Putative long-chain-fatty-acid-CoA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long-chain-fatty-acid-CoA ligase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGG0_LEIBR

TriTrypDb:

LbrM.28.1230 , LBRM2903_280018300

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGG0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004467	long-chain fatty acid-CoA ligase activity	3	5
GO:0015645	fatty acid ligase activity	2	5
GO:0016405	CoA-ligase activity	4	5
GO:0016874	ligase activity	2	11
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	5
GO:0016878	acid-thiol ligase activity	4	5
GO:0140657	ATP-dependent activity	1	5
GO:0031957	very long-chain fatty acid-CoA ligase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.355
CLV_MEL_PAP_1	454	460	PF00089	0.174
CLV_NRD_NRD_1	267	269	PF00675	0.604
CLV_NRD_NRD_1	456	458	PF00675	0.391
CLV_NRD_NRD_1	466	468	PF00675	0.396
CLV_NRD_NRD_1	643	645	PF00675	0.215
CLV_NRD_NRD_1	68	70	PF00675	0.482
CLV_PCSK_KEX2_1	235	237	PF00082	0.521
CLV_PCSK_KEX2_1	267	269	PF00082	0.626
CLV_PCSK_KEX2_1	456	458	PF00082	0.344
CLV_PCSK_KEX2_1	68	70	PF00082	0.468
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.556
CLV_PCSK_SKI1_1	236	240	PF00082	0.627
CLV_PCSK_SKI1_1	339	343	PF00082	0.288
CLV_PCSK_SKI1_1	35	39	PF00082	0.432
CLV_PCSK_SKI1_1	645	649	PF00082	0.206
CLV_PCSK_SKI1_1	679	683	PF00082	0.307
CLV_PCSK_SKI1_1	701	705	PF00082	0.347
CLV_PCSK_SKI1_1	733	737	PF00082	0.403
CLV_PCSK_SKI1_1	94	98	PF00082	0.526
CLV_Separin_Metazoa	41	45	PF03568	0.292
CLV_Separin_Metazoa	721	725	PF03568	0.273
DEG_Nend_Nbox_1	1	3	PF02207	0.508
DEG_ODPH_VHL_1	707	719	PF01847	0.331
DOC_ANK_TNKS_1	586	593	PF00023	0.174
DOC_CKS1_1	140	145	PF01111	0.541
DOC_CYCLIN_yClb5_NLxxxL_5	730	739	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	513	519	PF00134	0.273
DOC_MAPK_gen_1	343	353	PF00069	0.299
DOC_MAPK_gen_1	628	637	PF00069	0.436
DOC_MAPK_gen_1	700	706	PF00069	0.331
DOC_MAPK_gen_1	732	741	PF00069	0.430
DOC_MAPK_MEF2A_6	35	42	PF00069	0.238
DOC_MAPK_NFAT4_5	35	43	PF00069	0.250
DOC_PP1_RVXF_1	677	684	PF00149	0.331
DOC_PP2B_LxvP_1	40	43	PF13499	0.266
DOC_PP2B_LxvP_1	484	487	PF13499	0.273
DOC_PP2B_LxvP_1	706	709	PF13499	0.384
DOC_PP2B_LxvP_1	739	742	PF13499	0.335
DOC_PP4_FxxP_1	29	32	PF00568	0.254
DOC_PP4_FxxP_1	5	8	PF00568	0.552
DOC_USP7_MATH_1	205	209	PF00917	0.630
