Putative phenylalanine-4-hydroxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phenylalanine-4-hydroxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGH5_LEIBR

TriTrypDb:

LbrM.28.1380 , LBRM2903_280020100

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGH5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	4
GO:0006520	amino acid metabolic process	3	4
GO:0006558	L-phenylalanine metabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009072	aromatic amino acid metabolic process	4	4
GO:0009987	cellular process	1	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044281	small molecule metabolic process	2	4
GO:0071704	organic substance metabolic process	2	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004497	monooxygenase activity	3	9
GO:0004505	phenylalanine 4-monooxygenase activity	5	6
GO:0005488	binding	1	9
GO:0005506	iron ion binding	6	9
GO:0016491	oxidoreductase activity	2	9
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	9
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	4	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.378
CLV_C14_Caspase3-7	400	404	PF00656	0.463
CLV_NRD_NRD_1	167	169	PF00675	0.265
CLV_NRD_NRD_1	5	7	PF00675	0.487
CLV_PCSK_FUR_1	164	168	PF00082	0.330
CLV_PCSK_KEX2_1	166	168	PF00082	0.265
CLV_PCSK_KEX2_1	4	6	PF00082	0.484
CLV_PCSK_KEX2_1	446	448	PF00082	0.658
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.573
CLV_PCSK_SKI1_1	252	256	PF00082	0.285
CLV_PCSK_SKI1_1	261	265	PF00082	0.240
CLV_PCSK_SKI1_1	329	333	PF00082	0.330
CLV_PCSK_SKI1_1	5	9	PF00082	0.583
CLV_PCSK_SKI1_1	86	90	PF00082	0.374
DEG_APCC_DBOX_1	260	268	PF00400	0.530
DEG_APCC_DBOX_1	4	12	PF00400	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DOC_CDC14_PxL_1	297	305	PF14671	0.530
DOC_CKS1_1	285	290	PF01111	0.463
DOC_MAPK_gen_1	164	173	PF00069	0.518
DOC_MAPK_gen_1	175	185	PF00069	0.552
DOC_MAPK_gen_1	35	45	PF00069	0.455
DOC_MAPK_MEF2A_6	109	117	PF00069	0.310
DOC_MAPK_MEF2A_6	38	47	PF00069	0.431
DOC_PP1_RVXF_1	330	336	PF00149	0.463
DOC_USP7_UBL2_3	178	182	PF12436	0.414
DOC_USP7_UBL2_3	31	35	PF12436	0.585
DOC_WW_Pin1_4	284	289	PF00397	0.478
DOC_WW_Pin1_4	381	386	PF00397	0.530
LIG_14-3-3_CanoR_1	194	199	PF00244	0.539
LIG_14-3-3_CanoR_1	270	278	PF00244	0.463
LIG_14-3-3_CanoR_1	38	44	PF00244	0.400
LIG_14-3-3_CanoR_1	428	434	PF00244	0.527
LIG_14-3-3_CanoR_1	57	62	PF00244	0.365
LIG_14-3-3_CterR_2	447	452	PF00244	0.622
LIG_BRCT_BRCA1_1	259	263	PF00533	0.463
LIG_BRCT_BRCA1_1	336	340	PF00533	0.488
LIG_Dynein_DLC8_1	308	314	PF01221	0.467
