Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGG8_LEIBR

TriTrypDb:

LbrM.28.1310 , LBRM2903_280019400

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.561
CLV_C14_Caspase3-7	467	471	PF00656	0.729
CLV_C14_Caspase3-7	473	477	PF00656	0.723
CLV_NRD_NRD_1	147	149	PF00675	0.534
CLV_NRD_NRD_1	205	207	PF00675	0.735
CLV_NRD_NRD_1	209	211	PF00675	0.737
CLV_NRD_NRD_1	244	246	PF00675	0.705
CLV_NRD_NRD_1	250	252	PF00675	0.711
CLV_NRD_NRD_1	280	282	PF00675	0.495
CLV_NRD_NRD_1	379	381	PF00675	0.732
CLV_NRD_NRD_1	451	453	PF00675	0.694
CLV_NRD_NRD_1	556	558	PF00675	0.732
CLV_NRD_NRD_1	620	622	PF00675	0.607
CLV_NRD_NRD_1	682	684	PF00675	0.532
CLV_PCSK_FUR_1	206	210	PF00082	0.614
CLV_PCSK_FUR_1	247	251	PF00082	0.563
CLV_PCSK_FUR_1	278	282	PF00082	0.614
CLV_PCSK_KEX2_1	147	149	PF00082	0.538
CLV_PCSK_KEX2_1	205	207	PF00082	0.735
CLV_PCSK_KEX2_1	208	210	PF00082	0.737
CLV_PCSK_KEX2_1	243	245	PF00082	0.683
CLV_PCSK_KEX2_1	249	251	PF00082	0.722
CLV_PCSK_KEX2_1	280	282	PF00082	0.495
CLV_PCSK_KEX2_1	451	453	PF00082	0.694
CLV_PCSK_KEX2_1	556	558	PF00082	0.833
CLV_PCSK_KEX2_1	682	684	PF00082	0.532
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.812
CLV_PCSK_PC7_1	205	211	PF00082	0.584
CLV_PCSK_PC7_1	245	251	PF00082	0.559
CLV_PCSK_PC7_1	552	558	PF00082	0.581
CLV_PCSK_SKI1_1	159	163	PF00082	0.765
CLV_PCSK_SKI1_1	309	313	PF00082	0.702
CLV_PCSK_SKI1_1	359	363	PF00082	0.543
CLV_PCSK_SKI1_1	434	438	PF00082	0.546
CLV_PCSK_SKI1_1	683	687	PF00082	0.532
CLV_PCSK_SKI1_1	712	716	PF00082	0.536
DEG_APCC_DBOX_1	681	689	PF00400	0.660
DEG_Nend_UBRbox_3	1	3	PF02207	0.657
DEG_SCF_FBW7_1	196	201	PF00400	0.546
DEG_SCF_TRCP1_1	40	46	PF00400	0.536
DEG_SPOP_SBC_1	117	121	PF00917	0.714
DEG_SPOP_SBC_1	17	21	PF00917	0.749
DEG_SPOP_SBC_1	215	219	PF00917	0.796
DEG_SPOP_SBC_1	483	487	PF00917	0.574
DOC_CKS1_1	391	396	PF01111	0.555
DOC_CYCLIN_RxL_1	303	314	PF00134	0.461
DOC_CYCLIN_RxL_1	680	687	PF00134	0.530
DOC_MAPK_gen_1	579	588	PF00069	0.527
DOC_MAPK_gen_1	682	690	PF00069	0.528
DOC_MAPK_MEF2A_6	626	634	PF00069	0.543
DOC_MAPK_MEF2A_6	682	690	PF00069	0.528
DOC_PP2B_LxvP_1	686	689	PF13499	0.665
DOC_USP7_MATH_1	17	21	PF00917	0.771
DOC_USP7_MATH_1	200	204	PF00917	0.813
