Calmodulin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGC2_LEIBR

TriTrypDb:

LbrM.28.0840 , LBRM2903_280013800

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGC2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.284
CLV_NRD_NRD_1	13	15	PF00675	0.476
CLV_NRD_NRD_1	60	62	PF00675	0.175
CLV_PCSK_KEX2_1	60	62	PF00082	0.175
CLV_PCSK_KEX2_1	97	99	PF00082	0.388
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.388
CLV_PCSK_SKI1_1	107	111	PF00082	0.288
CLV_PCSK_SKI1_1	74	78	PF00082	0.275
CLV_PCSK_SKI1_1	87	91	PF00082	0.231
DEG_APCC_DBOX_1	106	114	PF00400	0.335
DOC_PP4_FxxP_1	100	103	PF00568	0.175
DOC_USP7_MATH_1	56	60	PF00917	0.447
DOC_WW_Pin1_4	146	151	PF00397	0.503
DOC_WW_Pin1_4	99	104	PF00397	0.388
LIG_14-3-3_CanoR_1	107	117	PF00244	0.289
LIG_14-3-3_CanoR_1	61	67	PF00244	0.345
LIG_BRCT_BRCA1_1	62	66	PF00533	0.275
LIG_FHA_2	110	116	PF00498	0.317
LIG_FHA_2	129	135	PF00498	0.493
LIG_FHA_2	45	51	PF00498	0.343
LIG_LIR_Gen_1	31	39	PF02991	0.338
LIG_LIR_Gen_1	63	73	PF02991	0.346
LIG_LIR_Gen_1	88	95	PF02991	0.193
LIG_LIR_Nem_3	31	36	PF02991	0.362
LIG_LIR_Nem_3	63	69	PF02991	0.258
LIG_LIR_Nem_3	88	93	PF02991	0.308
LIG_Pex14_2	13	17	PF04695	0.403
LIG_PTB_Apo_2	27	34	PF02174	0.248
LIG_REV1ctd_RIR_1	10	19	PF16727	0.414
LIG_SH2_STAT5	108	111	PF00017	0.257
LIG_SH2_STAT5	16	19	PF00017	0.324
LIG_TRAF2_1	118	121	PF00917	0.485
LIG_TRAF2_1	82	85	PF00917	0.582
MOD_CK2_1	115	121	PF00069	0.535
MOD_CK2_1	44	50	PF00069	0.320
MOD_CK2_1	79	85	PF00069	0.547
MOD_CK2_1	99	105	PF00069	0.270
MOD_GlcNHglycan	117	120	PF01048	0.531
MOD_GSK3_1	56	63	PF00069	0.460
MOD_NEK2_1	109	114	PF00069	0.335
MOD_NEK2_1	77	82	PF00069	0.528
MOD_PKA_1	60	66	PF00069	0.175
MOD_PKA_2	60	66	PF00069	0.275
MOD_Plk_1	45	51	PF00069	0.332
MOD_Plk_2-3	128	134	PF00069	0.469
MOD_Plk_2-3	79	85	PF00069	0.335
MOD_Plk_4	32	38	PF00069	0.397
MOD_ProDKin_1	146	152	PF00069	0.514
MOD_ProDKin_1	99	105	PF00069	0.388
TRG_DiLeu_BaEn_2	104	110	PF01217	0.333
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.175

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	32%	100%
A0A0N0P7S6	Leptomonas seymouri	59%	100%
A0A0N1PDC0	Leptomonas seymouri	24%	100%
A0A0S4INC8	Bodo saltans	29%	82%
A0A0S4IQZ8	Bodo saltans	42%	100%
A0A0S4IS38	Bodo saltans	32%	100%
A0A0S4IUE7	Bodo saltans	26%	99%
A0A0S4J7U6	Bodo saltans	28%	95%
A0A0S4JFC8	Bodo saltans	32%	91%
A0A0S4JFY6	Bodo saltans	32%	100%
A0A0S4JGV2	Bodo saltans	29%	99%
A0A1X0NMM5	Trypanosomatidae	32%	100%
A0A1X0NXC6	Trypanosomatidae	30%	97%
A0A1X0NYH1	Trypanosomatidae	53%	100%
A0A1X0P9X3	Trypanosomatidae	29%	85%
A0A3Q8IW81	Leishmania donovani	30%	99%
A0A3R7K2E4	Trypanosoma rangeli	30%	100%
A0A3R7NB96	Trypanosoma rangeli	51%	100%
A0A3S7WW96	Leishmania donovani	25%	100%
A0A3S7X1A1	Leishmania donovani	83%	100%
A0A422MQ47	Trypanosoma rangeli	32%	100%
A0A422NIM0	Trypanosoma rangeli	28%	100%
A2WN93	Oryza sativa subsp. indica	31%	100%
A2WNH1	Oryza sativa subsp. indica	31%	100%
A2Y609	Oryza sativa subsp. indica	32%	100%
A3E3H0	Pfiesteria piscicida	31%	100%
A3E4D8	Prorocentrum minimum	31%	100%
A3E4F9	Karlodinium veneficum	31%	100%
