Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGC4_LEIBR

TriTrypDb:

LbrM.28.0860 , LBRM2903_280014000

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.491
CLV_C14_Caspase3-7	291	295	PF00656	0.544
CLV_C14_Caspase3-7	44	48	PF00656	0.546
CLV_NRD_NRD_1	125	127	PF00675	0.435
CLV_NRD_NRD_1	164	166	PF00675	0.472
CLV_NRD_NRD_1	197	199	PF00675	0.361
CLV_NRD_NRD_1	203	205	PF00675	0.385
CLV_NRD_NRD_1	276	278	PF00675	0.434
CLV_NRD_NRD_1	434	436	PF00675	0.553
CLV_NRD_NRD_1	459	461	PF00675	0.569
CLV_NRD_NRD_1	77	79	PF00675	0.561
CLV_NRD_NRD_1	92	94	PF00675	0.486
CLV_PCSK_FUR_1	274	278	PF00082	0.556
CLV_PCSK_FUR_1	74	78	PF00082	0.669
CLV_PCSK_KEX2_1	203	205	PF00082	0.398
CLV_PCSK_KEX2_1	276	278	PF00082	0.432
CLV_PCSK_KEX2_1	434	436	PF00082	0.554
CLV_PCSK_KEX2_1	459	461	PF00082	0.569
CLV_PCSK_KEX2_1	76	78	PF00082	0.568
CLV_PCSK_KEX2_1	92	94	PF00082	0.496
CLV_PCSK_PC7_1	88	94	PF00082	0.630
CLV_PCSK_SKI1_1	109	113	PF00082	0.532
CLV_PCSK_SKI1_1	166	170	PF00082	0.533
CLV_PCSK_SKI1_1	198	202	PF00082	0.474
CLV_PCSK_SKI1_1	96	100	PF00082	0.533
CLV_Separin_Metazoa	341	345	PF03568	0.600
DEG_APCC_DBOX_1	138	146	PF00400	0.386
DEG_Nend_UBRbox_3	1	3	PF02207	0.470
DEG_SPOP_SBC_1	205	209	PF00917	0.699
DEG_SPOP_SBC_1	215	219	PF00917	0.483
DEG_SPOP_SBC_1	62	66	PF00917	0.708
DOC_CKS1_1	82	87	PF01111	0.622
DOC_MAPK_gen_1	368	377	PF00069	0.510
DOC_MAPK_gen_1	459	466	PF00069	0.469
DOC_MAPK_gen_1	485	493	PF00069	0.449
DOC_PP2B_LxvP_1	454	457	PF13499	0.487
DOC_PP4_FxxP_1	187	190	PF00568	0.522
DOC_PP4_FxxP_1	339	342	PF00568	0.489
DOC_PP4_FxxP_1	389	392	PF00568	0.701
DOC_USP7_MATH_1	180	184	PF00917	0.482
DOC_USP7_MATH_1	62	66	PF00917	0.699
DOC_USP7_UBL2_3	162	166	PF12436	0.544
DOC_WW_Pin1_4	20	25	PF00397	0.516
DOC_WW_Pin1_4	238	243	PF00397	0.560
DOC_WW_Pin1_4	297	302	PF00397	0.603
DOC_WW_Pin1_4	370	375	PF00397	0.802
DOC_WW_Pin1_4	64	69	PF00397	0.743
DOC_WW_Pin1_4	81	86	PF00397	0.616
LIG_14-3-3_CanoR_1	179	189	PF00244	0.515
LIG_14-3-3_CanoR_1	399	404	PF00244	0.585
LIG_14-3-3_CanoR_1	4	12	PF00244	0.644
LIG_14-3-3_CanoR_1	408	414	PF00244	0.460
LIG_14-3-3_CanoR_1	419	425	PF00244	0.399
LIG_14-3-3_CanoR_1	76	82	PF00244	0.554
LIG_Actin_WH2_2	135	153	PF00022	0.471
LIG_BIR_III_4	425	429	PF00653	0.538
LIG_BRCT_BRCA1_1	183	187	PF00533	0.594
