4-hydroxybenzoate polyprenyltransferase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prenyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGH9_LEIBR

TriTrypDb:

LbrM.28.1420 , LBRM2903_280020500

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGH9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006720	isoprenoid metabolic process	4	11
GO:0006743	ubiquinone metabolic process	5	11
GO:0006744	ubiquinone biosynthetic process	6	11
GO:0008152	metabolic process	1	11
GO:0008299	isoprenoid biosynthetic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11
GO:0042181	ketone biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901661	quinone metabolic process	4	11
GO:1901663	quinone biosynthetic process	5	11

Molecular functions
Term	Name	Level	Count
GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	6	11
GO:0002094	polyprenyltransferase activity	5	11
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	6	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.204
CLV_NRD_NRD_1	272	274	PF00675	0.242
CLV_NRD_NRD_1	289	291	PF00675	0.159
CLV_NRD_NRD_1	3	5	PF00675	0.401
CLV_NRD_NRD_1	445	447	PF00675	0.525
CLV_NRD_NRD_1	71	73	PF00675	0.317
CLV_PCSK_KEX2_1	215	217	PF00082	0.218
CLV_PCSK_KEX2_1	272	274	PF00082	0.292
CLV_PCSK_KEX2_1	3	5	PF00082	0.401
CLV_PCSK_KEX2_1	445	447	PF00082	0.525
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.218
CLV_PCSK_SKI1_1	215	219	PF00082	0.218
CLV_PCSK_SKI1_1	291	295	PF00082	0.232
CLV_PCSK_SKI1_1	394	398	PF00082	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DEG_SPOP_SBC_1	469	473	PF00917	0.249
DOC_CDC14_PxL_1	217	225	PF14671	0.411
DOC_CYCLIN_RxL_1	388	402	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.204
DOC_MAPK_gen_1	350	360	PF00069	0.452
DOC_MAPK_HePTP_8	213	225	PF00069	0.413
DOC_MAPK_HePTP_8	240	252	PF00069	0.238
DOC_MAPK_MEF2A_6	216	225	PF00069	0.413
DOC_MAPK_MEF2A_6	243	252	PF00069	0.204
DOC_MAPK_MEF2A_6	353	362	PF00069	0.302
DOC_PP1_RVXF_1	104	111	PF00149	0.238
DOC_PP1_RVXF_1	83	90	PF00149	0.548
DOC_PP2B_LxvP_1	118	121	PF13499	0.204
DOC_PP2B_LxvP_1	92	95	PF13499	0.257
DOC_PP4_FxxP_1	418	421	PF00568	0.350
DOC_PP4_FxxP_1	83	86	PF00568	0.567
DOC_USP7_MATH_1	312	316	PF00917	0.250
DOC_USP7_MATH_1	35	39	PF00917	0.599
DOC_USP7_MATH_1	370	374	PF00917	0.384
DOC_USP7_MATH_1	387	391	PF00917	0.308
DOC_USP7_UBL2_3	277	281	PF12436	0.423
DOC_WW_Pin1_4	191	196	PF00397	0.204
DOC_WW_Pin1_4	2	7	PF00397	0.669
DOC_WW_Pin1_4	202	207	PF00397	0.238
