Copine i-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

copine i-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGG6_LEIBR

TriTrypDb:

LbrM.28.1290 , LBRM2903_280019200

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGG6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051592	response to calcium ion	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071241	cellular response to inorganic substance	4	1
GO:0071248	cellular response to metal ion	5	1
GO:0071277	cellular response to calcium ion	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005543	phospholipid binding	3	9
GO:0005544	calcium-dependent phospholipid binding	4	9
GO:0008289	lipid binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.323
CLV_C14_Caspase3-7	415	419	PF00656	0.258
CLV_C14_Caspase3-7	444	448	PF00656	0.240
CLV_NRD_NRD_1	244	246	PF00675	0.417
CLV_NRD_NRD_1	462	464	PF00675	0.320
CLV_PCSK_FUR_1	456	460	PF00082	0.196
CLV_PCSK_KEX2_1	244	246	PF00082	0.430
CLV_PCSK_KEX2_1	458	460	PF00082	0.295
CLV_PCSK_KEX2_1	462	464	PF00082	0.317
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.430
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.181
CLV_PCSK_PC7_1	454	460	PF00082	0.181
CLV_PCSK_SKI1_1	138	142	PF00082	0.292
CLV_PCSK_SKI1_1	20	24	PF00082	0.202
CLV_PCSK_SKI1_1	308	312	PF00082	0.352
DOC_CKS1_1	502	507	PF01111	0.293
DOC_MAPK_gen_1	244	253	PF00069	0.375
DOC_MAPK_gen_1	393	403	PF00069	0.352
DOC_MAPK_gen_1	458	468	PF00069	0.259
DOC_MAPK_gen_1	82	91	PF00069	0.290
DOC_MAPK_MEF2A_6	103	111	PF00069	0.292
DOC_MAPK_MEF2A_6	128	135	PF00069	0.358
DOC_MAPK_MEF2A_6	368	375	PF00069	0.181
DOC_MAPK_MEF2A_6	396	405	PF00069	0.352
DOC_MAPK_MEF2A_6	70	77	PF00069	0.323
DOC_PP1_RVXF_1	291	298	PF00149	0.258
DOC_PP4_FxxP_1	297	300	PF00568	0.258
DOC_PP4_FxxP_1	375	378	PF00568	0.292
DOC_USP7_MATH_1	216	220	PF00917	0.232
DOC_USP7_MATH_1	270	274	PF00917	0.253
DOC_USP7_MATH_1	470	474	PF00917	0.446
DOC_USP7_UBL2_3	242	246	PF12436	0.408
DOC_WW_Pin1_4	181	186	PF00397	0.283
DOC_WW_Pin1_4	196	201	PF00397	0.421
DOC_WW_Pin1_4	296	301	PF00397	0.202
DOC_WW_Pin1_4	501	506	PF00397	0.455
LIG_14-3-3_CanoR_1	103	108	PF00244	0.337
LIG_14-3-3_CanoR_1	164	168	PF00244	0.323
LIG_14-3-3_CanoR_1	245	249	PF00244	0.336
LIG_14-3-3_CanoR_1	70	74	PF00244	0.290
LIG_BRCT_BRCA1_1	246	250	PF00533	0.391
LIG_BRCT_BRCA1_1	260	264	PF00533	0.422
LIG_BRCT_BRCA1_1	278	282	PF00533	0.185
LIG_BRCT_BRCA1_1	293	297	PF00533	0.204
LIG_BRCT_BRCA1_1	341	345	PF00533	0.292
LIG_CtBP_PxDLS_1	186	190	PF00389	0.232
LIG_EH1_1	398	406	PF00400	0.258
LIG_FHA_1	104	110	PF00498	0.278
LIG_FHA_1	114	120	PF00498	0.341
LIG_FHA_1	128	134	PF00498	0.289
LIG_FHA_1	398	404	PF00498	0.261
LIG_FHA_1	44	50	PF00498	0.267
LIG_FHA_1	70	76	PF00498	0.211
LIG_LIR_Apic_2	294	300	PF02991	0.258
