Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGF2_LEIBR

TriTrypDb:

LbrM.28.1150 , LBRM2903_280017400

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.562
CLV_NRD_NRD_1	19	21	PF00675	0.619
CLV_NRD_NRD_1	364	366	PF00675	0.457
CLV_NRD_NRD_1	397	399	PF00675	0.318
CLV_NRD_NRD_1	445	447	PF00675	0.436
CLV_NRD_NRD_1	648	650	PF00675	0.505
CLV_NRD_NRD_1	707	709	PF00675	0.642
CLV_NRD_NRD_1	84	86	PF00675	0.608
CLV_NRD_NRD_1	95	97	PF00675	0.561
CLV_PCSK_FUR_1	135	139	PF00082	0.549
CLV_PCSK_FUR_1	704	708	PF00082	0.534
CLV_PCSK_KEX2_1	135	137	PF00082	0.552
CLV_PCSK_KEX2_1	19	21	PF00082	0.768
CLV_PCSK_KEX2_1	201	203	PF00082	0.479
CLV_PCSK_KEX2_1	397	399	PF00082	0.519
CLV_PCSK_KEX2_1	437	439	PF00082	0.663
CLV_PCSK_KEX2_1	646	648	PF00082	0.491
CLV_PCSK_KEX2_1	706	708	PF00082	0.653
CLV_PCSK_KEX2_1	84	86	PF00082	0.608
CLV_PCSK_KEX2_1	95	97	PF00082	0.684
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.458
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.527
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.491
CLV_PCSK_PC7_1	15	21	PF00082	0.483
CLV_PCSK_PC7_1	702	708	PF00082	0.603
CLV_PCSK_SKI1_1	161	165	PF00082	0.417
CLV_PCSK_SKI1_1	350	354	PF00082	0.346
CLV_PCSK_SKI1_1	366	370	PF00082	0.416
CLV_PCSK_SKI1_1	406	410	PF00082	0.546
CLV_PCSK_SKI1_1	446	450	PF00082	0.456
CLV_PCSK_SKI1_1	476	480	PF00082	0.401
CLV_PCSK_SKI1_1	521	525	PF00082	0.571
CLV_PCSK_SKI1_1	597	601	PF00082	0.498
CLV_PCSK_SKI1_1	85	89	PF00082	0.523
DEG_SPOP_SBC_1	566	570	PF00917	0.686
DOC_CKS1_1	486	491	PF01111	0.511
DOC_CKS1_1	69	74	PF01111	0.632
DOC_CYCLIN_yCln2_LP_2	285	288	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.592
DOC_MAPK_FxFP_2	483	486	PF00069	0.664
DOC_MAPK_gen_1	119	126	PF00069	0.524
DOC_MAPK_gen_1	127	134	PF00069	0.515
DOC_MAPK_gen_1	19	25	PF00069	0.676
DOC_MAPK_gen_1	307	316	PF00069	0.559
DOC_MAPK_gen_1	397	405	PF00069	0.256
DOC_MAPK_MEF2A_6	309	318	PF00069	0.547
DOC_PP1_RVXF_1	149	155	PF00149	0.480
DOC_PP1_RVXF_1	159	166	PF00149	0.416
DOC_PP2B_LxvP_1	217	220	PF13499	0.438
DOC_PP2B_LxvP_1	285	288	PF13499	0.406
DOC_PP2B_LxvP_1	32	35	PF13499	0.642
DOC_PP2B_LxvP_1	66	69	PF13499	0.443
DOC_PP4_FxxP_1	154	157	PF00568	0.497
DOC_PP4_FxxP_1	228	231	PF00568	0.460
DOC_PP4_FxxP_1	483	486	PF00568	0.516
DOC_PP4_MxPP_1	114	117	PF00568	0.414
DOC_SPAK_OSR1_1	499	503	PF12202	0.380
DOC_USP7_MATH_1	35	39	PF00917	0.671
DOC_USP7_MATH_1	368	372	PF00917	0.440
DOC_USP7_MATH_1	411	415	PF00917	0.331
DOC_USP7_MATH_1	566	570	PF00917	0.734
DOC_USP7_MATH_1	76	80	PF00917	0.547
DOC_USP7_MATH_1	91	95	PF00917	0.617
DOC_USP7_MATH_2	288	294	PF00917	0.413
DOC_USP7_UBL2_3	353	357	PF12436	0.509
DOC_WW_Pin1_4	33	38	PF00397	0.587
