Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGF0_LEIBR

TriTrypDb:

LbrM.28.1130 , LBRM2903_280017200

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.800
CLV_NRD_NRD_1	140	142	PF00675	0.671
CLV_NRD_NRD_1	19	21	PF00675	0.675
CLV_NRD_NRD_1	207	209	PF00675	0.803
CLV_NRD_NRD_1	24	26	PF00675	0.644
CLV_NRD_NRD_1	248	250	PF00675	0.794
CLV_NRD_NRD_1	87	89	PF00675	0.727
CLV_PCSK_KEX2_1	140	142	PF00082	0.671
CLV_PCSK_KEX2_1	173	175	PF00082	0.610
CLV_PCSK_KEX2_1	19	21	PF00082	0.693
CLV_PCSK_KEX2_1	206	208	PF00082	0.810
CLV_PCSK_KEX2_1	24	26	PF00082	0.625
CLV_PCSK_KEX2_1	86	88	PF00082	0.731
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.610
CLV_PCSK_PC7_1	15	21	PF00082	0.704
CLV_PCSK_SKI1_1	53	57	PF00082	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.666
DOC_USP7_MATH_1	119	123	PF00917	0.809
DOC_USP7_MATH_1	224	228	PF00917	0.805
DOC_USP7_MATH_1	63	67	PF00917	0.491
DOC_WW_Pin1_4	102	107	PF00397	0.639
DOC_WW_Pin1_4	237	242	PF00397	0.760
DOC_WW_Pin1_4	373	378	PF00397	0.820
DOC_WW_Pin1_4	78	83	PF00397	0.558
LIG_14-3-3_CanoR_1	249	257	PF00244	0.570
LIG_14-3-3_CanoR_1	317	326	PF00244	0.527
LIG_14-3-3_CanoR_1	53	61	PF00244	0.552
LIG_APCC_ABBA_1	148	153	PF00400	0.512
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.513
LIG_FHA_1	176	182	PF00498	0.824
LIG_FHA_1	5	11	PF00498	0.768
LIG_FHA_2	134	140	PF00498	0.655
LIG_HCF-1_HBM_1	303	306	PF13415	0.532
LIG_Integrin_isoDGR_2	315	317	PF01839	0.545
LIG_Integrin_RGD_1	272	274	PF01839	0.593
LIG_LIR_Gen_1	153	163	PF02991	0.671
LIG_LIR_Nem_3	153	159	PF02991	0.623
LIG_LIR_Nem_3	329	335	PF02991	0.537
LIG_SH2_GRB2like	306	309	PF00017	0.719
LIG_SH2_SRC	335	338	PF00017	0.669
LIG_SH2_STAP1	310	314	PF00017	0.585
LIG_SH2_STAP1	394	398	PF00017	0.813
LIG_SH2_STAT5	177	180	PF00017	0.691
LIG_SH3_1	42	48	PF00018	0.548
LIG_SH3_2	188	193	PF14604	0.574
LIG_SH3_3	105	111	PF00018	0.567
LIG_SH3_3	182	188	PF00018	0.575
LIG_SH3_3	42	48	PF00018	0.762
LIG_SH3_3	76	82	PF00018	0.561
MOD_CDK_SPxxK_3	102	109	PF00069	0.558
MOD_CK1_1	259	265	PF00069	0.575
MOD_CK2_1	164	170	PF00069	0.577
MOD_CK2_1	219	225	PF00069	0.804
MOD_Cter_Amidation	171	174	PF01082	0.571
MOD_Cter_Amidation	204	207	PF01082	0.815
MOD_Cter_Amidation	22	25	PF01082	0.641
MOD_GlcNHglycan	119	122	PF01048	0.812
MOD_GlcNHglycan	153	156	PF01048	0.728
MOD_GlcNHglycan	166	169	PF01048	0.613
MOD_GlcNHglycan	181	184	PF01048	0.804
MOD_GlcNHglycan	225	229	PF01048	0.795
MOD_GlcNHglycan	250	253	PF01048	0.570
MOD_GSK3_1	115	122	PF00069	0.702
MOD_GSK3_1	175	182	PF00069	0.739
MOD_GSK3_1	337	344	PF00069	0.567
MOD_GSK3_1	78	85	PF00069	0.775
MOD_GSK3_1	97	104	PF00069	0.629
MOD_N-GLC_1	128	133	PF02516	0.679
MOD_N-GLC_2	219	221	PF02516	0.586
MOD_PKA_1	19	25	PF00069	0.702
MOD_PKA_2	19	25	PF00069	0.652
MOD_PKA_2	248	254	PF00069	0.572
MOD_Plk_4	63	69	PF00069	0.635
MOD_Plk_4	73	79	PF00069	0.670
MOD_ProDKin_1	102	108	PF00069	0.642
MOD_ProDKin_1	237	243	PF00069	0.761
MOD_ProDKin_1	373	379	PF00069	0.819
MOD_ProDKin_1	78	84	PF00069	0.559
TRG_ER_diArg_1	19	21	PF00400	0.576
TRG_ER_diArg_1	206	208	PF00400	0.815
TRG_ER_diArg_1	86	88	PF00400	0.831

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P454	Leptomonas seymouri	38%	100%
A0A3S7X1G1	Leishmania donovani	61%	100%
A4I3I1	Leishmania infantum	61%	100%
E9AZS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q8G1	Leishmania major	62%	100%