LIG_14-3-3_CanoR_1	216	224	PF00244	0.404
LIG_14-3-3_CanoR_1	381	387	PF00244	0.522
LIG_BRCT_BRCA1_1	473	477	PF00533	0.264
LIG_Clathr_ClatBox_1	80	84	PF01394	0.457
LIG_deltaCOP1_diTrp_1	147	153	PF00928	0.460
LIG_deltaCOP1_diTrp_1	340	348	PF00928	0.460
LIG_EH1_1	317	325	PF00400	0.183
LIG_FHA_1	103	109	PF00498	0.297
LIG_FHA_1	347	353	PF00498	0.535
LIG_FHA_1	55	61	PF00498	0.523
LIG_FHA_2	411	417	PF00498	0.261
LIG_FHA_2	474	480	PF00498	0.268
LIG_LIR_Apic_2	416	421	PF02991	0.344
LIG_LIR_Gen_1	150	161	PF02991	0.404
LIG_LIR_Gen_1	260	269	PF02991	0.242
LIG_LIR_Gen_1	393	401	PF02991	0.466
LIG_LIR_Gen_1	472	483	PF02991	0.337
LIG_LIR_Nem_3	205	211	PF02991	0.385
LIG_LIR_Nem_3	260	266	PF02991	0.282
LIG_LIR_Nem_3	393	398	PF02991	0.463
LIG_LIR_Nem_3	479	484	PF02991	0.356
LIG_LIR_Nem_3	5	11	PF02991	0.672
LIG_LYPXL_S_1	210	214	PF13949	0.286
LIG_LYPXL_S_1	7	11	PF13949	0.322
LIG_LYPXL_yS_3	211	214	PF13949	0.438
LIG_LYPXL_yS_3	8	11	PF13949	0.523
LIG_PCNA_PIPBox_1	130	139	PF02747	0.303
LIG_PCNA_yPIPBox_3	130	139	PF02747	0.303
LIG_PDZ_Class_2	484	489	PF00595	0.334
LIG_Pex14_1	149	153	PF04695	0.434
LIG_Pex14_1	259	263	PF04695	0.238
LIG_Pex14_1	414	418	PF04695	0.348
LIG_SH2_CRK	237	241	PF00017	0.258
LIG_SH2_CRK	263	267	PF00017	0.238
LIG_SH2_CRK	77	81	PF00017	0.384
LIG_SH2_NCK_1	263	267	PF00017	0.238
LIG_SH2_PTP2	319	322	PF00017	0.257
LIG_SH2_PTP2	357	360	PF00017	0.311
LIG_SH2_STAP1	237	241	PF00017	0.238
LIG_SH2_STAP1	263	267	PF00017	0.247
LIG_SH2_STAT3	267	270	PF00017	0.404
LIG_SH2_STAT3	448	451	PF00017	0.340
LIG_SH2_STAT5	136	139	PF00017	0.371
LIG_SH2_STAT5	253	256	PF00017	0.183
LIG_SH2_STAT5	292	295	PF00017	0.371
LIG_SH2_STAT5	319	322	PF00017	0.238
LIG_SH2_STAT5	357	360	PF00017	0.330
LIG_SH2_STAT5	407	410	PF00017	0.391
LIG_SH2_STAT5	448	451	PF00017	0.294
LIG_SH2_STAT5	475	478	PF00017	0.273
LIG_SH3_1	3	9	PF00018	0.662
LIG_SH3_3	118	124	PF00018	0.228
LIG_SH3_3	245	251	PF00018	0.217
LIG_SH3_3	3	9	PF00018	0.667
LIG_SH3_3	435	441	PF00018	0.412
LIG_TRAF2_1	45	48	PF00917	0.526
LIG_TYR_ITIM	235	240	PF00017	0.238
LIG_TYR_ITIM	261	266	PF00017	0.238
LIG_UBA3_1	209	215	PF00899	0.260
MOD_CK1_1	21	27	PF00069	0.574
MOD_CK1_1	390	396	PF00069	0.372
MOD_CK1_1	463	469	PF00069	0.396
MOD_CK1_1	471	477	PF00069	0.461
MOD_CK2_1	168	174	PF00069	0.417
MOD_CK2_1	370	376	PF00069	0.498
MOD_CK2_1	41	47	PF00069	0.597
MOD_GlcNHglycan	174	178	PF01048	0.296
MOD_GlcNHglycan	20	23	PF01048	0.373
MOD_GlcNHglycan	294	297	PF01048	0.229
MOD_GlcNHglycan	307	310	PF01048	0.225
