ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGF3_LEIBR

TriTrypDb:

LbrM.28.1160 , LBRM2903_280017500

Length:

787

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.525
CLV_C14_Caspase3-7	90	94	PF00656	0.392
CLV_NRD_NRD_1	199	201	PF00675	0.473
CLV_NRD_NRD_1	411	413	PF00675	0.398
CLV_NRD_NRD_1	439	441	PF00675	0.550
CLV_NRD_NRD_1	455	457	PF00675	0.664
CLV_NRD_NRD_1	605	607	PF00675	0.397
CLV_NRD_NRD_1	744	746	PF00675	0.473
CLV_PCSK_FUR_1	453	457	PF00082	0.666
CLV_PCSK_KEX2_1	199	201	PF00082	0.473
CLV_PCSK_KEX2_1	411	413	PF00082	0.398
CLV_PCSK_KEX2_1	455	457	PF00082	0.755
CLV_PCSK_KEX2_1	605	607	PF00082	0.468
CLV_PCSK_KEX2_1	744	746	PF00082	0.342
CLV_PCSK_PC7_1	451	457	PF00082	0.757
CLV_PCSK_SKI1_1	305	309	PF00082	0.447
CLV_PCSK_SKI1_1	590	594	PF00082	0.505
CLV_PCSK_SKI1_1	646	650	PF00082	0.513
DEG_APCC_DBOX_1	645	653	PF00400	0.307
DEG_Nend_Nbox_1	1	3	PF02207	0.499
DEG_SPOP_SBC_1	525	529	PF00917	0.506
DEG_SPOP_SBC_1	555	559	PF00917	0.330
DOC_CKS1_1	600	605	PF01111	0.547
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.480
DOC_MAPK_DCC_7	274	284	PF00069	0.338
DOC_MAPK_gen_1	272	280	PF00069	0.318
DOC_MAPK_MEF2A_6	274	282	PF00069	0.436
DOC_MAPK_MEF2A_6	44	52	PF00069	0.326
DOC_PP1_RVXF_1	303	309	PF00149	0.447
DOC_PP2B_LxvP_1	278	281	PF13499	0.554
DOC_PP4_FxxP_1	600	603	PF00568	0.567
DOC_PP4_FxxP_1	611	614	PF00568	0.414
DOC_USP7_MATH_1	193	197	PF00917	0.490
DOC_USP7_MATH_1	210	214	PF00917	0.516
DOC_USP7_MATH_1	233	237	PF00917	0.472
DOC_USP7_MATH_1	406	410	PF00917	0.547
DOC_USP7_MATH_1	548	552	PF00917	0.669
DOC_USP7_MATH_1	575	579	PF00917	0.328
DOC_USP7_MATH_1	727	731	PF00917	0.564
DOC_USP7_MATH_1	756	760	PF00917	0.577
DOC_USP7_MATH_1	98	102	PF00917	0.676
DOC_USP7_UBL2_3	699	703	PF12436	0.653
DOC_WW_Pin1_4	108	113	PF00397	0.671
DOC_WW_Pin1_4	455	460	PF00397	0.622
DOC_WW_Pin1_4	464	469	PF00397	0.709
DOC_WW_Pin1_4	528	533	PF00397	0.438
DOC_WW_Pin1_4	551	556	PF00397	0.539
DOC_WW_Pin1_4	599	604	PF00397	0.505
DOC_WW_Pin1_4	610	615	PF00397	0.344
LIG_14-3-3_CanoR_1	124	133	PF00244	0.423
LIG_14-3-3_CanoR_1	305	311	PF00244	0.480
LIG_14-3-3_CanoR_1	394	398	PF00244	0.469
LIG_14-3-3_CanoR_1	547	556	PF00244	0.439
LIG_14-3-3_CanoR_1	693	700	PF00244	0.596
LIG_Actin_WH2_2	360	378	PF00022	0.607
LIG_Actin_WH2_2	649	665	PF00022	0.327
LIG_BIR_III_4	422	426	PF00653	0.418
LIG_CSL_BTD_1	538	541	PF09270	0.413
LIG_deltaCOP1_diTrp_1	351	356	PF00928	0.335
LIG_eIF4E_1	135	141	PF01652	0.548
LIG_eIF4E_1	392	398	PF01652	0.517
