Cilia- and flagella-associated protein 52

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HGF6_LEIBR

TriTrypDb:

LbrM.28.1190 , LBRM2903_280017900

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005815	microtubule organizing center	2	1
GO:0005840	ribosome	5	12
GO:0005929	cilium	4	12
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12

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Expansion

Sequence features

A4HGF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF6

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.565
CLV_NRD_NRD_1	185	187	PF00675	0.470
CLV_NRD_NRD_1	199	201	PF00675	0.421
CLV_NRD_NRD_1	435	437	PF00675	0.224
CLV_NRD_NRD_1	500	502	PF00675	0.416
CLV_NRD_NRD_1	98	100	PF00675	0.416
CLV_PCSK_KEX2_1	199	201	PF00082	0.449
CLV_PCSK_KEX2_1	435	437	PF00082	0.414
CLV_PCSK_KEX2_1	500	502	PF00082	0.418
CLV_PCSK_KEX2_1	98	100	PF00082	0.432

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB29	Leptomonas seymouri	86%	100%
A0A0S4JJ02	Bodo saltans	59%	100%
A0A0S4JL38	Bodo saltans	23%	100%
A0A0S4JL93	Bodo saltans	24%	87%
A0A0S4KEW0	Bodo saltans	23%	98%
A0A1X0NYB9	Trypanosomatidae	68%	100%
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3R7N3I7	Trypanosoma rangeli	67%	99%
A0A3S7WR72	Leishmania donovani	21%	100%
A0A3S7X1E5	Leishmania donovani	94%	100%

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