Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGH6_LEIBR

TriTrypDb:

LbrM.28.1390 , LBRM2903_280020200

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.392
CLV_C14_Caspase3-7	86	90	PF00656	0.462
CLV_NRD_NRD_1	394	396	PF00675	0.501
CLV_NRD_NRD_1	412	414	PF00675	0.609
CLV_NRD_NRD_1	8	10	PF00675	0.540
CLV_NRD_NRD_1	83	85	PF00675	0.396
CLV_PCSK_KEX2_1	114	116	PF00082	0.509
CLV_PCSK_KEX2_1	299	301	PF00082	0.678
CLV_PCSK_KEX2_1	394	396	PF00082	0.554
CLV_PCSK_KEX2_1	412	414	PF00082	0.567
CLV_PCSK_KEX2_1	8	10	PF00082	0.554
CLV_PCSK_KEX2_1	83	85	PF00082	0.396
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.429
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.544
CLV_PCSK_PC7_1	4	10	PF00082	0.678
CLV_PCSK_SKI1_1	114	118	PF00082	0.501
DEG_APCC_KENBOX_2	207	211	PF00400	0.437
DEG_SPOP_SBC_1	266	270	PF00917	0.695
DEG_SPOP_SBC_1	344	348	PF00917	0.408
DOC_MAPK_gen_1	114	124	PF00069	0.457
DOC_MAPK_MEF2A_6	118	126	PF00069	0.455
DOC_PP4_FxxP_1	184	187	PF00568	0.376
DOC_USP7_MATH_1	103	107	PF00917	0.325
DOC_USP7_MATH_1	187	191	PF00917	0.598
DOC_USP7_MATH_1	265	269	PF00917	0.663
DOC_USP7_MATH_1	278	282	PF00917	0.816
DOC_USP7_MATH_1	31	35	PF00917	0.483
DOC_USP7_UBL2_3	114	118	PF12436	0.441
DOC_USP7_UBL2_3	15	19	PF12436	0.402
DOC_WW_Pin1_4	183	188	PF00397	0.362
DOC_WW_Pin1_4	224	229	PF00397	0.389
DOC_WW_Pin1_4	274	279	PF00397	0.630
DOC_WW_Pin1_4	375	380	PF00397	0.576
DOC_WW_Pin1_4	419	424	PF00397	0.539
LIG_BRCT_BRCA1_1	405	409	PF00533	0.646
LIG_FHA_1	175	181	PF00498	0.370
LIG_FHA_1	191	197	PF00498	0.572
LIG_FHA_1	41	47	PF00498	0.478
LIG_FHA_1	5	11	PF00498	0.557
LIG_FHA_2	153	159	PF00498	0.482
LIG_FHA_2	174	180	PF00498	0.500
LIG_FHA_2	338	344	PF00498	0.548
LIG_Integrin_RGD_1	321	323	PF01839	0.509
LIG_LIR_Gen_1	156	167	PF02991	0.407
LIG_LIR_Gen_1	67	77	PF02991	0.320
LIG_LIR_Gen_1	89	99	PF02991	0.463
LIG_LIR_Nem_3	156	162	PF02991	0.384
LIG_LIR_Nem_3	209	215	PF02991	0.550
LIG_LIR_Nem_3	323	329	PF02991	0.470
LIG_LIR_Nem_3	67	72	PF02991	0.322
LIG_LIR_Nem_3	89	94	PF02991	0.480
LIG_LYPXL_S_1	109	113	PF13949	0.438
LIG_LYPXL_yS_3	110	113	PF13949	0.447
LIG_PCNA_yPIPBox_3	93	107	PF02747	0.470
LIG_PDZ_Class_3	423	428	PF00595	0.561
LIG_Pex14_2	326	330	PF04695	0.415
LIG_SH2_CRK	159	163	PF00017	0.326
LIG_SH2_CRK	75	79	PF00017	0.344
LIG_SH2_CRK	91	95	PF00017	0.337
LIG_SH2_GRB2like	91	94	PF00017	0.552
LIG_SH2_STAP1	148	152	PF00017	0.414
LIG_SH2_STAP1	159	163	PF00017	0.286
LIG_SH2_STAT5	205	208	PF00017	0.384
LIG_SH2_STAT5	353	356	PF00017	0.497
LIG_SH3_1	75	81	PF00018	0.344
LIG_SH3_2	78	83	PF14604	0.357
LIG_SH3_3	113	119	PF00018	0.524
