Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGF8_LEIBR

TriTrypDb:

LbrM.28.1210 , LBRM2903_280018100

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HGF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.593
CLV_NRD_NRD_1	356	358	PF00675	0.503
CLV_PCSK_KEX2_1	355	357	PF00082	0.493
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.493
CLV_PCSK_SKI1_1	114	118	PF00082	0.362
CLV_PCSK_SKI1_1	147	151	PF00082	0.327
CLV_PCSK_SKI1_1	207	211	PF00082	0.504
DOC_CYCLIN_yCln2_LP_2	419	425	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.231
DOC_MAPK_gen_1	355	363	PF00069	0.227
DOC_MAPK_gen_1	427	436	PF00069	0.469
DOC_MAPK_HePTP_8	353	365	PF00069	0.217
DOC_MAPK_MEF2A_6	356	365	PF00069	0.217
DOC_MAPK_MEF2A_6	427	436	PF00069	0.530
DOC_PP2B_LxvP_1	375	378	PF13499	0.248
DOC_PP2B_LxvP_1	419	422	PF13499	0.274
DOC_PP2B_LxvP_1	495	498	PF13499	0.231
DOC_USP7_MATH_1	348	352	PF00917	0.218
DOC_USP7_MATH_1	401	405	PF00917	0.282
DOC_USP7_MATH_1	423	427	PF00917	0.204
DOC_WW_Pin1_4	136	141	PF00397	0.583
DOC_WW_Pin1_4	5	10	PF00397	0.682
DOC_WW_Pin1_4	55	60	PF00397	0.617
LIG_14-3-3_CanoR_1	247	251	PF00244	0.462
LIG_14-3-3_CanoR_1	356	362	PF00244	0.288
LIG_14-3-3_CanoR_1	427	433	PF00244	0.422
LIG_14-3-3_CanoR_1	455	464	PF00244	0.289
LIG_BRCT_BRCA1_1	157	161	PF00533	0.362
LIG_BRCT_BRCA1_1	340	344	PF00533	0.290
LIG_BRCT_BRCA1_1	401	405	PF00533	0.296
LIG_BRCT_BRCA1_1	432	436	PF00533	0.343
LIG_CaM_NSCaTE_8	502	509	PF13499	0.274
LIG_EH1_1	435	443	PF00400	0.274
LIG_eIF4E_1	250	256	PF01652	0.336
LIG_eIF4E_1	370	376	PF01652	0.293
LIG_FHA_1	118	124	PF00498	0.667
LIG_FHA_1	188	194	PF00498	0.198
LIG_FHA_1	219	225	PF00498	0.234
LIG_FHA_1	286	292	PF00498	0.248
LIG_FHA_1	358	364	PF00498	0.271
LIG_FHA_1	371	377	PF00498	0.258
LIG_FHA_1	429	435	PF00498	0.470
LIG_FHA_1	448	454	PF00498	0.381
LIG_FHA_2	206	212	PF00498	0.198
LIG_GBD_Chelix_1	310	318	PF00786	0.357
LIG_LIR_Apic_2	118	124	PF02991	0.635
LIG_LIR_Gen_1	249	260	PF02991	0.458
LIG_LIR_Gen_1	331	342	PF02991	0.336
LIG_LIR_Gen_1	402	413	PF02991	0.330
LIG_LIR_Gen_1	433	444	PF02991	0.439
LIG_LIR_Nem_3	248	253	PF02991	0.447
LIG_LIR_Nem_3	257	261	PF02991	0.320
LIG_LIR_Nem_3	331	337	PF02991	0.351
LIG_LIR_Nem_3	402	408	PF02991	0.359
LIG_LIR_Nem_3	433	439	PF02991	0.331
LIG_LIR_Nem_3	440	446	PF02991	0.319
LIG_LIR_Nem_3	467	472	PF02991	0.284
LIG_LIR_Nem_3	477	483	PF02991	0.296
LIG_LIR_Nem_3	484	489	PF02991	0.281
LIG_MYND_1	136	140	PF01753	0.541
LIG_NRBOX	233	239	PF00104	0.230
LIG_PAM2_1	254	266	PF00658	0.336
LIG_PAM2_1	295	307	PF00658	0.274
LIG_PDZ_Class_3	517	522	PF00595	0.540
LIG_Pex14_1	252	256	PF04695	0.336
LIG_Pex14_1	354	358	PF04695	0.288
LIG_Pex14_1	468	472	PF04695	0.198
LIG_Pex14_2	157	161	PF04695	0.383
LIG_Pex14_2	309	313	PF04695	0.421
LIG_SH2_CRK	121	125	PF00017	0.632
LIG_SH2_CRK	201	205	PF00017	0.203
LIG_SH2_CRK	219	223	PF00017	0.234
LIG_SH2_CRK	334	338	PF00017	0.349
LIG_SH2_CRK	472	476	PF00017	0.346
LIG_SH2_CRK	480	484	PF00017	0.357
LIG_SH2_NCK_1	201	205	PF00017	0.198
LIG_SH2_SRC	385	388	PF00017	0.198
LIG_SH2_STAP1	103	107	PF00017	0.583
LIG_SH2_STAT3	489	492	PF00017	0.293
LIG_SH2_STAT5	121	124	PF00017	0.620
LIG_SH2_STAT5	129	132	PF00017	0.546
LIG_SH2_STAT5	472	475	PF00017	0.198
LIG_SH2_STAT6	126	130	PF00017	0.539
LIG_SH3_3	134	140	PF00018	0.622
