Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HGG3_LEIBR

TriTrypDb:

LbrM.28.1260 , LBRM2903_280018600 , LBRM2903_280018700

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4HGG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.543
CLV_C14_Caspase3-7	483	487	PF00656	0.443
CLV_C14_Caspase3-7	963	967	PF00656	0.573
CLV_NRD_NRD_1	318	320	PF00675	0.625
CLV_NRD_NRD_1	676	678	PF00675	0.473
CLV_NRD_NRD_1	695	697	PF00675	0.558
CLV_NRD_NRD_1	937	939	PF00675	0.520
CLV_PCSK_FUR_1	58	62	PF00082	0.441
CLV_PCSK_KEX2_1	249	251	PF00082	0.636
CLV_PCSK_KEX2_1	318	320	PF00082	0.531
CLV_PCSK_KEX2_1	60	62	PF00082	0.454
CLV_PCSK_KEX2_1	676	678	PF00082	0.464
CLV_PCSK_KEX2_1	789	791	PF00082	0.522
CLV_PCSK_KEX2_1	937	939	PF00082	0.520
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.636
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.454
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.522
CLV_PCSK_SKI1_1	196	200	PF00082	0.502
CLV_PCSK_SKI1_1	250	254	PF00082	0.587
CLV_PCSK_SKI1_1	319	323	PF00082	0.606
CLV_PCSK_SKI1_1	338	342	PF00082	0.428
CLV_PCSK_SKI1_1	430	434	PF00082	0.506
CLV_PCSK_SKI1_1	514	518	PF00082	0.639
CLV_PCSK_SKI1_1	653	657	PF00082	0.645
CLV_PCSK_SKI1_1	696	700	PF00082	0.556
CLV_Separin_Metazoa	642	646	PF03568	0.437
DEG_APCC_DBOX_1	195	203	PF00400	0.605
DEG_APCC_DBOX_1	249	257	PF00400	0.580
DEG_APCC_DBOX_1	259	267	PF00400	0.423
DEG_APCC_DBOX_1	318	326	PF00400	0.599
DEG_Kelch_Keap1_1	875	880	PF01344	0.567
DEG_SCF_FBW7_1	958	965	PF00400	0.558
DEG_SPOP_SBC_1	844	848	PF00917	0.560
DEG_SPOP_SBC_1	910	914	PF00917	0.551
DOC_CDC14_PxL_1	547	555	PF14671	0.502
DOC_CYCLIN_RxL_1	427	436	PF00134	0.378
DOC_MAPK_gen_1	318	325	PF00069	0.605
DOC_MAPK_gen_1	694	704	PF00069	0.460
DOC_MAPK_MEF2A_6	318	325	PF00069	0.605
DOC_PP1_RVXF_1	61	68	PF00149	0.527
DOC_PP1_RVXF_1	790	796	PF00149	0.656
DOC_USP7_MATH_1	105	109	PF00917	0.544
DOC_USP7_MATH_1	146	150	PF00917	0.452
DOC_USP7_MATH_1	179	183	PF00917	0.596
DOC_USP7_MATH_1	400	404	PF00917	0.546
DOC_USP7_MATH_1	448	452	PF00917	0.677
DOC_USP7_MATH_1	539	543	PF00917	0.629
DOC_USP7_MATH_1	571	575	PF00917	0.408
DOC_USP7_MATH_1	646	650	PF00917	0.476
DOC_USP7_MATH_1	743	747	PF00917	0.624
DOC_USP7_MATH_1	761	765	PF00917	0.551
DOC_USP7_MATH_1	771	775	PF00917	0.700
DOC_USP7_MATH_1	839	843	PF00917	0.562
DOC_USP7_MATH_1	881	885	PF00917	0.613
DOC_USP7_MATH_1	910	914	PF00917	0.637