DOC_WW_Pin1_4	485	490	PF00397	0.510
DOC_WW_Pin1_4	662	667	PF00397	0.691
DOC_WW_Pin1_4	68	73	PF00397	0.628
LIG_14-3-3_CanoR_1	186	194	PF00244	0.357
LIG_14-3-3_CanoR_1	19	24	PF00244	0.478
LIG_14-3-3_CanoR_1	255	259	PF00244	0.522
LIG_14-3-3_CanoR_1	339	343	PF00244	0.588
LIG_14-3-3_CanoR_1	415	423	PF00244	0.486
LIG_14-3-3_CanoR_1	467	472	PF00244	0.446
LIG_14-3-3_CanoR_1	7	17	PF00244	0.548
LIG_14-3-3_CanoR_1	720	730	PF00244	0.496
LIG_14-3-3_CanoR_1	84	90	PF00244	0.445
LIG_APCC_ABBA_1	390	395	PF00400	0.262
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_BRCT_BRCA1_1	292	296	PF00533	0.443
LIG_deltaCOP1_diTrp_1	223	228	PF00928	0.517
LIG_deltaCOP1_diTrp_1	290	296	PF00928	0.435
LIG_eIF4E_1	280	286	PF01652	0.426
LIG_FHA_1	231	237	PF00498	0.417
LIG_FHA_1	260	266	PF00498	0.535
LIG_FHA_1	603	609	PF00498	0.735
LIG_FHA_1	632	638	PF00498	0.415
LIG_FHA_1	669	675	PF00498	0.774
LIG_FHA_1	69	75	PF00498	0.696
LIG_FHA_1	707	713	PF00498	0.555
LIG_FHA_1	717	723	PF00498	0.480
LIG_FHA_1	9	15	PF00498	0.473
LIG_FHA_2	219	225	PF00498	0.413
LIG_FHA_2	468	474	PF00498	0.541
LIG_FHA_2	555	561	PF00498	0.552
LIG_FHA_2	568	574	PF00498	0.615
LIG_FHA_2	711	717	PF00498	0.672
LIG_LIR_Apic_2	226	231	PF02991	0.472
LIG_LIR_Apic_2	480	486	PF02991	0.627
LIG_LIR_Apic_2	592	598	PF02991	0.630
LIG_LIR_Gen_1	189	199	PF02991	0.400
LIG_LIR_Gen_1	223	232	PF02991	0.467
LIG_LIR_Gen_1	270	281	PF02991	0.462
LIG_LIR_Gen_1	465	474	PF02991	0.505
LIG_LIR_Gen_1	494	504	PF02991	0.449
LIG_LIR_Gen_1	529	536	PF02991	0.473
LIG_LIR_Gen_1	546	556	PF02991	0.524
LIG_LIR_Nem_3	189	195	PF02991	0.394
LIG_LIR_Nem_3	223	228	PF02991	0.384
LIG_LIR_Nem_3	270	276	PF02991	0.416
LIG_LIR_Nem_3	293	299	PF02991	0.459
LIG_LIR_Nem_3	389	393	PF02991	0.424
LIG_LIR_Nem_3	418	423	PF02991	0.347
LIG_LIR_Nem_3	465	471	PF02991	0.484
LIG_LIR_Nem_3	480	484	PF02991	0.448
LIG_LIR_Nem_3	494	500	PF02991	0.350
LIG_LIR_Nem_3	506	511	PF02991	0.508
LIG_LIR_Nem_3	529	534	PF02991	0.464
LIG_LIR_Nem_3	546	552	PF02991	0.501
LIG_MYND_3	286	290	PF01753	0.445
LIG_PCNA_yPIPBox_3	339	352	PF02747	0.455
LIG_PDZ_Class_2	726	731	PF00595	0.628
LIG_Pex14_1	292	296	PF04695	0.443
LIG_Pex14_2	481	485	PF04695	0.555
LIG_PTB_Apo_2	517	524	PF02174	0.665
LIG_SH2_CRK	468	472	PF00017	0.487
LIG_SH2_CRK	508	512	PF00017	0.568
LIG_SH2_GRB2like	242	245	PF00017	0.253
LIG_SH2_GRB2like	280	283	PF00017	0.260
LIG_SH2_SRC	542	545	PF00017	0.560
LIG_SH2_STAP1	242	246	PF00017	0.404
LIG_SH2_STAT3	140	143	PF00017	0.503
LIG_SH2_STAT5	108	111	PF00017	0.543
LIG_SH2_STAT5	275	278	PF00017	0.395
LIG_SH2_STAT5	280	283	PF00017	0.365
LIG_SH2_STAT5	452	455	PF00017	0.427
LIG_SH2_STAT5	468	471	PF00017	0.565
LIG_SH2_STAT5	484	487	PF00017	0.582
