Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGD8_LEIBR

TriTrypDb:

LbrM.28.1010 , LBRM2903_280015700

Length:

967

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.393
CLV_C14_Caspase3-7	936	940	PF00656	0.306
CLV_NRD_NRD_1	113	115	PF00675	0.513
CLV_NRD_NRD_1	127	129	PF00675	0.595
CLV_NRD_NRD_1	283	285	PF00675	0.517
CLV_NRD_NRD_1	354	356	PF00675	0.272
CLV_NRD_NRD_1	4	6	PF00675	0.616
CLV_NRD_NRD_1	489	491	PF00675	0.324
CLV_NRD_NRD_1	665	667	PF00675	0.195
CLV_NRD_NRD_1	92	94	PF00675	0.523
CLV_NRD_NRD_1	925	927	PF00675	0.414
CLV_PCSK_FUR_1	113	117	PF00082	0.484
CLV_PCSK_KEX2_1	113	115	PF00082	0.429
CLV_PCSK_KEX2_1	127	129	PF00082	0.589
CLV_PCSK_KEX2_1	132	134	PF00082	0.676
CLV_PCSK_KEX2_1	283	285	PF00082	0.623
CLV_PCSK_KEX2_1	354	356	PF00082	0.272
CLV_PCSK_KEX2_1	451	453	PF00082	0.302
CLV_PCSK_KEX2_1	489	491	PF00082	0.324
CLV_PCSK_KEX2_1	578	580	PF00082	0.300
CLV_PCSK_KEX2_1	755	757	PF00082	0.528
CLV_PCSK_KEX2_1	925	927	PF00082	0.414
CLV_PCSK_KEX2_1	96	98	PF00082	0.495
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.395
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.503
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.302
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.300
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.528
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.497
CLV_PCSK_PC7_1	128	134	PF00082	0.550
CLV_PCSK_SKI1_1	207	211	PF00082	0.485
CLV_PCSK_SKI1_1	346	350	PF00082	0.454
CLV_PCSK_SKI1_1	46	50	PF00082	0.610
CLV_PCSK_SKI1_1	588	592	PF00082	0.314
CLV_PCSK_SKI1_1	65	69	PF00082	0.358
CLV_PCSK_SKI1_1	666	670	PF00082	0.406
CLV_PCSK_SKI1_1	738	742	PF00082	0.432
CLV_PCSK_SKI1_1	885	889	PF00082	0.401
CLV_PCSK_SKI1_1	960	964	PF00082	0.334
CLV_Separin_Metazoa	208	212	PF03568	0.475
DEG_APCC_DBOX_1	396	404	PF00400	0.515
DEG_APCC_DBOX_1	639	647	PF00400	0.273
DEG_SCF_FBW7_1	679	686	PF00400	0.516
DEG_SCF_FBW7_2	395	402	PF00400	0.512
DEG_SPOP_SBC_1	246	250	PF00917	0.501
DEG_SPOP_SBC_1	251	255	PF00917	0.497
DEG_SPOP_SBC_1	270	274	PF00917	0.582
DEG_SPOP_SBC_1	511	515	PF00917	0.550
DOC_CKS1_1	396	401	PF01111	0.522
DOC_CYCLIN_RxL_1	435	446	PF00134	0.400
DOC_CYCLIN_RxL_1	62	72	PF00134	0.360
DOC_CYCLIN_RxL_1	940	950	PF00134	0.293
DOC_CYCLIN_yCln2_LP_2	694	700	PF00134	0.546
DOC_MAPK_DCC_7	498	507	PF00069	0.527
DOC_MAPK_gen_1	354	362	PF00069	0.447
DOC_MAPK_gen_1	470	478	PF00069	0.463
DOC_MAPK_gen_1	583	592	PF00069	0.312
DOC_MAPK_gen_1	596	605	PF00069	0.273
DOC_MAPK_gen_1	635	643	PF00069	0.195
