Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGH2_LEIBR

TriTrypDb:

LbrM.28.1350 , LBRM2903_280019800

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGH2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.496
CLV_NRD_NRD_1	132	134	PF00675	0.713
CLV_NRD_NRD_1	163	165	PF00675	0.561
CLV_NRD_NRD_1	184	186	PF00675	0.675
CLV_NRD_NRD_1	333	335	PF00675	0.472
CLV_NRD_NRD_1	346	348	PF00675	0.285
CLV_NRD_NRD_1	410	412	PF00675	0.483
CLV_NRD_NRD_1	95	97	PF00675	0.399
CLV_PCSK_FUR_1	410	414	PF00082	0.492
CLV_PCSK_KEX2_1	132	134	PF00082	0.702
CLV_PCSK_KEX2_1	163	165	PF00082	0.561
CLV_PCSK_KEX2_1	184	186	PF00082	0.584
CLV_PCSK_KEX2_1	333	335	PF00082	0.493
CLV_PCSK_KEX2_1	410	412	PF00082	0.479
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.520
CLV_PCSK_SKI1_1	241	245	PF00082	0.431
CLV_PCSK_SKI1_1	327	331	PF00082	0.513
CLV_PCSK_SKI1_1	33	37	PF00082	0.406
CLV_PCSK_SKI1_1	48	52	PF00082	0.446
DEG_APCC_DBOX_1	32	40	PF00400	0.479
DEG_APCC_DBOX_1	332	340	PF00400	0.391
DEG_APCC_KENBOX_2	137	141	PF00400	0.490
DEG_SPOP_SBC_1	213	217	PF00917	0.507
DEG_SPOP_SBC_1	415	419	PF00917	0.392
DOC_CYCLIN_RxL_1	105	116	PF00134	0.312
DOC_MAPK_gen_1	12	22	PF00069	0.380
DOC_MAPK_gen_1	398	408	PF00069	0.564
DOC_MAPK_MEF2A_6	12	20	PF00069	0.361
DOC_PP2B_LxvP_1	110	113	PF13499	0.544
DOC_PP4_FxxP_1	22	25	PF00568	0.447
DOC_USP7_MATH_1	124	128	PF00917	0.621
DOC_USP7_MATH_1	131	135	PF00917	0.627
DOC_USP7_MATH_1	176	180	PF00917	0.670
DOC_USP7_MATH_1	214	218	PF00917	0.601
DOC_USP7_MATH_1	284	288	PF00917	0.345
DOC_USP7_MATH_1	414	418	PF00917	0.501
DOC_USP7_UBL2_3	97	101	PF12436	0.509
DOC_WW_Pin1_4	102	107	PF00397	0.333
DOC_WW_Pin1_4	127	132	PF00397	0.702
DOC_WW_Pin1_4	155	160	PF00397	0.661
DOC_WW_Pin1_4	166	171	PF00397	0.552
DOC_WW_Pin1_4	222	227	PF00397	0.507
DOC_WW_Pin1_4	422	427	PF00397	0.681
LIG_14-3-3_CanoR_1	114	122	PF00244	0.470
LIG_14-3-3_CanoR_1	163	171	PF00244	0.704
LIG_14-3-3_CanoR_1	255	260	PF00244	0.483
LIG_14-3-3_CanoR_1	96	104	PF00244	0.588
LIG_BIR_II_1	1	5	PF00653	0.398
LIG_BRCT_BRCA1_1	115	119	PF00533	0.402
LIG_BRCT_BRCA1_1	214	218	PF00533	0.510
LIG_BRCT_BRCA1_1	257	261	PF00533	0.315
LIG_eIF4E_1	239	245	PF01652	0.504
LIG_FHA_2	222	228	PF00498	0.455
LIG_FHA_2	273	279	PF00498	0.515
LIG_FHA_2	79	85	PF00498	0.434
LIG_FHA_2	98	104	PF00498	0.321
LIG_Integrin_RGD_1	276	278	PF01839	0.596