MOD_GlcNHglycan	384	387	PF01048	0.570
MOD_GlcNHglycan	39	42	PF01048	0.409
MOD_GlcNHglycan	427	430	PF01048	0.576
MOD_GlcNHglycan	43	46	PF01048	0.419
MOD_GlcNHglycan	453	456	PF01048	0.550
MOD_GSK3_1	198	205	PF00069	0.282
MOD_GSK3_1	35	42	PF00069	0.599
MOD_GSK3_1	382	389	PF00069	0.420
MOD_GSK3_1	399	406	PF00069	0.431
MOD_GSK3_1	447	454	PF00069	0.266
MOD_GSK3_1	465	472	PF00069	0.213
MOD_GSK3_1	9	16	PF00069	0.613
MOD_GSK3_1	98	105	PF00069	0.276
MOD_N-GLC_1	191	196	PF02516	0.410
MOD_N-GLC_1	451	456	PF02516	0.602
MOD_N-GLC_2	366	368	PF02516	0.303
MOD_NEK2_1	102	107	PF00069	0.238
MOD_NEK2_1	137	142	PF00069	0.265
MOD_NEK2_1	198	203	PF00069	0.426
MOD_NEK2_1	262	267	PF00069	0.326
MOD_NEK2_1	305	310	PF00069	0.254
MOD_PIKK_1	310	316	PF00454	0.238
MOD_PIKK_1	447	453	PF00454	0.438
MOD_PIKK_1	482	488	PF00454	0.298
MOD_PK_1	328	334	PF00069	0.161
MOD_PKA_1	215	221	PF00069	0.404
MOD_PKA_2	215	221	PF00069	0.404
MOD_PKA_2	380	386	PF00069	0.523
MOD_Plk_1	173	179	PF00069	0.328
MOD_Plk_1	403	409	PF00069	0.415
MOD_Plk_1	451	457	PF00069	0.396
MOD_Plk_1	463	469	PF00069	0.389
MOD_Plk_1	47	53	PF00069	0.664
MOD_Plk_1	54	60	PF00069	0.657
MOD_Plk_4	262	268	PF00069	0.278
MOD_Plk_4	328	334	PF00069	0.422
MOD_Plk_4	387	393	PF00069	0.379
MOD_Plk_4	473	479	PF00069	0.264
MOD_ProDKin_1	191	197	PF00069	0.204
MOD_ProDKin_1	2	8	PF00069	0.669
MOD_ProDKin_1	202	208	PF00069	0.238
MOD_SUMO_for_1	45	48	PF00179	0.536
MOD_SUMO_for_1	58	61	PF00179	0.562
MOD_SUMO_rev_2	147	153	PF00179	0.417
TRG_ENDOCYTIC_2	211	214	PF00928	0.438
TRG_ENDOCYTIC_2	237	240	PF00928	0.258
TRG_ENDOCYTIC_2	263	266	PF00928	0.238
TRG_ENDOCYTIC_2	319	322	PF00928	0.257
TRG_ENDOCYTIC_2	357	360	PF00928	0.330
TRG_ENDOCYTIC_2	475	478	PF00928	0.332
TRG_ENDOCYTIC_2	481	484	PF00928	0.342
TRG_ENDOCYTIC_2	77	80	PF00928	0.538
TRG_ENDOCYTIC_2	8	11	PF00928	0.548
TRG_ER_diArg_1	2	4	PF00400	0.605
TRG_ER_diArg_1	444	446	PF00400	0.330
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG5	Leptomonas seymouri	75%	100%
A0A1X0NRA0	Trypanosomatidae	62%	100%
A0A3Q8II29	Leishmania donovani	86%	100%
A0A3R7KN50	Trypanosoma rangeli	59%	100%
A4I3L1	Leishmania infantum	86%	100%
D0A8C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AZV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q10252	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q298G6	Drosophila pseudoobscura pseudoobscura	35%	100%
Q4Q8D4	Leishmania major	87%	100%
Q93YP7	Arabidopsis thaliana	32%	100%
V5BFC2	Trypanosoma cruzi	57%	100%