AN1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AN1-like zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HGG4_LEIBR

TriTrypDb:

LbrM.28.1270 , LBRM2903_280018800

Length:

100

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGG4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.354
CLV_NRD_NRD_1	60	62	PF00675	0.516
CLV_NRD_NRD_1	63	65	PF00675	0.538
CLV_NRD_NRD_1	86	88	PF00675	0.539
CLV_PCSK_FUR_1	61	65	PF00082	0.601
CLV_PCSK_KEX2_1	49	51	PF00082	0.587
CLV_PCSK_KEX2_1	60	62	PF00082	0.557
CLV_PCSK_KEX2_1	63	65	PF00082	0.589
CLV_PCSK_KEX2_1	73	75	PF00082	0.373
CLV_PCSK_KEX2_1	86	88	PF00082	0.474
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.519
CLV_PCSK_SKI1_1	50	54	PF00082	0.475
DOC_MAPK_MEF2A_6	8	17	PF00069	0.210
DOC_USP7_UBL2_3	73	77	PF12436	0.462
LIG_14-3-3_CanoR_1	27	35	PF00244	0.357
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_LIR_LC3C_4	12	17	PF02991	0.210
LIG_SH2_STAT3	23	26	PF00017	0.210
LIG_SH2_STAT5	23	26	PF00017	0.304
LIG_SH2_STAT5	28	31	PF00017	0.400
LIG_SH3_3	13	19	PF00018	0.400
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.210
MOD_PIKK_1	90	96	PF00454	0.470
MOD_PKA_1	87	93	PF00069	0.554
MOD_SUMO_for_1	19	22	PF00179	0.400
MOD_SUMO_rev_2	70	79	PF00179	0.569
TRG_ER_diArg_1	60	63	PF00400	0.589
TRG_ER_diLys_1	97	100	PF00400	0.606
TRG_NLS_Bipartite_1	72	92	PF00514	0.534
TRG_NLS_MonoExtC_3	86	91	PF00514	0.615
TRG_NLS_MonoExtN_4	86	92	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCY9	Leptomonas seymouri	78%	100%
A0A0S4KJP3	Bodo saltans	39%	100%
A0A1X0NYL9	Trypanosomatidae	56%	68%
A0A3Q8IGQ3	Leishmania donovani	88%	100%
A4I3J6	Leishmania infantum	88%	85%
E9AZT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8E9	Leishmania major	85%	100%