USP7_MATH_1	139	143	PF00917	0.630
DOC_USP7_MATH_1	18	22	PF00917	0.593
DOC_USP7_MATH_1	36	40	PF00917	0.622
DOC_WW_Pin1_4	137	142	PF00397	0.618
DOC_WW_Pin1_4	48	53	PF00397	0.629
LIG_14-3-3_CanoR_1	132	141	PF00244	0.487
LIG_14-3-3_CanoR_1	151	155	PF00244	0.419
LIG_14-3-3_CanoR_1	161	166	PF00244	0.356
LIG_14-3-3_CanoR_1	287	296	PF00244	0.341
LIG_14-3-3_CanoR_1	5	15	PF00244	0.545
LIG_Actin_WH2_2	272	289	PF00022	0.488
LIG_CtBP_PxDLS_1	145	151	PF00389	0.386
LIG_deltaCOP1_diTrp_1	56	62	PF00928	0.602
LIG_FHA_1	207	213	PF00498	0.425
LIG_FHA_1	258	264	PF00498	0.426
LIG_FHA_1	62	68	PF00498	0.708
LIG_FHA_2	214	220	PF00498	0.433
LIG_FHA_2	300	306	PF00498	0.437
LIG_LIR_Gen_1	219	228	PF02991	0.429
LIG_LIR_Gen_1	262	270	PF02991	0.293
LIG_LIR_Nem_3	219	223	PF02991	0.419
LIG_LIR_Nem_3	262	268	PF02991	0.384
LIG_LIR_Nem_3	272	277	PF02991	0.289
LIG_LIR_Nem_3	33	38	PF02991	0.524
LIG_MYND_1	108	112	PF01753	0.555
LIG_SH2_PTP2	220	223	PF00017	0.412
LIG_SH2_SRC	199	202	PF00017	0.453
LIG_SH2_STAT5	158	161	PF00017	0.443
LIG_SH2_STAT5	199	202	PF00017	0.595
LIG_SH2_STAT5	214	217	PF00017	0.434
LIG_SH2_STAT5	220	223	PF00017	0.356
LIG_SH2_STAT5	54	57	PF00017	0.497
LIG_SH3_2	104	109	PF14604	0.538
LIG_SH3_3	101	107	PF00018	0.799
LIG_SH3_3	207	213	PF00018	0.425
LIG_SUMO_SIM_par_1	191	198	PF11976	0.328
LIG_SUMO_SIM_par_1	259	264	PF11976	0.427
LIG_TYR_ITIM	218	223	PF00017	0.418
LIG_UBA3_1	66	72	PF00899	0.509
MOD_CDK_SPK_2	48	53	PF00069	0.523
MOD_CK1_1	153	159	PF00069	0.404
MOD_CK1_1	160	166	PF00069	0.343
MOD_CK1_1	269	275	PF00069	0.368
MOD_CK1_1	28	34	PF00069	0.647
MOD_CK1_1	44	50	PF00069	0.690
MOD_CK1_1	86	92	PF00069	0.560
MOD_CK2_1	113	119	PF00069	0.562
MOD_CK2_1	213	219	PF00069	0.436
MOD_GlcNHglycan	141	144	PF01048	0.568
MOD_GlcNHglycan	231	234	PF01048	0.578
MOD_GlcNHglycan	30	33	PF01048	0.681
MOD_GlcNHglycan	43	46	PF01048	0.702
MOD_GlcNHglycan	72	75	PF01048	0.590
MOD_GlcNHglycan	78	82	PF01048	0.665
MOD_GlcNHglycan	86	89	PF01048	0.603
MOD_GSK3_1	133	140	PF00069	0.607
MOD_GSK3_1	153	160	PF00069	0.271
MOD_GSK3_1	229	236	PF00069	0.649
MOD_GSK3_1	24	31	PF00069	0.645
MOD_GSK3_1	257	264	PF00069	0.436
MOD_GSK3_1	36	43	PF00069	0.533
MOD_GSK3_1	44	51	PF00069	0.621
MOD_LATS_1	22	28	PF00433	0.547
MOD_NEK2_1	157	162	PF00069	0.429
MOD_NEK2_1	195	200	PF00069	0.325
MOD_NEK2_1	308	313	PF00069	0.358
MOD_NEK2_1	61	66	PF00069	0.634
MOD_NEK2_2	36	41	PF00069	0.526
MOD_PIKK_1	86	92	PF00454	0.560
MOD_PKA_2	150	156	PF00069	0.471
MOD_PKA_2	160	166	PF00069	0.355
MOD_PKA_2	195	201	PF00069	0.459
MOD_PKA_2	40	46	PF00069	0.611
MOD_PKA_2	70	76	PF00069	0.683
MOD_Plk_1	261	267	PF00069	0.435
MOD_Plk_4	195	201	PF00069	0.459
MOD_Plk_4	206	212	PF00069	0.419
MOD_ProDKin_1	137	143	PF00069	0.614
MOD_ProDKin_1	48	54	PF00069	0.627
MOD_SUMO_for_1	108	111	PF00179	0.554
TRG_DiLeu_BaEn_1	189	194	PF01217	0.341
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.565
TRG_ENDOCYTIC_2	220	223	PF00928	0.412
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDS7	Leishmania donovani	64%	93%
A4I3L2	Leishmania infantum	64%	93%
E9AZV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	97%
Q4Q8D3	Leishmania major	63%	100%