Cilia- and flagella-associated protein 52

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HGF6_LEIBR

TriTrypDb:

LbrM.28.1190 , LBRM2903_280017900

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005840	ribosome	5	12
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HGF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.565
CLV_NRD_NRD_1	185	187	PF00675	0.470
CLV_NRD_NRD_1	199	201	PF00675	0.421
CLV_NRD_NRD_1	435	437	PF00675	0.224
CLV_NRD_NRD_1	500	502	PF00675	0.416
CLV_NRD_NRD_1	98	100	PF00675	0.416
CLV_PCSK_KEX2_1	199	201	PF00082	0.449
CLV_PCSK_KEX2_1	435	437	PF00082	0.414
CLV_PCSK_KEX2_1	500	502	PF00082	0.418
CLV_PCSK_KEX2_1	98	100	PF00082	0.432
CLV_PCSK_SKI1_1	103	107	PF00082	0.396
CLV_PCSK_SKI1_1	167	171	PF00082	0.392
CLV_PCSK_SKI1_1	399	403	PF00082	0.443
CLV_PCSK_SKI1_1	436	440	PF00082	0.349
CLV_PCSK_SKI1_1	572	576	PF00082	0.289
CLV_Separin_Metazoa	358	362	PF03568	0.396
DEG_APCC_DBOX_1	102	110	PF00400	0.403
DOC_ANK_TNKS_1	598	605	PF00023	0.531
DOC_MAPK_gen_1	108	116	PF00069	0.490
DOC_MAPK_gen_1	186	193	PF00069	0.529
DOC_MAPK_gen_1	199	207	PF00069	0.334
DOC_MAPK_gen_1	98	106	PF00069	0.407
DOC_MAPK_HePTP_8	183	195	PF00069	0.584
DOC_MAPK_MEF2A_6	177	185	PF00069	0.554
DOC_MAPK_MEF2A_6	186	195	PF00069	0.573
DOC_MAPK_MEF2A_6	581	589	PF00069	0.467
DOC_MAPK_MEF2A_6	63	71	PF00069	0.523
DOC_PP1_RVXF_1	154	161	PF00149	0.417
DOC_PP1_RVXF_1	397	403	PF00149	0.441
DOC_SPAK_OSR1_1	563	567	PF12202	0.500
DOC_USP7_UBL2_3	418	422	PF12436	0.576
DOC_WW_Pin1_4	114	119	PF00397	0.424
DOC_WW_Pin1_4	4	9	PF00397	0.549
DOC_WW_Pin1_4	556	561	PF00397	0.583
DOC_WW_Pin1_4	598	603	PF00397	0.500
LIG_14-3-3_CanoR_1	177	182	PF00244	0.450
LIG_14-3-3_CanoR_1	199	203	PF00244	0.464
LIG_14-3-3_CanoR_1	317	327	PF00244	0.414
LIG_14-3-3_CanoR_1	506	510	PF00244	0.527
LIG_BH_BH3_1	244	260	PF00452	0.536
LIG_BRCT_BRCA1_1	336	340	PF00533	0.382
LIG_BRCT_BRCA1_1	53	57	PF00533	0.529
LIG_CaM_IQ_9	264	280	PF13499	0.541
LIG_Clathr_ClatBox_1	359	363	PF01394	0.493
LIG_FHA_1	131	137	PF00498	0.554
LIG_FHA_1	153	159	PF00498	0.498
LIG_FHA_1	168	174	PF00498	0.295
LIG_FHA_1	178	184	PF00498	0.400
LIG_FHA_1	202	208	PF00498	0.399
LIG_FHA_1	253	259	PF00498	0.493
LIG_FHA_1	301	307	PF00498	0.518
LIG_FHA_1	355	361	PF00498	0.543
LIG_FHA_1	477	483	PF00498	0.508
LIG_FHA_1	494	500	PF00498	0.485
LIG_FHA_1	5	11	PF00498	0.497
LIG_FHA_1	548	554	PF00498	0.427
LIG_FHA_1	66	72	PF00498	0.564
LIG_FHA_2	217	223	PF00498	0.407
LIG_FHA_2	340	346	PF00498	0.502
LIG_FHA_2	481	487	PF00498	0.583
LIG_GBD_Chelix_1	491	499	PF00786	0.391
