Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGH8_LEIBR

TriTrypDb:

LbrM.28.1410 , LBRM2903_280020400

Length:

897

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGH8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003724	RNA helicase activity	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008186	ATP-dependent activity, acting on RNA	2	11
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	608	612	PF00656	0.634
CLV_C14_Caspase3-7	725	729	PF00656	0.644
CLV_C14_Caspase3-7	873	877	PF00656	0.647
CLV_NRD_NRD_1	12	14	PF00675	0.448
CLV_NRD_NRD_1	184	186	PF00675	0.248
CLV_NRD_NRD_1	298	300	PF00675	0.215
CLV_NRD_NRD_1	355	357	PF00675	0.237
CLV_NRD_NRD_1	48	50	PF00675	0.447
CLV_NRD_NRD_1	547	549	PF00675	0.564
CLV_NRD_NRD_1	645	647	PF00675	0.561
CLV_NRD_NRD_1	685	687	PF00675	0.582
CLV_NRD_NRD_1	721	723	PF00675	0.568
CLV_NRD_NRD_1	764	766	PF00675	0.487
CLV_NRD_NRD_1	767	769	PF00675	0.490
CLV_NRD_NRD_1	776	778	PF00675	0.544
CLV_NRD_NRD_1	856	858	PF00675	0.670
CLV_PCSK_FUR_1	765	769	PF00082	0.517
CLV_PCSK_KEX2_1	11	13	PF00082	0.440
CLV_PCSK_KEX2_1	186	188	PF00082	0.237
CLV_PCSK_KEX2_1	309	311	PF00082	0.227
CLV_PCSK_KEX2_1	355	357	PF00082	0.237
CLV_PCSK_KEX2_1	48	50	PF00082	0.478
CLV_PCSK_KEX2_1	643	645	PF00082	0.542
CLV_PCSK_KEX2_1	764	766	PF00082	0.494
CLV_PCSK_KEX2_1	767	769	PF00082	0.498
CLV_PCSK_KEX2_1	858	860	PF00082	0.649
CLV_PCSK_KEX2_1	891	893	PF00082	0.707
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.420
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.237
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.237
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.542
CLV_PCSK_PC1ET2_1	858	860	PF00082	0.672
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.698
CLV_PCSK_PC7_1	182	188	PF00082	0.161
CLV_PCSK_SKI1_1	167	171	PF00082	0.312
CLV_PCSK_SKI1_1	335	339	PF00082	0.237
CLV_PCSK_SKI1_1	440	444	PF00082	0.440
CLV_PCSK_SKI1_1	485	489	PF00082	0.289
CLV_PCSK_SKI1_1	518	522	PF00082	0.515
CLV_PCSK_SKI1_1	572	576	PF00082	0.645
CLV_PCSK_SKI1_1	663	667	PF00082	0.704
CLV_PCSK_SKI1_1	686	690	PF00082	0.604
CLV_PCSK_SKI1_1	827	831	PF00082	0.605
CLV_PCSK_SKI1_1	97	101	PF00082	0.199
DEG_APCC_DBOX_1	184	192	PF00400	0.449
DEG_Nend_UBRbox_1	1	4	PF02207	0.656
DEG_SPOP_SBC_1	60	64	PF00917	0.686
DOC_CKS1_1	195	200	PF01111	0.437
DOC_CKS1_1	420	425	PF01111	0.334
DOC_CYCLIN_yCln2_LP_2	381	387	PF00134	0.437