A4H5R9	Leishmania braziliensis	32%	100%
A4HBM1	Leishmania braziliensis	28%	100%
A4HU13	Leishmania infantum	32%	100%
A4HZA9	Leishmania infantum	25%	100%
A4I3F5	Leishmania infantum	82%	100%
A4IF97	Bos taurus	26%	90%
A4UHC0	Alexandrium fundyense	31%	100%
A8CEP3	Saccharina japonica	33%	100%
A8I1Q0	Heterocapsa triquetra	31%	100%
B1PSN3	Leishmania donovani	32%	100%
C9ZYU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A7Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D2DGW3	Tyrophagus putrescentiae	29%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AUY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AZP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O00897	Dictyostelium discoideum	26%	100%
O02367	Ciona intestinalis	31%	100%
O16305	Caenorhabditis elegans	33%	100%
O23184	Arabidopsis thaliana	29%	92%
O23320	Arabidopsis thaliana	32%	100%
O60041	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	100%
O82018	Mougeotia scalaris	29%	100%
O82659	Arabidopsis thaliana	28%	91%
O94739	Pleurotus ostreatus	29%	100%
O96081	Halocynthia roretzi	34%	100%
O96102	Physarum polycephalum	33%	100%
O97341	Suberites domuncula	33%	100%
P02585	Homo sapiens	27%	96%
P02586	Oryctolagus cuniculus	26%	96%
P02587	Sus scrofa	26%	97%
P02588	Gallus gallus	26%	94%
P02589	Pelophylax lessonae	27%	95%
P02594	Electrophorus electricus	33%	100%
P02595	Patinopecten sp.	33%	100%
P02597	Gallus gallus	34%	100%
P02598	Tetrahymena pyriformis	31%	100%
P02599	Dictyostelium discoideum	31%	100%
P02612	Gallus gallus	27%	90%
P04352	Chlamydomonas reinhardtii	33%	94%
P04353	Spinacia oleracea	31%	100%
P04464	Triticum aestivum	31%	100%
P04630	Caenorhabditis elegans	34%	96%
P05419	Gallus gallus	33%	100%
P05434	Chlamydomonas reinhardtii	28%	91%
P05932	Arbacia punctulata	34%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P06704	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	96%
P06787	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P07290	Mizuhopecten yessoensis	30%	99%
P07291	Argopecten irradians	31%	98%
P07463	Paramecium tetraurelia	30%	100%
P08053	Physarum polycephalum	27%	100%
P09402	Dictyostelium discoideum	30%	100%
P0DH95	Arabidopsis thaliana	32%	100%
P0DH96	Arabidopsis thaliana	32%	100%
P0DH97	Arabidopsis thaliana	30%	100%
P0DH98	Arabidopsis thaliana	30%	100%
P0DP23	Homo sapiens	33%	100%
P0DP24	Homo sapiens	33%	100%
P0DP25	Homo sapiens	33%	100%
P0DP26	Mus musculus	33%	100%
P0DP27	Mus musculus	33%	100%
P0DP28	Mus musculus	33%	100%
P0DP29	Rattus norvegicus	33%	100%
P0DP30	Rattus norvegicus	33%	100%
P0DP31	Rattus norvegicus	33%	100%
P0DP33	Xenopus laevis	33%	100%
P0DP34	Xenopus laevis	33%	100%
P0DP35	Xenopus laevis	33%	100%
P10246	Meleagris gallopavo	27%	95%
P11118	Euglena gracilis	30%	100%
P11120	Pleurotus cornucopiae	30%	100%
P11121	Pyuridae sp.	33%	100%
P13833	Dictyostelium discoideum	28%	96%
P13868	Solanum tuberosum	32%	100%
P14533	Doryteuthis pealeii	27%	100%
P15094	Achlya klebsiana	33%	100%
P15159	Tachypleus tridentatus	34%	100%
P15845	Schistosoma mansoni	25%	100%
P17928	Medicago sativa	30%	100%
P18061	Trypanosoma cruzi	32%	100%
P20801	Mus musculus	26%	96%
