Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGC7_LEIBR

TriTrypDb:

LbrM.28.0890 , LBRM2903_280014300

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGC7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.670
CLV_NRD_NRD_1	135	137	PF00675	0.463
CLV_NRD_NRD_1	373	375	PF00675	0.545
CLV_NRD_NRD_1	495	497	PF00675	0.515
CLV_NRD_NRD_1	499	501	PF00675	0.500
CLV_PCSK_KEX2_1	135	137	PF00082	0.463
CLV_PCSK_KEX2_1	375	377	PF00082	0.521
CLV_PCSK_KEX2_1	495	497	PF00082	0.517
CLV_PCSK_KEX2_1	499	501	PF00082	0.496
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.571
CLV_PCSK_PC7_1	495	501	PF00082	0.500
CLV_PCSK_SKI1_1	293	297	PF00082	0.508
DEG_APCC_DBOX_1	292	300	PF00400	0.447
DEG_SCF_FBW7_1	521	528	PF00400	0.559
DOC_CDC14_PxL_1	20	28	PF14671	0.755
DOC_CKS1_1	160	165	PF01111	0.570
DOC_CYCLIN_RxL_1	290	298	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.496
DOC_MAPK_DCC_7	16	25	PF00069	0.751
DOC_MAPK_DCC_7	522	531	PF00069	0.418
DOC_MAPK_gen_1	13	22	PF00069	0.717
DOC_MAPK_gen_1	374	382	PF00069	0.300
DOC_MAPK_gen_1	406	413	PF00069	0.477
DOC_MAPK_gen_1	441	450	PF00069	0.593
DOC_MAPK_HePTP_8	403	415	PF00069	0.351
DOC_MAPK_MEF2A_6	16	25	PF00069	0.751
DOC_MAPK_MEF2A_6	406	415	PF00069	0.550
DOC_MAPK_MEF2A_6	458	467	PF00069	0.524
DOC_MAPK_MEF2A_6	522	531	PF00069	0.414
DOC_PP4_FxxP_1	300	303	PF00568	0.497
DOC_USP7_MATH_1	154	158	PF00917	0.555
DOC_USP7_MATH_1	329	333	PF00917	0.441
DOC_USP7_MATH_1	378	382	PF00917	0.485
DOC_USP7_MATH_1	4	8	PF00917	0.546
DOC_USP7_MATH_1	437	441	PF00917	0.602
DOC_USP7_MATH_1	525	529	PF00917	0.587
DOC_USP7_MATH_2	31	37	PF00917	0.693
DOC_USP7_UBL2_3	483	487	PF12436	0.514
DOC_WW_Pin1_4	135	140	PF00397	0.512
DOC_WW_Pin1_4	144	149	PF00397	0.471
DOC_WW_Pin1_4	159	164	PF00397	0.509
DOC_WW_Pin1_4	319	324	PF00397	0.399
DOC_WW_Pin1_4	41	46	PF00397	0.675
DOC_WW_Pin1_4	521	526	PF00397	0.479
DOC_WW_Pin1_4	54	59	PF00397	0.681
DOC_WW_Pin1_4	72	77	PF00397	0.495
DOC_WW_Pin1_4	85	90	PF00397	0.503
LIG_14-3-3_CanoR_1	204	212	PF00244	0.540
LIG_14-3-3_CanoR_1	214	222	PF00244	0.495
LIG_14-3-3_CanoR_1	257	261	PF00244	0.465
LIG_14-3-3_CanoR_1	80	89	PF00244	0.605
LIG_Actin_WH2_2	263	278	PF00022	0.255
LIG_APCC_ABBA_1	189	194	PF00400	0.545
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BRCT_BRCA1_1	185	189	PF00533	0.521
LIG_BRCT_BRCA1_1	446	450	PF00533	0.408
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.539