DOC_MAPK_gen_1	185	193	PF00069	0.437
DOC_MAPK_gen_1	299	307	PF00069	0.289
DOC_MAPK_gen_1	338	347	PF00069	0.445
DOC_MAPK_gen_1	352	361	PF00069	0.416
DOC_MAPK_gen_1	365	372	PF00069	0.437
DOC_MAPK_gen_1	656	666	PF00069	0.562
DOC_MAPK_MEF2A_6	186	195	PF00069	0.437
DOC_MAPK_MEF2A_6	355	363	PF00069	0.448
DOC_MAPK_MEF2A_6	97	104	PF00069	0.523
DOC_MAPK_NFAT4_5	97	105	PF00069	0.523
DOC_PP1_RVXF_1	117	124	PF00149	0.437
DOC_PP1_RVXF_1	313	320	PF00149	0.437
DOC_PP1_RVXF_1	377	384	PF00149	0.437
DOC_PP1_RVXF_1	475	482	PF00149	0.289
DOC_PP1_RVXF_1	661	667	PF00149	0.671
DOC_PP1_SILK_1	237	242	PF00149	0.415
DOC_PP2B_LxvP_1	505	508	PF13499	0.294
DOC_PP4_FxxP_1	123	126	PF00568	0.437
DOC_PP4_FxxP_1	420	423	PF00568	0.327
DOC_PP4_FxxP_1	850	853	PF00568	0.499
DOC_USP7_MATH_1	235	239	PF00917	0.542
DOC_USP7_MATH_1	264	268	PF00917	0.400
DOC_USP7_MATH_1	508	512	PF00917	0.346
DOC_USP7_MATH_1	55	59	PF00917	0.546
DOC_USP7_MATH_1	60	64	PF00917	0.659
DOC_USP7_MATH_1	612	616	PF00917	0.759
DOC_USP7_MATH_1	692	696	PF00917	0.752
DOC_USP7_MATH_1	795	799	PF00917	0.676
DOC_USP7_UBL2_3	11	15	PF12436	0.607
DOC_USP7_UBL2_3	335	339	PF12436	0.448
DOC_USP7_UBL2_3	891	895	PF12436	0.711
DOC_WW_Pin1_4	145	150	PF00397	0.437
DOC_WW_Pin1_4	194	199	PF00397	0.437
DOC_WW_Pin1_4	281	286	PF00397	0.412
DOC_WW_Pin1_4	419	424	PF00397	0.334
DOC_WW_Pin1_4	90	95	PF00397	0.401
LIG_14-3-3_CanoR_1	2	6	PF00244	0.624
LIG_14-3-3_CanoR_1	247	251	PF00244	0.437
LIG_14-3-3_CanoR_1	272	279	PF00244	0.510
LIG_14-3-3_CanoR_1	365	372	PF00244	0.498
LIG_14-3-3_CanoR_1	414	419	PF00244	0.356
LIG_14-3-3_CanoR_1	86	95	PF00244	0.440
LIG_Actin_RPEL_3	175	194	PF02755	0.361
LIG_Actin_WH2_2	425	442	PF00022	0.321
LIG_APCC_ABBAyCdc20_2	572	578	PF00400	0.592
LIG_APCC_ABBAyCdc20_2	833	839	PF00400	0.627
LIG_BRCT_BRCA1_1	248	252	PF00533	0.542
LIG_BRCT_BRCA1_1	416	420	PF00533	0.335
LIG_BRCT_BRCA1_1	477	481	PF00533	0.289
LIG_Clathr_ClatBox_1	218	222	PF01394	0.478
LIG_DLG_GKlike_1	414	421	PF00625	0.348
LIG_EH1_1	157	165	PF00400	0.448
LIG_EH1_1	188	196	PF00400	0.498
LIG_FAT_LD_1	301	309	PF03623	0.437
LIG_FHA_1	148	154	PF00498	0.437
LIG_FHA_1	235	241	PF00498	0.498
LIG_FHA_1	255	261	PF00498	0.306
LIG_FHA_1	274	280	PF00498	0.495
LIG_FHA_1	709	715	PF00498	0.462
LIG_FHA_1	820	826	PF00498	0.657
LIG_FHA_2	2	8	PF00498	0.446
LIG_FHA_2	420	426	PF00498	0.336
LIG_FHA_2	545	551	PF00498	0.557