LIG_KLC1_Yacidic_2	514	518	PF13176	0.529
LIG_LIR_Nem_3	508	513	PF02991	0.387
LIG_MLH1_MIPbox_1	53	57	PF16413	0.574
LIG_PCNA_yPIPBox_3	563	577	PF02747	0.531
LIG_PDZ_Class_3	624	629	PF00595	0.637
LIG_Pex14_2	332	336	PF04695	0.438
LIG_SH2_STAT5	122	125	PF00017	0.500
LIG_SH2_STAT5	215	218	PF00017	0.352
LIG_SH2_STAT5	298	301	PF00017	0.382
LIG_SH2_STAT5	307	310	PF00017	0.357
LIG_SH2_STAT5	432	435	PF00017	0.424
LIG_SH2_STAT5	498	501	PF00017	0.507
LIG_SH2_STAT5	509	512	PF00017	0.339
LIG_SH2_STAT5	516	519	PF00017	0.274
LIG_SH2_STAT5	75	78	PF00017	0.421
LIG_SH3_3	123	129	PF00018	0.583
LIG_SH3_3	24	30	PF00018	0.542
LIG_SH3_3	327	333	PF00018	0.382
LIG_SH3_3	78	84	PF00018	0.542
LIG_SUMO_SIM_anti_2	288	296	PF11976	0.425
LIG_SUMO_SIM_par_1	130	138	PF11976	0.554
LIG_SUMO_SIM_par_1	179	184	PF11976	0.542
LIG_SUMO_SIM_par_1	203	208	PF11976	0.414
LIG_SUMO_SIM_par_1	606	613	PF11976	0.489
LIG_SUMO_SIM_par_1	67	72	PF11976	0.535
LIG_UBA3_1	100	108	PF00899	0.461
LIG_UBA3_1	233	241	PF00899	0.341
MOD_CDK_SPK_2	4	9	PF00069	0.549
MOD_CDK_SPxxK_3	556	563	PF00069	0.467
MOD_CDK_SPxxK_3	598	605	PF00069	0.351
MOD_CK1_1	201	207	PF00069	0.530
MOD_CK1_1	365	371	PF00069	0.581
MOD_CK1_1	383	389	PF00069	0.305
MOD_CK1_1	65	71	PF00069	0.466
MOD_CK2_1	114	120	PF00069	0.335
MOD_CK2_1	352	358	PF00069	0.455
MOD_CK2_1	458	464	PF00069	0.335
MOD_Cter_Amidation	433	436	PF01082	0.244
MOD_Cter_Amidation	603	606	PF01082	0.370
MOD_GlcNHglycan	18	21	PF01048	0.504
MOD_GlcNHglycan	219	222	PF01048	0.425
MOD_GlcNHglycan	243	246	PF01048	0.465
MOD_GlcNHglycan	261	264	PF01048	0.344
MOD_GlcNHglycan	382	385	PF01048	0.349
MOD_GlcNHglycan	396	399	PF01048	0.443
MOD_GlcNHglycan	71	74	PF01048	0.423
MOD_GlcNHglycan	77	80	PF01048	0.379
MOD_GSK3_1	246	253	PF00069	0.430
MOD_GSK3_1	273	280	PF00069	0.466
MOD_GSK3_1	335	342	PF00069	0.486
MOD_GSK3_1	372	379	PF00069	0.341
MOD_GSK3_1	454	461	PF00069	0.489
MOD_GSK3_1	472	479	PF00069	0.238
MOD_GSK3_1	482	489	PF00069	0.322
MOD_GSK3_1	505	512	PF00069	0.400
MOD_GSK3_1	517	524	PF00069	0.377
MOD_GSK3_1	552	559	PF00069	0.343
MOD_GSK3_1	589	596	PF00069	0.394
MOD_GSK3_1	65	72	PF00069	0.421
MOD_GSK3_1	75	82	PF00069	0.395
MOD_N-GLC_1	162	167	PF02516	0.451
MOD_N-GLC_1	273	278	PF02516	0.470
MOD_N-GLC_1	365	370	PF02516	0.546
MOD_N-GLC_1	454	459	PF02516	0.347
MOD_N-GLC_1	48	53	PF02516	0.369
MOD_N-GLC_2	354	356	PF02516	0.550
MOD_NEK2_1	16	21	PF00069	0.541
MOD_NEK2_1	198	203	PF00069	0.570
MOD_NEK2_1	259	264	PF00069	0.396
MOD_NEK2_1	293	298	PF00069	0.397
MOD_NEK2_1	318	323	PF00069	0.463
MOD_NEK2_1	380	385	PF00069	0.351
