PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGE6_LEIBR

TriTrypDb:

LbrM.28.1090 , LBRM2903_280016600

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.669
CLV_C14_Caspase3-7	368	372	PF00656	0.570
CLV_NRD_NRD_1	163	165	PF00675	0.508
CLV_NRD_NRD_1	257	259	PF00675	0.375
CLV_NRD_NRD_1	264	266	PF00675	0.392
CLV_NRD_NRD_1	28	30	PF00675	0.452
CLV_NRD_NRD_1	320	322	PF00675	0.293
CLV_NRD_NRD_1	426	428	PF00675	0.414
CLV_NRD_NRD_1	455	457	PF00675	0.408
CLV_NRD_NRD_1	541	543	PF00675	0.472
CLV_NRD_NRD_1	590	592	PF00675	0.363
CLV_PCSK_KEX2_1	163	165	PF00082	0.508
CLV_PCSK_KEX2_1	28	30	PF00082	0.452
CLV_PCSK_KEX2_1	426	428	PF00082	0.414
CLV_PCSK_KEX2_1	455	457	PF00082	0.408
CLV_PCSK_KEX2_1	540	542	PF00082	0.426
CLV_PCSK_KEX2_1	590	592	PF00082	0.328
CLV_PCSK_KEX2_1	84	86	PF00082	0.378
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.309
CLV_PCSK_SKI1_1	154	158	PF00082	0.363
CLV_PCSK_SKI1_1	346	350	PF00082	0.416
CLV_PCSK_SKI1_1	4	8	PF00082	0.449
CLV_PCSK_SKI1_1	416	420	PF00082	0.406
CLV_PCSK_SKI1_1	69	73	PF00082	0.317
CLV_PCSK_SKI1_1	98	102	PF00082	0.555
DEG_Nend_UBRbox_2	1	3	PF02207	0.575
DOC_CYCLIN_yCln2_LP_2	304	307	PF00134	0.368
DOC_MAPK_DCC_7	265	275	PF00069	0.412
DOC_MAPK_gen_1	321	329	PF00069	0.316
DOC_MAPK_gen_1	84	90	PF00069	0.412
DOC_MAPK_MEF2A_6	286	294	PF00069	0.382
DOC_MAPK_MEF2A_6	378	386	PF00069	0.422
DOC_PP1_SILK_1	292	297	PF00149	0.430
DOC_PP2B_LxvP_1	304	307	PF13499	0.368
DOC_USP7_MATH_1	195	199	PF00917	0.687
DOC_USP7_MATH_1	361	365	PF00917	0.436
DOC_USP7_MATH_1	440	444	PF00917	0.437
DOC_WW_Pin1_4	188	193	PF00397	0.731
DOC_WW_Pin1_4	206	211	PF00397	0.518
DOC_WW_Pin1_4	242	247	PF00397	0.536
DOC_WW_Pin1_4	268	273	PF00397	0.384
DOC_WW_Pin1_4	556	561	PF00397	0.290
DOC_WW_Pin1_4	620	625	PF00397	0.612
LIG_14-3-3_CanoR_1	346	355	PF00244	0.370
LIG_14-3-3_CanoR_1	360	366	PF00244	0.609
LIG_14-3-3_CanoR_1	378	383	PF00244	0.374
LIG_14-3-3_CanoR_1	430	435	PF00244	0.474
LIG_14-3-3_CanoR_1	459	464	PF00244	0.450
LIG_14-3-3_CanoR_1	596	602	PF00244	0.504
LIG_14-3-3_CanoR_1	98	107	PF00244	0.452
LIG_Actin_WH2_2	141	156	PF00022	0.438
LIG_APCC_ABBA_1	549	554	PF00400	0.409
LIG_BIR_III_4	371	375	PF00653	0.394
LIG_BRCT_BRCA1_1	622	626	PF00533	0.614
LIG_deltaCOP1_diTrp_1	486	490	PF00928	0.370
LIG_EH1_1	418	426	PF00400	0.270
LIG_eIF4E_1	506	512	PF01652	0.428
LIG_FHA_1	148	154	PF00498	0.362
LIG_FHA_1	269	275	PF00498	0.371
LIG_FHA_1	322	328	PF00498	0.311
LIG_FHA_1	447	453	PF00498	0.461
LIG_FHA_1	458	464	PF00498	0.536