DOC_USP7_MATH_1	221	225	PF00917	0.747
DOC_USP7_MATH_1	442	446	PF00917	0.546
DOC_USP7_MATH_1	483	487	PF00917	0.670
DOC_USP7_MATH_1	521	525	PF00917	0.681
DOC_USP7_MATH_1	545	549	PF00917	0.671
DOC_USP7_MATH_1	635	639	PF00917	0.535
DOC_USP7_MATH_1	64	68	PF00917	0.710
DOC_USP7_MATH_1	689	693	PF00917	0.736
DOC_USP7_MATH_1	730	734	PF00917	0.585
DOC_USP7_MATH_1	77	81	PF00917	0.633
DOC_WW_Pin1_4	113	118	PF00397	0.577
DOC_WW_Pin1_4	194	199	PF00397	0.691
DOC_WW_Pin1_4	209	214	PF00397	0.632
DOC_WW_Pin1_4	27	32	PF00397	0.809
DOC_WW_Pin1_4	352	357	PF00397	0.589
DOC_WW_Pin1_4	390	395	PF00397	0.621
DOC_WW_Pin1_4	437	442	PF00397	0.595
DOC_WW_Pin1_4	486	491	PF00397	0.703
DOC_WW_Pin1_4	539	544	PF00397	0.744
DOC_WW_Pin1_4	551	556	PF00397	0.793
DOC_WW_Pin1_4	570	575	PF00397	0.449
DOC_WW_Pin1_4	59	64	PF00397	0.790
DOC_WW_Pin1_4	620	625	PF00397	0.522
DOC_WW_Pin1_4	626	631	PF00397	0.522
DOC_WW_Pin1_4	68	73	PF00397	0.707
LIG_14-3-3_CanoR_1	148	158	PF00244	0.578
LIG_14-3-3_CanoR_1	159	164	PF00244	0.681
LIG_14-3-3_CanoR_1	233	238	PF00244	0.591
LIG_14-3-3_CanoR_1	251	261	PF00244	0.601
LIG_14-3-3_CanoR_1	359	368	PF00244	0.678
LIG_14-3-3_CanoR_1	374	379	PF00244	0.790
LIG_14-3-3_CanoR_1	426	431	PF00244	0.617
LIG_14-3-3_CanoR_1	507	513	PF00244	0.817
LIG_14-3-3_CanoR_1	682	686	PF00244	0.565
LIG_14-3-3_CanoR_1	712	717	PF00244	0.630
LIG_14-3-3_CanoR_1	84	94	PF00244	0.588
LIG_14-3-3_CanoR_1	99	105	PF00244	0.490
LIG_Actin_WH2_2	189	207	PF00022	0.553
LIG_BIR_III_2	199	203	PF00653	0.559
LIG_BRCT_BRCA1_1	66	70	PF00533	0.588
LIG_FHA_1	123	129	PF00498	0.733
LIG_FHA_1	173	179	PF00498	0.554
LIG_FHA_1	199	205	PF00498	0.570
LIG_FHA_1	215	221	PF00498	0.578
LIG_FHA_1	460	466	PF00498	0.809
LIG_FHA_1	507	513	PF00498	0.727
LIG_FHA_1	60	66	PF00498	0.555
LIG_FHA_1	685	691	PF00498	0.555
LIG_FHA_2	150	156	PF00498	0.578
LIG_FHA_2	762	768	PF00498	0.695
LIG_LIR_Apic_2	592	597	PF02991	0.523
LIG_LIR_Nem_3	271	275	PF02991	0.512
LIG_LIR_Nem_3	399	404	PF02991	0.593
LIG_LIR_Nem_3	523	529	PF02991	0.535
LIG_PCNA_PIPBox_1	519	528	PF02747	0.534
LIG_Pex14_1	90	94	PF04695	0.554
LIG_SH2_CRK	193	197	PF00017	0.580
LIG_SH2_CRK	3	7	PF00017	0.517
LIG_SH2_CRK	583	587	PF00017	0.536
LIG_SH2_NCK_1	339	343	PF00017	0.542
LIG_SH2_STAP1	339	343	PF00017	0.542