MOD_NEK2_1	400	405	PF00069	0.262
MOD_NEK2_1	458	463	PF00069	0.424
MOD_NEK2_1	564	569	PF00069	0.341
MOD_NEK2_1	589	594	PF00069	0.335
MOD_NEK2_1	617	622	PF00069	0.274
MOD_NEK2_1	67	72	PF00069	0.410
MOD_NEK2_2	172	177	PF00069	0.367
MOD_NEK2_2	335	340	PF00069	0.528
MOD_PIKK_1	48	54	PF00454	0.365
MOD_PIKK_1	517	523	PF00454	0.440
MOD_PK_1	606	612	PF00069	0.335
MOD_PKA_1	241	247	PF00069	0.514
MOD_PKA_2	198	204	PF00069	0.561
MOD_PKA_2	318	324	PF00069	0.404
MOD_PKA_2	505	511	PF00069	0.530
MOD_Plk_1	130	136	PF00069	0.425
MOD_Plk_1	273	279	PF00069	0.453
MOD_Plk_1	454	460	PF00069	0.472
MOD_Plk_1	493	499	PF00069	0.534
MOD_Plk_1	517	523	PF00069	0.395
MOD_Plk_4	130	136	PF00069	0.425
MOD_Plk_4	22	28	PF00069	0.471
MOD_Plk_4	247	253	PF00069	0.415
MOD_Plk_4	293	299	PF00069	0.303
MOD_Plk_4	335	341	PF00069	0.521
MOD_Plk_4	376	382	PF00069	0.341
MOD_Plk_4	505	511	PF00069	0.489
MOD_ProDKin_1	114	120	PF00069	0.244
MOD_ProDKin_1	4	10	PF00069	0.538
MOD_ProDKin_1	556	562	PF00069	0.467
MOD_ProDKin_1	598	604	PF00069	0.351
MOD_SUMO_rev_2	459	468	PF00179	0.338
MOD_SUMO_rev_2	601	607	PF00179	0.351
TRG_DiLeu_BaEn_1	96	101	PF01217	0.330
TRG_DiLeu_LyEn_5	96	101	PF01217	0.330
TRG_ER_diArg_1	198	200	PF00400	0.477
TRG_ER_diArg_1	317	320	PF00400	0.562
TRG_ER_diArg_1	435	437	PF00400	0.244
TRG_ER_diArg_1	499	501	PF00400	0.423
TRG_ER_diArg_1	98	100	PF00400	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB29	Leptomonas seymouri	86%	100%
A0A0S4JJ02	Bodo saltans	59%	100%
A0A0S4JL38	Bodo saltans	23%	100%
A0A0S4JL93	Bodo saltans	24%	87%
A0A0S4KEW0	Bodo saltans	23%	98%
A0A1X0NYB9	Trypanosomatidae	68%	100%
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3R7N3I7	Trypanosoma rangeli	67%	99%
A0A3S7WR72	Leishmania donovani	21%	100%
A0A3S7X1E5	Leishmania donovani	94%	100%
A4H666	Leishmania braziliensis	23%	100%
A4HDT7	Leishmania braziliensis	23%	100%
A4HUJ0	Leishmania infantum	21%	100%
A4I135	Leishmania infantum	23%	100%
A4I3I7	Leishmania infantum	95%	100%
A8ILK1	Chlamydomonas reinhardtii	47%	100%
D0A7V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E1BKF9	Bos taurus	43%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F1SS88	Sus scrofa	44%	100%
Q26613	Strongylocentrotus purpuratus	22%	92%
Q4Q8F5	Leishmania major	94%	100%
Q4QAA4	Leishmania major	24%	100%
Q4QHD6	Leishmania major	23%	100%
Q5F201	Mus musculus	43%	100%
Q8N1V2	Homo sapiens	42%	100%
Q95JL5	Macaca fascicularis	36%	100%
Q9LFE2	Arabidopsis thaliana	21%	72%
Q9VPR4	Drosophila melanogaster	22%	100%
Q9Y1C1	Lytechinus variegatus	22%	95%
V5BIZ5	Trypanosoma cruzi	68%	100%