Gluconokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gluconokinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGF4_LEIBR

TriTrypDb:

LbrM.28.1170 , LBRM2903_280017700

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0006082	organic acid metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009987	cellular process	1	7
GO:0016052	carbohydrate catabolic process	4	7
GO:0016054	organic acid catabolic process	4	7
GO:0016310	phosphorylation	5	7
GO:0019520	aldonic acid metabolic process	4	7
GO:0019521	D-gluconate metabolic process	5	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0032787	monocarboxylic acid metabolic process	6	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044262	obsolete cellular carbohydrate metabolic process	3	7
GO:0044275	obsolete cellular carbohydrate catabolic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	7
GO:0046176	aldonic acid catabolic process	5	7
GO:0046177	D-gluconate catabolic process	6	7
GO:0046395	carboxylic acid catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:0072329	monocarboxylic acid catabolic process	6	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	4
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0046316	gluconokinase activity	5	4
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	44	46	PF00675	0.376
CLV_PCSK_KEX2_1	43	45	PF00082	0.384
CLV_PCSK_SKI1_1	47	51	PF00082	0.393
DEG_APCC_DBOX_1	46	54	PF00400	0.536
DEG_Nend_UBRbox_1	1	4	PF02207	0.591
DEG_ODPH_VHL_1	24	37	PF01847	0.493
DOC_USP7_MATH_2	112	118	PF00917	0.506
LIG_14-3-3_CanoR_1	137	142	PF00244	0.529
LIG_FHA_1	116	122	PF00498	0.459
LIG_FHA_1	30	36	PF00498	0.548
LIG_FHA_2	6	12	PF00498	0.427
LIG_LIR_Gen_1	70	80	PF02991	0.414
LIG_LIR_Nem_3	70	76	PF02991	0.408
LIG_MYND_2	124	128	PF01753	0.556
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.428
LIG_SUMO_SIM_par_1	117	123	PF11976	0.549
MOD_CK1_1	31	37	PF00069	0.368
MOD_GlcNHglycan	2	5	PF01048	0.567
MOD_GlcNHglycan	39	42	PF01048	0.382
MOD_GlcNHglycan	76	79	PF01048	0.541
MOD_GSK3_1	95	102	PF00069	0.451
MOD_NEK2_1	37	42	PF00069	0.350
MOD_NEK2_1	99	104	PF00069	0.371
MOD_PIKK_1	99	105	PF00454	0.437
MOD_PKA_2	136	142	PF00069	0.485
MOD_PKB_1	18	26	PF00069	0.346
MOD_Plk_1	20	26	PF00069	0.345
MOD_Plk_4	31	37	PF00069	0.528
MOD_Plk_4	95	101	PF00069	0.360
MOD_SUMO_rev_2	77	83	PF00179	0.542
TRG_DiLeu_BaEn_1	70	75	PF01217	0.361
TRG_ENDOCYTIC_2	46	49	PF00928	0.329
TRG_ER_diArg_1	42	45	PF00400	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIM9	Leptomonas seymouri	57%	74%
A0A3Q8IES5	Leishmania donovani	72%	69%
A0A3R7MBD0	Trypanosoma rangeli	48%	69%
A4I3I5	Leishmania infantum	71%	92%
B0BML1	Xenopus tropicalis	36%	75%
E9AZS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
P39208	Escherichia coli (strain K12)	42%	76%
P46859	Escherichia coli (strain K12)	34%	81%
Q03786	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	74%
Q10242	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	74%
Q32PY9	Rattus norvegicus	43%	77%
Q54PI5	Dictyostelium discoideum	29%	71%
Q5FQ97	Gluconobacter oxydans (strain 621H)	41%	80%
Q5T6J7	Homo sapiens	39%	76%
Q8R0J8	Mus musculus	39%	77%
Q9SLE0	Arabidopsis thaliana	37%	75%