Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HGD0_LEIBR

TriTrypDb:

LbrM.28.0930 , LBRM2903_280014700

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.564
CLV_NRD_NRD_1	236	238	PF00675	0.534
CLV_NRD_NRD_1	316	318	PF00675	0.546
CLV_NRD_NRD_1	391	393	PF00675	0.546
CLV_PCSK_FUR_1	234	238	PF00082	0.539
CLV_PCSK_KEX2_1	196	198	PF00082	0.564
CLV_PCSK_KEX2_1	236	238	PF00082	0.534
CLV_PCSK_KEX2_1	316	318	PF00082	0.546
CLV_PCSK_SKI1_1	332	336	PF00082	0.611
CLV_PCSK_SKI1_1	47	51	PF00082	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.539
DEG_SPOP_SBC_1	135	139	PF00917	0.554
DEG_SPOP_SBC_1	262	266	PF00917	0.658
DEG_SPOP_SBC_1	345	349	PF00917	0.531
DEG_SPOP_SBC_1	76	80	PF00917	0.618
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.709
DOC_MAPK_gen_1	316	322	PF00069	0.546
DOC_PP2B_LxvP_1	173	176	PF13499	0.673
DOC_PP2B_LxvP_1	322	325	PF13499	0.714
DOC_PP4_FxxP_1	212	215	PF00568	0.561
DOC_USP7_MATH_1	108	112	PF00917	0.548
DOC_USP7_MATH_1	135	139	PF00917	0.578
DOC_USP7_MATH_1	199	203	PF00917	0.637
DOC_USP7_MATH_1	227	231	PF00917	0.575
DOC_USP7_MATH_1	253	257	PF00917	0.664
DOC_USP7_MATH_1	284	288	PF00917	0.552
DOC_USP7_MATH_1	289	293	PF00917	0.556
DOC_USP7_MATH_1	338	342	PF00917	0.676
DOC_USP7_MATH_1	343	347	PF00917	0.604
DOC_USP7_MATH_1	384	388	PF00917	0.562
DOC_USP7_MATH_1	391	395	PF00917	0.536
DOC_USP7_MATH_1	415	419	PF00917	0.608
DOC_USP7_MATH_1	64	68	PF00917	0.663
DOC_USP7_MATH_1	76	80	PF00917	0.698
DOC_WW_Pin1_4	150	155	PF00397	0.671
DOC_WW_Pin1_4	225	230	PF00397	0.564
DOC_WW_Pin1_4	267	272	PF00397	0.625
DOC_WW_Pin1_4	282	287	PF00397	0.585
DOC_WW_Pin1_4	346	351	PF00397	0.527
DOC_WW_Pin1_4	58	63	PF00397	0.684
DOC_WW_Pin1_4	6	11	PF00397	0.629
DOC_WW_Pin1_4	80	85	PF00397	0.577
LIG_14-3-3_CanoR_1	222	232	PF00244	0.687
LIG_14-3-3_CanoR_1	392	400	PF00244	0.603
LIG_14-3-3_CanoR_1	47	52	PF00244	0.580
LIG_14-3-3_CanoR_1	471	481	PF00244	0.434
LIG_APCC_ABBA_1	399	404	PF00400	0.508
LIG_BRCT_BRCA1_1	393	397	PF00533	0.533
LIG_EVH1_2	208	212	PF00568	0.534
LIG_FHA_1	168	174	PF00498	0.697
LIG_FHA_1	30	36	PF00498	0.661
LIG_FHA_1	346	352	PF00498	0.551
LIG_FHA_1	364	370	PF00498	0.630
LIG_FHA_1	433	439	PF00498	0.434
LIG_FHA_1	76	82	PF00498	0.616
LIG_FHA_2	66	72	PF00498	0.553
LIG_Integrin_RGD_1	96	98	PF01839	0.684
LIG_LIR_Gen_1	394	402	PF02991	0.523
LIG_LIR_Nem_3	38	44	PF02991	0.649
LIG_LIR_Nem_3	394	400	PF02991	0.527
LIG_LIR_Nem_3	461	467	PF02991	0.511
LIG_PCNA_PIPBox_1	241	250	PF02747	0.590
LIG_PCNA_yPIPBox_3	234	248	PF02747	0.592
LIG_PDZ_Class_3	476	481	PF00595	0.548
LIG_SH2_CRK	464	468	PF00017	0.485
LIG_SH2_NCK_1	431	435	PF00017	0.437
LIG_SH2_SRC	20	23	PF00017	0.529
LIG_SH2_STAP1	402	406	PF00017	0.491
LIG_SH2_STAT5	157	160	PF00017	0.544
LIG_SH2_STAT5	181	184	PF00017	0.688
LIG_SH2_STAT5	402	405	PF00017	0.653
LIG_SH2_STAT5	41	44	PF00017	0.496
LIG_SH2_STAT5	464	467	PF00017	0.486
LIG_SH3_2	208	213	PF14604	0.539
LIG_SH3_3	129	135	PF00018	0.548
LIG_SH3_3	202	208	PF00018	0.648
LIG_SH3_3	283	289	PF00018	0.675
LIG_SUMO_SIM_par_1	434	439	PF11976	0.469
LIG_SUMO_SIM_par_1	83	88	PF11976	0.540
LIG_TRAF2_1	239	242	PF00917	0.597
LIG_TRAF2_1	293	296	PF00917	0.701
LIG_TRFH_1	397	401	PF08558	0.520