LIG_SH2_STAT3	601	604	PF00017	0.634
LIG_SH2_STAT5	275	278	PF00017	0.386
LIG_SH2_STAT5	525	528	PF00017	0.688
LIG_SH3_2	574	579	PF14604	0.425
LIG_SH3_3	343	349	PF00018	0.564
LIG_SH3_3	388	394	PF00018	0.661
LIG_SH3_3	571	577	PF00018	0.515
LIG_SH3_3	58	64	PF00018	0.595
LIG_SH3_3	629	635	PF00018	0.569
LIG_SH3_3	685	691	PF00018	0.745
LIG_SH3_3	707	713	PF00018	0.634
LIG_SUMO_SIM_par_1	426	432	PF11976	0.545
LIG_SUMO_SIM_par_1	464	474	PF11976	0.670
LIG_SUMO_SIM_par_1	712	719	PF11976	0.528
LIG_TRAF2_1	764	767	PF00917	0.649
LIG_TYR_ITIM	191	196	PF00017	0.581
LIG_WRC_WIRS_1	690	695	PF05994	0.516
LIG_WW_3	623	627	PF00397	0.543
MOD_CDC14_SPxK_1	554	557	PF00782	0.667
MOD_CDK_SPK_2	352	357	PF00069	0.589
MOD_CDK_SPK_2	551	556	PF00069	0.838
MOD_CDK_SPxK_1	390	396	PF00069	0.556
MOD_CDK_SPxK_1	551	557	PF00069	0.672
MOD_CDK_SPxK_1	620	626	PF00069	0.529
MOD_CDK_SPxxK_3	198	205	PF00069	0.560
MOD_CDK_SPxxK_3	352	359	PF00069	0.520
MOD_CDK_SPxxK_3	543	550	PF00069	0.715
MOD_CDK_SPxxK_3	551	558	PF00069	0.801
MOD_CK1_1	116	122	PF00069	0.796
MOD_CK1_1	13	19	PF00069	0.649
MOD_CK1_1	153	159	PF00069	0.590
MOD_CK1_1	20	26	PF00069	0.765
MOD_CK1_1	252	258	PF00069	0.602
MOD_CK1_1	321	327	PF00069	0.695
MOD_CK1_1	335	341	PF00069	0.531
MOD_CK1_1	456	462	PF00069	0.764
MOD_CK1_1	471	477	PF00069	0.683
MOD_CK1_1	486	492	PF00069	0.727
MOD_CK1_1	524	530	PF00069	0.684
MOD_CK1_1	531	537	PF00069	0.703
MOD_CK1_1	538	544	PF00069	0.725
MOD_CK1_1	546	552	PF00069	0.738
MOD_CK1_1	68	74	PF00069	0.670
MOD_CK1_1	700	706	PF00069	0.658
MOD_CK1_1	733	739	PF00069	0.718
MOD_CK1_1	92	98	PF00069	0.743
MOD_CK2_1	149	155	PF00069	0.570
MOD_CK2_1	761	767	PF00069	0.646
MOD_Cter_Amidation	241	244	PF01082	0.581
MOD_Cter_Amidation	247	250	PF01082	0.592
MOD_Cter_Amidation	278	281	PF01082	0.529
MOD_Cter_Amidation	619	622	PF01082	0.507
MOD_GlcNHglycan	108	111	PF01048	0.602
MOD_GlcNHglycan	12	15	PF01048	0.624
MOD_GlcNHglycan	133	136	PF01048	0.746
MOD_GlcNHglycan	155	158	PF01048	0.653
MOD_GlcNHglycan	179	182	PF01048	0.652
MOD_GlcNHglycan	225	228	PF01048	0.768
MOD_GlcNHglycan	238	241	PF01048	0.734
MOD_GlcNHglycan	257	260	PF01048	0.450
MOD_GlcNHglycan	293	296	PF01048	0.625
MOD_GlcNHglycan	323	326	PF01048	0.600
