Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGF5_LEIBR

TriTrypDb:

LbrM.28.1180 , LBRM2903_280017800

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.674
CLV_C14_Caspase3-7	506	510	PF00656	0.602
CLV_NRD_NRD_1	245	247	PF00675	0.750
CLV_NRD_NRD_1	456	458	PF00675	0.483
CLV_NRD_NRD_1	849	851	PF00675	0.703
CLV_PCSK_KEX2_1	247	249	PF00082	0.757
CLV_PCSK_KEX2_1	258	260	PF00082	0.758
CLV_PCSK_KEX2_1	349	351	PF00082	0.847
CLV_PCSK_KEX2_1	4	6	PF00082	0.664
CLV_PCSK_KEX2_1	456	458	PF00082	0.483
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.757
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.758
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.847
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.625
CLV_PCSK_PC7_1	243	249	PF00082	0.748
CLV_PCSK_SKI1_1	49	53	PF00082	0.632
CLV_PCSK_SKI1_1	596	600	PF00082	0.669
CLV_PCSK_SKI1_1	643	647	PF00082	0.634
CLV_PCSK_SKI1_1	673	677	PF00082	0.510
CLV_PCSK_SKI1_1	71	75	PF00082	0.510
CLV_PCSK_SKI1_1	835	839	PF00082	0.514
DEG_SCF_FBW7_1	254	260	PF00400	0.752
DEG_SPOP_SBC_1	249	253	PF00917	0.754
DEG_SPOP_SBC_1	286	290	PF00917	0.588
DOC_CKS1_1	254	259	PF01111	0.696
DOC_CYCLIN_RxL_1	66	77	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.366
DOC_MAPK_gen_1	14	22	PF00069	0.543
DOC_MAPK_gen_1	4	11	PF00069	0.504
DOC_MAPK_gen_1	47	56	PF00069	0.543
DOC_MAPK_HePTP_8	44	56	PF00069	0.390
DOC_MAPK_MEF2A_6	17	24	PF00069	0.527
DOC_MAPK_MEF2A_6	47	56	PF00069	0.538
DOC_MAPK_NFAT4_5	47	55	PF00069	0.541
DOC_PP1_RVXF_1	69	75	PF00149	0.606
DOC_PP2B_LxvP_1	22	25	PF13499	0.602
DOC_PP2B_LxvP_1	52	55	PF13499	0.553
DOC_USP7_MATH_1	112	116	PF00917	0.727
DOC_USP7_MATH_1	225	229	PF00917	0.769
DOC_USP7_MATH_1	257	261	PF00917	0.793
DOC_USP7_MATH_1	297	301	PF00917	0.685
DOC_USP7_MATH_1	311	315	PF00917	0.734
DOC_USP7_MATH_1	396	400	PF00917	0.707
DOC_USP7_MATH_1	422	426	PF00917	0.602
DOC_USP7_MATH_1	718	722	PF00917	0.691
DOC_USP7_MATH_1	750	754	PF00917	0.621
DOC_USP7_MATH_2	75	81	PF00917	0.380
DOC_WW_Pin1_4	221	226	PF00397	0.743
DOC_WW_Pin1_4	250	255	PF00397	0.701
DOC_WW_Pin1_4	261	266	PF00397	0.678
DOC_WW_Pin1_4	319	324	PF00397	0.699
DOC_WW_Pin1_4	348	353	PF00397	0.773
DOC_WW_Pin1_4	602	607	PF00397	0.530
LIG_14-3-3_CanoR_1	119	127	PF00244	0.648
LIG_14-3-3_CanoR_1	133	137	PF00244	0.544
LIG_14-3-3_CanoR_1	248	254	PF00244	0.725
LIG_14-3-3_CanoR_1	270	276	PF00244	0.636
LIG_14-3-3_CanoR_1	449	454	PF00244	0.574
LIG_14-3-3_CanoR_1	517	525	PF00244	0.500
LIG_14-3-3_CanoR_1	652	660	PF00244	0.680
LIG_AP2alpha_2	412	414	PF02296	0.681
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	312	316	PF00533	0.818
LIG_BRCT_BRCA1_1	615	619	PF00533	0.669
LIG_BRCT_BRCA1_1	769	773	PF00533	0.587
LIG_FHA_1	106	112	PF00498	0.657
LIG_FHA_1	142	148	PF00498	0.498
LIG_FHA_1	250	256	PF00498	0.753
LIG_FHA_1	287	293	PF00498	0.619
LIG_FHA_1	39	45	PF00498	0.392
LIG_FHA_1	559	565	PF00498	0.483
LIG_FHA_1	656	662	PF00498	0.632
LIG_FHA_1	691	697	PF00498	0.605
LIG_FHA_2	121	127	PF00498	0.612
LIG_FHA_2	148	154	PF00498	0.508
