Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HGE8_LEIBR

TriTrypDb:

LbrM.28.1110 , LBRM2903_280016800

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.526
CLV_C14_Caspase3-7	436	440	PF00656	0.585
CLV_C14_Caspase3-7	562	566	PF00656	0.664
CLV_NRD_NRD_1	289	291	PF00675	0.656
CLV_NRD_NRD_1	373	375	PF00675	0.625
CLV_NRD_NRD_1	51	53	PF00675	0.590
CLV_NRD_NRD_1	55	57	PF00675	0.589
CLV_NRD_NRD_1	778	780	PF00675	0.582
CLV_NRD_NRD_1	894	896	PF00675	0.455
CLV_PCSK_KEX2_1	289	291	PF00082	0.656
CLV_PCSK_KEX2_1	373	375	PF00082	0.626
CLV_PCSK_KEX2_1	51	53	PF00082	0.590
CLV_PCSK_KEX2_1	778	780	PF00082	0.582
CLV_PCSK_KEX2_1	894	896	PF00082	0.455
CLV_PCSK_SKI1_1	136	140	PF00082	0.393
CLV_PCSK_SKI1_1	17	21	PF00082	0.642
CLV_PCSK_SKI1_1	219	223	PF00082	0.528
CLV_PCSK_SKI1_1	258	262	PF00082	0.491
CLV_PCSK_SKI1_1	367	371	PF00082	0.345
CLV_PCSK_SKI1_1	388	392	PF00082	0.472
CLV_PCSK_SKI1_1	397	401	PF00082	0.443
CLV_PCSK_SKI1_1	577	581	PF00082	0.546
CLV_PCSK_SKI1_1	63	67	PF00082	0.680
CLV_PCSK_SKI1_1	643	647	PF00082	0.553
CLV_Separin_Metazoa	891	895	PF03568	0.517
DEG_APCC_DBOX_1	257	265	PF00400	0.364
DEG_APCC_DBOX_1	396	404	PF00400	0.470
DEG_SCF_FBW7_1	631	636	PF00400	0.549
DEG_SPOP_SBC_1	32	36	PF00917	0.530
DEG_SPOP_SBC_1	653	657	PF00917	0.558
DOC_CKS1_1	195	200	PF01111	0.499
DOC_CKS1_1	678	683	PF01111	0.519
DOC_CKS1_1	862	867	PF01111	0.539
DOC_CYCLIN_RxL_1	14	23	PF00134	0.527
DOC_CYCLIN_RxL_1	574	584	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	844	847	PF00134	0.529
DOC_MAPK_DCC_7	4	14	PF00069	0.638
DOC_MAPK_DCC_7	820	830	PF00069	0.569
DOC_MAPK_gen_1	125	133	PF00069	0.372
DOC_MAPK_gen_1	373	380	PF00069	0.346
DOC_MAPK_MEF2A_6	112	120	PF00069	0.436
DOC_MAPK_MEF2A_6	126	135	PF00069	0.441
DOC_MAPK_MEF2A_6	171	179	PF00069	0.604
DOC_MAPK_MEF2A_6	609	617	PF00069	0.532
DOC_PP2B_LxvP_1	106	109	PF13499	0.522
DOC_PP2B_LxvP_1	510	513	PF13499	0.556
DOC_PP2B_LxvP_1	558	561	PF13499	0.574
DOC_PP2B_LxvP_1	572	575	PF13499	0.524
DOC_PP2B_LxvP_1	637	640	PF13499	0.567
DOC_PP2B_LxvP_1	768	771	PF13499	0.573
DOC_PP2B_LxvP_1	813	816	PF13499	0.576
DOC_PP2B_LxvP_1	844	847	PF13499	0.622
DOC_PP2B_LxvP_1	849	852	PF13499	0.632
DOC_PP2B_PxIxI_1	498	504	PF00149	0.573
DOC_PP4_FxxP_1	716	719	PF00568	0.569
DOC_USP7_MATH_1	161	165	PF00917	0.507
DOC_USP7_MATH_1	292	296	PF00917	0.630
DOC_USP7_MATH_1	421	425	PF00917	0.540
DOC_USP7_MATH_1	440	444	PF00917	0.421
DOC_USP7_MATH_1	504	508	PF00917	0.588
DOC_USP7_MATH_1	547	551	PF00917	0.610
DOC_USP7_MATH_1	552	556	PF00917	0.557