LIG_FHA_2	60	66	PF00498	0.681
LIG_FHA_2	629	635	PF00498	0.565
LIG_FHA_2	678	684	PF00498	0.521
LIG_FHA_2	778	784	PF00498	0.619
LIG_GBD_Chelix_1	153	161	PF00786	0.237
LIG_GBD_Chelix_1	293	301	PF00786	0.346
LIG_HCF-1_HBM_1	65	68	PF13415	0.631
LIG_IRF3_LxIS_1	71	77	PF10401	0.502
LIG_LIR_Apic_2	120	126	PF02991	0.437
LIG_LIR_Apic_2	417	423	PF02991	0.338
LIG_LIR_Apic_2	847	853	PF02991	0.498
LIG_LIR_Gen_1	454	464	PF02991	0.354
LIG_LIR_Gen_1	65	76	PF02991	0.439
LIG_LIR_Nem_3	357	363	PF02991	0.431
LIG_LIR_Nem_3	382	386	PF02991	0.437
LIG_LIR_Nem_3	454	459	PF02991	0.338
LIG_LIR_Nem_3	65	71	PF02991	0.467
LIG_LIR_Nem_3	865	869	PF02991	0.733
LIG_MAD2	335	343	PF02301	0.448
LIG_MLH1_MIPbox_1	477	481	PF16413	0.305
LIG_NRBOX	300	306	PF00104	0.437
LIG_NRBOX	824	830	PF00104	0.631
LIG_NRP_CendR_1	894	897	PF00754	0.747
LIG_Pex14_1	388	392	PF04695	0.437
LIG_PTB_Apo_2	267	274	PF02174	0.423
LIG_PTB_Phospho_1	267	273	PF10480	0.426
LIG_SH2_CRK	89	93	PF00017	0.459
LIG_SH2_NCK_1	392	396	PF00017	0.462
LIG_SH2_SRC	242	245	PF00017	0.523
LIG_SH2_SRC	431	434	PF00017	0.507
LIG_SH2_STAT3	466	469	PF00017	0.289
LIG_SH2_STAT5	242	245	PF00017	0.505
LIG_SH2_STAT5	273	276	PF00017	0.397
LIG_SH2_STAT5	401	404	PF00017	0.437
LIG_SH2_STAT5	431	434	PF00017	0.507
LIG_SH2_STAT5	448	451	PF00017	0.204
LIG_SH2_STAT5	475	478	PF00017	0.289
LIG_SH2_STAT5	480	483	PF00017	0.289
LIG_SH2_STAT5	89	92	PF00017	0.534
LIG_SH3_3	192	198	PF00018	0.448
LIG_SH3_3	619	625	PF00018	0.662
LIG_Sin3_3	209	216	PF02671	0.512
LIG_SUMO_SIM_par_1	503	509	PF11976	0.319
LIG_TRAF2_1	33	36	PF00917	0.556
LIG_TRAF2_1	451	454	PF00917	0.457
LIG_TRAF2_1	631	634	PF00917	0.653
LIG_TRAF2_1	673	676	PF00917	0.738
LIG_TRAF2_1	702	705	PF00917	0.717
LIG_TYR_ITIM	164	169	PF00017	0.346
LIG_UBA3_1	262	269	PF00899	0.511
LIG_UBA3_1	304	309	PF00899	0.289
LIG_UBA3_1	428	435	PF00899	0.372
LIG_WRC_WIRS_1	360	365	PF05994	0.305
MOD_CDC14_SPxK_1	148	151	PF00782	0.289
MOD_CDK_SPK_2	419	424	PF00069	0.391
MOD_CDK_SPxK_1	145	151	PF00069	0.289
MOD_CDK_SPxK_1	194	200	PF00069	0.289
MOD_CDK_SPxxK_3	90	97	PF00069	0.410
MOD_CK1_1	117	123	PF00069	0.278
MOD_CK1_1	30	36	PF00069	0.490
MOD_CK1_1	397	403	PF00069	0.289
MOD_CK1_1	544	550	PF00069	0.709
MOD_CK1_1	580	586	PF00069	0.608
MOD_CK1_1	610	616	PF00069	0.754
MOD_CK1_1	69	75	PF00069	0.445
MOD_CK1_1	695	701	PF00069	0.736
MOD_CK1_1	77	83	PF00069	0.337
MOD_CK1_1	776	782	PF00069	0.613
MOD_CK1_1	821	827	PF00069	0.602
MOD_CK1_1	890	896	PF00069	0.708
MOD_CK2_1	30	36	PF00069	0.464
MOD_CK2_1	419	425	PF00069	0.331
MOD_CK2_1	448	454	PF00069	0.474
MOD_CK2_1	544	550	PF00069	0.562
MOD_CK2_1	59	65	PF00069	0.682
MOD_CK2_1	628	634	PF00069	0.556
MOD_CK2_1	670	676	PF00069	0.710
MOD_CK2_1	695	701	PF00069	0.508
MOD_CK2_1	777	783	PF00069	0.592
MOD_CK2_1	795	801	PF00069	0.660
MOD_CK2_1	814	820	PF00069	0.740
MOD_Cter_Amidation	684	687	PF01082	0.534
MOD_GlcNHglycan	116	119	PF01048	0.289
MOD_GlcNHglycan	170	173	PF01048	0.289
MOD_GlcNHglycan	252	255	PF01048	0.301
MOD_GlcNHglycan	367	370	PF01048	0.374
MOD_GlcNHglycan	396	399	PF01048	0.289
MOD_GlcNHglycan	518	521	PF01048	0.632
MOD_GlcNHglycan	586	589	PF01048	0.772
MOD_GlcNHglycan	611	615	PF01048	0.739
MOD_GlcNHglycan	782	786	PF01048	0.643
MOD_GlcNHglycan	805	808	PF01048	0.732
MOD_GlcNHglycan	839	844	PF01048	0.598
MOD_GlcNHglycan	853	856	PF01048	0.740
MOD_GSK3_1	246	253	PF00069	0.305
MOD_GSK3_1	273	280	PF00069	0.457
MOD_GSK3_1	341	348	PF00069	0.324
MOD_GSK3_1	371	378	PF00069	0.410
MOD_GSK3_1	55	62	PF00069	0.519
MOD_GSK3_1	580	587	PF00069	0.655
MOD_GSK3_1	736	743	PF00069	0.672
MOD_GSK3_1	773	780	PF00069	0.574
MOD_GSK3_1	781	788	PF00069	0.630
MOD_GSK3_1	814	821	PF00069	0.663
MOD_GSK3_1	835	842	PF00069	0.686
MOD_GSK3_1	883	890	PF00069	0.752
MOD_N-GLC_1	60	65	PF02516	0.651
MOD_N-GLC_1	690	695	PF02516	0.563
MOD_N-GLC_1	814	819	PF02516	0.674
MOD_NEK2_1	250	255	PF00069	0.289
MOD_NEK2_1	319	324	PF00069	0.289
MOD_NEK2_1	331	336	PF00069	0.256
MOD_NEK2_1	345	350	PF00069	0.253
MOD_NEK2_1	498	503	PF00069	0.297
MOD_NEK2_1	516	521	PF00069	0.499
MOD_NEK2_2	264	269	PF00069	0.408
MOD_NEK2_2	475	480	PF00069	0.305
MOD_NEK2_2	612	617	PF00069	0.758
MOD_PIKK_1	252	258	PF00454	0.297
MOD_PIKK_1	273	279	PF00454	0.547
MOD_PIKK_1	449	455	PF00454	0.458
MOD_PIKK_1	529	535	PF00454	0.561
MOD_PIKK_1	74	80	PF00454	0.373
MOD_PKA_1	11	17	PF00069	0.377
MOD_PKA_1	777	783	PF00069	0.630
MOD_PKA_1	857	863	PF00069	0.763
MOD_PKA_2	1	7	PF00069	0.625
MOD_PKA_2	11	17	PF00069	0.586
MOD_PKA_2	246	252	PF00069	0.300
MOD_PKA_2	773	779	PF00069	0.589
MOD_Plk_1	440	446	PF00069	0.502
MOD_Plk_2-3	489	495	PF00069	0.351
MOD_Plk_2-3	589	595	PF00069	0.625
MOD_Plk_2-3	668	674	PF00069	0.722
MOD_Plk_2-3	835	841	PF00069	0.625
MOD_Plk_4	235	241	PF00069	0.354
MOD_Plk_4	246	252	PF00069	0.222
MOD_Plk_4	397	403	PF00069	0.286
