LeishMANIAdb
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DNA-directed RNA polymerases I, II, and III subunit RPABC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Gene product:
RNA polymerase B subunit RPB8, putative
Species:
Leishmania braziliensis
UniProt:
A4HGC3_LEIBR
TriTrypDb:
LbrM.28.0850 , LBRM2903_280013900
Length:
149

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0000428 DNA-directed RNA polymerase complex 4 11
GO:0005654 nucleoplasm 2 1
GO:0005665 RNA polymerase II, core complex 4 11
GO:0005666 RNA polymerase III complex 4 11
GO:0005736 RNA polymerase I complex 4 11
GO:0030880 RNA polymerase complex 3 11
GO:0032991 protein-containing complex 1 11
GO:0055029 nuclear DNA-directed RNA polymerase complex 3 11
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 11
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4HGC3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGC3

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006351 DNA-templated transcription 7 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0018130 heterocycle biosynthetic process 4 11
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0016779 nucleotidyltransferase activity 4 6
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_MEL_PAP_1 23 29 PF00089 0.312
CLV_PCSK_KEX2_1 145 147 PF00082 0.312
CLV_PCSK_PC1ET2_1 145 147 PF00082 0.312
CLV_PCSK_SKI1_1 145 149 PF00082 0.532
DOC_USP7_UBL2_3 71 75 PF12436 0.423
LIG_Actin_WH2_2 10 28 PF00022 0.354
LIG_Actin_WH2_2 117 134 PF00022 0.331
LIG_BIR_II_1 1 5 PF00653 0.501
LIG_BRCT_BRCA1_1 46 50 PF00533 0.423
LIG_FHA_1 20 26 PF00498 0.296
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IA68 Leptomonas seymouri 93% 100%
A0A0S4INZ3 Bodo saltans 52% 99%
A0A1X0NYD9 Trypanosomatidae 75% 100%
A0A3S7X1E3 Leishmania donovani 97% 100%
A0A422N350 Trypanosoma rangeli 72% 100%
A4I3F6 Leishmania infantum 97% 100%
A8XT81 Caenorhabditis briggsae 30% 100%
D0A7Y4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9AZP4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O81097 Arabidopsis thaliana 24% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS