Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGE2_LEIBR

TriTrypDb:

LbrM.28.1050 , LBRM2903_280016100

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HGE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.578
CLV_PCSK_KEX2_1	209	211	PF00082	0.578
DEG_APCC_DBOX_1	93	101	PF00400	0.534
DOC_CYCLIN_RxL_1	194	208	PF00134	0.369
DOC_PP1_RVXF_1	120	126	PF00149	0.371
DOC_PP1_RVXF_1	49	56	PF00149	0.573
DOC_PP1_RVXF_1	78	85	PF00149	0.610
DOC_PP2B_LxvP_1	219	222	PF13499	0.526
DOC_PP4_FxxP_1	125	128	PF00568	0.380
DOC_USP7_MATH_2	222	228	PF00917	0.468
LIG_14-3-3_CanoR_1	122	126	PF00244	0.409
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_BRCT_BRCA1_1	115	119	PF00533	0.274
LIG_BRCT_BRCA1_1	68	72	PF00533	0.713
LIG_EH_1	29	33	PF12763	0.650
LIG_FHA_1	107	113	PF00498	0.279
LIG_FHA_2	33	39	PF00498	0.501
LIG_IBAR_NPY_1	76	78	PF08397	0.640
LIG_LIR_Apic_2	124	128	PF02991	0.417
LIG_LIR_Gen_1	131	137	PF02991	0.464
LIG_LIR_Nem_3	116	121	PF02991	0.308
LIG_LIR_Nem_3	131	136	PF02991	0.417
LIG_LIR_Nem_3	42	48	PF02991	0.508
LIG_Pex14_1	55	59	PF04695	0.639
LIG_REV1ctd_RIR_1	70	76	PF16727	0.616
LIG_SH2_CRK	133	137	PF00017	0.297
LIG_SH2_CRK	61	65	PF00017	0.655
LIG_SH2_SRC	189	192	PF00017	0.359
LIG_SH2_STAP1	115	119	PF00017	0.323
LIG_SH2_STAT5	189	192	PF00017	0.387
LIG_SH2_STAT5	23	26	PF00017	0.595
LIG_SH2_STAT5	44	47	PF00017	0.590
LIG_SH3_4	141	148	PF00018	0.461
LIG_SUMO_SIM_anti_2	109	116	PF11976	0.391
LIG_SUMO_SIM_par_1	101	110	PF11976	0.493
LIG_TRFH_1	61	65	PF08558	0.689
LIG_TYR_ITSM	129	136	PF00017	0.296
MOD_CK1_1	106	112	PF00069	0.465
MOD_CK1_1	2	8	PF00069	0.690
MOD_CK2_1	85	91	PF00069	0.591
MOD_GlcNHglycan	224	229	PF01048	0.674
MOD_GlcNHglycan	48	51	PF01048	0.378
MOD_GlcNHglycan	68	71	PF01048	0.443
MOD_GlcNHglycan	8	11	PF01048	0.513
MOD_GSK3_1	113	120	PF00069	0.306
MOD_GSK3_1	2	9	PF00069	0.745
MOD_GSK3_1	99	106	PF00069	0.522
MOD_NEK2_1	117	122	PF00069	0.481
MOD_NEK2_1	137	142	PF00069	0.327
MOD_NEK2_1	32	37	PF00069	0.468
MOD_NEK2_1	85	90	PF00069	0.593
MOD_NEK2_2	128	133	PF00069	0.367
MOD_PKA_2	121	127	PF00069	0.417
MOD_PKA_2	2	8	PF00069	0.672
MOD_Plk_1	128	134	PF00069	0.363
MOD_Plk_1	85	91	PF00069	0.591
MOD_Plk_2-3	86	92	PF00069	0.586
MOD_Plk_4	103	109	PF00069	0.321
MOD_Plk_4	113	119	PF00069	0.290
MOD_Plk_4	121	127	PF00069	0.321
MOD_Plk_4	212	218	PF00069	0.401
TRG_ENDOCYTIC_2	133	136	PF00928	0.461
TRG_ENDOCYTIC_2	160	163	PF00928	0.431
TRG_ENDOCYTIC_2	61	64	PF00928	0.655
TRG_ENDOCYTIC_2	78	81	PF00928	0.664
TRG_NES_CRM1_1	173	187	PF08389	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK0	Leptomonas seymouri	64%	99%
A0A0S4IVH5	Bodo saltans	50%	99%
A0A0S4IXX7	Bodo saltans	49%	91%
A0A1X0NYZ9	Trypanosomatidae	66%	100%
A0A3Q8IGT4	Leishmania donovani	62%	99%
A0A422MZK8	Trypanosoma rangeli	62%	100%
A4HLG1	Leishmania braziliensis	57%	99%
A4I3H5	Leishmania infantum	83%	100%
A4I8X2	Leishmania infantum	62%	99%
E9AZR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9B3U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	99%
I1ZAQ0	Leishmania donovani	83%	100%
Q4Q483	Leishmania major	58%	100%
Q4Q8G9	Leishmania major	80%	100%
V5AL49	Trypanosoma cruzi	62%	94%