LIG_eIF4E_1	495	501	PF01652	0.360
LIG_EVH1_1	539	543	PF00568	0.411
LIG_FHA_1	108	114	PF00498	0.463
LIG_FHA_1	136	142	PF00498	0.564
LIG_FHA_1	144	150	PF00498	0.543
LIG_FHA_1	22	28	PF00498	0.503
LIG_FHA_1	261	267	PF00498	0.530
LIG_FHA_1	275	281	PF00498	0.526
LIG_FHA_1	362	368	PF00498	0.544
LIG_FHA_1	386	392	PF00498	0.323
LIG_FHA_1	555	561	PF00498	0.447
LIG_FHA_1	587	593	PF00498	0.547
LIG_FHA_1	605	611	PF00498	0.427
LIG_FHA_1	613	619	PF00498	0.396
LIG_FHA_1	621	627	PF00498	0.435
LIG_FHA_1	657	663	PF00498	0.601
LIG_FHA_2	262	268	PF00498	0.500
LIG_FHA_2	298	304	PF00498	0.408
LIG_FHA_2	563	569	PF00498	0.517
LIG_FHA_2	666	672	PF00498	0.603
LIG_FHA_2	692	698	PF00498	0.622
LIG_IRF3_LxIS_1	762	768	PF10401	0.280
LIG_LIR_Apic_2	354	359	PF02991	0.340
LIG_LIR_Apic_2	609	614	PF02991	0.496
LIG_LIR_Gen_1	117	126	PF02991	0.432
LIG_LIR_Gen_1	153	161	PF02991	0.481
LIG_LIR_Gen_1	163	173	PF02991	0.404
LIG_LIR_Gen_1	220	229	PF02991	0.570
LIG_LIR_Gen_1	292	301	PF02991	0.378
LIG_LIR_Gen_1	46	57	PF02991	0.434
LIG_LIR_Gen_1	496	504	PF02991	0.396
LIG_LIR_Gen_1	584	593	PF02991	0.478
LIG_LIR_Gen_1	72	80	PF02991	0.475
LIG_LIR_Gen_1	768	777	PF02991	0.464
LIG_LIR_Nem_3	117	121	PF02991	0.453
LIG_LIR_Nem_3	153	159	PF02991	0.432
LIG_LIR_Nem_3	163	168	PF02991	0.423
LIG_LIR_Nem_3	220	226	PF02991	0.581
LIG_LIR_Nem_3	292	297	PF02991	0.378
LIG_LIR_Nem_3	340	346	PF02991	0.411
LIG_LIR_Nem_3	46	52	PF02991	0.536
LIG_LIR_Nem_3	496	501	PF02991	0.374
LIG_LIR_Nem_3	536	542	PF02991	0.538
LIG_LIR_Nem_3	584	588	PF02991	0.407
LIG_LIR_Nem_3	72	77	PF02991	0.413
LIG_LIR_Nem_3	768	772	PF02991	0.347
LIG_PTB_Apo_2	73	80	PF02174	0.287
LIG_PTB_Phospho_1	73	79	PF10480	0.287
LIG_SH2_CRK	156	160	PF00017	0.475
LIG_SH2_CRK	223	227	PF00017	0.574
LIG_SH2_CRK	343	347	PF00017	0.408
LIG_SH2_CRK	498	502	PF00017	0.382
LIG_SH2_GRB2like	152	155	PF00017	0.529
LIG_SH2_GRB2like	156	159	PF00017	0.510
LIG_SH2_GRB2like	184	187	PF00017	0.491
LIG_SH2_GRB2like	79	82	PF00017	0.535
LIG_SH2_GRB2like	95	98	PF00017	0.384
LIG_SH2_NCK_1	152	156	PF00017	0.548
LIG_SH2_NCK_1	223	227	PF00017	0.574
LIG_SH2_SRC	152	155	PF00017	0.544
LIG_SH2_SRC	184	187	PF00017	0.422
LIG_SH2_SRC	330	333	PF00017	0.335
LIG_SH2_SRC	79	82	PF00017	0.359
LIG_SH2_SRC	95	98	PF00017	0.384
LIG_SH2_STAP1	137	141	PF00017	0.513
LIG_SH2_STAP1	152	156	PF00017	0.406
LIG_SH2_STAP1	498	502	PF00017	0.412
LIG_SH2_STAP1	742	746	PF00017	0.526
LIG_SH2_STAT3	392	395	PF00017	0.522
LIG_SH2_STAT5	137	140	PF00017	0.397
LIG_SH2_STAT5	184	187	PF00017	0.379
