RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGH7_LEIBR

TriTrypDb:

LbrM.28.1400 , LBRM2903_280020300

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGH7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.624
CLV_NRD_NRD_1	319	321	PF00675	0.317
CLV_NRD_NRD_1	44	46	PF00675	0.460
CLV_NRD_NRD_1	68	70	PF00675	0.454
CLV_PCSK_KEX2_1	27	29	PF00082	0.503
CLV_PCSK_KEX2_1	44	46	PF00082	0.503
CLV_PCSK_KEX2_1	52	54	PF00082	0.515
CLV_PCSK_KEX2_1	68	70	PF00082	0.411
CLV_PCSK_KEX2_1	89	91	PF00082	0.444
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.558
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.535
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.491
CLV_PCSK_SKI1_1	106	110	PF00082	0.406
CLV_PCSK_SKI1_1	294	298	PF00082	0.384
CLV_PCSK_SKI1_1	59	63	PF00082	0.641
CLV_PCSK_SKI1_1	68	72	PF00082	0.468
CLV_PCSK_SKI1_1	90	94	PF00082	0.409
CLV_Separin_Metazoa	76	80	PF03568	0.333
DEG_APCC_DBOX_1	207	215	PF00400	0.474
DEG_APCC_DBOX_1	43	51	PF00400	0.352
DEG_Nend_UBRbox_2	1	3	PF02207	0.521
DOC_CDC14_PxL_1	262	270	PF14671	0.271
DOC_CYCLIN_RxL_1	86	96	PF00134	0.441
DOC_MAPK_gen_1	172	181	PF00069	0.487
DOC_PP1_RVXF_1	87	94	PF00149	0.598
DOC_PP4_FxxP_1	241	244	PF00568	0.237
DOC_USP7_MATH_1	122	126	PF00917	0.394
DOC_USP7_UBL2_3	294	298	PF12436	0.384
LIG_14-3-3_CanoR_1	175	180	PF00244	0.440
LIG_Actin_WH2_2	321	338	PF00022	0.518
LIG_BH_BH3_1	21	37	PF00452	0.348
LIG_BRCT_BRCA1_1	278	282	PF00533	0.421
LIG_EH1_1	85	93	PF00400	0.316
LIG_FHA_1	112	118	PF00498	0.543
LIG_FHA_1	18	24	PF00498	0.577
LIG_FHA_1	223	229	PF00498	0.406
LIG_FHA_1	231	237	PF00498	0.245
LIG_FHA_1	82	88	PF00498	0.401
LIG_FHA_2	163	169	PF00498	0.458
LIG_FHA_2	238	244	PF00498	0.474
LIG_GBD_Chelix_1	32	40	PF00786	0.387
LIG_LIR_Apic_2	240	244	PF02991	0.243
LIG_LIR_Apic_2	267	272	PF02991	0.218
LIG_LIR_Nem_3	356	362	PF02991	0.518
LIG_LRP6_Inhibitor_1	307	313	PF00058	0.418
LIG_NRBOX	282	288	PF00104	0.360
LIG_PCNA_yPIPBox_3	79	92	PF02747	0.516
LIG_Rb_LxCxE_1	253	273	PF01857	0.335
LIG_SH2_CRK	176	180	PF00017	0.483
LIG_SH2_CRK	269	273	PF00017	0.404
LIG_SH2_STAT3	189	192	PF00017	0.514
LIG_SH2_STAT5	138	141	PF00017	0.429
LIG_SH2_STAT5	189	192	PF00017	0.514
LIG_SH3_3	12	18	PF00018	0.549
LIG_SH3_3	311	317	PF00018	0.469
LIG_SUMO_SIM_anti_2	37	44	PF11976	0.416
LIG_SUMO_SIM_par_1	353	358	PF11976	0.485
LIG_TRAF2_1	165	168	PF00917	0.463
LIG_UBA3_1	101	106	PF00899	0.423
LIG_UBA3_1	116	121	PF00899	0.433
LIG_UBA3_1	328	332	PF00899	0.352
MOD_CK1_1	111	117	PF00069	0.462
MOD_CK1_1	276	282	PF00069	0.368
MOD_CK1_1	38	44	PF00069	0.321
MOD_CK2_1	162	168	PF00069	0.464
MOD_GlcNHglycan	343	346	PF01048	0.633
MOD_GSK3_1	158	165	PF00069	0.384
MOD_GSK3_1	228	235	PF00069	0.530
MOD_GSK3_1	335	342	PF00069	0.575
MOD_GSK3_1	92	99	PF00069	0.398
MOD_NEK2_1	109	114	PF00069	0.335
MOD_NEK2_1	157	162	PF00069	0.455
MOD_NEK2_1	227	232	PF00069	0.528
MOD_NEK2_1	23	28	PF00069	0.500
MOD_NEK2_1	288	293	PF00069	0.426
MOD_NEK2_1	36	41	PF00069	0.329
MOD_NEK2_1	54	59	PF00069	0.489
MOD_NEK2_1	93	98	PF00069	0.434
MOD_PIKK_1	122	128	PF00454	0.382
MOD_PIKK_1	302	308	PF00454	0.490
MOD_PIKK_1	81	87	PF00454	0.523
MOD_PIKK_1	93	99	PF00454	0.510
MOD_PK_1	175	181	PF00069	0.490
MOD_PKA_2	335	341	PF00069	0.516
MOD_Plk_1	158	164	PF00069	0.388
MOD_Plk_1	228	234	PF00069	0.427
MOD_Plk_1	36	42	PF00069	0.455
MOD_Plk_4	264	270	PF00069	0.278
MOD_Plk_4	38	44	PF00069	0.362
MOD_SUMO_for_1	104	107	PF00179	0.425
MOD_SUMO_for_1	70	73	PF00179	0.515
MOD_SUMO_rev_2	118	123	PF00179	0.458
TRG_DiLeu_BaEn_1	73	78	PF01217	0.332
TRG_DiLeu_BaEn_4	118	124	PF01217	0.459
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.536
TRG_ENDOCYTIC_2	176	179	PF00928	0.533
TRG_ER_diArg_1	113	116	PF00400	0.563
TRG_ER_diArg_1	43	45	PF00400	0.368
TRG_ER_diArg_1	67	69	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.394
TRG_PTS2	1	36	PF00400	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6L8	Leptomonas seymouri	66%	100%
A0A1X0P3W0	Trypanosomatidae	47%	93%
A0A3R7KVC5	Trypanosoma rangeli	46%	90%
A0A3S7X1G5	Leishmania donovani	79%	91%
A4I3K9	Leishmania infantum	79%	91%
C9ZPW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	89%
E9AZU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	91%
Q4Q8D6	Leishmania major	79%	100%
V5AUY7	Trypanosoma cruzi	49%	80%