P21251	Stichopus japonicus	33%	100%
P21797	Balanus nubilus	26%	97%
P21798	Balanus nubilus	29%	100%
P23286	Candida albicans	29%	100%
P24032	Gallus gallus	26%	90%
P24044	Plasmodium falciparum	30%	100%
P24844	Homo sapiens	27%	90%
P27161	Solanum lycopersicum	31%	100%
P27163	Petunia hybrida	28%	100%
P27164	Petunia hybrida	30%	84%
P27165	Phytophthora infestans	33%	100%
P27166	Stylonychia lemnae	29%	100%
P27482	Homo sapiens	31%	100%
P29269	Sus scrofa	27%	90%
P29289	Homarus americanus	22%	100%
P30187	Arabidopsis thaliana	25%	81%
P35622	Mizuhopecten yessoensis	26%	100%
P41040	Zea mays	30%	100%
P41041	Pneumocystis carinii	30%	100%
P41208	Homo sapiens	29%	90%
P41209	Mus musculus	30%	90%
P41210	Atriplex nummularia	26%	92%
P43645	Spermatozopsis similis	28%	100%
P43646	Tetraselmis striata	29%	100%
P47947	Drosophila melanogaster	24%	100%
P47948	Drosophila melanogaster	25%	99%
P47949	Drosophila melanogaster	29%	99%
P48976	Malus domestica	30%	100%
P49258	Drosophila melanogaster	35%	100%
P53440	Naegleria gruberi	32%	99%
P53441	Naegleria gruberi	29%	90%
P54213	Dunaliella salina	29%	91%
P54357	Drosophila melanogaster	30%	100%
P59220	Arabidopsis thaliana	30%	100%
P60204	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	29%	100%
P60205	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	29%	100%
P60206	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	29%	100%
P61859	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	100%
P61860	Colletotrichum trifolii	30%	100%
P61861	Colletotrichum gloeosporioides	30%	100%
P62144	Anas platyrhynchos	33%	100%
P62145	Aplysia californica	33%	100%
P62146	Arbacia punctulata	33%	100%
P62147	Branchiostoma floridae	33%	100%
P62148	Branchiostoma lanceolatum	33%	100%
P62149	Gallus gallus	33%	100%
P62150	Oryzias latipes	33%	100%
P62151	Tetronarce californica	33%	100%
P62152	Drosophila melanogaster	33%	100%
P62153	Halocynthia roretzi	33%	100%
P62154	Locusta migratoria	33%	100%
P62156	Oncorhynchus sp.	33%	100%
P62157	Bos taurus	33%	100%
P62160	Oryctolagus cuniculus	33%	100%
P62162	Hordeum vulgare	31%	100%
P62163	Glycine max	31%	100%
P62184	Renilla reniformis	33%	100%
P62199	Petunia hybrida	30%	100%
P62200	Daucus carota	30%	100%
P62201	Lilium longiflorum	30%	100%
P62202	Bryonia dioica	30%	100%
P62203	Plasmodium falciparum (isolate 3D7)	30%	100%
P69097	Trypanosoma brucei brucei	30%	100%
P69098	Trypanosoma brucei gambiense	30%	100%
P80322	Branchiostoma lanceolatum	27%	94%
P81660	Anguilla anguilla	28%	96%
P84339	Agaricus bisporus	29%	100%
P93087	Capsicum annuum	30%	100%
P93171	Helianthus annuus	31%	100%
Q03509	Arabidopsis thaliana	31%	100%
Q06827	Scherffelia dubia	28%	92%
Q09196	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q09665	Caenorhabditis elegans	28%	96%
Q0IQB6	Oryza sativa subsp. japonica	30%	84%
Q0IUU4	Oryza sativa subsp. japonica	30%	84%
Q0JNL7	Oryza sativa subsp. japonica	32%	100%
Q0JNS6	Oryza sativa subsp. japonica	31%	100%
Q11083	Caenorhabditis elegans	27%	67%
Q12798	Homo sapiens	30%	90%
Q17133	Branchiostoma floridae	28%	100%
Q1A7B1	Blattella germanica	29%	100%
Q1A7B2	Blattella germanica	27%	100%