DOC_USP7_MATH_1	633	637	PF00917	0.581
DOC_USP7_MATH_1	654	658	PF00917	0.562
DOC_WW_Pin1_4	194	199	PF00397	0.511
DOC_WW_Pin1_4	294	299	PF00397	0.456
DOC_WW_Pin1_4	412	417	PF00397	0.665
DOC_WW_Pin1_4	50	55	PF00397	0.640
DOC_WW_Pin1_4	629	634	PF00397	0.549
DOC_WW_Pin1_4	666	671	PF00397	0.566
DOC_WW_Pin1_4	674	679	PF00397	0.515
DOC_WW_Pin1_4	710	715	PF00397	0.618
DOC_WW_Pin1_4	731	736	PF00397	0.673
DOC_WW_Pin1_4	759	764	PF00397	0.601
DOC_WW_Pin1_4	808	813	PF00397	0.554
DOC_WW_Pin1_4	814	819	PF00397	0.558
DOC_WW_Pin1_4	823	828	PF00397	0.532
DOC_WW_Pin1_4	830	835	PF00397	0.499
DOC_WW_Pin1_4	861	866	PF00397	0.545
LIG_14-3-3_CanoR_1	101	106	PF00244	0.534
LIG_14-3-3_CanoR_1	165	173	PF00244	0.600
LIG_14-3-3_CanoR_1	307	316	PF00244	0.670
LIG_14-3-3_CanoR_1	820	824	PF00244	0.573
LIG_Actin_WH2_2	274	291	PF00022	0.380
LIG_BRCT_BRCA1_1	385	389	PF00533	0.461
LIG_Clathr_ClatBox_1	172	176	PF01394	0.629
LIG_DLG_GKlike_1	101	108	PF00625	0.530
LIG_EH_1	515	519	PF12763	0.556
LIG_EVH1_1	849	853	PF00568	0.627
LIG_EVH1_1	862	866	PF00568	0.554
LIG_FHA_1	228	234	PF00498	0.474
LIG_FHA_1	250	256	PF00498	0.360
LIG_FHA_1	443	449	PF00498	0.514
LIG_FHA_1	454	460	PF00498	0.568
LIG_FHA_1	472	478	PF00498	0.530
LIG_FHA_1	546	552	PF00498	0.575
LIG_FHA_1	582	588	PF00498	0.665
LIG_FHA_1	644	650	PF00498	0.554
LIG_FHA_1	658	664	PF00498	0.537
LIG_FHA_1	678	684	PF00498	0.475
LIG_FHA_1	723	729	PF00498	0.603
LIG_FHA_1	852	858	PF00498	0.545
LIG_FHA_1	862	868	PF00498	0.508
LIG_FHA_2	112	118	PF00498	0.574
LIG_FHA_2	309	315	PF00498	0.585
LIG_FHA_2	340	346	PF00498	0.372
LIG_FHA_2	428	434	PF00498	0.755
LIG_FHA_2	560	566	PF00498	0.568
LIG_FHA_2	64	70	PF00498	0.615
LIG_FHA_2	755	761	PF00498	0.588
LIG_FHA_2	770	776	PF00498	0.531
LIG_Integrin_RGD_1	536	538	PF01839	0.579
LIG_LIR_Apic_2	659	664	PF02991	0.568
LIG_LIR_Apic_2	713	719	PF02991	0.584
LIG_LIR_Gen_1	26	33	PF02991	0.588
LIG_LIR_Gen_1	386	396	PF02991	0.485
LIG_LIR_Gen_1	682	692	PF02991	0.534
LIG_LIR_Nem_3	26	31	PF02991	0.593
LIG_LIR_Nem_3	386	392	PF02991	0.478
LIG_LIR_Nem_3	682	687	PF02991	0.532
LIG_MYND_1	842	846	PF01753	0.630
LIG_RPA_C_Fungi	160	172	PF08784	0.504
LIG_SH2_CRK	382	386	PF00017	0.465
LIG_SH2_CRK	684	688	PF00017	0.534
LIG_SH2_NCK_1	661	665	PF00017	0.565
LIG_SH2_STAP1	684	688	PF00017	0.534
LIG_SH2_STAT3	322	325	PF00017	0.487
LIG_SH2_STAT3	381	384	PF00017	0.472
LIG_SH3_3	172	178	PF00018	0.499
LIG_SH3_3	192	198	PF00018	0.513
LIG_SH3_3	491	497	PF00018	0.561
LIG_SH3_3	506	512	PF00018	0.618
