LSM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGE1_LEIBR

TriTrypDb:

LbrM.28.1040 , LBRM2903_280016000

Length:

163

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.390
CLV_NRD_NRD_1	136	138	PF00675	0.459
CLV_NRD_NRD_1	58	60	PF00675	0.430
CLV_PCSK_KEX2_1	136	138	PF00082	0.496
CLV_PCSK_KEX2_1	58	60	PF00082	0.430
CLV_PCSK_SKI1_1	44	48	PF00082	0.630
CLV_PCSK_SKI1_1	58	62	PF00082	0.486
CLV_Separin_Metazoa	96	100	PF03568	0.428
DEG_SPOP_SBC_1	35	39	PF00917	0.498
DOC_CKS1_1	154	159	PF01111	0.531
DOC_MAPK_gen_1	40	47	PF00069	0.625
DOC_MAPK_gen_1	58	64	PF00069	0.426
DOC_PP2B_LxvP_1	159	162	PF13499	0.598
DOC_USP7_MATH_1	16	20	PF00917	0.658
DOC_USP7_MATH_1	21	25	PF00917	0.638
DOC_USP7_MATH_1	35	39	PF00917	0.445
DOC_USP7_MATH_1	97	101	PF00917	0.637
DOC_WW_Pin1_4	153	158	PF00397	0.451
LIG_14-3-3_CanoR_1	141	147	PF00244	0.512
LIG_14-3-3_CanoR_1	58	63	PF00244	0.505
LIG_Actin_WH2_2	83	101	PF00022	0.346
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_FHA_1	154	160	PF00498	0.491
LIG_FHA_1	59	65	PF00498	0.512
LIG_LIR_Gen_1	149	159	PF02991	0.444
LIG_LIR_Gen_1	50	60	PF02991	0.525
LIG_LIR_Nem_3	125	131	PF02991	0.451
LIG_LIR_Nem_3	149	154	PF02991	0.476
LIG_LIR_Nem_3	50	56	PF02991	0.477
LIG_LIR_Nem_3	94	98	PF02991	0.377
LIG_PTAP_UEV_1	17	22	PF05743	0.542
LIG_PTB_Apo_2	145	152	PF02174	0.434
LIG_SH2_STAP1	49	53	PF00017	0.532
LIG_SH2_STAT5	93	96	PF00017	0.532
LIG_SH3_3	15	21	PF00018	0.733
LIG_SUMO_SIM_par_1	60	65	PF11976	0.465
LIG_TRAF2_1	100	103	PF00917	0.729
LIG_TYR_ITIM	47	52	PF00017	0.540
MOD_CK1_1	140	146	PF00069	0.522
MOD_CK1_1	34	40	PF00069	0.636
MOD_CK1_1	77	83	PF00069	0.533
MOD_CK1_1	8	14	PF00069	0.701
MOD_CK2_1	97	103	PF00069	0.721
MOD_Cter_Amidation	56	59	PF01082	0.447
MOD_GlcNHglycan	1	4	PF01048	0.611
MOD_GlcNHglycan	118	121	PF01048	0.744
MOD_GlcNHglycan	148	151	PF01048	0.461
MOD_GlcNHglycan	18	21	PF01048	0.618
MOD_GlcNHglycan	23	26	PF01048	0.747
MOD_GlcNHglycan	33	36	PF01048	0.436
MOD_GSK3_1	104	111	PF00069	0.727
MOD_GSK3_1	31	38	PF00069	0.615
MOD_GSK3_1	58	65	PF00069	0.507
MOD_N-GLC_1	5	10	PF02516	0.685
MOD_NEK2_1	146	151	PF00069	0.453
MOD_NEK2_1	31	36	PF00069	0.740
MOD_PIKK_1	140	146	PF00454	0.522
MOD_PIKK_1	65	71	PF00454	0.623
MOD_PKA_1	58	64	PF00069	0.507
MOD_PKA_2	140	146	PF00069	0.503
MOD_PKA_2	58	64	PF00069	0.443
MOD_PKA_2	98	104	PF00069	0.646
MOD_Plk_4	155	161	PF00069	0.549
MOD_Plk_4	58	64	PF00069	0.468
MOD_ProDKin_1	153	159	PF00069	0.502
TRG_ENDOCYTIC_2	128	131	PF00928	0.541
TRG_ENDOCYTIC_2	49	52	PF00928	0.488
TRG_ER_diArg_1	58	60	PF00400	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV6	Leptomonas seymouri	61%	100%
A0A1X0NYE6	Trypanosomatidae	34%	100%
A0A3Q8ID22	Leishmania donovani	75%	99%
A0A422MZL4	Trypanosoma rangeli	41%	100%
A4I3H4	Leishmania infantum	75%	99%
E9AZR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q8H0	Leishmania major	71%	100%