DOC_MAPK_gen_1	806	815	PF00069	0.530
DOC_MAPK_MEF2A_6	153	160	PF00069	0.639
DOC_MAPK_MEF2A_6	598	607	PF00069	0.273
DOC_PP1_RVXF_1	63	69	PF00149	0.581
DOC_PP1_RVXF_1	787	794	PF00149	0.650
DOC_PP2B_LxvP_1	694	697	PF13499	0.551
DOC_PP4_FxxP_1	68	71	PF00568	0.442
DOC_PP4_MxPP_1	321	324	PF00568	0.454
DOC_SPAK_OSR1_1	858	862	PF12202	0.315
DOC_USP7_MATH_1	105	109	PF00917	0.439
DOC_USP7_MATH_1	163	167	PF00917	0.537
DOC_USP7_MATH_1	245	249	PF00917	0.730
DOC_USP7_MATH_1	252	256	PF00917	0.699
DOC_USP7_MATH_1	271	275	PF00917	0.766
DOC_USP7_MATH_1	286	290	PF00917	0.463
DOC_USP7_MATH_1	512	516	PF00917	0.587
DOC_USP7_MATH_1	754	758	PF00917	0.522
DOC_USP7_MATH_1	800	804	PF00917	0.463
DOC_USP7_MATH_2	338	344	PF00917	0.291
DOC_USP7_UBL2_3	111	115	PF12436	0.476
DOC_WD40_RPTOR_TOS_1	644	650	PF00400	0.316
DOC_WW_Pin1_4	334	339	PF00397	0.444
DOC_WW_Pin1_4	364	369	PF00397	0.564
DOC_WW_Pin1_4	395	400	PF00397	0.455
DOC_WW_Pin1_4	500	505	PF00397	0.388
DOC_WW_Pin1_4	679	684	PF00397	0.517
DOC_WW_Pin1_4	830	835	PF00397	0.343
DOC_WW_Pin1_4	915	920	PF00397	0.372
LIG_14-3-3_CanoR_1	100	104	PF00244	0.494
LIG_14-3-3_CanoR_1	470	478	PF00244	0.316
LIG_14-3-3_CanoR_1	586	591	PF00244	0.453
LIG_14-3-3_CanoR_1	609	615	PF00244	0.406
LIG_14-3-3_CanoR_1	756	765	PF00244	0.511
LIG_14-3-3_CanoR_1	84	89	PF00244	0.475
LIG_14-3-3_CanoR_1	925	932	PF00244	0.343
LIG_AP2alpha_2	267	269	PF02296	0.492
LIG_APCC_ABBA_1	737	742	PF00400	0.569
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BIR_III_2	851	855	PF00653	0.461
LIG_Clathr_ClatBox_1	157	161	PF01394	0.617
LIG_Clathr_ClatBox_1	219	223	PF01394	0.406
LIG_Clathr_ClatBox_1	442	446	PF01394	0.464
LIG_Clathr_ClatBox_1	643	647	PF01394	0.273
LIG_deltaCOP1_diTrp_1	47	52	PF00928	0.456
LIG_deltaCOP1_diTrp_1	650	657	PF00928	0.252
LIG_deltaCOP1_diTrp_1	712	717	PF00928	0.394
LIG_EVH1_2	322	326	PF00568	0.482
LIG_FAT_LD_1	433	441	PF03623	0.409
LIG_FHA_1	292	298	PF00498	0.561
LIG_FHA_1	304	310	PF00498	0.501
LIG_FHA_1	376	382	PF00498	0.577
LIG_FHA_1	38	44	PF00498	0.603
LIG_FHA_1	471	477	PF00498	0.317
LIG_FHA_1	587	593	PF00498	0.315
LIG_FHA_1	616	622	PF00498	0.308
LIG_FHA_1	684	690	PF00498	0.422
LIG_FHA_1	720	726	PF00498	0.569
LIG_FHA_1	909	915	PF00498	0.335
LIG_FHA_2	143	149	PF00498	0.568
LIG_FHA_2	15	21	PF00498	0.714
LIG_FHA_2	167	173	PF00498	0.572
LIG_FHA_2	260	266	PF00498	0.652
LIG_FHA_2	388	394	PF00498	0.522
LIG_FHA_2	796	802	PF00498	0.491
LIG_FHA_2	892	898	PF00498	0.354
LIG_FHA_2	93	99	PF00498	0.494
