EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HGD5_LEIBR

TriTrypDb:

LbrM.28.0980 , LBRM2903_280015300

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HGD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.703
CLV_NRD_NRD_1	121	123	PF00675	0.441
CLV_PCSK_KEX2_1	121	123	PF00082	0.441
CLV_PCSK_SKI1_1	182	186	PF00082	0.681
CLV_PCSK_SKI1_1	26	30	PF00082	0.453
CLV_PCSK_SKI1_1	58	62	PF00082	0.413
CLV_PCSK_SKI1_1	75	79	PF00082	0.374
DEG_APCC_DBOX_1	181	189	PF00400	0.531
DOC_CKS1_1	114	119	PF01111	0.681
DOC_CYCLIN_RxL_1	122	133	PF00134	0.703
DOC_MAPK_gen_1	190	199	PF00069	0.493
DOC_MAPK_gen_1	82	91	PF00069	0.705
DOC_MAPK_MEF2A_6	26	35	PF00069	0.662
DOC_MAPK_MEF2A_6	84	93	PF00069	0.706
DOC_PP1_RVXF_1	56	63	PF00149	0.673
DOC_USP7_UBL2_3	101	105	PF12436	0.533
DOC_WW_Pin1_4	100	105	PF00397	0.473
DOC_WW_Pin1_4	113	118	PF00397	0.598
LIG_Actin_WH2_2	192	210	PF00022	0.507
LIG_BRCT_BRCA1_1	70	74	PF00533	0.693
LIG_BRCT_BRCA1_1	79	83	PF00533	0.636
LIG_FHA_1	114	120	PF00498	0.682
LIG_FHA_1	146	152	PF00498	0.636
LIG_FHA_1	161	167	PF00498	0.286
LIG_FHA_2	101	107	PF00498	0.455
LIG_FHA_2	76	82	PF00498	0.717
LIG_LIR_Gen_1	106	115	PF02991	0.610
LIG_LIR_Nem_3	45	51	PF02991	0.606
LIG_LIR_Nem_3	71	77	PF02991	0.627
LIG_NRBOX	241	247	PF00104	0.454
LIG_PCNA_yPIPBox_3	121	130	PF02747	0.681
LIG_PCNA_yPIPBox_3	82	94	PF02747	0.705
LIG_Pex14_2	51	55	PF04695	0.607
LIG_SH2_CRK	168	172	PF00017	0.396
LIG_SH2_CRK	237	241	PF00017	0.336
LIG_SH2_NCK_1	168	172	PF00017	0.504
LIG_SH2_STAP1	111	115	PF00017	0.583
LIG_SH2_STAP1	237	241	PF00017	0.386
LIG_SH2_STAT3	111	114	PF00017	0.692
LIG_SH2_STAT5	168	171	PF00017	0.420
LIG_SH3_3	211	217	PF00018	0.514
LIG_TYR_ITIM	166	171	PF00017	0.427
LIG_UBA3_1	50	58	PF00899	0.616
MOD_CDK_SPK_2	100	105	PF00069	0.473
MOD_CK1_1	40	46	PF00069	0.699
MOD_CK1_1	68	74	PF00069	0.682
MOD_CMANNOS	62	65	PF00535	0.496
MOD_GlcNHglycan	39	42	PF01048	0.469
MOD_GSK3_1	166	173	PF00069	0.490
MOD_GSK3_1	2	9	PF00069	0.672
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	110	115	PF00069	0.655
MOD_NEK2_1	166	171	PF00069	0.469
MOD_NEK2_1	220	225	PF00069	0.465
MOD_PIKK_1	110	116	PF00454	0.660
MOD_PIKK_1	66	72	PF00454	0.710
MOD_ProDKin_1	100	106	PF00069	0.473
MOD_ProDKin_1	113	119	PF00069	0.594
MOD_SUMO_rev_2	23	28	PF00179	0.656
MOD_SUMO_rev_2	95	103	PF00179	0.493
TRG_ENDOCYTIC_2	168	171	PF00928	0.392
TRG_ENDOCYTIC_2	237	240	PF00928	0.318
TRG_ENDOCYTIC_2	48	51	PF00928	0.678
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8G7	Leptomonas seymouri	54%	100%
A0A0S4IKQ0	Bodo saltans	34%	100%
A0A1X0NYF7	Trypanosomatidae	42%	100%
A0A3R7MYZ1	Trypanosoma rangeli	45%	100%
D0A7W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
V5DH41	Trypanosoma cruzi	46%	100%