J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGH4_LEIBR

TriTrypDb:

LbrM.28.1370 , LBRM2903_280020000

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.465
CLV_NRD_NRD_1	303	305	PF00675	0.460
CLV_PCSK_KEX2_1	202	204	PF00082	0.465
CLV_PCSK_KEX2_1	303	305	PF00082	0.460
CLV_PCSK_KEX2_1	432	434	PF00082	0.571
CLV_PCSK_KEX2_1	82	84	PF00082	0.326
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.571
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.326
CLV_PCSK_SKI1_1	115	119	PF00082	0.512
CLV_PCSK_SKI1_1	406	410	PF00082	0.495
CLV_PCSK_SKI1_1	412	416	PF00082	0.426
DEG_APCC_DBOX_1	94	102	PF00400	0.441
DEG_SPOP_SBC_1	126	130	PF00917	0.678
DEG_SPOP_SBC_1	228	232	PF00917	0.468
DEG_SPOP_SBC_1	342	346	PF00917	0.532
DOC_MAPK_gen_1	37	46	PF00069	0.315
DOC_MAPK_gen_1	432	442	PF00069	0.495
DOC_MAPK_MEF2A_6	37	46	PF00069	0.315
DOC_MAPK_MEF2A_6	435	444	PF00069	0.542
DOC_PP2B_LxvP_1	390	393	PF13499	0.621
DOC_USP7_MATH_1	126	130	PF00917	0.703
DOC_USP7_MATH_1	150	154	PF00917	0.619
DOC_USP7_MATH_1	228	232	PF00917	0.598
DOC_USP7_MATH_1	270	274	PF00917	0.580
DOC_USP7_MATH_1	302	306	PF00917	0.449
DOC_USP7_MATH_1	309	313	PF00917	0.530
DOC_USP7_MATH_1	342	346	PF00917	0.608
DOC_USP7_MATH_1	434	438	PF00917	0.601
DOC_USP7_MATH_2	181	187	PF00917	0.524
DOC_USP7_MATH_2	257	263	PF00917	0.478
DOC_USP7_UBL2_3	10	14	PF12436	0.517
DOC_WW_Pin1_4	177	182	PF00397	0.552
DOC_WW_Pin1_4	231	236	PF00397	0.593
DOC_WW_Pin1_4	329	334	PF00397	0.558
LIG_14-3-3_CanoR_1	195	200	PF00244	0.682
LIG_14-3-3_CanoR_1	227	236	PF00244	0.539
LIG_14-3-3_CanoR_1	406	415	PF00244	0.489
LIG_14-3-3_CanoR_1	433	442	PF00244	0.441
LIG_14-3-3_CanoR_1	69	77	PF00244	0.344
LIG_Actin_WH2_2	189	204	PF00022	0.594
LIG_APCC_ABBA_1	44	49	PF00400	0.315
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_Clathr_ClatBox_1	249	253	PF01394	0.611
LIG_FHA_1	114	120	PF00498	0.558
LIG_FHA_1	237	243	PF00498	0.666
LIG_FHA_1	279	285	PF00498	0.695
LIG_FHA_1	336	342	PF00498	0.601
LIG_FHA_1	344	350	PF00498	0.590
LIG_FHA_2	330	336	PF00498	0.568
LIG_FHA_2	55	61	PF00498	0.311
LIG_LIR_Gen_1	218	228	PF02991	0.445
LIG_LIR_Gen_1	357	368	PF02991	0.405
LIG_LIR_Gen_1	443	450	PF02991	0.562
LIG_LIR_Gen_1	71	80	PF02991	0.306
LIG_LIR_Nem_3	218	223	PF02991	0.471
LIG_LIR_Nem_3	239	243	PF02991	0.522
LIG_LIR_Nem_3	357	363	PF02991	0.402
LIG_LIR_Nem_3	443	447	PF02991	0.527
LIG_LIR_Nem_3	71	77	PF02991	0.306
LIG_LYPXL_SIV_4	354	362	PF13949	0.509
LIG_Rb_pABgroove_1	291	299	PF01858	0.404
LIG_RPA_C_Fungi	298	310	PF08784	0.439
LIG_SH2_CRK	220	224	PF00017	0.533
LIG_SH2_CRK	355	359	PF00017	0.495
LIG_SH2_CRK	360	364	PF00017	0.437
LIG_SH2_CRK	39	43	PF00017	0.315
LIG_SH2_CRK	67	71	PF00017	0.315
LIG_SH2_CRK	74	78	PF00017	0.315
LIG_SH2_NCK_1	355	359	PF00017	0.511
LIG_SH2_NCK_1	360	364	PF00017	0.452
LIG_SH2_SRC	187	190	PF00017	0.487
LIG_SH2_STAP1	236	240	PF00017	0.581
LIG_SH2_STAP1	355	359	PF00017	0.520
LIG_SH3_3	161	167	PF00018	0.708
LIG_SH3_3	266	272	PF00018	0.651
