Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGC5_LEIBR

TriTrypDb:

LbrM.28.0870 , LBRM2903_280014100

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.438
CLV_NRD_NRD_1	148	150	PF00675	0.458
CLV_NRD_NRD_1	6	8	PF00675	0.622
CLV_PCSK_KEX2_1	148	150	PF00082	0.526
CLV_PCSK_KEX2_1	206	208	PF00082	0.695
CLV_PCSK_KEX2_1	6	8	PF00082	0.527
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.622
CLV_PCSK_SKI1_1	35	39	PF00082	0.517
CLV_PCSK_SKI1_1	79	83	PF00082	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DEG_SCF_FBW7_1	152	158	PF00400	0.476
DOC_CKS1_1	152	157	PF01111	0.467
DOC_CKS1_1	84	89	PF01111	0.443
DOC_CYCLIN_yClb5_NLxxxL_5	219	228	PF00134	0.566
DOC_USP7_MATH_1	155	159	PF00917	0.639
DOC_USP7_MATH_1	75	79	PF00917	0.540
DOC_WW_Pin1_4	151	156	PF00397	0.519
DOC_WW_Pin1_4	199	204	PF00397	0.503
DOC_WW_Pin1_4	83	88	PF00397	0.455
LIG_14-3-3_CanoR_1	11	16	PF00244	0.573
LIG_14-3-3_CanoR_1	167	171	PF00244	0.451
LIG_14-3-3_CanoR_1	199	203	PF00244	0.499
LIG_14-3-3_CterR_2	244	248	PF00244	0.532
LIG_FHA_1	199	205	PF00498	0.510
LIG_FHA_1	223	229	PF00498	0.515
LIG_FHA_1	29	35	PF00498	0.484
LIG_FHA_2	90	96	PF00498	0.706
LIG_LIR_Gen_1	168	179	PF02991	0.550
LIG_LIR_Nem_3	168	174	PF02991	0.558
LIG_PCNA_yPIPBox_3	30	39	PF02747	0.363
LIG_SH2_CRK	127	131	PF00017	0.498
LIG_SH2_CRK	171	175	PF00017	0.539
LIG_SH2_GRB2like	127	130	PF00017	0.499
LIG_SH2_STAT5	110	113	PF00017	0.506
LIG_SH2_STAT5	171	174	PF00017	0.531
LIG_SH3_3	78	84	PF00018	0.341
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.519
LIG_TRFH_1	151	155	PF08558	0.408
LIG_UBA3_1	221	226	PF00899	0.569
MOD_CDK_SPxxK_3	199	206	PF00069	0.464
MOD_CK1_1	128	134	PF00069	0.675
MOD_CK1_1	169	175	PF00069	0.408
MOD_CK1_1	239	245	PF00069	0.687
MOD_CK1_1	26	32	PF00069	0.373
MOD_CK1_1	49	55	PF00069	0.467
MOD_CK2_1	128	134	PF00069	0.770
MOD_GlcNHglycan	233	237	PF01048	0.508
MOD_GlcNHglycan	48	51	PF01048	0.708
MOD_GSK3_1	136	143	PF00069	0.565
MOD_GSK3_1	151	158	PF00069	0.650
MOD_GSK3_1	165	172	PF00069	0.603
MOD_GSK3_1	232	239	PF00069	0.651
MOD_GSK3_1	24	31	PF00069	0.404
MOD_GSK3_1	240	247	PF00069	0.586
MOD_LATS_1	9	15	PF00433	0.594
MOD_N-GLC_1	128	133	PF02516	0.623
MOD_N-GLC_1	222	227	PF02516	0.551
MOD_N-GLC_1	240	245	PF02516	0.527
MOD_NEK2_1	209	214	PF00069	0.599
MOD_NEK2_1	222	227	PF00069	0.618
MOD_NEK2_1	99	104	PF00069	0.564
MOD_PIKK_1	26	32	PF00454	0.373
MOD_PKA_2	166	172	PF00069	0.451
MOD_PKA_2	198	204	PF00069	0.615
MOD_Plk_1	134	140	PF00069	0.497
MOD_Plk_1	175	181	PF00069	0.560
MOD_Plk_4	11	17	PF00069	0.563
MOD_Plk_4	166	172	PF00069	0.723
MOD_Plk_4	188	194	PF00069	0.425
MOD_ProDKin_1	151	157	PF00069	0.526
MOD_ProDKin_1	199	205	PF00069	0.503
MOD_ProDKin_1	83	89	PF00069	0.468
MOD_SUMO_rev_2	128	138	PF00179	0.602
MOD_SUMO_rev_2	58	63	PF00179	0.484
TRG_DiLeu_BaEn_1	217	222	PF01217	0.535
TRG_ENDOCYTIC_2	127	130	PF00928	0.499
TRG_ENDOCYTIC_2	171	174	PF00928	0.538
TRG_ER_diArg_1	147	149	PF00400	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGN7	Leishmania donovani	72%	98%
E9ADJ9	Leishmania major	71%	100%
E9AHH8	Leishmania infantum	73%	98%
E9AZP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%