LIG_TYR_ITIM	462	467	PF00017	0.481
LIG_WRC_WIRS_1	408	413	PF05994	0.493
MOD_CK1_1	111	117	PF00069	0.537
MOD_CK1_1	136	142	PF00069	0.688
MOD_CK1_1	180	186	PF00069	0.647
MOD_CK1_1	256	262	PF00069	0.679
MOD_CK1_1	264	270	PF00069	0.593
MOD_CK1_1	282	288	PF00069	0.513
MOD_CK1_1	341	347	PF00069	0.672
MOD_CK1_1	349	355	PF00069	0.576
MOD_CK1_1	387	393	PF00069	0.614
MOD_CK1_1	58	64	PF00069	0.680
MOD_CK1_1	80	86	PF00069	0.690
MOD_CK1_1	9	15	PF00069	0.612
MOD_CK2_1	139	145	PF00069	0.716
MOD_CK2_1	289	295	PF00069	0.592
MOD_CK2_1	383	389	PF00069	0.556
MOD_Cter_Amidation	234	237	PF01082	0.546
MOD_GlcNHglycan	11	14	PF01048	0.674
MOD_GlcNHglycan	115	118	PF01048	0.646
MOD_GlcNHglycan	192	195	PF01048	0.661
MOD_GlcNHglycan	201	204	PF01048	0.596
MOD_GlcNHglycan	225	228	PF01048	0.566
MOD_GlcNHglycan	259	262	PF01048	0.618
MOD_GlcNHglycan	281	284	PF01048	0.633
MOD_GlcNHglycan	291	294	PF01048	0.573
MOD_GlcNHglycan	386	389	PF01048	0.547
MOD_GlcNHglycan	393	396	PF01048	0.534
MOD_GlcNHglycan	404	407	PF01048	0.487
MOD_GlcNHglycan	417	420	PF01048	0.512
MOD_GlcNHglycan	57	60	PF01048	0.615
MOD_GlcNHglycan	62	65	PF01048	0.649
MOD_GSK3_1	108	115	PF00069	0.605
MOD_GSK3_1	130	137	PF00069	0.669
MOD_GSK3_1	140	147	PF00069	0.650
MOD_GSK3_1	183	190	PF00069	0.639
MOD_GSK3_1	223	230	PF00069	0.562
MOD_GSK3_1	253	260	PF00069	0.608
MOD_GSK3_1	261	268	PF00069	0.659
MOD_GSK3_1	29	36	PF00069	0.647
MOD_GSK3_1	328	335	PF00069	0.616
MOD_GSK3_1	341	348	PF00069	0.646
MOD_GSK3_1	349	356	PF00069	0.596
MOD_GSK3_1	364	371	PF00069	0.510
MOD_GSK3_1	378	385	PF00069	0.566
MOD_GSK3_1	387	394	PF00069	0.641
MOD_GSK3_1	400	407	PF00069	0.553
MOD_GSK3_1	432	439	PF00069	0.484
MOD_GSK3_1	47	54	PF00069	0.490
MOD_GSK3_1	58	65	PF00069	0.565
MOD_GSK3_1	76	83	PF00069	0.707
MOD_LATS_1	187	193	PF00433	0.530
MOD_N-GLC_1	112	117	PF02516	0.519
MOD_N-GLC_1	328	333	PF02516	0.705
MOD_N-GLC_1	395	400	PF02516	0.526
MOD_NEK2_1	240	245	PF00069	0.575
MOD_NEK2_1	276	281	PF00069	0.519
MOD_NEK2_1	467	472	PF00069	0.397
MOD_NEK2_1	55	60	PF00069	0.636
MOD_NEK2_2	169	174	PF00069	0.626
MOD_PIKK_1	378	384	PF00454	0.541
MOD_PKA_2	130	136	PF00069	0.560
MOD_PKA_2	289	295	PF00069	0.583
MOD_PKA_2	391	397	PF00069	0.606
MOD_Plk_1	378	384	PF00069	0.539
MOD_Plk_1	395	401	PF00069	0.482
MOD_Plk_1	76	82	PF00069	0.677
MOD_Plk_4	177	183	PF00069	0.679
MOD_Plk_4	364	370	PF00069	0.680
MOD_Plk_4	90	96	PF00069	0.683
MOD_ProDKin_1	150	156	PF00069	0.674
MOD_ProDKin_1	225	231	PF00069	0.561
MOD_ProDKin_1	267	273	PF00069	0.624
MOD_ProDKin_1	282	288	PF00069	0.647
MOD_ProDKin_1	346	352	PF00069	0.527
MOD_ProDKin_1	58	64	PF00069	0.686
MOD_ProDKin_1	6	12	PF00069	0.630
MOD_ProDKin_1	80	86	PF00069	0.578
MOD_SUMO_for_1	376	379	PF00179	0.607
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.512
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.698
TRG_ENDOCYTIC_2	464	467	PF00928	0.486
TRG_ER_diArg_1	195	197	PF00400	0.557
TRG_ER_diArg_1	233	236	PF00400	0.621
TRG_ER_diArg_1	316	318	PF00400	0.703
TRG_NES_CRM1_1	444	458	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IER7	Leishmania donovani	57%	95%
A4I3G3	Leishmania infantum	57%	95%
E9AZQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	99%
Q4Q8I1	Leishmania major	57%	100%