Q1A7B3	Blattella germanica	30%	100%
Q2R1Z5	Oryza sativa subsp. japonica	29%	91%
Q2TBN3	Bos taurus	30%	90%
Q32LE3	Bos taurus	31%	90%
Q39752	Fagus sylvatica	30%	100%
Q3SB08	Pseudechis porphyriacus	28%	99%
Q3SB09	Pseudechis australis	28%	99%
Q3SB10	Hoplocephalus stephensii	28%	99%
Q3SB11	Tropidechis carinatus	27%	99%
Q3SB12	Notechis scutatus scutatus	28%	99%
Q3SB13	Pseudonaja textilis	28%	99%
Q3SB14	Oxyuranus microlepidotus	28%	99%
Q3SB15	Oxyuranus scutellatus scutellatus	28%	99%
Q3T0E8	Bos taurus	23%	100%
Q40302	Macrocystis pyrifera	33%	100%
Q40642	Oryza sativa subsp. indica	32%	82%
Q41420	Solanum tuberosum	28%	100%
Q4Q8I9	Leishmania major	84%	100%
Q4QCJ3	Leishmania major	26%	100%
Q4QHT2	Leishmania major	32%	100%
Q5RAD2	Pongo abelii	33%	100%
Q5RBA4	Pongo abelii	27%	90%
Q5U206	Rattus norvegicus	32%	100%
Q64122	Rattus norvegicus	27%	90%
Q682T9	Arabidopsis thaliana	30%	100%
Q6BWS8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	89%
Q6F332	Oryza sativa subsp. japonica	32%	100%
Q6IT78	Ctenopharyngodon idella	33%	100%
Q6L5F4	Oryza sativa subsp. japonica	27%	89%
Q6PI52	Danio rerio	33%	100%
Q6R520	Oreochromis mossambicus	33%	100%
Q6YNX6	Ovis aries	33%	100%
Q71UH5	Globisporangium splendens	33%	100%
Q71UH6	Perca flavescens	33%	100%
Q757B7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	88%
Q7DMN9	Solanum tuberosum	31%	100%
Q7DMP0	Solanum tuberosum	31%	100%
Q7F0J0	Oryza sativa subsp. japonica	26%	91%
Q7T3T2	Epinephelus akaara	33%	100%
Q7Y052	Euphorbia characias	30%	100%
Q7Z2B8	Dictyostelium discoideum	28%	100%
Q84MN0	Oryza sativa subsp. japonica	27%	100%
Q84VG0	Oryza sativa subsp. japonica	28%	100%
Q8AY75	Bothrops insularis	29%	99%
Q8K4K1	Mus musculus	28%	92%
Q8S1Y9	Oryza sativa subsp. japonica	31%	82%
Q8STF0	Strongylocentrotus intermedius	33%	99%
Q8TD86	Homo sapiens	29%	85%
Q8VZ50	Arabidopsis thaliana	25%	100%
Q8X187	Paxillus involutus	29%	100%
Q948R0	Oryza sativa subsp. japonica	27%	93%
Q94AZ4	Arabidopsis thaliana	25%	100%
Q95NI4	Halichondria okadai	33%	100%
Q95NR9	Metridium senile	33%	100%
Q96GE6	Homo sapiens	22%	79%
Q9CQ19	Mus musculus	27%	90%
Q9CQ46	Mus musculus	30%	94%
Q9D6P8	Mus musculus	31%	100%
Q9FZ75	Arabidopsis thaliana	31%	98%
Q9GRJ1	Lumbricus rubellus	33%	100%
Q9HFY6	Blastocladiella emersonii	32%	100%
Q9JLK3	Mus musculus	31%	89%
Q9JLK4	Mus musculus	33%	71%
Q9JLK7	Mus musculus	32%	68%
Q9JM83	Mus musculus	28%	100%
Q9LE22	Arabidopsis thaliana	31%	91%
Q9LI84	Arabidopsis thaliana	31%	96%
Q9LIK5	Arabidopsis thaliana	31%	89%
Q9LQN4	Arabidopsis thaliana	26%	93%
Q9M8U1	Arabidopsis thaliana	27%	93%
Q9N1Q8	Bos taurus	33%	89%
Q9N1Q9	Bos taurus	34%	94%
Q9N1R0	Bos taurus	32%	68%
Q9NP86	Homo sapiens	32%	89%
Q9NPB3	Homo sapiens	33%	70%
Q9NZT1	Homo sapiens	31%	100%
Q9R1K9	Mus musculus	29%	90%
Q9S744	Arabidopsis thaliana	27%	100%
Q9SU00	Arabidopsis thaliana	26%	100%
Q9U6D3	Myxine glutinosa	32%	100%
Q9UB37	Branchiostoma lanceolatum	31%	100%
Q9UWF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	30%	100%
Q9XVI9	Caenorhabditis elegans	28%	100%
Q9XZP2	Branchiostoma floridae	33%	100%
Q9ZQE6	Arabidopsis thaliana	30%	82%