LIG_FHA_1	99	105	PF00498	0.344
LIG_FHA_2	201	207	PF00498	0.616
LIG_FHA_2	448	454	PF00498	0.310
LIG_FHA_2	534	540	PF00498	0.460
LIG_FHA_2	604	610	PF00498	0.571
LIG_FHA_2	620	626	PF00498	0.506
LIG_LIR_Apic_2	401	405	PF02991	0.310
LIG_LIR_Gen_1	252	261	PF02991	0.406
LIG_LIR_Gen_1	385	395	PF02991	0.379
LIG_LIR_Gen_1	417	425	PF02991	0.357
LIG_LIR_Gen_1	449	458	PF02991	0.396
LIG_LIR_Gen_1	486	493	PF02991	0.531
LIG_LIR_Gen_1	504	513	PF02991	0.353
LIG_LIR_Gen_1	568	577	PF02991	0.345
LIG_LIR_Nem_3	252	257	PF02991	0.353
LIG_LIR_Nem_3	385	390	PF02991	0.417
LIG_LIR_Nem_3	417	422	PF02991	0.412
LIG_LIR_Nem_3	449	454	PF02991	0.540
LIG_LIR_Nem_3	486	490	PF02991	0.472
LIG_LIR_Nem_3	568	573	PF02991	0.342
LIG_LIR_Nem_3	89	94	PF02991	0.468
LIG_PCNA_yPIPBox_3	248	259	PF02747	0.352
LIG_Pex14_1	415	419	PF04695	0.421
LIG_SH2_CRK	522	526	PF00017	0.409
LIG_SH2_CRK	91	95	PF00017	0.416
LIG_SH2_PTP2	87	90	PF00017	0.393
LIG_SH2_STAP1	310	314	PF00017	0.347
LIG_SH2_STAP1	437	441	PF00017	0.380
LIG_SH2_STAP1	552	556	PF00017	0.495
LIG_SH2_STAP1	613	617	PF00017	0.536
LIG_SH2_STAT5	152	155	PF00017	0.323
LIG_SH2_STAT5	474	477	PF00017	0.384
LIG_SH2_STAT5	517	520	PF00017	0.361
LIG_SH2_STAT5	87	90	PF00017	0.382
LIG_SH3_3	429	435	PF00018	0.487
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.437
LIG_SUMO_SIM_par_1	271	277	PF11976	0.388
LIG_TRAF2_1	167	170	PF00917	0.605
LIG_TRAF2_1	250	253	PF00917	0.387
LIG_TRAF2_1	351	354	PF00917	0.344
LIG_TRAF2_1	356	359	PF00917	0.375
LIG_TRFH_1	556	560	PF08558	0.404
MOD_CK1_1	186	192	PF00069	0.669
MOD_CK1_1	194	200	PF00069	0.670
MOD_CK1_1	242	248	PF00069	0.510
MOD_CK1_1	364	370	PF00069	0.474
MOD_CK2_1	164	170	PF00069	0.668
MOD_CK2_1	187	193	PF00069	0.808
MOD_CK2_1	200	206	PF00069	0.538
MOD_CK2_1	347	353	PF00069	0.336
MOD_CK2_1	440	446	PF00069	0.321
MOD_CK2_1	447	453	PF00069	0.337
MOD_CK2_1	459	465	PF00069	0.351
MOD_CK2_1	533	539	PF00069	0.401
MOD_CK2_1	603	609	PF00069	0.644
MOD_CK2_1	619	625	PF00069	0.653
MOD_Cter_Amidation	161	164	PF01082	0.477
MOD_GlcNHglycan	166	169	PF01048	0.646
MOD_GlcNHglycan	193	196	PF01048	0.642
MOD_GlcNHglycan	241	244	PF01048	0.580
MOD_GlcNHglycan	349	352	PF01048	0.366
MOD_GlcNHglycan	353	358	PF01048	0.397
MOD_GlcNHglycan	367	370	PF01048	0.638
MOD_GlcNHglycan	432	435	PF01048	0.423
MOD_GSK3_1	183	190	PF00069	0.721
MOD_GSK3_1	191	198	PF00069	0.669
MOD_GSK3_1	238	245	PF00069	0.508
MOD_GSK3_1	264	271	PF00069	0.614
MOD_GSK3_1	349	356	PF00069	0.475
MOD_GSK3_1	361	368	PF00069	0.483
MOD_GSK3_1	378	385	PF00069	0.496