LIG_deltaCOP1_diTrp_1	475	478	PF00928	0.390
LIG_EH1_1	268	276	PF00400	0.483
LIG_EH1_1	308	316	PF00400	0.528
LIG_FHA_1	122	128	PF00498	0.432
LIG_FHA_1	266	272	PF00498	0.412
LIG_FHA_1	392	398	PF00498	0.546
LIG_FHA_1	406	412	PF00498	0.467
LIG_FHA_1	460	466	PF00498	0.398
LIG_FHA_1	513	519	PF00498	0.410
LIG_FHA_1	72	78	PF00498	0.620
LIG_FHA_1	85	91	PF00498	0.780
LIG_FHA_1	98	104	PF00498	0.690
LIG_FHA_2	285	291	PF00498	0.456
LIG_FHA_2	55	61	PF00498	0.792
LIG_IRF3_LxIS_1	123	128	PF10401	0.506
LIG_LIR_Apic_2	298	303	PF02991	0.512
LIG_LIR_Gen_1	259	267	PF02991	0.268
LIG_LIR_Gen_1	354	365	PF02991	0.392
LIG_LIR_Gen_1	379	390	PF02991	0.478
LIG_LIR_Gen_1	447	456	PF02991	0.388
LIG_LIR_Gen_1	475	486	PF02991	0.418
LIG_LIR_Nem_3	124	129	PF02991	0.439
LIG_LIR_Nem_3	259	263	PF02991	0.416
LIG_LIR_Nem_3	280	285	PF02991	0.368
LIG_LIR_Nem_3	290	295	PF02991	0.395
LIG_LIR_Nem_3	336	340	PF02991	0.433
LIG_LIR_Nem_3	354	360	PF02991	0.172
LIG_LIR_Nem_3	379	385	PF02991	0.400
LIG_LIR_Nem_3	447	453	PF02991	0.401
LIG_LIR_Nem_3	46	51	PF02991	0.540
LIG_LIR_Nem_3	475	481	PF02991	0.399
LIG_LIR_Nem_3	484	489	PF02991	0.386
LIG_MYND_1	159	163	PF01753	0.522
LIG_Pex14_2	260	264	PF04695	0.404
LIG_PTB_Apo_2	310	317	PF02174	0.475
LIG_SH2_CRK	292	296	PF00017	0.521
LIG_SH2_CRK	486	490	PF00017	0.426
LIG_SH2_SRC	352	355	PF00017	0.370
LIG_SH2_STAP1	176	180	PF00017	0.283
LIG_SH2_STAP1	409	413	PF00017	0.389
LIG_SH2_STAT3	131	134	PF00017	0.447
LIG_SH2_STAT5	126	129	PF00017	0.475
LIG_SH2_STAT5	150	153	PF00017	0.641
LIG_SH2_STAT5	266	269	PF00017	0.308
LIG_SH2_STAT5	352	355	PF00017	0.370
LIG_SH2_STAT5	456	459	PF00017	0.381
LIG_SH2_STAT5	466	469	PF00017	0.390
LIG_SH3_3	148	154	PF00018	0.571
LIG_SH3_3	18	24	PF00018	0.725
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.392
LIG_SUMO_SIM_par_1	341	348	PF11976	0.406
LIG_SUMO_SIM_par_1	417	423	PF11976	0.486
LIG_TRAF2_1	207	210	PF00917	0.485
LIG_TRAF2_1	365	368	PF00917	0.344
LIG_UBA3_1	160	166	PF00899	0.608
LIG_UBA3_1	295	301	PF00899	0.513
MOD_CDK_SPxxK_3	159	166	PF00069	0.590
MOD_CK1_1	196	202	PF00069	0.546
MOD_CK1_1	319	325	PF00069	0.397
MOD_CK1_1	345	351	PF00069	0.365
MOD_CK1_1	38	44	PF00069	0.769
MOD_CK1_1	420	426	PF00069	0.447
MOD_CK1_1	54	60	PF00069	0.495
MOD_CK1_1	84	90	PF00069	0.817
MOD_CK1_1	97	103	PF00069	0.649
MOD_CK2_1	204	210	PF00069	0.506
MOD_GlcNHglycan	185	188	PF01048	0.542
MOD_GlcNHglycan	198	201	PF01048	0.433
MOD_GlcNHglycan	206	209	PF01048	0.503
