Tail fiber protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tail fiber protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGG5_LEIBR

TriTrypDb:

LbrM.28.1280 , LBRM2903_280018900

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.625
CLV_PCSK_KEX2_1	142	144	PF00082	0.625
CLV_PCSK_SKI1_1	216	220	PF00082	0.618
CLV_PCSK_SKI1_1	67	71	PF00082	0.620
DOC_CYCLIN_RxL_1	64	73	PF00134	0.616
DOC_PP1_RVXF_1	214	221	PF00149	0.616
DOC_USP7_MATH_1	108	112	PF00917	0.620
DOC_USP7_MATH_1	91	95	PF00917	0.644
DOC_WW_Pin1_4	59	64	PF00397	0.626
LIG_14-3-3_CanoR_1	199	208	PF00244	0.491
LIG_14-3-3_CanoR_1	74	80	PF00244	0.633
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BIR_III_2	204	208	PF00653	0.629
LIG_BRCT_BRCA1_1	222	226	PF00533	0.471
LIG_eIF4E_1	64	70	PF01652	0.594
LIG_FHA_1	149	155	PF00498	0.578
LIG_FHA_1	75	81	PF00498	0.619
LIG_FHA_2	126	132	PF00498	0.518
LIG_FHA_2	150	156	PF00498	0.700
LIG_FHA_2	210	216	PF00498	0.660
LIG_FHA_2	88	94	PF00498	0.563
LIG_LIR_Apic_2	168	173	PF02991	0.556
LIG_LIR_Nem_3	161	166	PF02991	0.637
LIG_LIR_Nem_3	17	22	PF02991	0.577
LIG_LIR_Nem_3	2	8	PF02991	0.722
LIG_MLH1_MIPbox_1	222	226	PF16413	0.471
LIG_REV1ctd_RIR_1	34	44	PF16727	0.635
LIG_SH2_CRK	163	167	PF00017	0.644
LIG_SH2_GRB2like	9	12	PF00017	0.615
LIG_SH2_STAP1	201	205	PF00017	0.644
LIG_SH2_STAT5	201	204	PF00017	0.562
LIG_SH3_3	134	140	PF00018	0.672
LIG_SH3_3	43	49	PF00018	0.659
LIG_WRC_WIRS_1	5	10	PF05994	0.503
MOD_CK1_1	96	102	PF00069	0.671
MOD_CK2_1	125	131	PF00069	0.604
MOD_CK2_1	135	141	PF00069	0.516
MOD_CK2_1	149	155	PF00069	0.599
MOD_CK2_1	4	10	PF00069	0.634
MOD_GlcNHglycan	110	113	PF01048	0.579
MOD_GlcNHglycan	12	16	PF01048	0.705
MOD_GlcNHglycan	95	98	PF01048	0.636
MOD_GSK3_1	102	109	PF00069	0.649
MOD_GSK3_1	11	18	PF00069	0.584
MOD_GSK3_1	131	138	PF00069	0.621
MOD_GSK3_1	154	161	PF00069	0.651
MOD_GSK3_1	216	223	PF00069	0.645
MOD_GSK3_1	32	39	PF00069	0.567
MOD_GSK3_1	47	54	PF00069	0.548
MOD_GSK3_1	70	77	PF00069	0.588
MOD_GSK3_1	87	94	PF00069	0.583
MOD_N-GLC_1	51	56	PF02516	0.653
MOD_NEK2_1	135	140	PF00069	0.615
MOD_NEK2_1	154	159	PF00069	0.611
MOD_NEK2_1	176	181	PF00069	0.533
MOD_NEK2_1	36	41	PF00069	0.675
MOD_NEK2_1	58	63	PF00069	0.615
MOD_NEK2_1	70	75	PF00069	0.486
MOD_NEK2_2	187	192	PF00069	0.595
MOD_NEK2_2	32	37	PF00069	0.634
MOD_NEK2_2	65	70	PF00069	0.617
MOD_PIKK_1	91	97	PF00454	0.658
MOD_PKA_2	15	21	PF00069	0.608
MOD_Plk_1	125	131	PF00069	0.604
MOD_Plk_1	176	182	PF00069	0.582
MOD_Plk_1	209	215	PF00069	0.654
MOD_Plk_2-3	119	125	PF00069	0.525
MOD_Plk_2-3	131	137	PF00069	0.594
MOD_Plk_4	15	21	PF00069	0.538
MOD_Plk_4	176	182	PF00069	0.567
MOD_Plk_4	32	38	PF00069	0.449
MOD_Plk_4	4	10	PF00069	0.591
MOD_Plk_4	52	58	PF00069	0.476
MOD_Plk_4	75	81	PF00069	0.619
MOD_ProDKin_1	59	65	PF00069	0.623
TRG_ENDOCYTIC_2	163	166	PF00928	0.640
TRG_ENDOCYTIC_2	5	8	PF00928	0.575
TRG_ER_diArg_1	142	144	PF00400	0.630
TRG_ER_diArg_1	222	225	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYM4	Trypanosomatidae	42%	94%
A0A3Q8IDW1	Leishmania donovani	84%	100%
A0A422N2Z7	Trypanosoma rangeli	39%	89%
A4I3J7	Leishmania infantum	84%	100%
D0A7U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AZT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q8E8	Leishmania major	83%	100%