LIG_LIR_Gen_1	247	258	PF02991	0.308
LIG_LIR_Gen_1	26	33	PF02991	0.258
LIG_LIR_Gen_1	261	270	PF02991	0.277
LIG_LIR_Gen_1	364	373	PF02991	0.232
LIG_LIR_Gen_1	439	446	PF02991	0.282
LIG_LIR_Nem_3	149	155	PF02991	0.258
LIG_LIR_Nem_3	247	253	PF02991	0.298
LIG_LIR_Nem_3	26	32	PF02991	0.297
LIG_LIR_Nem_3	261	267	PF02991	0.307
LIG_LIR_Nem_3	323	329	PF02991	0.292
LIG_LIR_Nem_3	341	347	PF02991	0.292
LIG_LIR_Nem_3	364	369	PF02991	0.352
LIG_LIR_Nem_3	495	500	PF02991	0.310
LIG_MLH1_MIPbox_1	341	345	PF16413	0.352
LIG_Pex14_2	278	282	PF04695	0.317
LIG_PTB_Apo_2	51	58	PF02174	0.292
LIG_SH2_CRK	248	252	PF00017	0.208
LIG_SH2_CRK	29	33	PF00017	0.232
LIG_SH2_CRK	366	370	PF00017	0.352
LIG_SH2_CRK	399	403	PF00017	0.258
LIG_SH2_GRB2like	355	358	PF00017	0.323
LIG_SH2_SRC	355	358	PF00017	0.323
LIG_SH2_STAP1	29	33	PF00017	0.232
LIG_SH2_STAP1	366	370	PF00017	0.232
LIG_SH2_STAP1	399	403	PF00017	0.258
LIG_SH2_STAT5	11	14	PF00017	0.344
LIG_SH2_STAT5	123	126	PF00017	0.510
LIG_SH2_STAT5	152	155	PF00017	0.262
LIG_SH2_STAT5	258	261	PF00017	0.380
LIG_SH2_STAT5	267	270	PF00017	0.384
LIG_SH2_STAT5	306	309	PF00017	0.258
LIG_SH2_STAT5	355	358	PF00017	0.258
LIG_SH2_STAT5	399	402	PF00017	0.258
LIG_SH2_STAT5	66	69	PF00017	0.293
LIG_SH3_3	180	186	PF00018	0.181
LIG_SH3_3	194	200	PF00018	0.150
LIG_SH3_3	286	292	PF00018	0.426
LIG_SH3_3	297	303	PF00018	0.204
LIG_SUMO_SIM_anti_2	400	407	PF11976	0.258
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.258
LIG_SUMO_SIM_par_1	105	110	PF11976	0.499
LIG_SUMO_SIM_par_1	115	120	PF11976	0.334
LIG_SUMO_SIM_par_1	309	314	PF11976	0.292
LIG_SUMO_SIM_par_1	400	407	PF11976	0.258
LIG_WRC_WIRS_1	217	222	PF05994	0.352
LIG_WRC_WIRS_1	471	476	PF05994	0.283
MOD_CDK_SPxK_1	501	507	PF00069	0.292
MOD_CK1_1	102	108	PF00069	0.299
MOD_CK1_1	115	121	PF00069	0.333
MOD_CK1_1	3	9	PF00069	0.413
MOD_CK1_1	376	382	PF00069	0.352
MOD_CK2_1	260	266	PF00069	0.230
MOD_CK2_1	438	444	PF00069	0.252
MOD_Cter_Amidation	242	245	PF01082	0.453
MOD_GlcNHglycan	135	138	PF01048	0.259
MOD_GlcNHglycan	160	163	PF01048	0.323
MOD_GlcNHglycan	347	350	PF01048	0.397
MOD_GlcNHglycan	375	378	PF01048	0.348
MOD_GSK3_1	113	120	PF00069	0.334
MOD_GSK3_1	123	130	PF00069	0.429
MOD_GSK3_1	158	165	PF00069	0.358
MOD_GSK3_1	216	223	PF00069	0.292
MOD_GSK3_1	276	283	PF00069	0.303
MOD_GSK3_1	287	294	PF00069	0.397
MOD_GSK3_1	335	342	PF00069	0.352
MOD_GSK3_1	98	105	PF00069	0.275
MOD_N-GLC_1	338	343	PF02516	0.348
MOD_NEK2_1	107	112	PF00069	0.405
MOD_NEK2_1	119	124	PF00069	0.367
MOD_NEK2_1	153	158	PF00069	0.323
MOD_NEK2_1	282	287	PF00069	0.324
MOD_NEK2_1	311	316	PF00069	0.352
MOD_NEK2_1	373	378	PF00069	0.377
MOD_NEK2_1	57	62	PF00069	0.341
MOD_NEK2_1	99	104	PF00069	0.309
MOD_PIKK_1	123	129	PF00454	0.432
MOD_PKA_1	244	250	PF00069	0.343
