Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGD1_LEIBR

TriTrypDb:

LbrM.28.0940 , LBRM2903_280014800

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HGD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.510
CLV_NRD_NRD_1	116	118	PF00675	0.407
CLV_NRD_NRD_1	146	148	PF00675	0.412
CLV_NRD_NRD_1	192	194	PF00675	0.498
CLV_NRD_NRD_1	231	233	PF00675	0.321
CLV_PCSK_FUR_1	229	233	PF00082	0.322
CLV_PCSK_KEX2_1	192	194	PF00082	0.498
CLV_PCSK_KEX2_1	231	233	PF00082	0.319
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.315
CLV_PCSK_SKI1_1	203	207	PF00082	0.464
CLV_PCSK_SKI1_1	222	226	PF00082	0.206
CLV_PCSK_SKI1_1	255	259	PF00082	0.413
CLV_PCSK_SKI1_1	31	35	PF00082	0.537
CLV_PCSK_SKI1_1	381	385	PF00082	0.316
CLV_PCSK_SKI1_1	500	504	PF00082	0.391
CLV_Separin_Metazoa	497	501	PF03568	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.458
DOC_CKS1_1	427	432	PF01111	0.517
DOC_CKS1_1	461	466	PF01111	0.589
DOC_CYCLIN_RxL_1	418	429	PF00134	0.440
DOC_CYCLIN_yClb3_PxF_3	430	438	PF00134	0.580
DOC_MAPK_gen_1	100	110	PF00069	0.542
DOC_MAPK_gen_1	419	427	PF00069	0.486
DOC_MAPK_MEF2A_6	15	24	PF00069	0.301
DOC_MAPK_MEF2A_6	207	214	PF00069	0.580
DOC_MAPK_MEF2A_6	419	427	PF00069	0.477
DOC_MAPK_MEF2A_6	438	445	PF00069	0.481
DOC_MAPK_MEF2A_6	55	63	PF00069	0.195
DOC_MAPK_MEF2A_6	80	89	PF00069	0.503
DOC_PP1_RVXF_1	295	302	PF00149	0.466
DOC_PP1_SILK_1	203	208	PF00149	0.593
DOC_PP4_FxxP_1	427	430	PF00568	0.614
DOC_PP4_FxxP_1	566	569	PF00568	0.579
DOC_USP7_UBL2_3	15	19	PF12436	0.380
DOC_USP7_UBL2_3	364	368	PF12436	0.560
DOC_WW_Pin1_4	191	196	PF00397	0.681
DOC_WW_Pin1_4	215	220	PF00397	0.488
DOC_WW_Pin1_4	426	431	PF00397	0.518
DOC_WW_Pin1_4	460	465	PF00397	0.594
DOC_WW_Pin1_4	567	572	PF00397	0.600
LIG_14-3-3_CanoR_1	232	237	PF00244	0.532
LIG_14-3-3_CanoR_1	293	301	PF00244	0.480
LIG_14-3-3_CanoR_1	306	312	PF00244	0.510
LIG_14-3-3_CanoR_1	323	329	PF00244	0.534
LIG_14-3-3_CanoR_1	345	352	PF00244	0.510
LIG_14-3-3_CanoR_1	80	84	PF00244	0.580
LIG_14-3-3_CanoR_1	9	14	PF00244	0.308
LIG_AP2alpha_1	294	298	PF02296	0.555
LIG_APCC_ABBA_1	441	446	PF00400	0.492
LIG_BRCT_BRCA1_1	519	523	PF00533	0.565
LIG_DLG_GKlike_1	9	17	PF00625	0.306
LIG_FHA_1	24	30	PF00498	0.408
LIG_FHA_1	263	269	PF00498	0.566
LIG_FHA_1	284	290	PF00498	0.602
LIG_FHA_1	357	363	PF00498	0.664
LIG_FHA_1	73	79	PF00498	0.222
LIG_FHA_1	94	100	PF00498	0.537
LIG_FHA_2	130	136	PF00498	0.580
LIG_FHA_2	192	198	PF00498	0.685
LIG_FHA_2	345	351	PF00498	0.550
LIG_FHA_2	449	455	PF00498	0.517
LIG_FHA_2	508	514	PF00498	0.528
LIG_IRF3_LxIS_1	81	88	PF10401	0.494
LIG_LIR_Gen_1	254	264	PF02991	0.505
LIG_LIR_Gen_1	295	303	PF02991	0.541
LIG_LIR_Gen_1	437	445	PF02991	0.478
LIG_LIR_Gen_1	520	531	PF02991	0.508
LIG_LIR_Nem_3	254	260	PF02991	0.492
LIG_LIR_Nem_3	295	301	PF02991	0.473
LIG_LIR_Nem_3	437	443	PF02991	0.482
LIG_LIR_Nem_3	520	526	PF02991	0.516
LIG_NRBOX	60	66	PF00104	0.210
LIG_Pex14_2	294	298	PF04695	0.636
LIG_Rb_pABgroove_1	526	534	PF01858	0.552
LIG_SH2_CRK	11	15	PF00017	0.348
LIG_SH2_CRK	440	444	PF00017	0.513
LIG_SH2_NCK_1	512	516	PF00017	0.455
LIG_SH2_SRC	21	24	PF00017	0.315
LIG_SH2_SRC	557	560	PF00017	0.506
LIG_SH2_STAP1	277	281	PF00017	0.534
LIG_SH2_STAT3	277	280	PF00017	0.538
LIG_SH2_STAT3	453	456	PF00017	0.545
LIG_SH2_STAT3	532	535	PF00017	0.540
LIG_SH2_STAT5	21	24	PF00017	0.411
LIG_SH2_STAT5	223	226	PF00017	0.503