LIG_FHA_2	27	33	PF00498	0.623
LIG_FHA_2	506	512	PF00498	0.443
LIG_FHA_2	739	745	PF00498	0.575
LIG_FHA_2	826	832	PF00498	0.532
LIG_GBD_Chelix_1	814	822	PF00786	0.683
LIG_IBAR_NPY_1	421	423	PF08397	0.472
LIG_KLC1_Yacidic_2	6	10	PF13176	0.480
LIG_LIR_Gen_1	6	15	PF02991	0.489
LIG_LIR_Gen_1	644	651	PF02991	0.668
LIG_LIR_Gen_1	775	784	PF02991	0.683
LIG_LIR_Nem_3	540	546	PF02991	0.513
LIG_LIR_Nem_3	558	563	PF02991	0.384
LIG_LIR_Nem_3	6	11	PF02991	0.475
LIG_LIR_Nem_3	644	649	PF02991	0.675
LIG_LIR_Nem_3	775	781	PF02991	0.672
LIG_Pex14_1	180	184	PF04695	0.676
LIG_Pex14_2	7	11	PF04695	0.469
LIG_PTB_Apo_2	554	561	PF02174	0.392
LIG_REV1ctd_RIR_1	692	702	PF16727	0.610
LIG_SH2_STAP1	765	769	PF00017	0.536
LIG_SH2_STAT3	140	143	PF00017	0.554
LIG_SH2_STAT3	567	570	PF00017	0.588
LIG_SH2_STAT3	584	587	PF00017	0.419
LIG_SH2_STAT5	140	143	PF00017	0.518
LIG_SH2_STAT5	146	149	PF00017	0.457
LIG_SH2_STAT5	418	421	PF00017	0.620
LIG_SH2_STAT5	567	570	PF00017	0.517
LIG_SH2_STAT5	8	11	PF00017	0.471
LIG_SH2_STAT5	800	803	PF00017	0.650
LIG_SH3_2	254	259	PF14604	0.754
LIG_SH3_3	196	202	PF00018	0.727
LIG_SH3_3	219	225	PF00018	0.580
LIG_SH3_3	251	257	PF00018	0.751
LIG_SH3_3	317	323	PF00018	0.736
LIG_SH3_3	407	413	PF00018	0.725
LIG_SH3_3	478	484	PF00018	0.457
LIG_SH3_3	723	729	PF00018	0.676
LIG_SUMO_SIM_par_1	18	23	PF11976	0.530
LIG_SUMO_SIM_par_1	224	230	PF11976	0.554
LIG_SUMO_SIM_par_1	377	382	PF11976	0.519
LIG_TRAF2_1	302	305	PF00917	0.580
LIG_UBA3_1	50	58	PF00899	0.547
MOD_CDC14_SPxK_1	351	354	PF00782	0.570
MOD_CDK_SPK_2	253	258	PF00069	0.753
MOD_CDK_SPxK_1	253	259	PF00069	0.755
MOD_CDK_SPxK_1	348	354	PF00069	0.763
MOD_CK1_1	115	121	PF00069	0.665
MOD_CK1_1	221	227	PF00069	0.723
MOD_CK1_1	260	266	PF00069	0.758
MOD_CK1_1	287	293	PF00069	0.672
MOD_CK1_1	300	306	PF00069	0.684
MOD_CK1_1	629	635	PF00069	0.404
MOD_CK1_1	653	659	PF00069	0.675
MOD_CK2_1	120	126	PF00069	0.612
MOD_CK2_1	235	241	PF00069	0.632
MOD_CK2_1	653	659	PF00069	0.635
MOD_CK2_1	718	724	PF00069	0.555
MOD_CK2_1	77	83	PF00069	0.379
MOD_CK2_1	825	831	PF00069	0.542
MOD_Cter_Amidation	347	350	PF01082	0.844
MOD_GlcNHglycan	101	104	PF01048	0.578
MOD_GlcNHglycan	26	29	PF01048	0.471
MOD_GlcNHglycan	266	269	PF01048	0.749
MOD_GlcNHglycan	289	292	PF01048	0.625
MOD_GlcNHglycan	313	316	PF01048	0.766
MOD_GlcNHglycan	609	612	PF01048	0.646
MOD_GlcNHglycan	628	631	PF01048	0.327
MOD_GlcNHglycan	655	658	PF01048	0.639
MOD_GlcNHglycan	752	755	PF01048	0.714
MOD_GlcNHglycan	95	98	PF01048	0.532
MOD_GSK3_1	111	118	PF00069	0.658
MOD_GSK3_1	217	224	PF00069	0.689
MOD_GSK3_1	249	256	PF00069	0.694
MOD_GSK3_1	257	264	PF00069	0.695
MOD_GSK3_1	270	277	PF00069	0.623
MOD_GSK3_1	280	287	PF00069	0.595
MOD_GSK3_1	293	300	PF00069	0.585
MOD_GSK3_1	311	318	PF00069	0.774
MOD_GSK3_1	396	403	PF00069	0.798
MOD_GSK3_1	437	444	PF00069	0.524
MOD_GSK3_1	445	452	PF00069	0.496
MOD_GSK3_1	501	508	PF00069	0.497
MOD_GSK3_1	629	636	PF00069	0.489
MOD_GSK3_1	651	658	PF00069	0.709
MOD_GSK3_1	814	821	PF00069	0.681