MOD_PKA_2	102	108	PF00069	0.292
MOD_PKA_2	127	133	PF00069	0.408
MOD_PKA_2	163	169	PF00069	0.323
MOD_PKA_2	244	250	PF00069	0.343
MOD_PKA_2	69	75	PF00069	0.181
MOD_Plk_1	235	241	PF00069	0.310
MOD_Plk_1	438	444	PF00069	0.320
MOD_Plk_1	92	98	PF00069	0.302
MOD_Plk_2-3	210	216	PF00069	0.232
MOD_Plk_2-3	439	445	PF00069	0.245
MOD_Plk_4	119	125	PF00069	0.424
MOD_Plk_4	163	169	PF00069	0.323
MOD_Plk_4	216	222	PF00069	0.344
MOD_Plk_4	260	266	PF00069	0.230
MOD_Plk_4	3	9	PF00069	0.286
MOD_Plk_4	302	308	PF00069	0.370
MOD_Plk_4	397	403	PF00069	0.264
MOD_Plk_4	426	432	PF00069	0.292
MOD_Plk_4	448	454	PF00069	0.181
MOD_ProDKin_1	181	187	PF00069	0.283
MOD_ProDKin_1	196	202	PF00069	0.421
MOD_ProDKin_1	296	302	PF00069	0.202
MOD_ProDKin_1	501	507	PF00069	0.463
MOD_SUMO_rev_2	473	479	PF00179	0.343
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.352
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.181
TRG_ENDOCYTIC_2	152	155	PF00928	0.292
TRG_ENDOCYTIC_2	248	251	PF00928	0.240
TRG_ENDOCYTIC_2	262	265	PF00928	0.384
TRG_ENDOCYTIC_2	29	32	PF00928	0.329
TRG_ENDOCYTIC_2	366	369	PF00928	0.352
TRG_ENDOCYTIC_2	399	402	PF00928	0.258
TRG_ENDOCYTIC_2	66	69	PF00928	0.181
TRG_NLS_MonoExtN_4	241	248	PF00514	0.428
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFI3	Leptomonas seymouri	73%	100%
A0A0S4IZ47	Bodo saltans	50%	97%
A0A0S4JTD9	Bodo saltans	46%	95%
A0A0S4KHJ0	Bodo saltans	36%	93%
A0A3S7X1G3	Leishmania donovani	83%	100%
A4I3J8	Leishmania infantum	83%	100%
A8WMY4	Caenorhabditis briggsae	34%	81%
D4A1R8	Rattus norvegicus	41%	95%
E9AZT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
H1UBN0	Rattus norvegicus	40%	91%
O75131	Homo sapiens	41%	95%
O95741	Homo sapiens	37%	91%
P59108	Mus musculus	39%	93%
Q08DB4	Bos taurus	42%	95%
Q09219	Caenorhabditis elegans	25%	71%
Q0VE82	Mus musculus	40%	91%
Q1RLL3	Mus musculus	36%	92%
Q1ZXB3	Dictyostelium discoideum	30%	92%
Q2KHY1	Bos taurus	37%	91%
Q4Q8E7	Leishmania major	83%	100%
Q54FY7	Dictyostelium discoideum	39%	88%
Q54P51	Dictyostelium discoideum	36%	94%
Q55GG1	Dictyostelium discoideum	35%	96%
Q5BJS7	Rattus norvegicus	36%	92%
Q5R4W6	Pongo abelii	36%	91%
Q5RAE1	Pongo abelii	41%	95%
Q5S1W2	Arabidopsis thaliana	34%	87%
Q5XQC7	Arabidopsis thaliana	34%	87%
Q7YXU4	Dictyostelium discoideum	38%	85%
Q86K21	Dictyostelium discoideum	39%	96%
Q86YQ8	Homo sapiens	39%	90%
Q8BLR2	Mus musculus	39%	91%
Q8BT60	Mus musculus	41%	95%
Q8C166	Mus musculus	41%	95%
Q8IYJ1	Homo sapiens	36%	92%
Q8JZW4	Mus musculus	37%	86%
Q941L3	Arabidopsis thaliana	34%	88%
Q96A23	Homo sapiens	39%	91%
Q96FN4	Homo sapiens	40%	93%
Q99829	Homo sapiens	43%	95%
Q9DC53	Mus musculus	39%	88%
Q9HCH3	Homo sapiens	37%	86%
Q9UBL6	Homo sapiens	41%	80%
Q9XUB9	Caenorhabditis elegans	33%	80%
Q9Z140	Mus musculus	36%	91%