LIG_Integrin_isoDGR_2	838	840	PF01839	0.411
LIG_LIR_Gen_1	296	307	PF02991	0.355
LIG_LIR_Gen_1	655	665	PF02991	0.273
LIG_LIR_Gen_1	712	717	PF02991	0.415
LIG_LIR_Gen_1	83	92	PF02991	0.471
LIG_LIR_Nem_3	102	106	PF02991	0.580
LIG_LIR_Nem_3	232	237	PF02991	0.411
LIG_LIR_Nem_3	255	261	PF02991	0.528
LIG_LIR_Nem_3	296	302	PF02991	0.377
LIG_LIR_Nem_3	450	456	PF02991	0.573
LIG_LIR_Nem_3	520	525	PF02991	0.461
LIG_LIR_Nem_3	655	660	PF02991	0.273
LIG_LIR_Nem_3	712	716	PF02991	0.412
LIG_LIR_Nem_3	790	796	PF02991	0.523
LIG_LIR_Nem_3	83	89	PF02991	0.479
LIG_LIR_Nem_3	867	873	PF02991	0.375
LIG_LIR_Nem_3	952	958	PF02991	0.326
LIG_LIR_Nem_3	961	965	PF02991	0.312
LIG_LYPXL_yS_3	258	261	PF13949	0.507
LIG_MYND_1	735	739	PF01753	0.407
LIG_NRBOX	138	144	PF00104	0.640
LIG_PCNA_yPIPBox_3	541	554	PF02747	0.500
LIG_PCNA_yPIPBox_3	951	963	PF02747	0.382
LIG_Pex14_1	713	717	PF04695	0.391
LIG_Pex14_2	958	962	PF04695	0.298
LIG_SH2_CRK	310	314	PF00017	0.379
LIG_SH2_CRK	557	561	PF00017	0.342
LIG_SH2_CRK	665	669	PF00017	0.406
LIG_SH2_CRK	86	90	PF00017	0.453
LIG_SH2_GRB2like	905	908	PF00017	0.345
LIG_SH2_NCK_1	525	529	PF00017	0.523
LIG_SH2_NCK_1	86	90	PF00017	0.472
LIG_SH2_NCK_1	899	903	PF00017	0.269
LIG_SH2_SRC	312	315	PF00017	0.436
LIG_SH2_SRC	525	528	PF00017	0.517
LIG_SH2_STAP1	37	41	PF00017	0.631
LIG_SH2_STAP1	531	535	PF00017	0.357
LIG_SH2_STAP1	601	605	PF00017	0.408
LIG_SH2_STAP1	685	689	PF00017	0.419
LIG_SH2_STAP1	796	800	PF00017	0.505
LIG_SH2_STAT3	117	120	PF00017	0.566
LIG_SH2_STAT3	317	320	PF00017	0.535
LIG_SH2_STAT3	796	799	PF00017	0.545
LIG_SH2_STAT5	117	120	PF00017	0.566
LIG_SH2_STAT5	312	315	PF00017	0.436
LIG_SH2_STAT5	344	347	PF00017	0.352
LIG_SH2_STAT5	522	525	PF00017	0.436
LIG_SH2_STAT5	685	688	PF00017	0.425
LIG_SH2_STAT5	74	77	PF00017	0.475
LIG_SH2_STAT5	79	82	PF00017	0.452
LIG_SH2_STAT5	86	89	PF00017	0.419
LIG_SH3_3	157	163	PF00018	0.697
LIG_SH3_3	253	259	PF00018	0.736
LIG_SH3_3	265	271	PF00018	0.759
LIG_SH3_3	332	338	PF00018	0.543
LIG_SH3_3	393	399	PF00018	0.574
LIG_SH3_3	426	432	PF00018	0.496
LIG_SH3_3	530	536	PF00018	0.358
LIG_SH3_3	72	78	PF00018	0.538
LIG_SH3_3	722	728	PF00018	0.507
LIG_SH3_3	851	857	PF00018	0.467
LIG_Sin3_3	356	363	PF02671	0.494
LIG_SUMO_SIM_anti_2	441	446	PF11976	0.464
LIG_SUMO_SIM_par_1	155	161	PF11976	0.592
LIG_SUMO_SIM_par_1	337	343	PF11976	0.502
LIG_SUMO_SIM_par_1	378	385	PF11976	0.585
LIG_SUMO_SIM_par_1	38	45	PF11976	0.687
LIG_SUMO_SIM_par_1	441	446	PF11976	0.464
LIG_SUMO_SIM_par_1	588	593	PF11976	0.305