DOC_USP7_MATH_1	251	255	PF00917	0.670
DOC_USP7_MATH_1	258	262	PF00917	0.624
DOC_USP7_MATH_1	410	414	PF00917	0.386
DOC_USP7_UBL2_3	235	239	PF12436	0.678
DOC_USP7_UBL2_3	729	733	PF12436	0.433
DOC_WW_Pin1_4	100	105	PF00397	0.686
DOC_WW_Pin1_4	139	144	PF00397	0.526
DOC_WW_Pin1_4	456	461	PF00397	0.256
DOC_WW_Pin1_4	527	532	PF00397	0.334
DOC_WW_Pin1_4	77	82	PF00397	0.528
LIG_14-3-3_CanoR_1	3	8	PF00244	0.593
LIG_14-3-3_CanoR_1	503	513	PF00244	0.255
LIG_14-3-3_CanoR_1	619	623	PF00244	0.423
LIG_14-3-3_CanoR_1	679	684	PF00244	0.248
LIG_Actin_WH2_2	215	232	PF00022	0.414
LIG_APCC_ABBAyCdc20_2	644	650	PF00400	0.299
LIG_BRCT_BRCA1_1	213	217	PF00533	0.599
LIG_Clathr_ClatBox_1	318	322	PF01394	0.331
LIG_deltaCOP1_diTrp_1	381	385	PF00928	0.362
LIG_EH1_1	397	405	PF00400	0.273
LIG_eIF4E_1	223	229	PF01652	0.586
LIG_FHA_1	124	130	PF00498	0.376
LIG_FHA_1	168	174	PF00498	0.668
LIG_FHA_1	214	220	PF00498	0.532
LIG_FHA_1	224	230	PF00498	0.476
LIG_FHA_1	239	245	PF00498	0.523
LIG_FHA_1	37	43	PF00498	0.250
LIG_FHA_1	386	392	PF00498	0.285
LIG_FHA_1	446	452	PF00498	0.236
LIG_FHA_1	534	540	PF00498	0.198
LIG_FHA_1	694	700	PF00498	0.354
LIG_FHA_1	725	731	PF00498	0.273
LIG_FHA_2	219	225	PF00498	0.515
LIG_FHA_2	343	349	PF00498	0.331
LIG_FHA_2	418	424	PF00498	0.273
LIG_FHA_2	497	503	PF00498	0.273
LIG_FHA_2	580	586	PF00498	0.273
LIG_FHA_2	680	686	PF00498	0.246
LIG_IRF3_LxIS_1	561	567	PF10401	0.174
LIG_LIR_Apic_2	27	32	PF02991	0.250
LIG_LIR_Apic_2	83	87	PF02991	0.600
LIG_LIR_Gen_1	438	447	PF02991	0.323
LIG_LIR_Gen_1	714	723	PF02991	0.304
LIG_LIR_Nem_3	180	184	PF02991	0.505
LIG_LIR_Nem_3	438	443	PF02991	0.331
LIG_LIR_Nem_3	445	450	PF02991	0.269
LIG_LIR_Nem_3	51	55	PF02991	0.344
LIG_LIR_Nem_3	569	575	PF02991	0.236
LIG_LIR_Nem_3	714	719	PF02991	0.318
LIG_PCNA_yPIPBox_3	20	29	PF02747	0.374
LIG_Pex14_2	572	576	PF04695	0.255
LIG_PTB_Apo_2	44	51	PF02174	0.308
LIG_SH2_CRK	125	129	PF00017	0.330
LIG_SH2_CRK	15	19	PF00017	0.448
LIG_SH2_CRK	337	341	PF00017	0.307
LIG_SH2_CRK	447	451	PF00017	0.197
LIG_SH2_CRK	52	56	PF00017	0.383
LIG_SH2_CRK	614	618	PF00017	0.386
LIG_SH2_CRK	710	714	PF00017	0.273
LIG_SH2_GRB2like	575	578	PF00017	0.386
LIG_SH2_PTP2	716	719	PF00017	0.334
LIG_SH2_SRC	716	719	PF00017	0.269
LIG_SH2_STAP1	115	119	PF00017	0.530
LIG_SH2_STAP1	125	129	PF00017	0.304
LIG_SH2_STAP1	15	19	PF00017	0.494
LIG_SH2_STAP1	223	227	PF00017	0.554