LIG_eIF4E_1	217	223	PF01652	0.530
LIG_FHA_1	253	259	PF00498	0.493
LIG_FHA_1	273	279	PF00498	0.395
LIG_FHA_1	310	316	PF00498	0.531
LIG_FHA_1	85	91	PF00498	0.443
LIG_FHA_2	16	22	PF00498	0.525
LIG_FHA_2	187	193	PF00498	0.463
LIG_FHA_2	257	263	PF00498	0.543
LIG_LIR_Apic_2	120	124	PF02991	0.371
LIG_LIR_Gen_1	197	208	PF02991	0.472
LIG_LIR_Gen_1	305	315	PF02991	0.472
LIG_LIR_Gen_1	437	445	PF02991	0.534
LIG_LIR_Gen_1	87	96	PF02991	0.386
LIG_LIR_Nem_3	110	115	PF02991	0.308
LIG_LIR_Nem_3	197	203	PF02991	0.498
LIG_LIR_Nem_3	305	311	PF02991	0.476
LIG_LIR_Nem_3	421	426	PF02991	0.465
LIG_LIR_Nem_3	437	441	PF02991	0.415
LIG_LIR_Nem_3	87	92	PF02991	0.379
LIG_NRBOX	54	60	PF00104	0.390
LIG_PCNA_yPIPBox_3	405	417	PF02747	0.498
LIG_PDZ_Class_2	447	452	PF00595	0.653
LIG_Pex14_1	196	200	PF04695	0.555
LIG_SH2_CRK	215	219	PF00017	0.530
LIG_SH2_GRB2like	79	82	PF00017	0.571
LIG_SH2_PTP2	217	220	PF00017	0.530
LIG_SH2_STAP1	273	277	PF00017	0.488
LIG_SH2_STAP1	336	340	PF00017	0.463
LIG_SH2_STAP1	426	430	PF00017	0.463
LIG_SH2_STAP1	79	83	PF00017	0.478
LIG_SH2_STAT3	273	276	PF00017	0.488
LIG_SH2_STAT5	188	191	PF00017	0.463
LIG_SH2_STAT5	217	220	PF00017	0.533
LIG_SH2_STAT5	277	280	PF00017	0.463
LIG_SH2_STAT5	286	289	PF00017	0.463
LIG_SH2_STAT5	395	398	PF00017	0.463
LIG_SH2_STAT5	420	423	PF00017	0.510
LIG_SH2_STAT5	95	98	PF00017	0.417
LIG_SH3_3	121	127	PF00018	0.300
LIG_SH3_3	148	154	PF00018	0.485
LIG_SH3_3	372	378	PF00018	0.463
LIG_SH3_3	58	64	PF00018	0.431
LIG_SUMO_SIM_par_1	219	225	PF11976	0.518
LIG_TRAF2_1	143	146	PF00917	0.530
LIG_TRAF2_1	189	192	PF00917	0.463
LIG_TRAF2_1	413	416	PF00917	0.518
LIG_TYR_ITIM	198	203	PF00017	0.518
LIG_UBA3_1	326	332	PF00899	0.530
MOD_CK1_1	25	31	PF00069	0.463
MOD_CK1_1	39	45	PF00069	0.480
MOD_CK1_1	46	52	PF00069	0.553
MOD_CK2_1	186	192	PF00069	0.471
MOD_CK2_1	356	362	PF00069	0.492
MOD_CK2_1	410	416	PF00069	0.552
MOD_GlcNHglycan	15	18	PF01048	0.467
MOD_GlcNHglycan	224	227	PF01048	0.205
MOD_GlcNHglycan	25	28	PF01048	0.410
MOD_GlcNHglycan	359	362	PF01048	0.252
MOD_GlcNHglycan	50	54	PF01048	0.354
MOD_GSK3_1	22	29	PF00069	0.585
MOD_GSK3_1	222	229	PF00069	0.481
MOD_GSK3_1	252	259	PF00069	0.546
MOD_GSK3_1	316	323	PF00069	0.488
MOD_GSK3_1	34	41	PF00069	0.435
MOD_GSK3_1	418	425	PF00069	0.487
MOD_GSK3_1	45	52	PF00069	0.391
MOD_N-GLC_1	186	191	PF02516	0.288
MOD_N-GLC_1	67	72	PF02516	0.421
MOD_NEK2_1	108	113	PF00069	0.391
MOD_NEK2_1	13	18	PF00069	0.588
MOD_NEK2_1	136	141	PF00069	0.463
MOD_NEK2_1	222	227	PF00069	0.536
MOD_NEK2_1	228	233	PF00069	0.501