MOD_GlcNHglycan	235	238	PF01048	0.433
MOD_GlcNHglycan	347	350	PF01048	0.397
MOD_GlcNHglycan	53	56	PF01048	0.803
MOD_GlcNHglycan	96	99	PF01048	0.747
MOD_GSK3_1	121	128	PF00069	0.459
MOD_GSK3_1	34	41	PF00069	0.796
MOD_GSK3_1	407	414	PF00069	0.412
MOD_GSK3_1	46	53	PF00069	0.791
MOD_GSK3_1	521	528	PF00069	0.559
MOD_GSK3_1	80	87	PF00069	0.720
MOD_N-GLC_1	512	517	PF02516	0.428
MOD_N-GLC_1	80	85	PF02516	0.757
MOD_NEK2_1	125	130	PF00069	0.465
MOD_NEK2_1	316	321	PF00069	0.385
MOD_NEK2_1	34	39	PF00069	0.701
MOD_NEK2_1	405	410	PF00069	0.539
MOD_NEK2_1	481	486	PF00069	0.418
MOD_NEK2_1	51	56	PF00069	0.603
MOD_NEK2_1	71	76	PF00069	0.462
MOD_NEK2_2	121	126	PF00069	0.442
MOD_PIKK_1	102	108	PF00454	0.621
MOD_PIKK_1	213	219	PF00454	0.560
MOD_PIKK_1	4	10	PF00454	0.539
MOD_PK_1	16	22	PF00069	0.644
MOD_PK_1	407	413	PF00069	0.549
MOD_PKA_2	213	219	PF00069	0.492
MOD_PKA_2	256	262	PF00069	0.462
MOD_PKA_2	79	85	PF00069	0.781
MOD_PKB_1	374	382	PF00069	0.496
MOD_PKB_1	441	449	PF00069	0.567
MOD_Plk_1	391	397	PF00069	0.292
MOD_Plk_1	443	449	PF00069	0.431
MOD_Plk_1	512	518	PF00069	0.437
MOD_Plk_4	121	127	PF00069	0.468
MOD_Plk_4	256	262	PF00069	0.430
MOD_Plk_4	329	335	PF00069	0.446
MOD_Plk_4	426	432	PF00069	0.422
MOD_Plk_4	459	465	PF00069	0.490
MOD_Plk_4	481	487	PF00069	0.435
MOD_ProDKin_1	135	141	PF00069	0.508
MOD_ProDKin_1	144	150	PF00069	0.467
MOD_ProDKin_1	159	165	PF00069	0.508
MOD_ProDKin_1	319	325	PF00069	0.397
MOD_ProDKin_1	41	47	PF00069	0.676
MOD_ProDKin_1	521	527	PF00069	0.486
MOD_ProDKin_1	54	60	PF00069	0.682
MOD_ProDKin_1	72	78	PF00069	0.493
MOD_ProDKin_1	85	91	PF00069	0.502
MOD_SUMO_rev_2	368	377	PF00179	0.352
TRG_DiLeu_BaEn_4	210	216	PF01217	0.523
TRG_ENDOCYTIC_2	176	179	PF00928	0.538
TRG_ENDOCYTIC_2	235	238	PF00928	0.438
TRG_ENDOCYTIC_2	292	295	PF00928	0.417
TRG_ENDOCYTIC_2	485	488	PF00928	0.408
TRG_ER_diArg_1	374	377	PF00400	0.477
TRG_ER_diArg_1	494	496	PF00400	0.495
TRG_ER_diArg_1	498	500	PF00400	0.496
TRG_ER_diArg_1	519	522	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z5	Leptomonas seymouri	68%	100%
A0A0S4IP32	Bodo saltans	40%	100%
A0A1X0NYG7	Trypanosomatidae	52%	100%
A0A3Q8IDT7	Leishmania donovani	86%	100%
A0A3R7LMJ5	Trypanosoma rangeli	54%	100%
A4I3F9	Leishmania infantum	85%	100%
D0A7X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AZP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q8I5	Leishmania major	85%	100%
V5DH50	Trypanosoma cruzi	54%	100%