Archaic_translocase_outer_mitochondrial_membrane_ 40_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM46, putative

Species:

Leishmania braziliensis

UniProt:

A4HGD7_LEIBR

TriTrypDb:

LbrM.28.1000 , LBRM2903_280015500 , LBRM2903_280015600

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A4HGD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD7

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.301
CLV_NRD_NRD_1	249	251	PF00675	0.601
CLV_NRD_NRD_1	376	378	PF00675	0.578
CLV_NRD_NRD_1	47	49	PF00675	0.407
CLV_NRD_NRD_1	73	75	PF00675	0.441
CLV_PCSK_FUR_1	374	378	PF00082	0.634
CLV_PCSK_KEX2_1	249	251	PF00082	0.602
CLV_PCSK_KEX2_1	374	376	PF00082	0.544
CLV_PCSK_KEX2_1	73	75	PF00082	0.478
CLV_PCSK_SKI1_1	110	114	PF00082	0.364
CLV_PCSK_SKI1_1	133	137	PF00082	0.293
CLV_PCSK_SKI1_1	348	352	PF00082	0.600
CLV_PCSK_SKI1_1	41	45	PF00082	0.361
CLV_PCSK_SKI1_1	56	60	PF00082	0.277
DEG_APCC_DBOX_1	122	130	PF00400	0.506
DEG_Nend_UBRbox_2	1	3	PF02207	0.385
DEG_SPOP_SBC_1	318	322	PF00917	0.337
DOC_MAPK_MEF2A_6	84	92	PF00069	0.589
DOC_PP2B_LxvP_1	351	354	PF13499	0.411
DOC_USP7_MATH_1	176	180	PF00917	0.538
DOC_USP7_MATH_1	335	339	PF00917	0.347
DOC_USP7_MATH_1	389	393	PF00917	0.278
DOC_USP7_MATH_1	78	82	PF00917	0.578
DOC_WW_Pin1_4	331	336	PF00397	0.332
LIG_14-3-3_CanoR_1	187	193	PF00244	0.536
LIG_14-3-3_CanoR_1	352	358	PF00244	0.383
LIG_14-3-3_CanoR_1	79	85	PF00244	0.556
LIG_Actin_WH2_2	32	50	PF00022	0.447
LIG_FHA_1	18	24	PF00498	0.416
LIG_FHA_1	180	186	PF00498	0.546
LIG_FHA_1	297	303	PF00498	0.312
LIG_FHA_1	40	46	PF00498	0.620
LIG_FHA_2	136	142	PF00498	0.491
LIG_FHA_2	160	166	PF00498	0.514
LIG_FHA_2	217	223	PF00498	0.409
LIG_FHA_2	324	330	PF00498	0.293
LIG_LIR_Gen_1	211	220	PF02991	0.279
LIG_LIR_Gen_1	238	247	PF02991	0.299
LIG_LIR_Gen_1	312	323	PF02991	0.224
LIG_LIR_Gen_1	42	50	PF02991	0.523
LIG_LIR_Nem_3	130	135	PF02991	0.521
LIG_LIR_Nem_3	211	217	PF02991	0.279
LIG_LIR_Nem_3	238	243	PF02991	0.286
LIG_LIR_Nem_3	25	30	PF02991	0.285
LIG_LIR_Nem_3	312	318	PF02991	0.315
LIG_LIR_Nem_3	42	47	PF02991	0.461
LIG_NRBOX	345	351	PF00104	0.277
LIG_Pex14_1	10	14	PF04695	0.230
LIG_REV1ctd_RIR_1	237	246	PF16727	0.302
LIG_SH2_CRK	132	136	PF00017	0.496
LIG_SH2_CRK	85	89	PF00017	0.577
LIG_SH2_SRC	114	117	PF00017	0.568
LIG_SH2_STAT3	382	385	PF00017	0.460
LIG_SH2_STAT5	114	117	PF00017	0.568
LIG_SH3_3	1	7	PF00018	0.369
LIG_SH3_3	197	203	PF00018	0.429
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.249
LIG_SUMO_SIM_par_1	19	25	PF11976	0.258
LIG_SUMO_SIM_par_1	290	296	PF11976	0.362
LIG_UBA3_1	300	309	PF00899	0.271
MOD_CDC14_SPxK_1	334	337	PF00782	0.425
MOD_CDK_SPxK_1	331	337	PF00069	0.412
MOD_CK1_1	179	185	PF00069	0.441
MOD_CK1_1	22	28	PF00069	0.212
MOD_CK1_1	235	241	PF00069	0.307
MOD_CK1_1	296	302	PF00069	0.336
MOD_CK1_1	338	344	PF00069	0.488
MOD_CK2_1	135	141	PF00069	0.348
MOD_CK2_1	216	222	PF00069	0.409
MOD_CK2_1	323	329	PF00069	0.327
MOD_CK2_1	338	344	PF00069	0.347
MOD_GlcNHglycan	228	231	PF01048	0.383
MOD_GlcNHglycan	234	237	PF01048	0.280
MOD_GlcNHglycan	76	79	PF01048	0.409
MOD_GlcNHglycan	80	83	PF01048	0.351
MOD_GSK3_1	202	209	PF00069	0.397
MOD_GSK3_1	313	320	PF00069	0.364
MOD_GSK3_1	331	338	PF00069	0.278
MOD_GSK3_1	35	42	PF00069	0.352
MOD_GSK3_1	74	81	PF00069	0.461
MOD_GSK3_1	97	104	PF00069	0.375
MOD_N-GLC_2	216	218	PF02516	0.279
MOD_NEK2_1	135	140	PF00069	0.333
MOD_NEK2_1	206	211	PF00069	0.403
MOD_NEK2_1	304	309	PF00069	0.414
MOD_NEK2_2	335	340	PF00069	0.419
MOD_PIKK_1	389	395	PF00454	0.378
MOD_PKA_2	78	84	PF00069	0.366
MOD_Plk_1	335	341	PF00069	0.503
MOD_Plk_2-3	159	165	PF00069	0.484
MOD_Plk_4	202	208	PF00069	0.349
MOD_Plk_4	22	28	PF00069	0.263
MOD_Plk_4	235	241	PF00069	0.326
MOD_Plk_4	293	299	PF00069	0.289
MOD_Plk_4	319	325	PF00069	0.324
MOD_Plk_4	405	411	PF00069	0.592
MOD_ProDKin_1	331	337	PF00069	0.412
MOD_SUMO_for_1	93	96	PF00179	0.259
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.317
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.460
TRG_ENDOCYTIC_2	132	135	PF00928	0.358
TRG_ER_diArg_1	249	251	PF00400	0.505
TRG_ER_diArg_1	339	342	PF00400	0.506
TRG_ER_diArg_1	374	377	PF00400	0.488
TRG_ER_diArg_1	72	74	PF00400	0.597
TRG_NES_CRM1_1	276	290	PF08389	0.400
TRG_NES_CRM1_1	393	406	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T6	Leptomonas seymouri	79%	100%
A0A0S4IQ39	Bodo saltans	41%	99%
A0A1X0NZX9	Trypanosomatidae	50%	98%
A0A3R7JYC9	Trypanosoma rangeli	50%	100%
A0A3S7X1C8	Leishmania donovani	89%	100%
A4I3H0	Leishmania infantum	89%	100%
D0A7W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9AZQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8H4	Leishmania major	88%	100%
V5B0R0	Trypanosoma cruzi	51%	100%