Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGD2_LEIBR

TriTrypDb:

LbrM.28.0950 , LBRM2903_280014900

Length:

176

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.554
CLV_NRD_NRD_1	123	125	PF00675	0.657
CLV_NRD_NRD_1	36	38	PF00675	0.544
CLV_NRD_NRD_1	76	78	PF00675	0.537
CLV_NRD_NRD_1	9	11	PF00675	0.578
CLV_PCSK_KEX2_1	106	108	PF00082	0.530
CLV_PCSK_KEX2_1	125	127	PF00082	0.643
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.530
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.643
CLV_PCSK_SKI1_1	46	50	PF00082	0.564
DEG_APCC_DBOX_1	76	84	PF00400	0.583
DEG_Kelch_Keap1_1	134	139	PF01344	0.326
DEG_Nend_UBRbox_1	1	4	PF02207	0.731
DEG_SPOP_SBC_1	96	100	PF00917	0.666
DOC_CYCLIN_RxL_1	46	57	PF00134	0.482
DOC_MAPK_gen_1	10	18	PF00069	0.582
DOC_MAPK_gen_1	106	112	PF00069	0.521
DOC_MAPK_gen_1	22	30	PF00069	0.572
DOC_MAPK_gen_1	46	54	PF00069	0.549
DOC_PP1_RVXF_1	12	19	PF00149	0.562
DOC_PP1_RVXF_1	22	28	PF00149	0.559
DOC_PP1_RVXF_1	48	55	PF00149	0.439
DOC_PP2B_LxvP_1	118	121	PF13499	0.642
DOC_PP2B_PxIxI_1	57	63	PF00149	0.488
DOC_USP7_MATH_1	105	109	PF00917	0.486
DOC_USP7_MATH_1	95	99	PF00917	0.633
DOC_USP7_UBL2_3	11	15	PF12436	0.485
LIG_14-3-3_CanoR_1	13	19	PF00244	0.563
LIG_14-3-3_CanoR_1	69	79	PF00244	0.486
LIG_FHA_1	113	119	PF00498	0.595
LIG_FHA_1	42	48	PF00498	0.445
LIG_FHA_2	155	161	PF00498	0.302
LIG_LIR_Gen_1	108	117	PF02991	0.501
LIG_LIR_Nem_3	108	112	PF02991	0.473
LIG_PDZ_Class_3	171	176	PF00595	0.563
LIG_Pex14_2	165	169	PF04695	0.415
LIG_RPA_C_Fungi	17	29	PF08784	0.676
LIG_SH2_PTP2	109	112	PF00017	0.495
LIG_SH2_STAT5	109	112	PF00017	0.507
LIG_SH3_3	143	149	PF00018	0.432
LIG_SH3_4	78	85	PF00018	0.431
LIG_ULM_U2AF65_1	124	130	PF00076	0.627
LIG_WW_3	30	34	PF00397	0.553
MOD_CK1_1	100	106	PF00069	0.574
MOD_CK1_1	134	140	PF00069	0.477
MOD_CK2_1	105	111	PF00069	0.497
MOD_CK2_1	133	139	PF00069	0.384
MOD_GlcNHglycan	136	139	PF01048	0.492
MOD_GSK3_1	134	141	PF00069	0.461
MOD_GSK3_1	96	103	PF00069	0.665
MOD_NEK2_1	154	159	PF00069	0.344
MOD_NEK2_1	41	46	PF00069	0.555
MOD_NEK2_1	70	75	PF00069	0.398
MOD_PIKK_1	31	37	PF00454	0.614
MOD_PIKK_1	41	47	PF00454	0.586
MOD_PIKK_1	78	84	PF00454	0.656
MOD_PKA_1	14	20	PF00069	0.593
MOD_PKA_2	154	160	PF00069	0.436
TRG_ENDOCYTIC_2	109	112	PF00928	0.507
TRG_ER_diArg_1	126	129	PF00400	0.363
TRG_ER_diArg_1	152	155	PF00400	0.499
TRG_NLS_Bipartite_1	106	128	PF00514	0.347
TRG_NLS_MonoExtC_3	123	128	PF00514	0.393
TRG_NLS_MonoExtC_3	9	14	PF00514	0.657
TRG_NLS_MonoExtN_4	121	128	PF00514	0.395
TRG_NLS_MonoExtN_4	9	14	PF00514	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM05	Leptomonas seymouri	69%	100%
A0A0S4IWE5	Bodo saltans	26%	100%
A0A0S4IZV2	Bodo saltans	28%	100%
A0A1X0NYD0	Trypanosomatidae	38%	99%
A0A3R7KRX2	Trypanosoma rangeli	41%	96%
A0A3S7X1F6	Leishmania donovani	88%	100%
A4I3G5	Leishmania infantum	87%	100%
D0A7X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AZQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8H9	Leishmania major	87%	100%