MOD_GSK3_1	40	47	PF00069	0.422
MOD_LATS_1	134	140	PF00433	0.508
MOD_N-GLC_1	136	141	PF02516	0.528
MOD_N-GLC_1	187	192	PF02516	0.559
MOD_N-GLC_1	533	538	PF02516	0.459
MOD_NEK2_1	10	15	PF00069	0.432
MOD_NEK2_1	157	162	PF00069	0.418
MOD_NEK2_1	274	279	PF00069	0.370
MOD_NEK2_1	290	295	PF00069	0.303
MOD_NEK2_1	333	338	PF00069	0.436
MOD_NEK2_1	347	352	PF00069	0.486
MOD_NEK2_1	365	370	PF00069	0.641
MOD_NEK2_1	382	387	PF00069	0.347
MOD_NEK2_1	457	462	PF00069	0.463
MOD_PIKK_1	183	189	PF00454	0.718
MOD_PIKK_1	213	219	PF00454	0.558
MOD_PIKK_1	232	238	PF00454	0.491
MOD_PIKK_1	276	282	PF00454	0.416
MOD_PIKK_1	321	327	PF00454	0.332
MOD_PIKK_1	40	46	PF00454	0.420
MOD_PIKK_1	533	539	PF00454	0.412
MOD_PIKK_1	611	617	PF00454	0.585
MOD_PKA_1	321	327	PF00069	0.264
MOD_PKA_2	10	16	PF00069	0.492
MOD_PKA_2	264	270	PF00069	0.381
MOD_PKA_2	27	33	PF00069	0.495
MOD_PKA_2	361	367	PF00069	0.584
MOD_PKB_1	483	491	PF00069	0.273
MOD_PKB_1	96	104	PF00069	0.377
MOD_Plk_1	341	347	PF00069	0.363
MOD_Plk_1	485	491	PF00069	0.276
MOD_Plk_4	290	296	PF00069	0.423
MOD_Plk_4	382	388	PF00069	0.352
MOD_Plk_4	447	453	PF00069	0.280
MOD_Plk_4	466	472	PF00069	0.466
MOD_Plk_4	521	527	PF00069	0.423
MOD_Plk_4	597	603	PF00069	0.458
MOD_ProDKin_1	188	194	PF00069	0.730
MOD_ProDKin_1	206	212	PF00069	0.520
MOD_ProDKin_1	242	248	PF00069	0.527
MOD_ProDKin_1	268	274	PF00069	0.376
MOD_ProDKin_1	556	562	PF00069	0.283
MOD_ProDKin_1	620	626	PF00069	0.620
MOD_SUMO_rev_2	539	549	PF00179	0.517
TRG_AP2beta_CARGO_1	417	426	PF09066	0.432
TRG_DiLeu_BaEn_1	453	458	PF01217	0.428
TRG_DiLeu_BaEn_4	252	258	PF01217	0.394
TRG_DiLeu_BaEn_4	553	559	PF01217	0.426
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.360
TRG_DiLeu_LyEn_5	269	274	PF01217	0.471
TRG_ENDOCYTIC_2	506	509	PF00928	0.417
TRG_ENDOCYTIC_2	522	525	PF00928	0.340
TRG_ENDOCYTIC_2	87	90	PF00928	0.356
TRG_ENDOCYTIC_2	91	94	PF00928	0.369
TRG_ER_diArg_1	163	165	PF00400	0.508
TRG_ER_diArg_1	425	427	PF00400	0.405
TRG_ER_diArg_1	454	456	PF00400	0.435
TRG_ER_diArg_1	482	485	PF00400	0.373
TRG_ER_diArg_1	540	542	PF00400	0.484
TRG_ER_diArg_1	589	591	PF00400	0.326
TRG_ER_diArg_1	96	99	PF00400	0.430
TRG_NES_CRM1_1	557	571	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P278	Leptomonas seymouri	66%	100%
A0A0S4IQ65	Bodo saltans	30%	88%
A0A1X0NYR6	Trypanosomatidae	45%	100%
A0A3Q8IDU9	Leishmania donovani	85%	100%
A4I3J2	Leishmania infantum	85%	100%
E9AZR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8G5	Leishmania major	86%	100%