Serine incorporator

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Serine incorporator

Gene product:

Serine incorporator (Serinc), putative

Species:

Leishmania braziliensis

UniProt:

A4HGE3_LEIBR

TriTrypDb:

LbrM.28.1060 , LBRM2903_280016400

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HGE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	83	89	PF00089	0.314
CLV_NRD_NRD_1	12	14	PF00675	0.527
CLV_PCSK_KEX2_1	11	13	PF00082	0.514
CLV_PCSK_SKI1_1	119	123	PF00082	0.261
CLV_PCSK_SKI1_1	125	129	PF00082	0.308
CLV_PCSK_SKI1_1	276	280	PF00082	0.558
DEG_MDM2_SWIB_1	95	102	PF02201	0.258
DOC_CDC14_PxL_1	55	63	PF14671	0.340
DOC_MAPK_gen_1	30	39	PF00069	0.411
DOC_MAPK_HePTP_8	27	39	PF00069	0.517
DOC_MAPK_HePTP_8	83	95	PF00069	0.227
DOC_MAPK_MEF2A_6	125	134	PF00069	0.314
DOC_MAPK_MEF2A_6	21	29	PF00069	0.610
DOC_MAPK_MEF2A_6	30	39	PF00069	0.389
DOC_MAPK_MEF2A_6	86	95	PF00069	0.215
DOC_MAPK_NFAT4_5	32	40	PF00069	0.428
DOC_PP1_RVXF_1	84	90	PF00149	0.293
DOC_PP2B_LxvP_1	137	140	PF13499	0.374
DOC_PP2B_LxvP_1	395	398	PF13499	0.301
DOC_USP7_MATH_1	195	199	PF00917	0.403
DOC_USP7_MATH_1	225	229	PF00917	0.248
DOC_USP7_MATH_1	244	248	PF00917	0.467
DOC_USP7_MATH_1	278	282	PF00917	0.175
DOC_USP7_MATH_1	309	313	PF00917	0.494
DOC_USP7_MATH_1	66	70	PF00917	0.330
DOC_WW_Pin1_4	21	26	PF00397	0.584
LIG_14-3-3_CanoR_1	110	117	PF00244	0.525
LIG_14-3-3_CanoR_1	380	385	PF00244	0.348
LIG_14-3-3_CanoR_1	48	58	PF00244	0.393
LIG_14-3-3_CanoR_1	86	90	PF00244	0.290
LIG_BRCT_BRCA1_1	251	255	PF00533	0.379
LIG_BRCT_BRCA1_1	51	55	PF00533	0.294
LIG_BRCT_BRCA1_2	51	57	PF00533	0.202
LIG_eIF4E_1	147	153	PF01652	0.348
LIG_eIF4E_1	257	263	PF01652	0.428
LIG_eIF4E_1	36	42	PF01652	0.332
LIG_FHA_1	104	110	PF00498	0.458
LIG_FHA_1	124	130	PF00498	0.119
LIG_FHA_1	134	140	PF00498	0.274
LIG_FHA_1	198	204	PF00498	0.405
LIG_FHA_1	225	231	PF00498	0.259
LIG_FHA_1	256	262	PF00498	0.306
LIG_FHA_1	283	289	PF00498	0.279
LIG_FHA_1	292	298	PF00498	0.341
LIG_FHA_1	330	336	PF00498	0.529
LIG_FHA_1	341	347	PF00498	0.335
LIG_FHA_2	267	273	PF00498	0.300
LIG_LIR_Gen_1	145	153	PF02991	0.271
LIG_LIR_Gen_1	155	166	PF02991	0.270
LIG_LIR_Gen_1	258	266	PF02991	0.293
LIG_LIR_Gen_1	283	292	PF02991	0.334
LIG_LIR_Gen_1	298	308	PF02991	0.329
LIG_LIR_Gen_1	336	346	PF02991	0.462
LIG_LIR_Gen_1	349	355	PF02991	0.263
LIG_LIR_Gen_1	382	392	PF02991	0.331
LIG_LIR_Gen_1	52	61	PF02991	0.256
LIG_LIR_Nem_3	120	124	PF02991	0.294
LIG_LIR_Nem_3	145	150	PF02991	0.260
LIG_LIR_Nem_3	209	213	PF02991	0.321
LIG_LIR_Nem_3	258	263	PF02991	0.255
LIG_LIR_Nem_3	283	289	PF02991	0.323
LIG_LIR_Nem_3	298	303	PF02991	0.287