LIG_SH2_STAP1	347	351	PF00017	0.331
LIG_SH2_STAP1	447	451	PF00017	0.168
LIG_SH2_STAP1	649	653	PF00017	0.386
LIG_SH2_STAT3	538	541	PF00017	0.331
LIG_SH2_STAT5	115	118	PF00017	0.574
LIG_SH2_STAT5	125	128	PF00017	0.322
LIG_SH2_STAT5	156	159	PF00017	0.516
LIG_SH2_STAT5	185	188	PF00017	0.575
LIG_SH2_STAT5	354	357	PF00017	0.255
LIG_SH2_STAT5	447	450	PF00017	0.245
LIG_SH2_STAT5	538	541	PF00017	0.386
LIG_SH2_STAT5	614	617	PF00017	0.386
LIG_SH2_STAT5	716	719	PF00017	0.334
LIG_SH3_3	40	46	PF00018	0.415
LIG_SH3_3	513	519	PF00018	0.273
LIG_SH3_3	525	531	PF00018	0.273
LIG_SH3_3	605	611	PF00018	0.263
LIG_SH3_3	717	723	PF00018	0.273
LIG_SH3_3	84	90	PF00018	0.556
LIG_SH3_5	104	108	PF00018	0.555
LIG_SUMO_SIM_anti_2	620	627	PF11976	0.431
LIG_SUMO_SIM_anti_2	663	670	PF11976	0.343
LIG_SUMO_SIM_par_1	224	231	PF11976	0.588
LIG_TRAF2_1	582	585	PF00917	0.174
LIG_TYR_ITIM	13	18	PF00017	0.510
LIG_UBA3_1	228	235	PF00899	0.444
LIG_WRC_WIRS_1	419	424	PF05994	0.355
MOD_CDK_SPxxK_3	456	463	PF00069	0.334
MOD_CK1_1	208	214	PF00069	0.632
MOD_CK1_1	356	362	PF00069	0.267
MOD_CK1_1	496	502	PF00069	0.273
MOD_CK1_1	567	573	PF00069	0.326
MOD_CK1_1	689	695	PF00069	0.416
MOD_CK2_1	197	203	PF00069	0.604
MOD_CK2_1	456	462	PF00069	0.256
MOD_CK2_1	496	502	PF00069	0.273
MOD_CK2_1	579	585	PF00069	0.273
MOD_CK2_1	630	636	PF00069	0.364
MOD_CK2_1	679	685	PF00069	0.249
MOD_GlcNHglycan	159	163	PF01048	0.600
MOD_GlcNHglycan	207	210	PF01048	0.561
MOD_GlcNHglycan	253	256	PF01048	0.544
MOD_GlcNHglycan	260	263	PF01048	0.562
MOD_GlcNHglycan	355	358	PF01048	0.270
MOD_GlcNHglycan	480	483	PF01048	0.264
MOD_GlcNHglycan	494	498	PF01048	0.289
MOD_GlcNHglycan	551	554	PF01048	0.470
MOD_GlcNHglycan	632	635	PF01048	0.342
MOD_GSK3_1	109	116	PF00069	0.608
MOD_GSK3_1	123	130	PF00069	0.319
MOD_GSK3_1	158	165	PF00069	0.615
MOD_GSK3_1	352	359	PF00069	0.273
MOD_GSK3_1	527	534	PF00069	0.318
MOD_GSK3_1	686	693	PF00069	0.382
MOD_N-GLC_1	577	582	PF02516	0.433
MOD_N-GLC_1	724	729	PF02516	0.304
MOD_NEK2_1	109	114	PF00069	0.574
MOD_NEK2_1	144	149	PF00069	0.577
MOD_NEK2_1	218	223	PF00069	0.573
MOD_NEK2_1	238	243	PF00069	0.639
MOD_NEK2_1	352	357	PF00069	0.277
MOD_NEK2_1	511	516	PF00069	0.314
MOD_NEK2_1	617	622	PF00069	0.278
MOD_NEK2_2	14	19	PF00069	0.443
MOD_NEK2_2	240	245	PF00069	0.467
MOD_NEK2_2	320	325	PF00069	0.174
MOD_NEK2_2	435	440	PF00069	0.386
MOD_NEK2_2	470	475	PF00069	0.331