DOC_USP7_MATH_1	960	964	PF00917	0.705
DOC_WW_Pin1_4	392	397	PF00397	0.741
DOC_WW_Pin1_4	654	659	PF00397	0.516
DOC_WW_Pin1_4	660	665	PF00397	0.470
DOC_WW_Pin1_4	830	835	PF00397	0.600
DOC_WW_Pin1_4	956	961	PF00397	0.690
LIG_14-3-3_CanoR_1	133	139	PF00244	0.493
LIG_14-3-3_CanoR_1	260	264	PF00244	0.525
LIG_14-3-3_CanoR_1	338	347	PF00244	0.749
LIG_14-3-3_CanoR_1	366	375	PF00244	0.633
LIG_14-3-3_CanoR_1	398	406	PF00244	0.616
LIG_14-3-3_CanoR_1	579	583	PF00244	0.660
LIG_14-3-3_CanoR_1	586	592	PF00244	0.674
LIG_14-3-3_CanoR_1	676	681	PF00244	0.565
LIG_14-3-3_CanoR_1	781	788	PF00244	0.647
LIG_14-3-3_CanoR_1	790	796	PF00244	0.757
LIG_14-3-3_CanoR_1	828	835	PF00244	0.609
LIG_Actin_WH2_2	452	467	PF00022	0.591
LIG_Actin_WH2_2	565	581	PF00022	0.604
LIG_AP2alpha_1	922	926	PF02296	0.507
LIG_BIR_III_2	233	237	PF00653	0.688
LIG_BRCT_BRCA1_1	169	173	PF00533	0.399
LIG_BRCT_BRCA1_1	402	406	PF00533	0.469
LIG_BRCT_BRCA1_1	852	856	PF00533	0.555
LIG_Clathr_ClatBox_1	432	436	PF01394	0.528
LIG_Clathr_ClatBox_1	502	506	PF01394	0.482
LIG_Clathr_ClatBox_1	801	805	PF01394	0.534
LIG_deltaCOP1_diTrp_1	15	23	PF00928	0.478
LIG_EH_1	277	281	PF12763	0.470
LIG_FHA_1	219	225	PF00498	0.587
LIG_FHA_1	253	259	PF00498	0.611
LIG_FHA_1	272	278	PF00498	0.413
LIG_FHA_1	280	286	PF00498	0.566
LIG_FHA_1	290	296	PF00498	0.346
LIG_FHA_1	33	39	PF00498	0.546
LIG_FHA_1	368	374	PF00498	0.530
LIG_FHA_1	436	442	PF00498	0.651
LIG_FHA_1	468	474	PF00498	0.643
LIG_FHA_1	660	666	PF00498	0.572
LIG_FHA_1	677	683	PF00498	0.618
LIG_FHA_1	699	705	PF00498	0.647
LIG_FHA_1	845	851	PF00498	0.647
LIG_FHA_2	121	127	PF00498	0.570
LIG_FHA_2	237	243	PF00498	0.556
LIG_FHA_2	408	414	PF00498	0.406
LIG_FHA_2	505	511	PF00498	0.603
LIG_FHA_2	727	733	PF00498	0.790
LIG_FHA_2	753	759	PF00498	0.595
LIG_IBAR_NPY_1	417	419	PF08397	0.267
LIG_IRF3_LxIS_1	477	483	PF10401	0.404
LIG_LIR_Gen_1	294	303	PF02991	0.608
LIG_LIR_Gen_1	383	392	PF02991	0.456
LIG_LIR_Gen_1	403	414	PF02991	0.425
LIG_LIR_Gen_1	794	802	PF02991	0.681
LIG_LIR_Gen_1	853	862	PF02991	0.752
LIG_LIR_Nem_3	21	26	PF02991	0.458
LIG_LIR_Nem_3	294	300	PF02991	0.583
LIG_LIR_Nem_3	403	409	PF02991	0.459
LIG_LIR_Nem_3	455	459	PF02991	0.640
LIG_LIR_Nem_3	794	798	PF02991	0.674
LIG_LIR_Nem_3	853	859	PF02991	0.764
LIG_MLH1_MIPbox_1	402	406	PF16413	0.469
LIG_MYND_3	199	203	PF01753	0.568
LIG_NRBOX	428	434	PF00104	0.608