LIG_SH3_3	546	552	PF00018	0.575
LIG_SH3_3	558	564	PF00018	0.605
LIG_SH3_3	583	589	PF00018	0.542
LIG_SH3_3	613	619	PF00018	0.533
LIG_SH3_3	648	654	PF00018	0.660
LIG_SH3_3	672	678	PF00018	0.546
LIG_SH3_3	715	721	PF00018	0.663
LIG_SH3_3	748	754	PF00018	0.672
LIG_SH3_3	797	803	PF00018	0.518
LIG_SH3_3	813	819	PF00018	0.534
LIG_SH3_3	821	827	PF00018	0.569
LIG_SH3_3	840	846	PF00018	0.600
LIG_SH3_3	847	853	PF00018	0.581
LIG_SH3_3	860	866	PF00018	0.565
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.510
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.349
LIG_SUMO_SIM_par_1	473	480	PF11976	0.572
LIG_TRAF2_1	291	294	PF00917	0.490
LIG_TRAF2_1	730	733	PF00917	0.585
LIG_TYR_ITIM	380	385	PF00017	0.337
LIG_UBA3_1	222	231	PF00899	0.505
LIG_WW_3	497	501	PF00397	0.561
LIG_WW_3	817	821	PF00397	0.573
MOD_CDC14_SPxK_1	415	418	PF00782	0.676
MOD_CDC14_SPxK_1	53	56	PF00782	0.562
MOD_CDC14_SPxK_1	817	820	PF00782	0.571
MOD_CDK_SPxK_1	412	418	PF00069	0.668
MOD_CDK_SPxK_1	50	56	PF00069	0.570
MOD_CDK_SPxK_1	814	820	PF00069	0.574
MOD_CDK_SPxxK_3	294	301	PF00069	0.464
MOD_CDK_SPxxK_3	50	57	PF00069	0.617
MOD_CK1_1	104	110	PF00069	0.662
MOD_CK1_1	111	117	PF00069	0.553
MOD_CK1_1	164	170	PF00069	0.542
MOD_CK1_1	297	303	PF00069	0.556
MOD_CK1_1	443	449	PF00069	0.467
MOD_CK1_1	476	482	PF00069	0.558
MOD_CK1_1	559	565	PF00069	0.577
MOD_CK1_1	657	663	PF00069	0.575
MOD_CK1_1	671	677	PF00069	0.521
MOD_CK1_1	808	814	PF00069	0.558
MOD_CK2_1	111	117	PF00069	0.577
MOD_CK2_1	339	345	PF00069	0.363
MOD_CK2_1	427	433	PF00069	0.649
MOD_CK2_1	769	775	PF00069	0.568
MOD_GlcNHglycan	151	155	PF01048	0.571
MOD_GlcNHglycan	167	170	PF01048	0.535
MOD_GlcNHglycan	375	378	PF01048	0.370
MOD_GlcNHglycan	38	41	PF01048	0.809
MOD_GlcNHglycan	385	388	PF01048	0.411
MOD_GlcNHglycan	423	426	PF01048	0.633
MOD_GlcNHglycan	43	46	PF01048	0.745
MOD_GlcNHglycan	600	603	PF01048	0.540
MOD_GlcNHglycan	608	612	PF01048	0.573
MOD_GlcNHglycan	656	659	PF01048	0.698
MOD_GlcNHglycan	670	673	PF01048	0.561
MOD_GSK3_1	104	111	PF00069	0.670
MOD_GSK3_1	160	167	PF00069	0.555
MOD_GSK3_1	292	299	PF00069	0.467
MOD_GSK3_1	32	39	PF00069	0.574
MOD_GSK3_1	453	460	PF00069	0.586
MOD_GSK3_1	467	474	PF00069	0.537
MOD_GSK3_1	552	559	PF00069	0.579
MOD_GSK3_1	625	632	PF00069	0.658
MOD_GSK3_1	653	660	PF00069	0.583
MOD_GSK3_1	700	707	PF00069	0.582
MOD_GSK3_1	720	727	PF00069	0.653
MOD_GSK3_1	731	738	PF00069	0.619
MOD_GSK3_1	80	87	PF00069	0.664
MOD_GSK3_1	814	821	PF00069	0.575
MOD_GSK3_1	857	864	PF00069	0.557
MOD_GSK3_1	88	95	PF00069	0.627