LIG_LIR_Nem_3	336	341	PF02991	0.470
LIG_LIR_Nem_3	382	388	PF02991	0.305
LIG_LIR_Nem_3	52	58	PF02991	0.256
LIG_LIR_Nem_3	92	97	PF02991	0.402
LIG_NRBOX	127	133	PF00104	0.284
LIG_PDZ_Class_3	411	416	PF00595	0.671
LIG_PDZ_Wminus1_1	414	416	PF00595	0.680
LIG_Pex14_2	165	169	PF04695	0.323
LIG_Pex14_2	260	264	PF04695	0.197
LIG_Pex14_2	95	99	PF04695	0.251
LIG_PTB_Apo_2	138	145	PF02174	0.301
LIG_PTB_Apo_2	159	166	PF02174	0.329
LIG_Rb_pABgroove_1	49	57	PF01858	0.236
LIG_REV1ctd_RIR_1	119	129	PF16727	0.458
LIG_REV1ctd_RIR_1	261	271	PF16727	0.343
LIG_SH2_CRK	286	290	PF00017	0.328
LIG_SH2_CRK	304	308	PF00017	0.164
LIG_SH2_NCK_1	286	290	PF00017	0.318
LIG_SH2_NCK_1	304	308	PF00017	0.293
LIG_SH2_SRC	213	216	PF00017	0.192
LIG_SH2_SRC	242	245	PF00017	0.396
LIG_SH2_STAP1	257	261	PF00017	0.329
LIG_SH2_STAP1	304	308	PF00017	0.428
LIG_SH2_STAP1	33	37	PF00017	0.314
LIG_SH2_STAP1	342	346	PF00017	0.369
LIG_SH2_STAT5	158	161	PF00017	0.317
LIG_SH2_STAT5	190	193	PF00017	0.313
LIG_SH2_STAT5	213	216	PF00017	0.207
LIG_SH2_STAT5	236	239	PF00017	0.348
LIG_SH2_STAT5	242	245	PF00017	0.334
LIG_SH2_STAT5	257	260	PF00017	0.220
LIG_SH2_STAT5	342	345	PF00017	0.338
LIG_SH2_STAT5	351	354	PF00017	0.306
LIG_SH2_STAT5	36	39	PF00017	0.314
LIG_SH2_STAT5	391	394	PF00017	0.294
LIG_SH2_STAT5	399	402	PF00017	0.283
LIG_Sin3_3	38	45	PF02671	0.333
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.329
LIG_TRAF2_1	17	20	PF00917	0.690
LIG_TRAF2_1	410	413	PF00917	0.502
LIG_TYR_ITIM	302	307	PF00017	0.328
LIG_TYR_ITSM	282	289	PF00017	0.175
LIG_UBA3_1	27	32	PF00899	0.540
LIG_UBA3_1	50	57	PF00899	0.314
LIG_Vh1_VBS_1	277	295	PF01044	0.175
LIG_WRC_WIRS_1	196	201	PF05994	0.416
LIG_WRC_WIRS_1	207	212	PF05994	0.305
LIG_WRC_WIRS_1	257	262	PF05994	0.197
MOD_CK1_1	103	109	PF00069	0.458
MOD_CK1_1	120	126	PF00069	0.314
MOD_CK1_1	281	287	PF00069	0.315
MOD_CK1_1	312	318	PF00069	0.530
MOD_CK2_1	13	19	PF00069	0.719
MOD_CK2_1	266	272	PF00069	0.340
MOD_GlcNHglycan	15	18	PF01048	0.449
MOD_GlcNHglycan	154	157	PF01048	0.316
MOD_GlcNHglycan	311	314	PF01048	0.284
MOD_GlcNHglycan	361	364	PF01048	0.456
MOD_GSK3_1	171	178	PF00069	0.455
MOD_GSK3_1	244	251	PF00069	0.482
MOD_GSK3_1	262	269	PF00069	0.301
MOD_GSK3_1	276	283	PF00069	0.220
MOD_GSK3_1	284	291	PF00069	0.254
MOD_GSK3_1	298	305	PF00069	0.312
MOD_GSK3_1	329	336	PF00069	0.517
MOD_GSK3_1	355	362	PF00069	0.352
MOD_GSK3_1	85	92	PF00069	0.411
MOD_N-GLC_2	222	224	PF02516	0.540
MOD_NEK2_1	117	122	PF00069	0.492
MOD_NEK2_1	132	137	PF00069	0.215
MOD_NEK2_1	152	157	PF00069	0.465
MOD_NEK2_1	237	242	PF00069	0.384
MOD_NEK2_1	255	260	PF00069	0.158