LIG_LIR_Apic_2	19	25	PF02991	0.433
LIG_LIR_Gen_1	2	11	PF02991	0.443
LIG_LIR_Gen_1	247	257	PF02991	0.416
LIG_LIR_Gen_1	268	274	PF02991	0.416
LIG_LIR_Gen_1	290	299	PF02991	0.332
LIG_LIR_Gen_1	400	408	PF02991	0.455
LIG_LIR_Gen_1	60	70	PF02991	0.407
LIG_LIR_Gen_1	74	85	PF02991	0.414
LIG_LIR_Gen_1	88	95	PF02991	0.338
LIG_LIR_Nem_3	116	122	PF02991	0.310
LIG_LIR_Nem_3	247	253	PF02991	0.388
LIG_LIR_Nem_3	268	273	PF02991	0.466
LIG_LIR_Nem_3	290	294	PF02991	0.357
LIG_LIR_Nem_3	296	301	PF02991	0.395
LIG_LIR_Nem_3	400	406	PF02991	0.436
LIG_LIR_Nem_3	60	65	PF02991	0.421
LIG_LIR_Nem_3	74	80	PF02991	0.414
LIG_LIR_Nem_3	88	92	PF02991	0.338
LIG_MLH1_MIPbox_1	115	119	PF16413	0.421
LIG_Pex14_2	250	254	PF04695	0.346
LIG_Pex14_2	294	298	PF04695	0.398
LIG_PTB_Apo_2	300	307	PF02174	0.475
LIG_PTB_Phospho_1	300	306	PF10480	0.472
LIG_SH2_CRK	306	310	PF00017	0.446
LIG_SH2_CRK	89	93	PF00017	0.356
LIG_SH2_STAP1	120	124	PF00017	0.369
LIG_SH2_STAP1	365	369	PF00017	0.567
LIG_SH2_STAP1	403	407	PF00017	0.461
LIG_SH2_STAP1	89	93	PF00017	0.375
LIG_SH2_STAT5	231	234	PF00017	0.467
LIG_SH2_STAT5	272	275	PF00017	0.351
LIG_SH2_STAT5	297	300	PF00017	0.438
LIG_SH2_STAT5	53	56	PF00017	0.609
LIG_SH2_STAT5	93	96	PF00017	0.384
LIG_SH3_3	15	21	PF00018	0.385
LIG_SH3_3	180	186	PF00018	0.594
LIG_SH3_3	188	194	PF00018	0.586
LIG_SH3_3	205	211	PF00018	0.640
LIG_SH3_3	256	262	PF00018	0.492
LIG_SUMO_SIM_anti_2	81	88	PF11976	0.362
LIG_TRAF2_1	397	400	PF00917	0.493
LIG_TYR_ITIM	304	309	PF00017	0.437
LIG_WW_3	181	185	PF00397	0.602
MOD_CDC14_SPxK_1	105	108	PF00782	0.348
MOD_CDC14_SPxK_1	169	172	PF00782	0.701
MOD_CDK_SPK_2	127	132	PF00069	0.475
MOD_CDK_SPxK_1	102	108	PF00069	0.340
MOD_CDK_SPxK_1	127	133	PF00069	0.466
MOD_CDK_SPxK_1	166	172	PF00069	0.713
MOD_CDK_SPxK_1	222	228	PF00069	0.538
MOD_CK1_1	127	133	PF00069	0.715
MOD_CK1_1	174	180	PF00069	0.590
MOD_CK2_1	221	227	PF00069	0.456
MOD_CK2_1	394	400	PF00069	0.505
MOD_DYRK1A_RPxSP_1	422	426	PF00069	0.715
MOD_GlcNHglycan	124	127	PF01048	0.486
MOD_GlcNHglycan	164	167	PF01048	0.649
MOD_GlcNHglycan	173	176	PF01048	0.674
MOD_GlcNHglycan	178	181	PF01048	0.522
MOD_GlcNHglycan	197	200	PF01048	0.637
MOD_GlcNHglycan	286	289	PF01048	0.490
MOD_GSK3_1	127	134	PF00069	0.654
MOD_GSK3_1	149	156	PF00069	0.600
MOD_GSK3_1	162	169	PF00069	0.552
MOD_GSK3_1	171	178	PF00069	0.636