LIG_SUMO_SIM_par_1	727	732	PF11976	0.589
LIG_SUMO_SIM_par_1	770	777	PF11976	0.473
LIG_TRAF2_1	515	518	PF00917	0.576
LIG_TRFH_1	930	934	PF08558	0.516
LIG_TYR_ITIM	256	261	PF00017	0.507
LIG_TYR_ITIM	555	560	PF00017	0.354
MOD_CDK_SPK_2	915	920	PF00069	0.372
MOD_CDK_SPxxK_3	915	922	PF00069	0.384
MOD_CK1_1	166	172	PF00069	0.652
MOD_CK1_1	272	278	PF00069	0.693
MOD_CK1_1	316	322	PF00069	0.514
MOD_CK1_1	382	388	PF00069	0.460
MOD_CK1_1	419	425	PF00069	0.488
MOD_CK1_1	757	763	PF00069	0.674
MOD_CK1_1	908	914	PF00069	0.324
MOD_CK2_1	14	20	PF00069	0.538
MOD_CK2_1	142	148	PF00069	0.461
MOD_CK2_1	166	172	PF00069	0.570
MOD_CK2_1	200	206	PF00069	0.527
MOD_CK2_1	259	265	PF00069	0.651
MOD_CK2_1	279	285	PF00069	0.473
MOD_CK2_1	334	340	PF00069	0.408
MOD_CK2_1	408	414	PF00069	0.574
MOD_CK2_1	461	467	PF00069	0.520
MOD_CK2_1	50	56	PF00069	0.474
MOD_CK2_1	511	517	PF00069	0.425
MOD_CK2_1	795	801	PF00069	0.481
MOD_CK2_1	861	867	PF00069	0.289
MOD_CK2_1	92	98	PF00069	0.496
MOD_GlcNHglycan	139	142	PF01048	0.681
MOD_GlcNHglycan	186	189	PF01048	0.708
MOD_GlcNHglycan	202	205	PF01048	0.362
MOD_GlcNHglycan	237	240	PF01048	0.711
MOD_GlcNHglycan	493	496	PF01048	0.487
MOD_GlcNHglycan	58	61	PF01048	0.566
MOD_GlcNHglycan	759	762	PF01048	0.752
MOD_GlcNHglycan	863	866	PF01048	0.317
MOD_GlcNHglycan	894	897	PF01048	0.351
MOD_GSK3_1	105	112	PF00069	0.489
MOD_GSK3_1	241	248	PF00069	0.768
MOD_GSK3_1	270	277	PF00069	0.746
MOD_GSK3_1	287	294	PF00069	0.524
MOD_GSK3_1	371	378	PF00069	0.742
MOD_GSK3_1	382	389	PF00069	0.552
MOD_GSK3_1	416	423	PF00069	0.590
MOD_GSK3_1	52	59	PF00069	0.360
MOD_GSK3_1	586	593	PF00069	0.406
MOD_GSK3_1	610	617	PF00069	0.429
MOD_GSK3_1	675	682	PF00069	0.273
MOD_GSK3_1	80	87	PF00069	0.473
MOD_GSK3_1	874	881	PF00069	0.363
MOD_GSK3_1	908	915	PF00069	0.330
MOD_N-GLC_1	198	203	PF02516	0.386
MOD_N-GLC_1	246	251	PF02516	0.501
MOD_N-GLC_1	757	762	PF02516	0.547
MOD_N-GLC_1	861	866	PF02516	0.327
MOD_NEK2_1	142	147	PF00069	0.564
MOD_NEK2_1	300	305	PF00069	0.348
MOD_NEK2_1	371	376	PF00069	0.498
MOD_NEK2_1	386	391	PF00069	0.561
MOD_NEK2_1	491	496	PF00069	0.325
MOD_NEK2_1	542	547	PF00069	0.486
MOD_NEK2_1	603	608	PF00069	0.307
MOD_NEK2_1	615	620	PF00069	0.342
MOD_NEK2_1	700	705	PF00069	0.451
MOD_NEK2_1	80	85	PF00069	0.462
MOD_NEK2_1	873	878	PF00069	0.498
MOD_NEK2_1	891	896	PF00069	0.241
MOD_NEK2_1	947	952	PF00069	0.315
MOD_NEK2_2	479	484	PF00069	0.370
MOD_PIKK_1	300	306	PF00454	0.324
MOD_PIKK_1	316	322	PF00454	0.348
MOD_PIKK_1	420	426	PF00454	0.622
MOD_PIKK_1	470	476	PF00454	0.333