MOD_NEK2_1	12	17	PF00069	0.662
MOD_NEK2_1	20	25	PF00069	0.639
MOD_NEK2_1	333	338	PF00069	0.374
MOD_NEK2_1	467	472	PF00069	0.569
MOD_NEK2_1	722	727	PF00069	0.659
MOD_NEK2_1	806	811	PF00069	0.543
MOD_NEK2_1	89	94	PF00069	0.533
MOD_NEK2_2	191	196	PF00069	0.519
MOD_PIKK_1	314	320	PF00454	0.503
MOD_PIKK_1	419	425	PF00454	0.561
MOD_PIKK_1	80	86	PF00454	0.551
MOD_PIKK_1	881	887	PF00454	0.404
MOD_PK_1	171	177	PF00069	0.608
MOD_PKA_1	373	379	PF00069	0.346
MOD_PKA_1	625	631	PF00069	0.553
MOD_PKA_1	63	69	PF00069	0.598
MOD_PKA_2	111	117	PF00069	0.523
MOD_PKA_2	149	155	PF00069	0.621
MOD_PKA_2	164	170	PF00069	0.497
MOD_PKA_2	373	379	PF00069	0.414
MOD_PKA_2	434	440	PF00069	0.604
MOD_PKA_2	819	825	PF00069	0.573
MOD_Plk_1	116	122	PF00069	0.538
MOD_Plk_1	217	223	PF00069	0.530
MOD_Plk_1	292	298	PF00069	0.570
MOD_Plk_1	427	433	PF00069	0.614
MOD_Plk_1	443	449	PF00069	0.456
MOD_Plk_1	467	473	PF00069	0.514
MOD_Plk_1	556	562	PF00069	0.575
MOD_Plk_1	581	587	PF00069	0.538
MOD_Plk_1	633	639	PF00069	0.563
MOD_Plk_4	101	107	PF00069	0.535
MOD_Plk_4	116	122	PF00069	0.494
MOD_Plk_4	391	397	PF00069	0.358
MOD_Plk_4	582	588	PF00069	0.536
MOD_Plk_4	679	685	PF00069	0.526
MOD_Plk_4	724	730	PF00069	0.580
MOD_Plk_4	857	863	PF00069	0.558
MOD_ProDKin_1	194	200	PF00069	0.503
MOD_ProDKin_1	294	300	PF00069	0.460
MOD_ProDKin_1	412	418	PF00069	0.668
MOD_ProDKin_1	50	56	PF00069	0.640
MOD_ProDKin_1	629	635	PF00069	0.548
MOD_ProDKin_1	666	672	PF00069	0.566
MOD_ProDKin_1	674	680	PF00069	0.513
MOD_ProDKin_1	710	716	PF00069	0.622
MOD_ProDKin_1	731	737	PF00069	0.669
MOD_ProDKin_1	759	765	PF00069	0.605
MOD_ProDKin_1	808	814	PF00069	0.558
MOD_ProDKin_1	823	829	PF00069	0.531
MOD_ProDKin_1	830	836	PF00069	0.518
MOD_ProDKin_1	861	867	PF00069	0.541
MOD_SUMO_for_1	264	267	PF00179	0.365
MOD_SUMO_rev_2	621	628	PF00179	0.553
TRG_DiLeu_BaEn_1	218	223	PF01217	0.529
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.492
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.520
TRG_ENDOCYTIC_2	321	324	PF00928	0.490
TRG_ENDOCYTIC_2	382	385	PF00928	0.465
TRG_ENDOCYTIC_2	684	687	PF00928	0.536
TRG_ER_diArg_1	288	290	PF00400	0.657
TRG_ER_diArg_1	70	73	PF00400	0.554
TRG_ER_diArg_1	777	779	PF00400	0.575
TRG_ER_diArg_1	893	895	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	577	582	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1D3	Leishmania donovani	52%	100%
A4I3H9	Leishmania infantum	52%	93%
E9AZS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4Q8G3	Leishmania major	49%	90%