FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGG9_LEIBR

TriTrypDb:

LbrM.28.1320 , LBRM2903_280019500

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.676
CLV_NRD_NRD_1	402	404	PF00675	0.434
CLV_NRD_NRD_1	412	414	PF00675	0.550
CLV_PCSK_KEX2_1	216	218	PF00082	0.611
CLV_PCSK_KEX2_1	402	404	PF00082	0.434
CLV_PCSK_KEX2_1	411	413	PF00082	0.538
CLV_PCSK_KEX2_1	466	468	PF00082	0.643
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.560
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.646
CLV_PCSK_SKI1_1	116	120	PF00082	0.531
CLV_PCSK_SKI1_1	244	248	PF00082	0.612
CLV_PCSK_SKI1_1	412	416	PF00082	0.580
DEG_APCC_DBOX_1	51	59	PF00400	0.385
DEG_SCF_FBW7_1	419	426	PF00400	0.463
DEG_SPOP_SBC_1	447	451	PF00917	0.670
DOC_CKS1_1	420	425	PF01111	0.470
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.469
DOC_MAPK_gen_1	16	24	PF00069	0.397
DOC_MAPK_MEF2A_6	16	24	PF00069	0.397
DOC_MAPK_MEF2A_6	244	251	PF00069	0.579
DOC_PP2B_LxvP_1	160	163	PF13499	0.428
DOC_PP2B_LxvP_1	192	195	PF13499	0.608
DOC_PP2B_LxvP_1	392	395	PF13499	0.348
DOC_USP7_MATH_1	120	124	PF00917	0.552
DOC_USP7_MATH_1	435	439	PF00917	0.692
DOC_USP7_UBL2_3	320	324	PF12436	0.430
DOC_WW_Pin1_4	262	267	PF00397	0.707
DOC_WW_Pin1_4	296	301	PF00397	0.575
DOC_WW_Pin1_4	419	424	PF00397	0.643
DOC_WW_Pin1_4	458	463	PF00397	0.669
DOC_WW_Pin1_4	78	83	PF00397	0.607
DOC_WW_Pin1_4	95	100	PF00397	0.602
LIG_14-3-3_CanoR_1	108	115	PF00244	0.342
LIG_14-3-3_CanoR_1	19	25	PF00244	0.405
LIG_14-3-3_CanoR_1	274	281	PF00244	0.580
LIG_14-3-3_CanoR_1	370	375	PF00244	0.329
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BRCT_BRCA1_1	360	364	PF00533	0.491
LIG_BRCT_BRCA1_2	360	366	PF00533	0.506
LIG_CSL_BTD_1	58	61	PF09270	0.395
LIG_FHA_1	110	116	PF00498	0.383
LIG_FHA_1	127	133	PF00498	0.453
LIG_FHA_1	162	168	PF00498	0.485
LIG_FHA_1	178	184	PF00498	0.558
LIG_FHA_1	191	197	PF00498	0.527
LIG_FHA_1	28	34	PF00498	0.386
LIG_FHA_1	371	377	PF00498	0.385
LIG_FHA_1	4	10	PF00498	0.500
LIG_FHA_2	173	179	PF00498	0.672
LIG_FHA_2	185	191	PF00498	0.546
LIG_FHA_2	90	96	PF00498	0.520
LIG_Integrin_RGD_1	87	89	PF01839	0.501
LIG_LIR_LC3C_4	17	22	PF02991	0.327
LIG_LIR_Nem_3	242	246	PF02991	0.504
LIG_LIR_Nem_3	331	336	PF02991	0.414
LIG_NRP_CendR_1	467	470	PF00754	0.521
LIG_PCNA_yPIPBox_3	335	344	PF02747	0.405
LIG_PTB_Apo_2	69	76	PF02174	0.436
LIG_SH2_STAP1	390	394	PF00017	0.329
LIG_SH2_STAT5	31	34	PF00017	0.388
LIG_SH2_STAT5	372	375	PF00017	0.398
LIG_SH3_3	127	133	PF00018	0.433
LIG_SH3_3	151	157	PF00018	0.494
LIG_SH3_3	260	266	PF00018	0.571
LIG_SH3_3	418	424	PF00018	0.514
LIG_SH3_3	55	61	PF00018	0.457
LIG_SUMO_SIM_anti_2	135	142	PF11976	0.405