MOD_NEK2_1	272	277	PF00069	0.473
MOD_NEK2_1	311	316	PF00069	0.530
MOD_NEK2_1	43	48	PF00069	0.396
MOD_NEK2_1	445	450	PF00069	0.617
MOD_NEK2_2	15	20	PF00069	0.568
MOD_NEK2_2	418	423	PF00069	0.530
MOD_NEK2_2	84	89	PF00069	0.491
MOD_PIKK_1	228	234	PF00454	0.474
MOD_PIKK_1	272	278	PF00454	0.463
MOD_PIKK_1	309	315	PF00454	0.530
MOD_PIKK_1	411	417	PF00454	0.518
MOD_PIKK_1	67	73	PF00454	0.499
MOD_PK_1	194	200	PF00069	0.405
MOD_PK_1	57	63	PF00069	0.405
MOD_PKA_2	108	114	PF00069	0.386
MOD_PKA_2	39	45	PF00069	0.586
MOD_Plk_1	136	142	PF00069	0.481
MOD_Plk_1	67	73	PF00069	0.431
MOD_Plk_4	117	123	PF00069	0.383
MOD_Plk_4	418	424	PF00069	0.588
MOD_Plk_4	57	63	PF00069	0.579
MOD_ProDKin_1	284	290	PF00069	0.478
MOD_ProDKin_1	381	387	PF00069	0.530
MOD_SUMO_rev_2	28	37	PF00179	0.559
TRG_DiLeu_BaEn_1	54	59	PF01217	0.464
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.538
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.530
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.568
TRG_DiLeu_LyEn_5	54	59	PF01217	0.307
TRG_ENDOCYTIC_2	200	203	PF00928	0.530
TRG_ENDOCYTIC_2	215	218	PF00928	0.463
TRG_ER_diArg_1	163	166	PF00400	0.530
TRG_ER_diArg_1	3	6	PF00400	0.566
TRG_NES_CRM1_1	291	305	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A060X6Z0	Oncorhynchus mykiss	43%	92%
A0A0N1HZV2	Leptomonas seymouri	81%	100%
A0A0S4JDM5	Bodo saltans	56%	100%
A0A3S5H7J2	Leishmania donovani	92%	100%
A4I3K7	Leishmania infantum	92%	100%
A8X3V8	Caenorhabditis briggsae	45%	87%
B6DT73	Bodo saltans	54%	100%
E9AZU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O17446	Schistosoma mansoni	41%	97%
O42091	Anguilla anguilla	43%	93%
P00439	Homo sapiens	44%	100%
P04176	Rattus norvegicus	43%	100%
P04177	Rattus norvegicus	42%	91%
P07101	Homo sapiens	42%	86%
P09810	Rattus norvegicus	43%	100%
P11982	Phasianidae sp.	42%	92%
P16331	Mus musculus	43%	100%
P17276	Drosophila melanogaster	43%	100%
P17289	Bos taurus	41%	92%
P17290	Oryctolagus cuniculus	43%	100%
P17532	Mus musculus	43%	100%
P17752	Homo sapiens	43%	100%
P18459	Drosophila melanogaster	41%	78%
P24529	Mus musculus	43%	91%
P70080	Gallus gallus	44%	100%
P90925	Caenorhabditis elegans	45%	99%
P90986	Caenorhabditis elegans	46%	87%
Q0EAB8	Equus caballus	41%	92%
Q2HZ26	Macaca mulatta	41%	92%
Q2KIH7	Bos taurus	44%	100%
Q54XS1	Dictyostelium discoideum	47%	100%
Q6WRI4	Leishmania major	91%	100%
Q76IQ3	Canis lupus familiaris	42%	91%
Q8CGU9	Rattus norvegicus	42%	93%
Q8CGV2	Mus musculus	41%	93%
Q8IWU9	Homo sapiens	42%	92%
Q92142	Xenopus laevis	42%	94%