LIG_SH2_STAT5	501	504	PF00017	0.275
LIG_SH2_STAT5	614	617	PF00017	0.585
LIG_SH3_3	160	166	PF00018	0.510
LIG_SH3_3	36	42	PF00018	0.458
LIG_SH3_3	45	51	PF00018	0.472
LIG_SH3_3	483	489	PF00018	0.543
LIG_SH3_3	550	556	PF00018	0.569
LIG_SH3_3	66	72	PF00018	0.455
LIG_TRAF2_1	300	303	PF00917	0.510
LIG_TRAF2_1	341	344	PF00917	0.535
LIG_TRAF2_1	424	427	PF00917	0.533
LIG_TRAF2_1	535	538	PF00917	0.511
LIG_TRFH_1	485	489	PF08558	0.518
LIG_TRFH_1	552	556	PF08558	0.578
LIG_UBA3_1	195	201	PF00899	0.454
LIG_UBA3_1	208	214	PF00899	0.368
MOD_CDK_SPK_2	38	43	PF00069	0.575
MOD_CK1_1	122	128	PF00069	0.404
MOD_CK1_1	248	254	PF00069	0.404
MOD_CK1_1	338	344	PF00069	0.529
MOD_CK1_1	38	44	PF00069	0.700
MOD_CK1_1	462	468	PF00069	0.449
MOD_CK1_1	49	55	PF00069	0.548
MOD_CK1_1	565	571	PF00069	0.642
MOD_CK1_1	574	580	PF00069	0.586
MOD_CK1_1	582	588	PF00069	0.536
MOD_CK1_1	710	716	PF00069	0.651
MOD_CK1_1	718	724	PF00069	0.637
MOD_CK1_1	79	85	PF00069	0.496
MOD_CK2_1	338	344	PF00069	0.424
MOD_CK2_1	376	382	PF00069	0.400
MOD_CK2_1	421	427	PF00069	0.612
MOD_CK2_1	532	538	PF00069	0.488
MOD_CK2_1	554	560	PF00069	0.698
MOD_CK2_1	567	573	PF00069	0.725
MOD_CK2_1	678	684	PF00069	0.767
MOD_CK2_1	710	716	PF00069	0.675
MOD_Cter_Amidation	100	103	PF01082	0.470
MOD_Cter_Amidation	444	447	PF01082	0.399
MOD_Cter_Amidation	644	647	PF01082	0.472
MOD_Cter_Amidation	704	707	PF01082	0.604
MOD_GlcNHglycan	2	5	PF01048	0.501
MOD_GlcNHglycan	562	565	PF01048	0.670
MOD_GlcNHglycan	581	584	PF01048	0.706
MOD_GlcNHglycan	709	712	PF01048	0.788
MOD_GlcNHglycan	723	726	PF01048	0.469
MOD_GSK3_1	186	193	PF00069	0.532
MOD_GSK3_1	230	237	PF00069	0.455
MOD_GSK3_1	245	252	PF00069	0.410
MOD_GSK3_1	254	261	PF00069	0.403
MOD_GSK3_1	312	319	PF00069	0.467
MOD_GSK3_1	411	418	PF00069	0.399
MOD_GSK3_1	462	469	PF00069	0.479
MOD_GSK3_1	487	494	PF00069	0.365
MOD_GSK3_1	49	56	PF00069	0.505
MOD_GSK3_1	562	569	PF00069	0.623
MOD_GSK3_1	585	592	PF00069	0.668
MOD_GSK3_1	706	713	PF00069	0.689
MOD_N-GLC_1	169	174	PF02516	0.584
MOD_N-GLC_1	281	286	PF02516	0.385
MOD_N-GLC_1	386	391	PF02516	0.273
MOD_N-GLC_1	462	467	PF02516	0.346
MOD_NEK2_1	13	18	PF00069	0.506
MOD_NEK2_1	168	173	PF00069	0.531
MOD_NEK2_1	185	190	PF00069	0.386
MOD_NEK2_1	256	261	PF00069	0.450
MOD_NEK2_1	281	286	PF00069	0.556
MOD_NEK2_1	459	464	PF00069	0.476
MOD_NEK2_1	510	515	PF00069	0.496
MOD_NEK2_1	602	607	PF00069	0.518
MOD_NEK2_2	268	273	PF00069	0.456
MOD_NEK2_2	429	434	PF00069	0.453
MOD_NEK2_2	53	58	PF00069	0.476
MOD_PIKK_1	328	334	PF00454	0.282
MOD_PIKK_1	462	468	PF00454	0.500
MOD_PIKK_1	582	588	PF00454	0.771
MOD_PIKK_1	600	606	PF00454	0.604
MOD_PIKK_1	657	663	PF00454	0.526
MOD_PIKK_1	678	684	PF00454	0.515