LIG_SH2_STAT5	223	226	PF00017	0.576
LIG_SH2_STAT5	257	260	PF00017	0.405
LIG_SH2_STAT5	299	302	PF00017	0.349
LIG_SH2_STAT5	330	333	PF00017	0.335
LIG_SH2_STAT5	336	339	PF00017	0.335
LIG_SH2_STAT5	416	419	PF00017	0.382
LIG_SH2_STAT5	503	506	PF00017	0.340
LIG_SH2_STAT5	62	65	PF00017	0.445
LIG_SH2_STAT5	766	769	PF00017	0.419
LIG_SH2_STAT5	79	82	PF00017	0.365
LIG_SH2_STAT5	95	98	PF00017	0.496
LIG_SH3_3	109	115	PF00018	0.557
LIG_SH3_3	280	286	PF00018	0.417
LIG_SH3_3	535	541	PF00018	0.447
LIG_SH3_3	592	598	PF00018	0.672
LIG_SH3_5	180	184	PF00018	0.397
LIG_SUMO_SIM_par_1	472	477	PF11976	0.431
LIG_SUMO_SIM_par_1	606	613	PF11976	0.466
LIG_TRAF2_1	32	35	PF00917	0.610
LIG_TRAF2_1	370	373	PF00917	0.587
LIG_TRAF2_1	565	568	PF00917	0.539
LIG_TYR_ITIM	341	346	PF00017	0.408
LIG_UBA3_1	51	58	PF00899	0.574
LIG_WRC_WIRS_1	582	587	PF05994	0.428
MOD_CDK_SPK_2	528	533	PF00069	0.438
MOD_CDK_SPxK_1	599	605	PF00069	0.557
MOD_CDK_SPxxK_3	599	606	PF00069	0.335
MOD_CK1_1	101	107	PF00069	0.727
MOD_CK1_1	236	242	PF00069	0.588
MOD_CK1_1	317	323	PF00069	0.447
MOD_CK1_1	528	534	PF00069	0.625
MOD_CK1_1	551	557	PF00069	0.436
MOD_CK1_1	612	618	PF00069	0.512
MOD_CK1_1	635	641	PF00069	0.532
MOD_CK1_1	642	648	PF00069	0.538
MOD_CK1_1	665	671	PF00069	0.464
MOD_CK1_1	713	719	PF00069	0.594
MOD_CK1_1	730	736	PF00069	0.563
MOD_CK2_1	306	312	PF00069	0.419
MOD_CK2_1	367	373	PF00069	0.512
MOD_CK2_1	464	470	PF00069	0.628
MOD_CK2_1	562	568	PF00069	0.515
MOD_CK2_1	575	581	PF00069	0.485
MOD_CK2_1	652	658	PF00069	0.564
MOD_CK2_1	665	671	PF00069	0.602
MOD_CK2_1	713	719	PF00069	0.386
MOD_CK2_1	737	743	PF00069	0.341
MOD_CMANNOS	353	356	PF00535	0.335
MOD_GlcNHglycan	100	103	PF01048	0.651
MOD_GlcNHglycan	173	176	PF01048	0.531
MOD_GlcNHglycan	287	290	PF01048	0.355
MOD_GlcNHglycan	369	372	PF01048	0.551
MOD_GlcNHglycan	408	411	PF01048	0.549
MOD_GlcNHglycan	41	44	PF01048	0.301
MOD_GlcNHglycan	550	553	PF01048	0.660
MOD_GlcNHglycan	637	640	PF01048	0.582
MOD_GlcNHglycan	689	692	PF01048	0.595
MOD_GlcNHglycan	725	728	PF01048	0.441
MOD_GSK3_1	217	224	PF00069	0.519
MOD_GSK3_1	22	29	PF00069	0.528
MOD_GSK3_1	232	239	PF00069	0.558
MOD_GSK3_1	285	292	PF00069	0.335
MOD_GSK3_1	313	320	PF00069	0.298
MOD_GSK3_1	361	368	PF00069	0.491
MOD_GSK3_1	39	46	PF00069	0.287
MOD_GSK3_1	512	519	PF00069	0.572
MOD_GSK3_1	524	531	PF00069	0.545
MOD_GSK3_1	551	558	PF00069	0.433
MOD_GSK3_1	577	584	PF00069	0.505
MOD_GSK3_1	609	616	PF00069	0.509
MOD_GSK3_1	635	642	PF00069	0.504
MOD_GSK3_1	652	659	PF00069	0.462