MOD_Plk_4	414	420	PF00069	0.277
MOD_Plk_4	427	433	PF00069	0.328
MOD_Plk_4	617	623	PF00069	0.754
MOD_ProDKin_1	145	151	PF00069	0.289
MOD_ProDKin_1	194	200	PF00069	0.289
MOD_ProDKin_1	281	287	PF00069	0.406
MOD_ProDKin_1	419	425	PF00069	0.331
MOD_ProDKin_1	90	96	PF00069	0.289
MOD_SUMO_for_1	464	467	PF00179	0.305
MOD_SUMO_rev_2	180	188	PF00179	0.289
TRG_DiLeu_BaEn_1	223	228	PF01217	0.289
TRG_DiLeu_BaEn_2	736	742	PF01217	0.446
TRG_DiLeu_BaEn_4	183	189	PF01217	0.305
TRG_DiLeu_BaEn_4	35	41	PF01217	0.537
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.420
TRG_DiLeu_BaLyEn_6	824	829	PF01217	0.636
TRG_DiLeu_LyEn_5	223	228	PF01217	0.289
TRG_ENDOCYTIC_2	166	169	PF00928	0.346
TRG_ENDOCYTIC_2	559	562	PF00928	0.561
TRG_ENDOCYTIC_2	68	71	PF00928	0.433
TRG_ENDOCYTIC_2	866	869	PF00928	0.738
TRG_ENDOCYTIC_2	89	92	PF00928	0.413
TRG_ER_diArg_1	185	188	PF00400	0.305
TRG_ER_diArg_1	354	356	PF00400	0.289
TRG_ER_diArg_1	47	49	PF00400	0.541
TRG_ER_diArg_1	644	646	PF00400	0.546
TRG_ER_diArg_1	653	656	PF00400	0.568
TRG_ER_diArg_1	719	722	PF00400	0.721
TRG_ER_diArg_1	763	765	PF00400	0.528
TRG_ER_diArg_1	766	768	PF00400	0.484
TRG_ER_diLys_1	894	897	PF00400	0.495
TRG_NLS_MonoCore_2	642	647	PF00514	0.611
TRG_NLS_MonoExtC_3	599	604	PF00514	0.565
TRG_NLS_MonoExtC_3	760	765	PF00514	0.510
TRG_NLS_MonoExtC_3	856	861	PF00514	0.739
TRG_NLS_MonoExtC_3	890	895	PF00514	0.493
TRG_NLS_MonoExtN_4	335	342	PF00514	0.305
TRG_NLS_MonoExtN_4	641	647	PF00514	0.530
TRG_NLS_MonoExtN_4	759	765	PF00514	0.512
TRG_NLS_MonoExtN_4	857	862	PF00514	0.660
TRG_NLS_MonoExtN_4	889	895	PF00514	0.698
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	767	772	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J1	Leptomonas seymouri	73%	100%
A0A0S4JDX4	Bodo saltans	56%	100%
A0A1X0P3K1	Trypanosomatidae	53%	96%
A0A3S7X1H1	Leishmania donovani	86%	100%
A0A3S7XAN8	Leishmania donovani	38%	100%
A0A422NYB4	Trypanosoma rangeli	58%	100%
A4HP48	Leishmania braziliensis	39%	100%
A4I3L0	Leishmania infantum	86%	100%
A4IDF5	Leishmania infantum	38%	100%
C9ZPV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ASV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AZV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q0UMB9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	39%	100%
Q4Q1P0	Leishmania major	38%	100%
Q4Q8D5	Leishmania major	85%	100%
V5DAZ9	Trypanosoma cruzi	57%	95%