LIG_deltaCOP1_diTrp_1	325	331	PF00928	0.375
LIG_FHA_1	287	293	PF00498	0.412
LIG_FHA_1	370	376	PF00498	0.683
LIG_FHA_2	113	119	PF00498	0.415
LIG_FHA_2	130	136	PF00498	0.467
LIG_FHA_2	216	222	PF00498	0.737
LIG_FHA_2	336	342	PF00498	0.586
LIG_FHA_2	410	416	PF00498	0.638
LIG_FHA_2	492	498	PF00498	0.525
LIG_FHA_2	82	88	PF00498	0.487
LIG_GBD_Chelix_1	142	150	PF00786	0.398
LIG_HCF-1_HBM_1	94	97	PF13415	0.405
LIG_LIR_Apic_2	184	190	PF02991	0.558
LIG_LIR_Apic_2	338	342	PF02991	0.471
LIG_LIR_Apic_2	387	392	PF02991	0.691
LIG_LIR_Gen_1	128	138	PF02991	0.444
LIG_LIR_Nem_3	105	111	PF02991	0.645
LIG_LIR_Nem_3	128	133	PF02991	0.466
LIG_LIR_Nem_3	303	308	PF02991	0.473
LIG_LIR_Nem_3	427	433	PF02991	0.541
LIG_Pex14_1	326	330	PF04695	0.376
LIG_RPA_C_Fungi	153	165	PF08784	0.538
LIG_SH2_CRK	167	171	PF00017	0.431
LIG_SH2_STAP1	32	36	PF00017	0.608
LIG_SH2_STAT5	116	119	PF00017	0.464
LIG_SH2_STAT5	149	152	PF00017	0.397
LIG_SH2_STAT5	26	29	PF00017	0.693
LIG_SH2_STAT5	32	35	PF00017	0.691
LIG_SH2_STAT5	330	333	PF00017	0.409
LIG_SH3_1	101	107	PF00018	0.513
LIG_SH3_2	104	109	PF14604	0.643
LIG_SH3_3	101	107	PF00018	0.513
LIG_SH3_3	461	467	PF00018	0.531
LIG_SH3_3	65	71	PF00018	0.752
LIG_SH3_3	79	85	PF00018	0.571
LIG_TRAF2_1	261	264	PF00917	0.571
LIG_WW_3	341	345	PF00397	0.600
MOD_CDK_SPK_2	81	86	PF00069	0.631
MOD_CDK_SPxxK_3	81	88	PF00069	0.628
MOD_CK1_1	206	212	PF00069	0.634
MOD_CK1_1	22	28	PF00069	0.570
MOD_CK1_1	255	261	PF00069	0.568
MOD_CK1_1	297	303	PF00069	0.662
MOD_CK1_1	480	486	PF00069	0.639
MOD_CK1_1	52	58	PF00069	0.689
MOD_CK1_1	64	70	PF00069	0.583
MOD_CK2_1	258	264	PF00069	0.639
MOD_CK2_1	335	341	PF00069	0.576
MOD_CK2_1	355	361	PF00069	0.646
MOD_CK2_1	434	440	PF00069	0.691
MOD_CK2_1	449	455	PF00069	0.704
MOD_CK2_1	491	497	PF00069	0.461
MOD_CK2_1	81	87	PF00069	0.495
MOD_Cter_Amidation	124	127	PF01082	0.397
MOD_Cter_Amidation	457	460	PF01082	0.584
MOD_GlcNHglycan	183	186	PF01048	0.536
MOD_GlcNHglycan	254	257	PF01048	0.693
MOD_GlcNHglycan	302	305	PF01048	0.511
MOD_GlcNHglycan	9	12	PF01048	0.478
MOD_GSK3_1	18	25	PF00069	0.607
MOD_GSK3_1	203	210	PF00069	0.525
MOD_GSK3_1	211	218	PF00069	0.603
MOD_GSK3_1	233	240	PF00069	0.649
MOD_GSK3_1	254	261	PF00069	0.569
MOD_GSK3_1	3	10	PF00069	0.552
MOD_GSK3_1	315	322	PF00069	0.451