LIG_PCNA_yPIPBox_3	426	439	PF02747	0.384
LIG_Pex14_1	110	114	PF04695	0.362
LIG_Pex14_1	219	223	PF04695	0.531
LIG_Pex14_2	377	381	PF04695	0.641
LIG_Pex14_2	922	926	PF04695	0.507
LIG_RPA_C_Fungi	517	529	PF08784	0.511
LIG_SH2_CRK	547	551	PF00017	0.476
LIG_SH2_CRK	782	786	PF00017	0.499
LIG_SH2_SRC	549	552	PF00017	0.664
LIG_SH2_SRC	582	585	PF00017	0.709
LIG_SH2_SRC	956	959	PF00017	0.550
LIG_SH2_STAP1	782	786	PF00017	0.499
LIG_SH2_STAT5	223	226	PF00017	0.593
LIG_SH2_STAT5	419	422	PF00017	0.267
LIG_SH2_STAT5	547	550	PF00017	0.578
LIG_SH2_STAT5	681	684	PF00017	0.554
LIG_SH2_STAT5	718	721	PF00017	0.589
LIG_SH2_STAT5	956	959	PF00017	0.550
LIG_SH3_3	140	146	PF00018	0.668
LIG_SH3_3	442	448	PF00018	0.484
LIG_SH3_3	661	667	PF00018	0.683
LIG_SUMO_SIM_anti_2	640	645	PF11976	0.498
LIG_SUMO_SIM_par_1	291	296	PF11976	0.406
LIG_SUMO_SIM_par_1	501	507	PF11976	0.487
LIG_SUMO_SIM_par_1	554	560	PF11976	0.520
LIG_SUMO_SIM_par_1	637	642	PF11976	0.572
LIG_SUMO_SIM_par_1	669	675	PF11976	0.493
LIG_TRAF2_1	509	512	PF00917	0.442
LIG_TRAF2_1	730	733	PF00917	0.624
LIG_TRAF2_1	806	809	PF00917	0.522
LIG_UBA3_1	523	531	PF00899	0.507
LIG_UBA3_1	692	700	PF00899	0.646
LIG_WRC_WIRS_1	111	116	PF05994	0.514
MOD_CDC14_SPxK_1	395	398	PF00782	0.733
MOD_CDK_SPxK_1	392	398	PF00069	0.738
MOD_CK1_1	104	110	PF00069	0.556
MOD_CK1_1	120	126	PF00069	0.365
MOD_CK1_1	156	162	PF00069	0.541
MOD_CK1_1	180	186	PF00069	0.691
MOD_CK1_1	222	228	PF00069	0.372
MOD_CK1_1	244	250	PF00069	0.523
MOD_CK1_1	296	302	PF00069	0.649
MOD_CK1_1	32	38	PF00069	0.589
MOD_CK1_1	42	48	PF00069	0.340
MOD_CK1_1	559	565	PF00069	0.519
MOD_CK1_1	585	591	PF00069	0.759
MOD_CK1_1	707	713	PF00069	0.447
MOD_CK1_1	760	766	PF00069	0.681
MOD_CK1_1	774	780	PF00069	0.527
MOD_CK1_1	814	820	PF00069	0.780
MOD_CK1_1	842	848	PF00069	0.657
MOD_CK1_1	875	881	PF00069	0.785
MOD_CK1_1	913	919	PF00069	0.679
MOD_CK2_1	329	335	PF00069	0.575
MOD_CK2_1	504	510	PF00069	0.630
MOD_CK2_1	646	652	PF00069	0.469
MOD_CK2_1	726	732	PF00069	0.784
MOD_CK2_1	752	758	PF00069	0.768
MOD_CK2_1	874	880	PF00069	0.630
MOD_GlcNHglycan	103	106	PF01048	0.554
MOD_GlcNHglycan	136	139	PF01048	0.512
MOD_GlcNHglycan	155	158	PF01048	0.393
MOD_GlcNHglycan	179	182	PF01048	0.673
MOD_GlcNHglycan	191	194	PF01048	0.727
MOD_GlcNHglycan	314	317	PF01048	0.654
MOD_GlcNHglycan	41	44	PF01048	0.540
MOD_GlcNHglycan	496	499	PF01048	0.599