LIG_SH3_3	279	285	PF00018	0.465
LIG_SUMO_SIM_par_1	279	288	PF11976	0.442
LIG_SUMO_SIM_par_1	289	294	PF11976	0.380
LIG_TRAF2_1	186	189	PF00917	0.495
LIG_TYR_ITIM	353	358	PF00017	0.515
LIG_WW_1	18	21	PF00397	0.443
MOD_CDK_SPxxK_3	231	238	PF00069	0.519
MOD_CK1_1	127	133	PF00069	0.656
MOD_CK1_1	13	19	PF00069	0.628
MOD_CK1_1	165	171	PF00069	0.564
MOD_CK1_1	177	183	PF00069	0.561
MOD_CK1_1	231	237	PF00069	0.553
MOD_CK1_1	305	311	PF00069	0.617
MOD_CK1_1	318	324	PF00069	0.532
MOD_CK1_1	340	346	PF00069	0.591
MOD_CK2_1	177	183	PF00069	0.620
MOD_CK2_1	329	335	PF00069	0.614
MOD_CK2_1	341	347	PF00069	0.522
MOD_CK2_1	404	410	PF00069	0.487
MOD_CK2_1	54	60	PF00069	0.311
MOD_CK2_1	75	81	PF00069	0.305
MOD_GlcNHglycan	141	144	PF01048	0.733
MOD_GlcNHglycan	15	18	PF01048	0.468
MOD_GlcNHglycan	231	234	PF01048	0.562
MOD_GlcNHglycan	304	307	PF01048	0.653
MOD_GlcNHglycan	406	409	PF01048	0.493
MOD_GlcNHglycan	83	86	PF01048	0.320
MOD_GSK3_1	124	131	PF00069	0.698
MOD_GSK3_1	135	142	PF00069	0.659
MOD_GSK3_1	173	180	PF00069	0.725
MOD_GSK3_1	223	230	PF00069	0.567
MOD_GSK3_1	305	312	PF00069	0.728
MOD_GSK3_1	314	321	PF00069	0.787
MOD_GSK3_1	337	344	PF00069	0.632
MOD_GSK3_1	396	403	PF00069	0.472
MOD_GSK3_1	406	413	PF00069	0.457
MOD_LATS_1	38	44	PF00433	0.227
MOD_N-GLC_1	177	182	PF02516	0.552
MOD_N-GLC_1	318	323	PF02516	0.661
MOD_N-GLC_1	400	405	PF02516	0.567
MOD_N-GLC_1	54	59	PF02516	0.233
MOD_NEK2_1	113	118	PF00069	0.543
MOD_NEK2_1	125	130	PF00069	0.605
MOD_NEK2_1	223	228	PF00069	0.443
MOD_NEK2_1	229	234	PF00069	0.447
MOD_NEK2_1	291	296	PF00069	0.430
MOD_NEK2_1	353	358	PF00069	0.583
MOD_PIKK_1	215	221	PF00454	0.424
MOD_PIKK_1	400	406	PF00454	0.461
MOD_PKA_1	40	46	PF00069	0.315
MOD_PKA_2	302	308	PF00069	0.608
MOD_PKA_2	434	440	PF00069	0.497
MOD_PKA_2	68	74	PF00069	0.330
MOD_Plk_1	162	168	PF00069	0.552
MOD_Plk_1	318	324	PF00069	0.523
MOD_Plk_1	393	399	PF00069	0.556
MOD_Plk_2-3	183	189	PF00069	0.519
MOD_Plk_4	270	276	PF00069	0.487
MOD_Plk_4	278	284	PF00069	0.522
MOD_Plk_4	393	399	PF00069	0.518
MOD_ProDKin_1	177	183	PF00069	0.551
MOD_ProDKin_1	231	237	PF00069	0.588
MOD_ProDKin_1	329	335	PF00069	0.561
TRG_DiLeu_BaEn_1	245	250	PF01217	0.565
TRG_DiLeu_BaEn_1	347	352	PF01217	0.480
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.571
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.524
TRG_ENDOCYTIC_2	21	24	PF00928	0.315
TRG_ENDOCYTIC_2	220	223	PF00928	0.530
TRG_ENDOCYTIC_2	355	358	PF00928	0.496
TRG_ENDOCYTIC_2	360	363	PF00928	0.438
TRG_ENDOCYTIC_2	39	42	PF00928	0.315
TRG_ENDOCYTIC_2	67	70	PF00928	0.315
TRG_ENDOCYTIC_2	74	77	PF00928	0.315
TRG_ER_diArg_1	201	203	PF00400	0.453
TRG_ER_diArg_1	63	66	PF00400	0.270
TRG_ER_diArg_1	94	97	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU4	Leptomonas seymouri	42%	96%
A0A3Q8IEL1	Leishmania donovani	71%	96%
A4I3K6	Leishmania infantum	71%	96%
E9AZU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	94%
Q4Q8D9	Leishmania major	70%	100%