MOD_GSK3_1	349	356	PF00069	0.528
MOD_GSK3_1	52	59	PF00069	0.652
MOD_GSK3_1	62	69	PF00069	0.577
MOD_GSK3_1	77	84	PF00069	0.451
MOD_NEK2_1	12	17	PF00069	0.478
MOD_NEK2_1	150	155	PF00069	0.496
MOD_NEK2_1	169	174	PF00069	0.460
MOD_NEK2_1	233	238	PF00069	0.598
MOD_NEK2_1	283	288	PF00069	0.510
MOD_NEK2_1	3	8	PF00069	0.547
MOD_NEK2_1	31	36	PF00069	0.638
MOD_NEK2_1	409	414	PF00069	0.501
MOD_NEK2_1	63	68	PF00069	0.702
MOD_PIKK_1	66	72	PF00454	0.622
MOD_PKA_1	126	132	PF00069	0.482
MOD_PKA_1	203	209	PF00069	0.533
MOD_PKA_1	434	440	PF00069	0.644
MOD_PKA_1	76	82	PF00069	0.537
MOD_PKA_2	150	156	PF00069	0.556
MOD_PKA_2	203	209	PF00069	0.631
MOD_PKA_2	233	239	PF00069	0.607
MOD_PKA_2	3	9	PF00069	0.551
MOD_PKA_2	369	375	PF00069	0.576
MOD_PKA_2	420	426	PF00069	0.536
MOD_PKA_2	434	440	PF00069	0.542
MOD_PKA_2	491	497	PF00069	0.461
MOD_PKA_2	76	82	PF00069	0.481
MOD_PKB_1	74	82	PF00069	0.643
MOD_Plk_1	315	321	PF00069	0.446
MOD_Plk_2-3	335	341	PF00069	0.572
MOD_Plk_2-3	353	359	PF00069	0.598
MOD_Plk_2-3	49	55	PF00069	0.662
MOD_Plk_4	112	118	PF00069	0.544
MOD_Plk_4	319	325	PF00069	0.387
MOD_Plk_4	56	62	PF00069	0.476
MOD_ProDKin_1	20	26	PF00069	0.520
MOD_ProDKin_1	238	244	PF00069	0.563
MOD_ProDKin_1	297	303	PF00069	0.602
MOD_ProDKin_1	370	376	PF00069	0.801
MOD_ProDKin_1	64	70	PF00069	0.744
MOD_ProDKin_1	81	87	PF00069	0.614
MOD_SUMO_rev_2	224	233	PF00179	0.491
MOD_SUMO_rev_2	90	98	PF00179	0.600
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.473
TRG_ENDOCYTIC_2	167	170	PF00928	0.412
TRG_ENDOCYTIC_2	430	433	PF00928	0.690
TRG_ER_diArg_1	274	277	PF00400	0.425
TRG_ER_diArg_1	308	311	PF00400	0.413
TRG_ER_diArg_1	343	346	PF00400	0.624
TRG_ER_diArg_1	406	409	PF00400	0.511
TRG_ER_diArg_1	433	435	PF00400	0.558
TRG_ER_diArg_1	459	461	PF00400	0.569
TRG_ER_diArg_1	75	78	PF00400	0.604
TRG_ER_diArg_1	91	93	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8G0	Leptomonas seymouri	65%	100%
A0A0S4IT28	Bodo saltans	34%	100%
A0A1X0NYF9	Trypanosomatidae	48%	100%
A0A3Q8IDQ0	Leishmania donovani	81%	100%
A0A3R7M5S0	Trypanosoma rangeli	46%	100%
A4I3F7	Leishmania infantum	81%	100%
D0A7Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AZP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q8I7	Leishmania major	79%	100%
V5BKT5	Trypanosoma cruzi	47%	100%