MOD_GlcNHglycan	537	540	PF01048	0.736
MOD_GlcNHglycan	564	567	PF01048	0.621
MOD_GlcNHglycan	573	576	PF01048	0.446
MOD_GlcNHglycan	589	592	PF01048	0.730
MOD_GlcNHglycan	611	614	PF01048	0.610
MOD_GlcNHglycan	689	692	PF01048	0.553
MOD_GlcNHglycan	758	762	PF01048	0.698
MOD_GlcNHglycan	763	766	PF01048	0.693
MOD_GlcNHglycan	771	774	PF01048	0.573
MOD_GlcNHglycan	782	785	PF01048	0.597
MOD_GlcNHglycan	830	833	PF01048	0.646
MOD_GlcNHglycan	841	844	PF01048	0.717
MOD_GlcNHglycan	847	850	PF01048	0.672
MOD_GlcNHglycan	852	855	PF01048	0.577
MOD_GlcNHglycan	877	880	PF01048	0.632
MOD_GlcNHglycan	919	922	PF01048	0.541
MOD_GlcNHglycan	949	952	PF01048	0.695
MOD_GSK3_1	101	108	PF00069	0.516
MOD_GSK3_1	168	175	PF00069	0.619
MOD_GSK3_1	185	192	PF00069	0.567
MOD_GSK3_1	218	225	PF00069	0.524
MOD_GSK3_1	241	248	PF00069	0.545
MOD_GSK3_1	267	274	PF00069	0.449
MOD_GSK3_1	289	296	PF00069	0.583
MOD_GSK3_1	29	36	PF00069	0.597
MOD_GSK3_1	435	442	PF00069	0.650
MOD_GSK3_1	448	455	PF00069	0.485
MOD_GSK3_1	535	542	PF00069	0.674
MOD_GSK3_1	545	552	PF00069	0.586
MOD_GSK3_1	578	585	PF00069	0.614
MOD_GSK3_1	672	679	PF00069	0.644
MOD_GSK3_1	696	703	PF00069	0.576
MOD_GSK3_1	707	714	PF00069	0.426
MOD_GSK3_1	757	764	PF00069	0.591
MOD_GSK3_1	769	776	PF00069	0.499
MOD_GSK3_1	807	814	PF00069	0.529
MOD_GSK3_1	830	837	PF00069	0.741
MOD_GSK3_1	839	846	PF00069	0.616
MOD_GSK3_1	909	916	PF00069	0.655
MOD_GSK3_1	952	959	PF00069	0.722
MOD_N-GLC_1	153	158	PF02516	0.527
MOD_N-GLC_1	659	664	PF02516	0.533
MOD_N-GLC_1	71	76	PF02516	0.401
MOD_NEK2_1	134	139	PF00069	0.643
MOD_NEK2_1	168	173	PF00069	0.538
MOD_NEK2_1	201	206	PF00069	0.536
MOD_NEK2_1	245	250	PF00069	0.617
MOD_NEK2_1	252	257	PF00069	0.521
MOD_NEK2_1	271	276	PF00069	0.516
MOD_NEK2_1	329	334	PF00069	0.590
MOD_NEK2_1	33	38	PF00069	0.552
MOD_NEK2_1	420	425	PF00069	0.351
MOD_NEK2_1	480	485	PF00069	0.559
MOD_NEK2_1	5	10	PF00069	0.573
MOD_NEK2_1	578	583	PF00069	0.582
MOD_NEK2_1	609	614	PF00069	0.712
MOD_NEK2_1	629	634	PF00069	0.511
MOD_NEK2_1	672	677	PF00069	0.567
MOD_NEK2_1	687	692	PF00069	0.511
MOD_NEK2_1	698	703	PF00069	0.623
MOD_NEK2_1	704	709	PF00069	0.554
MOD_NEK2_1	757	762	PF00069	0.713
MOD_NEK2_1	791	796	PF00069	0.574
MOD_NEK2_1	874	879	PF00069	0.569
MOD_NEK2_1	911	916	PF00069	0.744
MOD_NEK2_2	146	151	PF00069	0.397
MOD_NEK2_2	400	405	PF00069	0.482
MOD_NEK2_2	50	55	PF00069	0.412
MOD_PIKK_1	398	404	PF00454	0.505
