Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

Tctex-1 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HGD9_LEIBR

TriTrypDb:

LbrM.28.1020 , LBRM2903_280015800

Length:

126

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HGD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	10	14	PF00082	0.446
CLV_PCSK_SKI1_1	74	78	PF00082	0.348
DOC_PP4_FxxP_1	13	16	PF00568	0.541
DOC_PP4_FxxP_1	22	25	PF00568	0.488
LIG_APCC_ABBA_1	121	126	PF00400	0.420
LIG_APCC_ABBAyCdc20_2	43	49	PF00400	0.299
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_eIF4E_1	47	53	PF01652	0.222
LIG_eIF4E_1	70	76	PF01652	0.323
LIG_FHA_1	63	69	PF00498	0.428
LIG_FHA_2	78	84	PF00498	0.316
LIG_LIR_Apic_2	11	16	PF02991	0.517
LIG_LIR_Apic_2	19	25	PF02991	0.383
LIG_LIR_Gen_1	110	121	PF02991	0.377
LIG_LIR_Nem_3	101	107	PF02991	0.319
LIG_LIR_Nem_3	110	116	PF02991	0.332
LIG_LIR_Nem_3	71	76	PF02991	0.339
LIG_LRP6_Inhibitor_1	26	32	PF00058	0.222
LIG_Pex14_2	121	125	PF04695	0.445
LIG_SH2_CRK	73	77	PF00017	0.299
LIG_SH2_NCK_1	47	51	PF00017	0.323
LIG_SH2_NCK_1	5	9	PF00017	0.634
LIG_SH2_PTP2	113	116	PF00017	0.222
LIG_SH2_SRC	113	116	PF00017	0.294
LIG_SH2_SRC	47	50	PF00017	0.323
LIG_SH2_STAP1	109	113	PF00017	0.388
LIG_SH2_STAT3	109	112	PF00017	0.364
LIG_SH2_STAT5	107	110	PF00017	0.332
LIG_SH2_STAT5	113	116	PF00017	0.311
LIG_SH2_STAT5	45	48	PF00017	0.299
MOD_CK1_1	20	26	PF00069	0.367
MOD_CK2_1	77	83	PF00069	0.310
MOD_GSK3_1	103	110	PF00069	0.358
MOD_GSK3_1	11	18	PF00069	0.378
MOD_GSK3_1	79	86	PF00069	0.470
MOD_PIKK_1	108	114	PF00454	0.222
MOD_PIKK_1	83	89	PF00454	0.456
MOD_SUMO_rev_2	18	23	PF00179	0.334
TRG_DiLeu_BaEn_1	48	53	PF01217	0.411
TRG_ENDOCYTIC_2	113	116	PF00928	0.411
TRG_ENDOCYTIC_2	73	76	PF00928	0.299
TRG_NES_CRM1_1	112	126	PF08389	0.416
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B2	Leptomonas seymouri	29%	100%
A0A0N1PFP4	Leptomonas seymouri	78%	100%
A0A0S4IQE7	Bodo saltans	59%	100%
A0A0S4JDH6	Bodo saltans	31%	91%
A0A1X0NYC6	Trypanosomatidae	61%	100%
A0A1X0P6I3	Trypanosomatidae	28%	100%
A0A3R7LJS7	Trypanosoma rangeli	57%	100%
A0A3S5H7J0	Leishmania donovani	86%	100%
A0A3S7X9I4	Leishmania donovani	30%	100%
A0A422P2R8	Trypanosoma rangeli	27%	100%
A2VDD2	Xenopus laevis	34%	72%
A4HMV8	Leishmania braziliensis	30%	100%
A4I3H2	Leishmania infantum	86%	100%
A4IBH9	Leishmania infantum	30%	100%
C9ZZ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A4G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AFB5	Leishmania major	30%	100%
E9AZR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B6H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
F1QMY1	Danio rerio	29%	84%
Q32P71	Bos taurus	27%	83%
Q3B8D7	Xenopus laevis	33%	71%
Q4Q8H2	Leishmania major	86%	100%
Q66IC8	Danio rerio	29%	73%
Q8N7M0	Homo sapiens	30%	70%
Q8WW35	Homo sapiens	29%	89%
Q9CQ66	Mus musculus	28%	88%
Q9D5I4	Mus musculus	30%	73%
V5BTL3	Trypanosoma cruzi	28%	100%