MOD_PIKK_1	144	150	PF00454	0.535
MOD_PIKK_1	167	173	PF00454	0.412
MOD_PIKK_1	511	517	PF00454	0.299
MOD_PKA_2	342	348	PF00069	0.295
MOD_PKA_2	385	391	PF00069	0.393
MOD_PKA_2	618	624	PF00069	0.409
MOD_PKB_1	677	685	PF00069	0.246
MOD_Plk_1	223	229	PF00069	0.633
MOD_Plk_1	435	441	PF00069	0.278
MOD_Plk_1	690	696	PF00069	0.306
MOD_Plk_4	115	121	PF00069	0.530
MOD_Plk_4	123	129	PF00069	0.334
MOD_Plk_4	14	20	PF00069	0.438
MOD_Plk_4	213	219	PF00069	0.564
MOD_Plk_4	223	229	PF00069	0.464
MOD_Plk_4	24	30	PF00069	0.320
MOD_Plk_4	387	393	PF00069	0.269
MOD_Plk_4	442	448	PF00069	0.255
MOD_Plk_4	496	502	PF00069	0.285
MOD_Plk_4	534	540	PF00069	0.346
MOD_Plk_4	567	573	PF00069	0.259
MOD_Plk_4	612	618	PF00069	0.411
MOD_Plk_4	661	667	PF00069	0.377
MOD_Plk_4	80	86	PF00069	0.436
MOD_ProDKin_1	100	106	PF00069	0.684
MOD_ProDKin_1	139	145	PF00069	0.532
MOD_ProDKin_1	456	462	PF00069	0.256
MOD_ProDKin_1	527	533	PF00069	0.334
MOD_ProDKin_1	77	83	PF00069	0.531
MOD_SUMO_rev_2	175	184	PF00179	0.562
MOD_SUMO_rev_2	231	241	PF00179	0.665
MOD_SUMO_rev_2	692	702	PF00179	0.291
TRG_DiLeu_BaEn_1	638	643	PF01217	0.174
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.393
TRG_ENDOCYTIC_2	125	128	PF00928	0.316
TRG_ENDOCYTIC_2	15	18	PF00928	0.460
TRG_ENDOCYTIC_2	181	184	PF00928	0.486
TRG_ENDOCYTIC_2	21	24	PF00928	0.332
TRG_ENDOCYTIC_2	447	450	PF00928	0.271
TRG_ENDOCYTIC_2	52	55	PF00928	0.360
TRG_ENDOCYTIC_2	614	617	PF00928	0.386
TRG_ENDOCYTIC_2	716	719	PF00928	0.334
TRG_ER_diArg_1	266	268	PF00400	0.418
TRG_ER_diArg_1	456	458	PF00400	0.434
TRG_ER_diArg_1	67	69	PF00400	0.627
TRG_NES_CRM1_1	316	327	PF08389	0.174
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IL67	Bodo saltans	42%	96%
A0A1X0NYK4	Trypanosomatidae	52%	100%
A0A3Q8ID29	Leishmania donovani	82%	100%
A0A3R7KRF3	Trypanosoma rangeli	51%	100%
A0A3S7WVH9	Leishmania donovani	21%	100%
A0A3S7WVL1	Leishmania donovani	22%	100%
A4HA52	Leishmania braziliensis	21%	100%
A4HYA8	Leishmania infantum	22%	100%
A4HYB7	Leishmania infantum	21%	100%
A4I3J3	Leishmania infantum	82%	100%
D0A7V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AGS6	Leishmania infantum	22%	100%
E9AZT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O24146	Nicotiana tabacum	24%	100%
Q4Q8F1	Leishmania major	81%	100%
Q4QDB5	Leishmania major	22%	100%
Q4QDB6	Leishmania major	22%	100%
V5AUI9	Trypanosoma cruzi	52%	100%