MOD_GlcNHglycan	40	43	PF01048	0.642
MOD_GlcNHglycan	455	458	PF01048	0.714
MOD_GlcNHglycan	490	493	PF01048	0.621
MOD_GlcNHglycan	530	533	PF01048	0.588
MOD_GlcNHglycan	644	647	PF01048	0.719
MOD_GlcNHglycan	67	70	PF01048	0.670
MOD_GlcNHglycan	671	674	PF01048	0.643
MOD_GlcNHglycan	695	698	PF01048	0.585
MOD_GlcNHglycan	727	730	PF01048	0.667
MOD_GlcNHglycan	735	738	PF01048	0.714
MOD_GlcNHglycan	740	743	PF01048	0.653
MOD_GlcNHglycan	79	82	PF01048	0.776
MOD_GlcNHglycan	91	94	PF01048	0.582
MOD_GlcNHglycan	96	99	PF01048	0.488
MOD_GSK3_1	106	113	PF00069	0.635
MOD_GSK3_1	116	123	PF00069	0.778
MOD_GSK3_1	12	19	PF00069	0.692
MOD_GSK3_1	124	131	PF00069	0.825
MOD_GSK3_1	149	156	PF00069	0.573
MOD_GSK3_1	194	201	PF00069	0.791
MOD_GSK3_1	21	28	PF00069	0.620
MOD_GSK3_1	215	222	PF00069	0.667
MOD_GSK3_1	232	239	PF00069	0.565
MOD_GSK3_1	251	258	PF00069	0.466
MOD_GSK3_1	286	293	PF00069	0.473
MOD_GSK3_1	334	341	PF00069	0.801
MOD_GSK3_1	344	351	PF00069	0.592
MOD_GSK3_1	368	375	PF00069	0.785
MOD_GSK3_1	466	473	PF00069	0.805
MOD_GSK3_1	478	485	PF00069	0.633
MOD_GSK3_1	486	493	PF00069	0.521
MOD_GSK3_1	520	527	PF00069	0.683
MOD_GSK3_1	528	535	PF00069	0.691
MOD_GSK3_1	539	546	PF00069	0.727
MOD_GSK3_1	635	642	PF00069	0.670
MOD_GSK3_1	64	71	PF00069	0.673
MOD_GSK3_1	665	672	PF00069	0.511
MOD_GSK3_1	689	696	PF00069	0.769
MOD_GSK3_1	712	719	PF00069	0.656
MOD_GSK3_1	85	92	PF00069	0.714
MOD_GSK3_1	93	100	PF00069	0.714
MOD_N-GLC_1	121	126	PF02516	0.846
MOD_N-GLC_1	128	133	PF02516	0.655
MOD_N-GLC_1	442	447	PF02516	0.588
MOD_N-GLC_1	478	483	PF02516	0.736
MOD_N-GLC_1	693	698	PF02516	0.521
MOD_N-GLC_1	725	730	PF02516	0.502
MOD_N-GLC_1	733	738	PF02516	0.485
MOD_NEK2_1	12	17	PF00069	0.519
MOD_NEK2_1	204	209	PF00069	0.670
MOD_NEK2_1	311	316	PF00069	0.519
MOD_NEK2_1	639	644	PF00069	0.503
MOD_NEK2_1	65	70	PF00069	0.701
MOD_NEK2_1	693	698	PF00069	0.631
MOD_NEK2_1	716	721	PF00069	0.667
MOD_NEK2_1	725	730	PF00069	0.714
MOD_NEK2_2	259	264	PF00069	0.515
MOD_PIKK_1	252	258	PF00454	0.536
MOD_PIKK_1	311	317	PF00454	0.522
MOD_PIKK_1	600	606	PF00454	0.545
MOD_PK_1	374	380	PF00069	0.553
MOD_PK_1	426	432	PF00069	0.545
MOD_PKA_1	249	255	PF00069	0.613
MOD_PKA_2	141	147	PF00069	0.570
MOD_PKA_2	204	210	PF00069	0.687