MOD_N-GLC_1	750	755	PF02516	0.622
MOD_N-GLC_2	415	417	PF02516	0.590
MOD_N-GLC_2	475	477	PF02516	0.364
MOD_NEK2_1	120	125	PF00069	0.612
MOD_NEK2_1	141	146	PF00069	0.518
MOD_NEK2_1	15	20	PF00069	0.525
MOD_NEK2_1	216	221	PF00069	0.532
MOD_NEK2_1	379	384	PF00069	0.520
MOD_NEK2_1	437	442	PF00069	0.534
MOD_NEK2_1	466	471	PF00069	0.608
MOD_NEK2_1	690	695	PF00069	0.553
MOD_NEK2_1	814	819	PF00069	0.684
MOD_NEK2_1	93	98	PF00069	0.370
MOD_NEK2_2	26	31	PF00069	0.516
MOD_NEK2_2	280	285	PF00069	0.602
MOD_NEK2_2	641	646	PF00069	0.362
MOD_NEK2_2	671	676	PF00069	0.558
MOD_OFUCOSY	435	441	PF10250	0.521
MOD_OFUCOSY	474	480	PF10250	0.324
MOD_PIKK_1	189	195	PF00454	0.646
MOD_PIKK_1	227	233	PF00454	0.559
MOD_PIKK_1	300	306	PF00454	0.839
MOD_PIKK_1	816	822	PF00454	0.679
MOD_PKA_2	132	138	PF00069	0.568
MOD_PKA_2	141	147	PF00069	0.511
MOD_PKA_2	242	248	PF00069	0.759
MOD_PKA_2	260	266	PF00069	0.562
MOD_PKA_2	269	275	PF00069	0.522
MOD_PKA_2	300	306	PF00069	0.745
MOD_PKA_2	500	506	PF00069	0.518
MOD_PKA_2	516	522	PF00069	0.513
MOD_PKA_2	651	657	PF00069	0.751
MOD_PKA_2	718	724	PF00069	0.586
MOD_PKB_1	246	254	PF00069	0.754
MOD_Plk_1	115	121	PF00069	0.638
MOD_Plk_1	280	286	PF00069	0.671
MOD_Plk_1	304	310	PF00069	0.585
MOD_Plk_1	38	44	PF00069	0.543
MOD_Plk_1	495	501	PF00069	0.390
MOD_Plk_1	538	544	PF00069	0.679
MOD_Plk_1	690	696	PF00069	0.560
MOD_Plk_1	774	780	PF00069	0.577
MOD_Plk_1	835	841	PF00069	0.518
MOD_Plk_2-3	505	511	PF00069	0.462
MOD_Plk_2-3	539	545	PF00069	0.674
MOD_Plk_4	15	21	PF00069	0.523
MOD_Plk_4	342	348	PF00069	0.570
MOD_Plk_4	396	402	PF00069	0.715
MOD_Plk_4	495	501	PF00069	0.522
MOD_Plk_4	65	71	PF00069	0.629
MOD_Plk_4	690	696	PF00069	0.543
MOD_Plk_4	835	841	PF00069	0.518
MOD_ProDKin_1	221	227	PF00069	0.744
MOD_ProDKin_1	250	256	PF00069	0.702
MOD_ProDKin_1	261	267	PF00069	0.677
MOD_ProDKin_1	319	325	PF00069	0.702
MOD_ProDKin_1	348	354	PF00069	0.772
MOD_ProDKin_1	602	608	PF00069	0.532
MOD_SUMO_for_1	3	6	PF00179	0.639
MOD_SUMO_rev_2	32	41	PF00179	0.417
MOD_SUMO_rev_2	6	15	PF00179	0.489
TRG_DiLeu_BaEn_1	116	121	PF01217	0.638
TRG_DiLeu_BaEn_1	305	310	PF01217	0.584
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.533
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.637
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.527
TRG_DiLeu_LyEn_5	305	310	PF01217	0.584
TRG_ENDOCYTIC_2	455	458	PF00928	0.451
TRG_ENDOCYTIC_2	461	464	PF00928	0.441
TRG_ENDOCYTIC_2	621	624	PF00928	0.521
TRG_ENDOCYTIC_2	8	11	PF00928	0.471
TRG_ER_diArg_1	455	457	PF00400	0.479
TRG_NES_CRM1_1	779	791	PF08389	0.605
TRG_NLS_Bipartite_1	246	262	PF00514	0.754
TRG_NLS_MonoExtC_3	245	250	PF00514	0.754
TRG_NLS_MonoExtN_4	243	250	PF00514	0.749
TRG_NLS_MonoExtN_4	257	262	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	704	709	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU94	Leptomonas seymouri	60%	100%
A0A3S7X1F3	Leishmania donovani	79%	100%
A4I3I6	Leishmania infantum	79%	100%
E9AZS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q8F6	Leishmania major	79%	100%