LIG_SH3_3	227	233	PF00018	0.308
LIG_SH3_3	71	77	PF00018	0.355
LIG_SUMO_SIM_par_1	135	141	PF11976	0.299
LIG_TRAF2_1	61	64	PF00917	0.521
LIG_WRC_WIRS_1	130	135	PF05994	0.450
LIG_WRC_WIRS_1	96	101	PF05994	0.340
MOD_CDK_SPK_2	274	279	PF00069	0.523
MOD_CK1_1	132	138	PF00069	0.530
MOD_CK1_1	151	157	PF00069	0.283
MOD_CK1_1	18	24	PF00069	0.506
MOD_CK1_1	190	196	PF00069	0.567
MOD_CK1_1	269	275	PF00069	0.710
MOD_CK1_1	280	286	PF00069	0.717
MOD_CK1_1	346	352	PF00069	0.651
MOD_CK1_1	359	365	PF00069	0.475
MOD_CK1_1	408	414	PF00069	0.667
MOD_CK1_1	95	101	PF00069	0.337
MOD_CK2_1	152	158	PF00069	0.534
MOD_CK2_1	337	343	PF00069	0.533
MOD_CK2_1	344	350	PF00069	0.644
MOD_CK2_1	58	64	PF00069	0.435
MOD_CK2_1	95	101	PF00069	0.371
MOD_GlcNHglycan	134	137	PF01048	0.302
MOD_GlcNHglycan	272	275	PF01048	0.656
MOD_GlcNHglycan	282	285	PF01048	0.793
MOD_GlcNHglycan	295	298	PF01048	0.661
MOD_GlcNHglycan	339	343	PF01048	0.477
MOD_GlcNHglycan	373	376	PF01048	0.633
MOD_GlcNHglycan	405	408	PF01048	0.438
MOD_GSK3_1	147	154	PF00069	0.413
MOD_GSK3_1	169	176	PF00069	0.528
MOD_GSK3_1	183	190	PF00069	0.540
MOD_GSK3_1	224	231	PF00069	0.383
MOD_GSK3_1	265	272	PF00069	0.614
MOD_GSK3_1	273	280	PF00069	0.653
MOD_GSK3_1	371	378	PF00069	0.629
MOD_N-GLC_1	173	178	PF02516	0.552
MOD_N-GLC_1	92	97	PF02516	0.503
MOD_NEK2_1	152	157	PF00069	0.385
MOD_NEK2_1	405	410	PF00069	0.620
MOD_NEK2_1	417	422	PF00069	0.562
MOD_NEK2_2	211	216	PF00069	0.434
MOD_PIKK_1	228	234	PF00454	0.514
MOD_PKA_2	174	180	PF00069	0.448
MOD_Plk_1	173	179	PF00069	0.502
MOD_Plk_1	92	98	PF00069	0.501
MOD_Plk_4	216	222	PF00069	0.341
MOD_Plk_4	95	101	PF00069	0.343
MOD_ProDKin_1	183	189	PF00069	0.371
MOD_ProDKin_1	224	230	PF00069	0.392
MOD_ProDKin_1	274	280	PF00069	0.629
MOD_ProDKin_1	375	381	PF00069	0.577
MOD_ProDKin_1	419	425	PF00069	0.538
TRG_DiLeu_BaEn_1	158	163	PF01217	0.472
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.275
TRG_ENDOCYTIC_2	110	113	PF00928	0.447
TRG_ENDOCYTIC_2	159	162	PF00928	0.371
TRG_ENDOCYTIC_2	212	215	PF00928	0.425
TRG_ENDOCYTIC_2	91	94	PF00928	0.433
TRG_ER_diArg_1	122	125	PF00400	0.543
TRG_ER_diArg_1	412	414	PF00400	0.577
TRG_ER_diArg_1	8	10	PF00400	0.585
TRG_ER_diArg_1	82	84	PF00400	0.364
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK1	Leptomonas seymouri	62%	100%
A0A0S4JAC2	Bodo saltans	28%	100%
A0A1X0P2Q2	Trypanosomatidae	40%	100%
A0A3Q8ID39	Leishmania donovani	82%	97%
A0A422NY97	Trypanosoma rangeli	40%	100%
A4I3K8	Leishmania infantum	82%	97%
C9ZPW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q4Q8D7	Leishmania major	82%	100%
V5BAD6	Trypanosoma cruzi	43%	100%