Coiled-coil domain-containing protein 153

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGD4_LEIBR

TriTrypDb:

LbrM.28.0970 , LBRM2903_280015100

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.602
CLV_C14_Caspase3-7	299	303	PF00656	0.714
CLV_MEL_PAP_1	276	282	PF00089	0.436
CLV_NRD_NRD_1	133	135	PF00675	0.402
CLV_NRD_NRD_1	149	151	PF00675	0.627
CLV_NRD_NRD_1	166	168	PF00675	0.589
CLV_NRD_NRD_1	227	229	PF00675	0.613
CLV_NRD_NRD_1	278	280	PF00675	0.632
CLV_NRD_NRD_1	38	40	PF00675	0.522
CLV_NRD_NRD_1	74	76	PF00675	0.629
CLV_PCSK_FUR_1	104	108	PF00082	0.618
CLV_PCSK_KEX2_1	106	108	PF00082	0.562
CLV_PCSK_KEX2_1	131	133	PF00082	0.413
CLV_PCSK_KEX2_1	149	151	PF00082	0.644
CLV_PCSK_KEX2_1	271	273	PF00082	0.589
CLV_PCSK_KEX2_1	278	280	PF00082	0.659
CLV_PCSK_KEX2_1	74	76	PF00082	0.589
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.574
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.488
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.589
CLV_PCSK_PC7_1	102	108	PF00082	0.592
CLV_PCSK_SKI1_1	167	171	PF00082	0.470
CLV_PCSK_SKI1_1	39	43	PF00082	0.523
CLV_PCSK_SKI1_1	74	78	PF00082	0.532
CLV_PCSK_SKI1_1	79	83	PF00082	0.482
DEG_APCC_DBOX_1	83	91	PF00400	0.530
DOC_CKS1_1	62	67	PF01111	0.494
DOC_MAPK_gen_1	104	112	PF00069	0.577
DOC_MAPK_gen_1	186	196	PF00069	0.566
DOC_MAPK_gen_1	39	46	PF00069	0.560
DOC_MAPK_MEF2A_6	189	198	PF00069	0.593
DOC_MAPK_MEF2A_6	39	46	PF00069	0.560
DOC_MAPK_NFAT4_5	39	47	PF00069	0.608
DOC_MAPK_RevD_3	27	40	PF00069	0.459
DOC_PP1_RVXF_1	37	44	PF00149	0.550
DOC_USP7_MATH_1	286	290	PF00917	0.512
DOC_USP7_MATH_1	55	59	PF00917	0.474
DOC_WW_Pin1_4	61	66	PF00397	0.666
LIG_14-3-3_CanoR_1	167	176	PF00244	0.456
LIG_14-3-3_CanoR_1	231	235	PF00244	0.639
LIG_14-3-3_CanoR_1	95	101	PF00244	0.463
LIG_Actin_WH2_2	123	141	PF00022	0.533
LIG_Actin_WH2_2	255	273	PF00022	0.577
LIG_APCC_ABBAyCdc20_2	39	45	PF00400	0.563
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_Clathr_ClatBox_1	41	45	PF01394	0.564
LIG_FHA_1	168	174	PF00498	0.493
LIG_FHA_2	124	130	PF00498	0.552
LIG_FHA_2	197	203	PF00498	0.492
LIG_FHA_2	219	225	PF00498	0.605
LIG_FHA_2	62	68	PF00498	0.752
LIG_LIR_Apic_2	59	65	PF02991	0.501
LIG_LIR_Gen_1	273	280	PF02991	0.411
LIG_LIR_Nem_3	273	277	PF02991	0.607
LIG_NRBOX	258	264	PF00104	0.537
LIG_SH2_CRK	274	278	PF00017	0.478
LIG_SH2_STAT5	97	100	PF00017	0.387
LIG_SH3_3	60	66	PF00018	0.694
LIG_TRAF2_1	126	129	PF00917	0.357
LIG_UBA3_1	41	49	PF00899	0.357
MOD_CK1_1	289	295	PF00069	0.523
MOD_CK2_1	123	129	PF00069	0.551
MOD_CK2_1	169	175	PF00069	0.432
MOD_CK2_1	218	224	PF00069	0.568
MOD_CK2_1	230	236	PF00069	0.573
MOD_CK2_1	61	67	PF00069	0.762
MOD_GlcNHglycan	288	291	PF01048	0.627
MOD_GlcNHglycan	58	61	PF01048	0.663
MOD_GSK3_1	14	21	PF00069	0.706
MOD_GSK3_1	300	307	PF00069	0.510
MOD_NEK2_1	169	174	PF00069	0.501
MOD_NEK2_1	300	305	PF00069	0.509
MOD_PIKK_1	14	20	PF00454	0.568
MOD_PIKK_1	261	267	PF00454	0.469
MOD_PKA_1	167	173	PF00069	0.361
MOD_PKA_1	74	80	PF00069	0.399
MOD_PKA_2	230	236	PF00069	0.546
MOD_PKA_2	286	292	PF00069	0.516
MOD_PKA_2	74	80	PF00069	0.399
MOD_Plk_1	122	128	PF00069	0.385
MOD_Plk_2-3	123	129	PF00069	0.457
MOD_ProDKin_1	61	67	PF00069	0.668
MOD_SUMO_rev_2	264	273	PF00179	0.572
MOD_SUMO_rev_2	33	42	PF00179	0.512
TRG_DiLeu_BaEn_3	236	242	PF01217	0.492
TRG_DiLeu_BaEn_4	164	170	PF01217	0.496
TRG_DiLeu_BaEn_4	254	260	PF01217	0.538
TRG_ENDOCYTIC_2	274	277	PF00928	0.571
TRG_ER_diArg_1	101	104	PF00400	0.638
TRG_ER_diArg_1	132	134	PF00400	0.450
TRG_ER_diArg_1	149	152	PF00400	0.559
TRG_ER_diArg_1	277	279	PF00400	0.545
TRG_ER_diArg_1	74	76	PF00400	0.685
TRG_NES_CRM1_1	171	182	PF08389	0.536
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM76	Leptomonas seymouri	56%	98%
A0A1X0NYF4	Trypanosomatidae	31%	100%
A0A3S7X1C2	Leishmania donovani	72%	100%
A0A422N3X5	Trypanosoma rangeli	28%	100%
A4I3G7	Leishmania infantum	72%	100%
E9AZQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q8H7	Leishmania major	70%	100%
V5B0R4	Trypanosoma cruzi	30%	100%