MOD_PIKK_1	594	600	PF00454	0.569
MOD_PIKK_1	707	713	PF00454	0.609
MOD_PIKK_1	811	817	PF00454	0.541
MOD_PKA_1	676	682	PF00069	0.445
MOD_PKA_1	696	702	PF00069	0.547
MOD_PKA_2	259	265	PF00069	0.566
MOD_PKA_2	578	584	PF00069	0.666
MOD_PKA_2	585	591	PF00069	0.788
MOD_PKA_2	676	682	PF00069	0.558
MOD_PKA_2	780	786	PF00069	0.643
MOD_PKA_2	791	797	PF00069	0.699
MOD_PKA_2	827	833	PF00069	0.608
MOD_PKA_2	875	881	PF00069	0.756
MOD_PKB_1	336	344	PF00069	0.496
MOD_PKB_1	694	702	PF00069	0.552
MOD_Plk_1	120	126	PF00069	0.401
MOD_Plk_1	241	247	PF00069	0.554
MOD_Plk_1	293	299	PF00069	0.434
MOD_Plk_1	33	39	PF00069	0.546
MOD_Plk_1	539	545	PF00069	0.663
MOD_Plk_1	559	565	PF00069	0.483
MOD_Plk_1	71	77	PF00069	0.411
MOD_Plk_1	774	780	PF00069	0.648
MOD_Plk_2-3	34	40	PF00069	0.536
MOD_Plk_2-3	504	510	PF00069	0.458
MOD_Plk_2-3	71	77	PF00069	0.411
MOD_Plk_4	168	174	PF00069	0.565
MOD_Plk_4	201	207	PF00069	0.530
MOD_Plk_4	219	225	PF00069	0.321
MOD_Plk_4	267	273	PF00069	0.385
MOD_Plk_4	400	406	PF00069	0.481
MOD_Plk_4	452	458	PF00069	0.671
MOD_Plk_4	545	551	PF00069	0.674
MOD_Plk_4	629	635	PF00069	0.469
MOD_Plk_4	676	682	PF00069	0.620
MOD_Plk_4	797	803	PF00069	0.752
MOD_Plk_4	881	887	PF00069	0.560
MOD_Plk_4	952	958	PF00069	0.541
MOD_ProDKin_1	392	398	PF00069	0.738
MOD_ProDKin_1	654	660	PF00069	0.518
MOD_ProDKin_1	830	836	PF00069	0.602
MOD_ProDKin_1	956	962	PF00069	0.690
MOD_SUMO_for_1	599	602	PF00179	0.560
MOD_SUMO_rev_2	783	791	PF00179	0.512
TRG_DiLeu_BaEn_1	540	545	PF01217	0.547
TRG_DiLeu_BaEn_1	650	655	PF01217	0.493
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.548
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.636
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.429
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.547
TRG_ENDOCYTIC_2	386	389	PF00928	0.520
TRG_ENDOCYTIC_2	547	550	PF00928	0.475
TRG_ENDOCYTIC_2	782	785	PF00928	0.498
TRG_ER_diArg_1	336	339	PF00400	0.491
TRG_ER_diArg_1	693	696	PF00400	0.560
TRG_ER_diArg_1	790	793	PF00400	0.519
TRG_NLS_MonoExtC_3	59	64	PF00514	0.426
TRG_NLS_MonoExtN_4	58	64	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.631
TRG_PTS1	967	970	PF00515	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV9	Leptomonas seymouri	28%	100%
A0A3Q8IDR9	Leishmania donovani	61%	100%
A4I3J5	Leishmania infantum	61%	100%
E9AZT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%