MOD_PIKK_1	537	543	PF00454	0.360
MOD_PIKK_1	652	658	PF00454	0.273
MOD_PIKK_1	795	801	PF00454	0.524
MOD_PKA_2	126	132	PF00069	0.546
MOD_PKA_2	892	898	PF00069	0.354
MOD_PKA_2	92	98	PF00069	0.479
MOD_PKA_2	924	930	PF00069	0.347
MOD_PKA_2	99	105	PF00069	0.476
MOD_Plk_1	198	204	PF00069	0.526
MOD_Plk_1	37	43	PF00069	0.566
MOD_Plk_1	479	485	PF00069	0.309
MOD_Plk_1	537	543	PF00069	0.360
MOD_Plk_1	787	793	PF00069	0.634
MOD_Plk_1	861	867	PF00069	0.325
MOD_Plk_2-3	402	408	PF00069	0.292
MOD_Plk_2-3	461	467	PF00069	0.414
MOD_Plk_4	382	388	PF00069	0.483
MOD_Plk_4	603	609	PF00069	0.278
MOD_Plk_4	610	616	PF00069	0.304
MOD_Plk_4	807	813	PF00069	0.434
MOD_Plk_4	84	90	PF00069	0.598
MOD_ProDKin_1	334	340	PF00069	0.441
MOD_ProDKin_1	364	370	PF00069	0.568
MOD_ProDKin_1	395	401	PF00069	0.462
MOD_ProDKin_1	500	506	PF00069	0.394
MOD_ProDKin_1	679	685	PF00069	0.518
MOD_ProDKin_1	830	836	PF00069	0.341
MOD_ProDKin_1	915	921	PF00069	0.381
MOD_SUMO_for_1	131	134	PF00179	0.502
MOD_SUMO_for_1	178	181	PF00179	0.521
MOD_SUMO_rev_2	108	112	PF00179	0.471
TRG_DiLeu_BaEn_1	208	213	PF01217	0.472
TRG_DiLeu_BaEn_1	296	301	PF01217	0.430
TRG_DiLeu_BaEn_1	771	776	PF01217	0.680
TRG_DiLeu_BaEn_4	26	32	PF01217	0.699
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.598
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.492
TRG_ENDOCYTIC_2	234	237	PF00928	0.423
TRG_ENDOCYTIC_2	258	261	PF00928	0.507
TRG_ENDOCYTIC_2	310	313	PF00928	0.345
TRG_ENDOCYTIC_2	525	528	PF00928	0.449
TRG_ENDOCYTIC_2	557	560	PF00928	0.347
TRG_ENDOCYTIC_2	564	567	PF00928	0.318
TRG_ENDOCYTIC_2	665	668	PF00928	0.406
TRG_ENDOCYTIC_2	86	89	PF00928	0.450
TRG_ENDOCYTIC_2	955	958	PF00928	0.311
TRG_ENDOCYTIC_2	959	962	PF00928	0.302
TRG_ER_diArg_1	113	116	PF00400	0.482
TRG_ER_diArg_1	126	128	PF00400	0.588
TRG_ER_diArg_1	489	491	PF00400	0.324
TRG_ER_diArg_1	585	588	PF00400	0.258
TRG_NES_CRM1_1	434	446	PF08389	0.480
TRG_NLS_Bipartite_1	96	118	PF00514	0.493
TRG_NLS_MonoExtC_3	279	284	PF00514	0.732
TRG_NLS_MonoExtN_4	111	118	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	789	794	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P863	Leptomonas seymouri	68%	96%
A0A1X0NZS2	Trypanosomatidae	56%	100%
A0A3R7KME7	Trypanosoma rangeli	57%	100%
A0A3S7X1C4	Leishmania donovani	81%	99%
A4I3H1	Leishmania infantum	81%	99%
D0A7W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AZR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q8H3	Leishmania major	80%	100%
V5BG64	Trypanosoma cruzi	56%	100%