LIG_SH2_STAT5	256	259	PF00017	0.503
LIG_SH2_STAT5	94	97	PF00017	0.519
LIG_SH3_3	427	433	PF00018	0.550
LIG_SUMO_SIM_anti_2	337	344	PF11976	0.521
LIG_SUMO_SIM_anti_2	346	353	PF11976	0.504
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.400
LIG_SUMO_SIM_par_1	337	344	PF11976	0.535
LIG_SUMO_SIM_par_1	69	76	PF11976	0.294
LIG_TRAF2_1	161	164	PF00917	0.777
LIG_UBA3_1	142	148	PF00899	0.608
LIG_WRC_WIRS_1	467	472	PF05994	0.546
MOD_CDK_SPxxK_3	215	222	PF00069	0.440
MOD_CK1_1	191	197	PF00069	0.726
MOD_CK1_1	240	246	PF00069	0.504
MOD_CK1_1	304	310	PF00069	0.579
MOD_CK1_1	338	344	PF00069	0.648
MOD_CK2_1	158	164	PF00069	0.619
MOD_CK2_1	344	350	PF00069	0.521
MOD_CK2_1	507	513	PF00069	0.529
MOD_CK2_1	567	573	PF00069	0.516
MOD_GlcNHglycan	156	159	PF01048	0.622
MOD_GlcNHglycan	171	174	PF01048	0.395
MOD_GlcNHglycan	303	306	PF01048	0.369
MOD_GlcNHglycan	354	357	PF01048	0.493
MOD_GlcNHglycan	370	373	PF01048	0.400
MOD_GlcNHglycan	39	42	PF01048	0.533
MOD_GlcNHglycan	519	522	PF01048	0.380
MOD_GlcNHglycan	554	557	PF01048	0.306
MOD_GlcNHglycan	6	9	PF01048	0.606
MOD_GSK3_1	154	161	PF00069	0.647
MOD_GSK3_1	187	194	PF00069	0.754
MOD_GSK3_1	227	234	PF00069	0.525
MOD_GSK3_1	279	286	PF00069	0.555
MOD_GSK3_1	301	308	PF00069	0.629
MOD_GSK3_1	309	316	PF00069	0.552
MOD_GSK3_1	352	359	PF00069	0.579
MOD_GSK3_1	456	463	PF00069	0.677
MOD_GSK3_1	466	473	PF00069	0.572
MOD_GSK3_1	567	574	PF00069	0.544
MOD_NEK2_1	169	174	PF00069	0.627
MOD_NEK2_1	187	192	PF00069	0.698
MOD_NEK2_1	214	219	PF00069	0.516
MOD_NEK2_1	301	306	PF00069	0.446
MOD_NEK2_1	324	329	PF00069	0.553
MOD_NEK2_1	35	40	PF00069	0.428
MOD_NEK2_1	384	389	PF00069	0.573
MOD_NEK2_1	552	557	PF00069	0.498
MOD_NEK2_1	85	90	PF00069	0.533
MOD_NEK2_2	448	453	PF00069	0.536
MOD_NEK2_2	507	512	PF00069	0.548
MOD_PIKK_1	103	109	PF00454	0.606
MOD_PIKK_1	457	463	PF00454	0.615
MOD_PK_1	505	511	PF00069	0.516
MOD_PKA_1	103	109	PF00069	0.545
MOD_PKA_1	231	237	PF00069	0.562
MOD_PKA_2	151	157	PF00069	0.660
MOD_PKA_2	231	237	PF00069	0.541
MOD_PKA_2	292	298	PF00069	0.495
MOD_PKA_2	305	311	PF00069	0.549
MOD_PKA_2	344	350	PF00069	0.529
MOD_PKA_2	392	398	PF00069	0.622
MOD_PKA_2	79	85	PF00069	0.492
MOD_Plk_1	240	246	PF00069	0.547
MOD_Plk_1	283	289	PF00069	0.537
MOD_Plk_2-3	344	350	PF00069	0.521
MOD_Plk_4	138	144	PF00069	0.589
MOD_Plk_4	201	207	PF00069	0.532
MOD_Plk_4	232	238	PF00069	0.522
MOD_Plk_4	335	341	PF00069	0.582
MOD_Plk_4	384	390	PF00069	0.566
MOD_Plk_4	448	454	PF00069	0.548
MOD_Plk_4	507	513	PF00069	0.507
MOD_Plk_4	9	15	PF00069	0.417
MOD_ProDKin_1	191	197	PF00069	0.683
MOD_ProDKin_1	215	221	PF00069	0.488
MOD_ProDKin_1	426	432	PF00069	0.518
MOD_ProDKin_1	460	466	PF00069	0.592
MOD_ProDKin_1	567	573	PF00069	0.612
MOD_SUMO_rev_2	111	119	PF00179	0.540
TRG_DiLeu_BaEn_2	124	130	PF01217	0.637
TRG_DiLeu_BaEn_4	126	132	PF01217	0.581
TRG_ENDOCYTIC_2	11	14	PF00928	0.347
TRG_ENDOCYTIC_2	21	24	PF00928	0.336
TRG_ENDOCYTIC_2	223	226	PF00928	0.530
TRG_ENDOCYTIC_2	440	443	PF00928	0.468
TRG_ENDOCYTIC_2	495	498	PF00928	0.583
TRG_NLS_MonoExtN_4	229	235	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S9	Leptomonas seymouri	63%	100%
A0A1X0NYG1	Trypanosomatidae	43%	100%
A0A3S7X1B3	Leishmania donovani	76%	99%
A0A422N3T8	Trypanosoma rangeli	43%	100%
E9AZQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q8I0	Leishmania major	76%	100%