LIG_SUMO_SIM_anti_2	233	240	PF11976	0.247
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.277
LIG_SUMO_SIM_par_1	220	226	PF11976	0.258
LIG_WRC_WIRS_1	255	260	PF05994	0.336
LIG_WRC_WIRS_1	330	335	PF05994	0.264
MOD_CDK_SPxxK_3	136	143	PF00069	0.341
MOD_CK1_1	108	114	PF00069	0.462
MOD_CK1_1	202	208	PF00069	0.242
MOD_CK1_1	233	239	PF00069	0.430
MOD_CK1_1	437	443	PF00069	0.333
MOD_CK1_1	447	453	PF00069	0.304
MOD_CK1_1	60	66	PF00069	0.517
MOD_CK1_1	91	97	PF00069	0.523
MOD_CK2_1	66	72	PF00069	0.552
MOD_GlcNHglycan	180	184	PF01048	0.466
MOD_GlcNHglycan	2	5	PF01048	0.539
MOD_GlcNHglycan	201	204	PF01048	0.252
MOD_GlcNHglycan	476	479	PF01048	0.445
MOD_GlcNHglycan	86	89	PF01048	0.562
MOD_GlcNHglycan	90	93	PF01048	0.618
MOD_GSK3_1	233	240	PF00069	0.375
MOD_GSK3_1	344	351	PF00069	0.288
MOD_GSK3_1	430	437	PF00069	0.357
MOD_GSK3_1	470	477	PF00069	0.268
MOD_GSK3_1	60	67	PF00069	0.658
MOD_GSK3_1	80	87	PF00069	0.537
MOD_N-GLC_1	199	204	PF02516	0.286
MOD_N-GLC_1	348	353	PF02516	0.225
MOD_N-GLC_1	378	383	PF02516	0.387
MOD_NEK2_1	107	112	PF00069	0.629
MOD_NEK2_1	161	166	PF00069	0.333
MOD_NEK2_1	218	223	PF00069	0.361
MOD_NEK2_1	237	242	PF00069	0.349
MOD_NEK2_1	254	259	PF00069	0.302
MOD_NEK2_1	261	266	PF00069	0.343
MOD_NEK2_1	285	290	PF00069	0.349
MOD_NEK2_1	295	300	PF00069	0.243
MOD_NEK2_1	313	318	PF00069	0.361
MOD_NEK2_1	338	343	PF00069	0.421
MOD_NEK2_1	344	349	PF00069	0.249
MOD_NEK2_1	399	404	PF00069	0.373
MOD_NEK2_1	406	411	PF00069	0.384
MOD_NEK2_1	444	449	PF00069	0.462
MOD_NEK2_1	506	511	PF00069	0.436
MOD_PIKK_1	393	399	PF00454	0.222
MOD_PK_1	430	436	PF00069	0.274
MOD_PKA_2	246	252	PF00069	0.331
MOD_PKA_2	456	462	PF00069	0.348
MOD_Plk_1	117	123	PF00069	0.527
MOD_Plk_1	187	193	PF00069	0.204
MOD_Plk_1	199	205	PF00069	0.233
MOD_Plk_1	348	354	PF00069	0.269
MOD_Plk_4	223	229	PF00069	0.354
MOD_Plk_4	230	236	PF00069	0.381
MOD_Plk_4	295	301	PF00069	0.323
MOD_Plk_4	329	335	PF00069	0.399
MOD_Plk_4	338	344	PF00069	0.437
MOD_Plk_4	349	355	PF00069	0.342
MOD_Plk_4	379	385	PF00069	0.425
MOD_Plk_4	401	407	PF00069	0.339
MOD_Plk_4	430	436	PF00069	0.316
MOD_Plk_4	444	450	PF00069	0.365
MOD_Plk_4	464	470	PF00069	0.279
MOD_Plk_4	506	512	PF00069	0.361
MOD_Plk_4	57	63	PF00069	0.547
MOD_Plk_4	80	86	PF00069	0.551
MOD_ProDKin_1	136	142	PF00069	0.454
MOD_ProDKin_1	5	11	PF00069	0.598
MOD_ProDKin_1	55	61	PF00069	0.511
TRG_ENDOCYTIC_2	127	130	PF00928	0.393
TRG_ENDOCYTIC_2	201	204	PF00928	0.274
TRG_ENDOCYTIC_2	219	222	PF00928	0.192
TRG_ENDOCYTIC_2	250	253	PF00928	0.341
TRG_ENDOCYTIC_2	334	337	PF00928	0.401
TRG_ENDOCYTIC_2	472	475	PF00928	0.336
TRG_ENDOCYTIC_2	480	483	PF00928	0.336
TRG_ER_diArg_1	356	358	PF00400	0.247
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	30%	100%
A0A0N1PC74	Leptomonas seymouri	54%	100%
A0A0N1PCA2	Leptomonas seymouri	28%	100%
A0A3Q8I8Q6	Leishmania donovani	29%	100%
A0A3S7WR28	Leishmania donovani	28%	100%
A0A3S7X1E1	Leishmania donovani	71%	100%
A4H605	Leishmania braziliensis	27%	100%
A4H606	Leishmania braziliensis	28%	100%
A4HUD2	Leishmania infantum	29%	100%
A4HUD3	Leishmania infantum	28%	100%
A4I3I9	Leishmania infantum	71%	100%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q8F3	Leishmania major	69%	100%
Q4QHJ3	Leishmania major	27%	100%
Q4QHJ4	Leishmania major	29%	100%