MOD_GSK3_1	280	287	PF00069	0.463
MOD_GSK3_1	416	423	PF00069	0.674
MOD_N-GLC_1	139	144	PF02516	0.609
MOD_N-GLC_1	97	102	PF02516	0.499
MOD_NEK2_1	1	6	PF00069	0.453
MOD_NEK2_1	122	127	PF00069	0.645
MOD_NEK2_1	323	328	PF00069	0.322
MOD_NEK2_2	214	219	PF00069	0.502
MOD_PIKK_1	71	77	PF00454	0.487
MOD_PK_1	255	261	PF00069	0.304
MOD_PK_1	385	391	PF00069	0.460
MOD_PKA_1	132	138	PF00069	0.696
MOD_PKA_1	96	102	PF00069	0.568
MOD_PKA_2	113	119	PF00069	0.441
MOD_PKA_2	131	137	PF00069	0.703
MOD_PKA_2	162	168	PF00069	0.693
MOD_PKA_2	171	177	PF00069	0.655
MOD_PKA_2	307	313	PF00069	0.429
MOD_PKA_2	394	400	PF00069	0.479
MOD_Plk_1	385	391	PF00069	0.345
MOD_Plk_1	78	84	PF00069	0.368
MOD_Plk_2-3	73	79	PF00069	0.431
MOD_Plk_4	214	220	PF00069	0.660
MOD_Plk_4	293	299	PF00069	0.431
MOD_Plk_4	385	391	PF00069	0.460
MOD_ProDKin_1	102	108	PF00069	0.340
MOD_ProDKin_1	127	133	PF00069	0.707
MOD_ProDKin_1	155	161	PF00069	0.662
MOD_ProDKin_1	166	172	PF00069	0.555
MOD_ProDKin_1	222	228	PF00069	0.499
MOD_ProDKin_1	422	428	PF00069	0.683
MOD_SUMO_rev_2	116	125	PF00179	0.354
TRG_DiLeu_BaEn_1	378	383	PF01217	0.427
TRG_DiLeu_BaEn_4	378	384	PF01217	0.443
TRG_ENDOCYTIC_2	297	300	PF00928	0.385
TRG_ENDOCYTIC_2	306	309	PF00928	0.329
TRG_ENDOCYTIC_2	403	406	PF00928	0.465
TRG_ENDOCYTIC_2	89	92	PF00928	0.363
TRG_ER_diArg_1	131	133	PF00400	0.487
TRG_ER_diArg_1	162	164	PF00400	0.687
TRG_ER_diArg_1	183	185	PF00400	0.585
TRG_ER_diArg_1	410	413	PF00400	0.480
TRG_NLS_MonoExtN_4	410	415	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J6	Leptomonas seymouri	59%	94%
A0A0N1II86	Leptomonas seymouri	23%	75%
A0A0S4JFD7	Bodo saltans	26%	71%
A0A0S4KKB5	Bodo saltans	26%	100%
A0A1X0NMV7	Trypanosomatidae	26%	74%
A0A1X0NYM5	Trypanosomatidae	35%	99%
A0A3R7KQJ5	Trypanosoma rangeli	34%	100%
A0A3S5H6A9	Leishmania donovani	25%	75%
A0A3S7X1F4	Leishmania donovani	78%	100%
A0A422NE50	Trypanosoma rangeli	25%	75%
A4H5I7	Leishmania braziliensis	26%	75%
A4HTS8	Leishmania infantum	25%	75%
A4I3K4	Leishmania infantum	78%	100%
D0A836	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A989	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	75%
E9AML1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	75%
E9AZU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q8E1	Leishmania major	78%	100%
Q4QI25	Leishmania major	25%	75%
V5DJB6	Trypanosoma cruzi	24%	68%