Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGE9_LEIBR

TriTrypDb:

LbrM.28.1120 , LBRM2903_280016900

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.608
CLV_NRD_NRD_1	195	197	PF00675	0.611
CLV_NRD_NRD_1	286	288	PF00675	0.330
CLV_NRD_NRD_1	365	367	PF00675	0.394
CLV_PCSK_KEX2_1	195	197	PF00082	0.611
CLV_PCSK_KEX2_1	286	288	PF00082	0.330
DEG_APCC_DBOX_1	82	90	PF00400	0.460
DEG_SCF_SKP2-CKS1_1	123	130	PF00560	0.530
DOC_CKS1_1	141	146	PF01111	0.457
DOC_CYCLIN_RxL_1	283	294	PF00134	0.353
DOC_MAPK_MEF2A_6	21	29	PF00069	0.555
DOC_MAPK_MEF2A_6	216	225	PF00069	0.512
DOC_PP1_RVXF_1	284	291	PF00149	0.390
DOC_PP2B_LxvP_1	378	381	PF13499	0.369
DOC_USP7_MATH_1	23	27	PF00917	0.709
DOC_USP7_MATH_1	233	237	PF00917	0.633
DOC_USP7_MATH_1	239	243	PF00917	0.466
DOC_USP7_MATH_1	312	316	PF00917	0.606
DOC_USP7_MATH_1	396	400	PF00917	0.556
DOC_WW_Pin1_4	124	129	PF00397	0.621
DOC_WW_Pin1_4	140	145	PF00397	0.448
DOC_WW_Pin1_4	159	164	PF00397	0.368
DOC_WW_Pin1_4	225	230	PF00397	0.723
DOC_WW_Pin1_4	293	298	PF00397	0.536
DOC_WW_Pin1_4	54	59	PF00397	0.642
LIG_14-3-3_CanoR_1	331	336	PF00244	0.548
LIG_14-3-3_CanoR_1	386	392	PF00244	0.507
LIG_14-3-3_CanoR_1	400	404	PF00244	0.367
LIG_Actin_WH2_2	180	197	PF00022	0.305
LIG_BIR_II_1	1	5	PF00653	0.746
LIG_BIR_III_4	65	69	PF00653	0.421
LIG_BRCT_BRCA1_1	331	335	PF00533	0.367
LIG_DLG_GKlike_1	331	338	PF00625	0.541
LIG_FHA_1	114	120	PF00498	0.530
LIG_FHA_1	236	242	PF00498	0.340
LIG_FHA_2	166	172	PF00498	0.537
LIG_LIR_Apic_2	265	271	PF02991	0.529
LIG_LIR_Nem_3	332	338	PF02991	0.510
LIG_PDZ_Class_2	403	408	PF00595	0.347
LIG_RPA_C_Fungi	326	338	PF08784	0.490
LIG_SH2_NCK_1	70	74	PF00017	0.367
LIG_SH2_PTP2	268	271	PF00017	0.535
LIG_SH2_SRC	205	208	PF00017	0.524
LIG_SH2_STAT5	102	105	PF00017	0.398
LIG_SH2_STAT5	268	271	PF00017	0.535
LIG_SH2_STAT5	358	361	PF00017	0.400
LIG_SH3_2	101	106	PF14604	0.547
LIG_SH3_2	156	161	PF14604	0.364
LIG_SH3_3	142	148	PF00018	0.536
LIG_SH3_3	153	159	PF00018	0.419
LIG_SH3_3	215	221	PF00018	0.688
LIG_SH3_3	98	104	PF00018	0.554
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.509
LIG_TRAF2_1	337	340	PF00917	0.301
MOD_CDK_SPxK_1	124	130	PF00069	0.531
MOD_CDK_SPxxK_3	54	61	PF00069	0.663
MOD_CK1_1	219	225	PF00069	0.511
MOD_CK1_1	228	234	PF00069	0.630
MOD_CK1_1	235	241	PF00069	0.479
MOD_CK1_1	30	36	PF00069	0.588
MOD_CK1_1	329	335	PF00069	0.397
MOD_CK1_1	346	352	PF00069	0.254
MOD_CK1_1	399	405	PF00069	0.524
MOD_CK2_1	44	50	PF00069	0.556
MOD_GlcNHglycan	10	13	PF01048	0.531
MOD_GlcNHglycan	17	20	PF01048	0.769
MOD_GlcNHglycan	29	32	PF01048	0.613
MOD_GlcNHglycan	343	346	PF01048	0.395
MOD_GlcNHglycan	64	69	PF01048	0.456
MOD_GlcNHglycan	92	95	PF01048	0.578
MOD_GSK3_1	206	213	PF00069	0.565
MOD_GSK3_1	228	235	PF00069	0.670
MOD_GSK3_1	23	30	PF00069	0.712
MOD_GSK3_1	258	265	PF00069	0.368
MOD_GSK3_1	325	332	PF00069	0.653
MOD_GSK3_1	341	348	PF00069	0.292
MOD_GSK3_1	380	387	PF00069	0.317
MOD_GSK3_1	45	52	PF00069	0.641
MOD_N-GLC_1	27	32	PF02516	0.686
MOD_N-GLC_1	33	38	PF02516	0.516
MOD_N-GLC_1	396	401	PF02516	0.542
MOD_NEK2_1	113	118	PF00069	0.661
MOD_NEK2_1	262	267	PF00069	0.507
MOD_NEK2_1	274	279	PF00069	0.363
MOD_NEK2_1	341	346	PF00069	0.339
MOD_NEK2_1	79	84	PF00069	0.594
MOD_NEK2_2	281	286	PF00069	0.406
MOD_PIKK_1	239	245	PF00454	0.530
MOD_PKA_2	385	391	PF00069	0.394
MOD_PKA_2	399	405	PF00069	0.481
MOD_PKA_2	8	14	PF00069	0.758
MOD_Plk_1	33	39	PF00069	0.546
MOD_Plk_2-3	45	51	PF00069	0.590
MOD_Plk_4	113	119	PF00069	0.519
MOD_Plk_4	380	386	PF00069	0.543
MOD_ProDKin_1	124	130	PF00069	0.624
MOD_ProDKin_1	140	146	PF00069	0.434
MOD_ProDKin_1	159	165	PF00069	0.359
MOD_ProDKin_1	225	231	PF00069	0.717
MOD_ProDKin_1	293	299	PF00069	0.532
MOD_ProDKin_1	54	60	PF00069	0.638
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.555
TRG_ENDOCYTIC_2	102	105	PF00928	0.398
TRG_ER_diArg_1	194	196	PF00400	0.578
TRG_ER_diArg_1	285	287	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYD6	Trypanosomatidae	32%	83%
A0A3S7X1C6	Leishmania donovani	70%	100%
A4I3I0	Leishmania infantum	70%	100%
E9AZS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q8G2	Leishmania major	70%	100%