MOD_PIKK_1	687	693	PF00454	0.676
MOD_PIKK_1	710	716	PF00454	0.535
MOD_PK_1	19	25	PF00069	0.476
MOD_PKA_1	119	125	PF00069	0.604
MOD_PKA_1	19	25	PF00069	0.476
MOD_PKA_1	437	443	PF00069	0.540
MOD_PKA_1	706	712	PF00069	0.554
MOD_PKA_2	122	128	PF00069	0.644
MOD_PKA_2	18	24	PF00069	0.477
MOD_PKA_2	185	191	PF00069	0.378
MOD_PKA_2	254	260	PF00069	0.522
MOD_PKA_2	338	344	PF00069	0.585
MOD_PKA_2	411	417	PF00069	0.373
MOD_PKA_2	429	435	PF00069	0.543
MOD_PKA_2	437	443	PF00069	0.598
MOD_PKA_2	466	472	PF00069	0.330
MOD_PKA_2	706	712	PF00069	0.579
MOD_PKA_2	8	14	PF00069	0.532
MOD_PKB_1	704	712	PF00069	0.622
MOD_Plk_1	130	136	PF00069	0.598
MOD_Plk_1	169	175	PF00069	0.572
MOD_Plk_1	281	287	PF00069	0.467
MOD_Plk_1	386	392	PF00069	0.267
MOD_Plk_1	625	631	PF00069	0.680
MOD_Plk_2-3	532	538	PF00069	0.525
MOD_Plk_4	245	251	PF00069	0.460
MOD_Plk_4	268	274	PF00069	0.567
MOD_Plk_4	35	41	PF00069	0.455
MOD_Plk_4	386	392	PF00069	0.510
MOD_Plk_4	631	637	PF00069	0.416
MOD_Plk_4	70	76	PF00069	0.721
MOD_Plk_4	85	91	PF00069	0.436
MOD_ProDKin_1	33	39	PF00069	0.586
MOD_ProDKin_1	485	491	PF00069	0.503
MOD_ProDKin_1	662	668	PF00069	0.692
MOD_ProDKin_1	68	74	PF00069	0.631
MOD_SUMO_rev_2	112	122	PF00179	0.535
MOD_SUMO_rev_2	147	152	PF00179	0.510
MOD_SUMO_rev_2	358	368	PF00179	0.393
MOD_SUMO_rev_2	379	386	PF00179	0.372
TRG_DiLeu_BaEn_1	344	349	PF01217	0.410
TRG_DiLeu_BaEn_2	202	208	PF01217	0.457
TRG_ENDOCYTIC_2	253	256	PF00928	0.519
TRG_ENDOCYTIC_2	431	434	PF00928	0.452
TRG_ENDOCYTIC_2	468	471	PF00928	0.484
TRG_ENDOCYTIC_2	484	487	PF00928	0.398
TRG_ENDOCYTIC_2	501	504	PF00928	0.358
TRG_ENDOCYTIC_2	508	511	PF00928	0.564
TRG_ENDOCYTIC_2	549	552	PF00928	0.674
TRG_ER_diArg_1	126	129	PF00400	0.496
TRG_ER_diArg_1	134	137	PF00400	0.531
TRG_ER_diArg_1	173	176	PF00400	0.600
TRG_ER_diArg_1	397	399	PF00400	0.371
TRG_ER_diArg_1	428	431	PF00400	0.462
TRG_ER_diArg_1	6	9	PF00400	0.480
TRG_ER_diArg_1	647	649	PF00400	0.500
TRG_ER_diArg_1	701	704	PF00400	0.669
TRG_ER_diArg_1	706	708	PF00400	0.641
TRG_ER_diArg_1	95	97	PF00400	0.659
TRG_NES_CRM1_1	206	218	PF08389	0.490
TRG_NLS_Bipartite_1	84	106	PF00514	0.527
TRG_NLS_MonoCore_2	645	650	PF00514	0.491
TRG_NLS_MonoExtN_4	99	106	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	421	426	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J5	Leptomonas seymouri	38%	100%
A0A1X0NYQ6	Trypanosomatidae	29%	100%
A0A3Q8IAY3	Leishmania donovani	72%	100%
A0A3R7LLJ8	Trypanosoma rangeli	31%	100%
A4I3I3	Leishmania infantum	72%	100%
D0A7W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AZS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q8F9	Leishmania major	74%	100%
V5DAI7	Trypanosoma cruzi	30%	100%