MOD_PKA_2	232	238	PF00069	0.643
MOD_PKA_2	249	255	PF00069	0.785
MOD_PKA_2	321	327	PF00069	0.703
MOD_PKA_2	373	379	PF00069	0.787
MOD_PKA_2	506	512	PF00069	0.565
MOD_PKA_2	614	620	PF00069	0.634
MOD_PKA_2	681	687	PF00069	0.547
MOD_PKB_1	247	255	PF00069	0.782
MOD_PKB_1	330	338	PF00069	0.545
MOD_PKB_1	357	365	PF00069	0.543
MOD_Plk_1	335	341	PF00069	0.767
MOD_Plk_1	646	652	PF00069	0.582
MOD_Plk_2-3	614	620	PF00069	0.478
MOD_Plk_4	233	239	PF00069	0.543
MOD_Plk_4	426	432	PF00069	0.616
MOD_Plk_4	508	514	PF00069	0.585
MOD_Plk_4	521	527	PF00069	0.646
MOD_Plk_4	647	653	PF00069	0.516
MOD_Plk_4	697	703	PF00069	0.766
MOD_Plk_4	720	726	PF00069	0.610
MOD_ProDKin_1	113	119	PF00069	0.580
MOD_ProDKin_1	194	200	PF00069	0.692
MOD_ProDKin_1	209	215	PF00069	0.629
MOD_ProDKin_1	27	33	PF00069	0.809
MOD_ProDKin_1	352	358	PF00069	0.585
MOD_ProDKin_1	390	396	PF00069	0.619
MOD_ProDKin_1	437	443	PF00069	0.598
MOD_ProDKin_1	486	492	PF00069	0.700
MOD_ProDKin_1	539	545	PF00069	0.743
MOD_ProDKin_1	551	557	PF00069	0.792
MOD_ProDKin_1	570	576	PF00069	0.435
MOD_ProDKin_1	59	65	PF00069	0.792
MOD_ProDKin_1	620	626	PF00069	0.529
MOD_ProDKin_1	68	74	PF00069	0.708
MOD_SUMO_rev_2	429	436	PF00179	0.541
TRG_DiLeu_BaEn_1	363	368	PF01217	0.509
TRG_DiLeu_BaEn_1	400	405	PF01217	0.587
TRG_DiLeu_BaEn_4	766	772	PF01217	0.708
TRG_ENDOCYTIC_2	193	196	PF00928	0.582
TRG_ENDOCYTIC_2	583	586	PF00928	0.541
TRG_ER_diArg_1	146	148	PF00400	0.576
TRG_ER_diArg_1	204	206	PF00400	0.733
TRG_ER_diArg_1	208	210	PF00400	0.736
TRG_ER_diArg_1	243	245	PF00400	0.688
TRG_ER_diArg_1	247	250	PF00400	0.695
TRG_ER_diArg_1	278	281	PF00400	0.630
TRG_ER_diArg_1	327	330	PF00400	0.767
TRG_ER_diArg_1	356	359	PF00400	0.585
TRG_ER_diArg_1	450	452	PF00400	0.659
TRG_ER_diArg_1	557	560	PF00400	0.764
TRG_NLS_MonoCore_2	555	560	PF00514	0.611
TRG_NLS_MonoExtC_3	556	561	PF00514	0.723
TRG_NLS_MonoExtN_4	555	562	PF00514	0.724
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	402	407	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I844	Leptomonas seymouri	34%	100%
A0A3S7X1G0	Leishmania donovani	60%	99%
A4I3K0	Leishmania infantum	59%	99%
E9AZU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
Q4Q8E5	Leishmania major	62%	100%