LIG_SUMO_SIM_par_1	126	131	PF11976	0.485
LIG_SUMO_SIM_par_1	20	25	PF11976	0.396
MOD_CDK_SPxxK_3	458	465	PF00069	0.587
MOD_CDK_SPxxK_3	78	85	PF00069	0.587
MOD_CK1_1	262	268	PF00069	0.780
MOD_CK1_1	291	297	PF00069	0.561
MOD_CK1_1	438	444	PF00069	0.702
MOD_CK1_1	446	452	PF00069	0.651
MOD_CK1_1	454	460	PF00069	0.594
MOD_CK2_1	184	190	PF00069	0.592
MOD_CK2_1	209	215	PF00069	0.637
MOD_CK2_1	423	429	PF00069	0.596
MOD_CK2_1	438	444	PF00069	0.655
MOD_CK2_1	89	95	PF00069	0.519
MOD_GlcNHglycan	109	112	PF01048	0.484
MOD_GlcNHglycan	122	125	PF01048	0.488
MOD_GlcNHglycan	235	240	PF01048	0.793
MOD_GlcNHglycan	3	6	PF01048	0.593
MOD_GlcNHglycan	302	305	PF01048	0.751
MOD_GlcNHglycan	360	363	PF01048	0.531
MOD_GSK3_1	116	123	PF00069	0.532
MOD_GSK3_1	132	139	PF00069	0.471
MOD_GSK3_1	177	184	PF00069	0.621
MOD_GSK3_1	20	27	PF00069	0.582
MOD_GSK3_1	219	226	PF00069	0.644
MOD_GSK3_1	258	265	PF00069	0.614
MOD_GSK3_1	284	291	PF00069	0.595
MOD_GSK3_1	296	303	PF00069	0.525
MOD_GSK3_1	419	426	PF00069	0.591
MOD_GSK3_1	434	441	PF00069	0.656
MOD_GSK3_1	443	450	PF00069	0.633
MOD_GSK3_1	451	458	PF00069	0.722
MOD_GSK3_1	91	98	PF00069	0.524
MOD_N-GLC_1	27	32	PF02516	0.340
MOD_N-GLC_2	397	399	PF02516	0.341
MOD_NEK2_1	1	6	PF00069	0.562
MOD_NEK2_1	109	114	PF00069	0.499
MOD_NEK2_1	76	81	PF00069	0.567
MOD_NEK2_2	150	155	PF00069	0.415
MOD_NEK2_2	163	168	PF00069	0.412
MOD_PIKK_1	219	225	PF00454	0.550
MOD_PIKK_1	274	280	PF00454	0.602
MOD_PIKK_1	285	291	PF00454	0.527
MOD_PK_1	349	355	PF00069	0.342
MOD_PKA_2	107	113	PF00069	0.471
MOD_PKA_2	401	407	PF00069	0.445
MOD_Plk_1	27	33	PF00069	0.333
MOD_Plk_1	349	355	PF00069	0.453
MOD_Plk_1	438	444	PF00069	0.594
MOD_Plk_2-3	126	132	PF00069	0.607
MOD_Plk_2-3	209	215	PF00069	0.637
MOD_Plk_2-3	428	434	PF00069	0.634
MOD_Plk_2-3	440	446	PF00069	0.657
MOD_Plk_2-3	89	95	PF00069	0.523
MOD_Plk_4	136	142	PF00069	0.478
MOD_Plk_4	27	33	PF00069	0.333
MOD_Plk_4	71	77	PF00069	0.434
MOD_ProDKin_1	262	268	PF00069	0.707
MOD_ProDKin_1	296	302	PF00069	0.576
MOD_ProDKin_1	419	425	PF00069	0.654
MOD_ProDKin_1	458	464	PF00069	0.672
MOD_ProDKin_1	78	84	PF00069	0.606
MOD_ProDKin_1	95	101	PF00069	0.592
TRG_DiLeu_BaEn_1	242	247	PF01217	0.506
TRG_ER_diArg_1	401	403	PF00400	0.417
TRG_ER_diArg_1	411	413	PF00400	0.536
TRG_ER_diArg_1	467	470	PF00400	0.751
TRG_ER_diArg_1	84	87	PF00400	0.469
TRG_NLS_MonoCore_2	464	469	PF00514	0.616
TRG_NLS_MonoExtC_3	464	469	PF00514	0.653
TRG_NLS_MonoExtN_4	462	469	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J3	Leptomonas seymouri	54%	98%
A0A3Q8IQI6	Leishmania donovani	72%	100%
A4I3K1	Leishmania infantum	72%	100%
E9AZU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q8E4	Leishmania major	73%	100%