MOD_NEK2_1	262	267	PF00069	0.301
MOD_NEK2_1	295	300	PF00069	0.340
MOD_NEK2_1	302	307	PF00069	0.286
MOD_NEK2_1	340	345	PF00069	0.320
MOD_NEK2_1	354	359	PF00069	0.257
MOD_NEK2_1	369	374	PF00069	0.258
MOD_NEK2_1	41	46	PF00069	0.326
MOD_NEK2_1	50	55	PF00069	0.252
MOD_NEK2_1	89	94	PF00069	0.411
MOD_NEK2_2	142	147	PF00069	0.330
MOD_PKA_2	109	115	PF00069	0.375
MOD_PKA_2	266	272	PF00069	0.340
MOD_PKA_2	379	385	PF00069	0.317
MOD_PKA_2	85	91	PF00069	0.301
MOD_PKB_1	11	19	PF00069	0.701
MOD_Plk_4	123	129	PF00069	0.299
MOD_Plk_4	133	139	PF00069	0.270
MOD_Plk_4	206	212	PF00069	0.320
MOD_Plk_4	225	231	PF00069	0.157
MOD_Plk_4	237	243	PF00069	0.357
MOD_Plk_4	244	250	PF00069	0.537
MOD_Plk_4	256	262	PF00069	0.181
MOD_Plk_4	284	290	PF00069	0.274
MOD_Plk_4	291	297	PF00069	0.281
MOD_Plk_4	302	308	PF00069	0.199
MOD_Plk_4	340	346	PF00069	0.330
MOD_Plk_4	380	386	PF00069	0.314
MOD_Plk_4	41	47	PF00069	0.319
MOD_Plk_4	50	56	PF00069	0.301
MOD_Plk_4	89	95	PF00069	0.410
MOD_ProDKin_1	21	27	PF00069	0.576
TRG_DiLeu_BaEn_4	330	336	PF01217	0.523
TRG_ENDOCYTIC_2	147	150	PF00928	0.303
TRG_ENDOCYTIC_2	158	161	PF00928	0.295
TRG_ENDOCYTIC_2	236	239	PF00928	0.379
TRG_ENDOCYTIC_2	257	260	PF00928	0.370
TRG_ENDOCYTIC_2	286	289	PF00928	0.328
TRG_ENDOCYTIC_2	304	307	PF00928	0.164
TRG_ENDOCYTIC_2	338	341	PF00928	0.309
TRG_ENDOCYTIC_2	342	345	PF00928	0.305
TRG_ENDOCYTIC_2	351	354	PF00928	0.280
TRG_ENDOCYTIC_2	36	39	PF00928	0.314
TRG_ER_diArg_1	11	13	PF00400	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS92	Leptomonas seymouri	73%	100%
A0A0S4JS67	Bodo saltans	40%	90%
A0A0S4KHE1	Bodo saltans	30%	100%
A0A1X0NWP2	Trypanosomatidae	55%	100%
A0A3Q8II09	Leishmania donovani	84%	100%
A0A3R7M259	Trypanosoma rangeli	53%	100%
A4FUZ5	Bos taurus	22%	88%
A4I3H6	Leishmania infantum	84%	100%
A7S4N4	Nematostella vectensis	24%	91%
D0A7F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AZR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q12116	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	88%
Q13530	Homo sapiens	25%	88%
Q3MHV9	Bos taurus	25%	92%
Q4Q8G8	Leishmania major	84%	100%
Q4R6L9	Macaca fascicularis	24%	98%
Q54UF8	Dictyostelium discoideum	23%	100%
Q58CW5	Bos taurus	25%	92%
Q5R419	Pongo abelii	25%	92%
Q5R533	Pongo abelii	24%	88%
Q63175	Rattus norvegicus	23%	90%
Q7TNK0	Rattus norvegicus	25%	92%
Q803X0	Danio rerio	23%	90%
Q8BHJ6	Mus musculus	22%	90%
Q8K0E7	Mus musculus	25%	92%
Q96SA4	Homo sapiens	24%	91%
Q9HDY3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	94%
Q9NRX5	Homo sapiens	25%	92%
Q9QZI8	Mus musculus	25%	92%
Q9QZI9	Mus musculus	24%	88%
V5BWF9	Trypanosoma cruzi	54%	100%