MOD_GSK3_1	687	694	PF00069	0.541
MOD_GSK3_1	723	730	PF00069	0.523
MOD_N-GLC_1	106	111	PF02516	0.758
MOD_N-GLC_1	64	69	PF02516	0.473
MOD_N-GLC_1	737	742	PF02516	0.466
MOD_N-GLC_1	80	85	PF02516	0.482
MOD_N-GLC_2	428	430	PF02516	0.502
MOD_NEK2_1	556	561	PF00069	0.468
MOD_NEK2_1	588	593	PF00069	0.552
MOD_NEK2_1	619	624	PF00069	0.320
MOD_NEK2_1	641	646	PF00069	0.545
MOD_NEK2_1	652	657	PF00069	0.490
MOD_NEK2_1	662	667	PF00069	0.467
MOD_NEK2_1	721	726	PF00069	0.572
MOD_NEK2_1	765	770	PF00069	0.434
MOD_NEK2_1	775	780	PF00069	0.310
MOD_NEK2_1	80	85	PF00069	0.505
MOD_PIKK_1	314	320	PF00454	0.338
MOD_PIKK_1	756	762	PF00454	0.548
MOD_PKA_2	314	320	PF00069	0.447
MOD_PKA_2	37	43	PF00069	0.565
MOD_PKA_2	393	399	PF00069	0.521
MOD_PKA_2	548	554	PF00069	0.667
MOD_PKA_2	586	592	PF00069	0.490
MOD_PKA_2	604	610	PF00069	0.232
MOD_PKA_2	662	668	PF00069	0.354
MOD_PKA_2	692	698	PF00069	0.634
MOD_PKB_1	122	130	PF00069	0.325
MOD_Plk_1	414	420	PF00069	0.495
MOD_Plk_1	737	743	PF00069	0.590
MOD_Plk_1	770	776	PF00069	0.544
MOD_Plk_4	26	32	PF00069	0.548
MOD_Plk_4	274	280	PF00069	0.543
MOD_Plk_4	386	392	PF00069	0.475
MOD_Plk_4	393	399	PF00069	0.466
MOD_Plk_4	496	502	PF00069	0.461
MOD_Plk_4	556	562	PF00069	0.445
MOD_Plk_4	737	743	PF00069	0.516
MOD_ProDKin_1	108	114	PF00069	0.666
MOD_ProDKin_1	455	461	PF00069	0.624
MOD_ProDKin_1	464	470	PF00069	0.700
MOD_ProDKin_1	528	534	PF00069	0.433
MOD_ProDKin_1	551	557	PF00069	0.523
MOD_ProDKin_1	599	605	PF00069	0.505
MOD_ProDKin_1	610	616	PF00069	0.341
MOD_SUMO_rev_2	696	700	PF00179	0.595
TRG_DiLeu_LyEn_5	470	475	PF01217	0.340
TRG_ENDOCYTIC_2	137	140	PF00928	0.435
TRG_ENDOCYTIC_2	156	159	PF00928	0.404
TRG_ENDOCYTIC_2	223	226	PF00928	0.576
TRG_ENDOCYTIC_2	343	346	PF00928	0.408
TRG_ENDOCYTIC_2	498	501	PF00928	0.348
TRG_ENDOCYTIC_2	769	772	PF00928	0.497
TRG_ER_diArg_1	121	124	PF00400	0.512
TRG_ER_diArg_1	199	201	PF00400	0.479
TRG_ER_diArg_1	411	413	PF00400	0.389
TRG_ER_diArg_1	451	454	PF00400	0.692
TRG_ER_diArg_1	546	549	PF00400	0.584
TRG_ER_diArg_1	604	606	PF00400	0.466
TRG_ER_diArg_1	744	746	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P453	Leptomonas seymouri	50%	94%
A0A1X0NYA4	Trypanosomatidae	35%	100%
A0A3S7X1H2	Leishmania donovani	78%	100%
A0A422N237	Trypanosoma rangeli	38%	100%
A4I3I4	Leishmania infantum	78%	100%
D0A7V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AZS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	90%
Q4Q8F8	Leishmania major	78%	100%
V5BEJ5	Trypanosoma cruzi	34%	94%