Putative putative dual-specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

putative dual-specificity protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGC1_LEIBR

TriTrypDb:

LbrM.28.0830 , LBRM2903_280013700

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGC1

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016311	dephosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0007165	signal transduction	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0004725	protein tyrosine phosphatase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.211
CLV_C14_Caspase3-7	441	445	PF00656	0.375
CLV_NRD_NRD_1	117	119	PF00675	0.510
CLV_NRD_NRD_1	151	153	PF00675	0.510
CLV_NRD_NRD_1	271	273	PF00675	0.539
CLV_NRD_NRD_1	90	92	PF00675	0.586
CLV_PCSK_KEX2_1	117	119	PF00082	0.492
CLV_PCSK_KEX2_1	271	273	PF00082	0.546
CLV_PCSK_KEX2_1	90	92	PF00082	0.569
CLV_PCSK_SKI1_1	117	121	PF00082	0.487
CLV_PCSK_SKI1_1	352	356	PF00082	0.560
CLV_PCSK_SKI1_1	452	456	PF00082	0.585
CLV_PCSK_SKI1_1	460	464	PF00082	0.559
CLV_PCSK_SKI1_1	544	548	PF00082	0.340
CLV_PCSK_SKI1_1	600	604	PF00082	0.228
DEG_APCC_DBOX_1	603	611	PF00400	0.531
DEG_Nend_UBRbox_2	1	3	PF02207	0.365
DEG_SPOP_SBC_1	109	113	PF00917	0.252
DOC_CYCLIN_RxL_1	215	225	PF00134	0.242
DOC_CYCLIN_RxL_1	541	551	PF00134	0.353
DOC_CYCLIN_yCln2_LP_2	411	417	PF00134	0.298
DOC_MAPK_gen_1	117	124	PF00069	0.317
DOC_MAPK_gen_1	245	253	PF00069	0.383
DOC_MAPK_gen_1	452	461	PF00069	0.228
DOC_MAPK_MEF2A_6	207	216	PF00069	0.207
DOC_MAPK_MEF2A_6	455	463	PF00069	0.222
DOC_PP1_RVXF_1	216	223	PF00149	0.188
DOC_PP1_RVXF_1	482	488	PF00149	0.369
DOC_PP2B_LxvP_1	418	421	PF13499	0.342
DOC_USP7_MATH_1	110	114	PF00917	0.331
DOC_USP7_MATH_1	404	408	PF00917	0.256
DOC_USP7_MATH_1	478	482	PF00917	0.385
DOC_USP7_MATH_1	499	503	PF00917	0.350
DOC_USP7_MATH_1	523	527	PF00917	0.263
DOC_USP7_MATH_1	581	585	PF00917	0.478
DOC_WW_Pin1_4	126	131	PF00397	0.266
DOC_WW_Pin1_4	339	344	PF00397	0.264
LIG_14-3-3_CanoR_1	218	223	PF00244	0.297
LIG_14-3-3_CanoR_1	371	377	PF00244	0.350
LIG_APCC_ABBA_1	419	424	PF00400	0.349
LIG_BRCT_BRCA1_1	411	415	PF00533	0.272
LIG_BRCT_BRCA1_1	468	472	PF00533	0.334
LIG_deltaCOP1_diTrp_1	431	439	PF00928	0.379
LIG_FHA_1	129	135	PF00498	0.337
LIG_FHA_1	204	210	PF00498	0.328
LIG_FHA_1	456	462	PF00498	0.320
LIG_FHA_1	504	510	PF00498	0.297
LIG_FHA_1	52	58	PF00498	0.227
LIG_FHA_1	617	623	PF00498	0.564
LIG_FHA_2	282	288	PF00498	0.314
LIG_FHA_2	439	445	PF00498	0.419
LIG_LIR_Gen_1	160	171	PF02991	0.344
LIG_LIR_Gen_1	221	231	PF02991	0.356
LIG_LIR_Gen_1	305	315	PF02991	0.325
LIG_LIR_Gen_1	364	373	PF02991	0.348
LIG_LIR_Gen_1	375	385	PF02991	0.262
LIG_LIR_Gen_1	412	423	PF02991	0.279
LIG_LIR_Gen_1	424	431	PF02991	0.339
LIG_LIR_Gen_1	480	488	PF02991	0.393
LIG_LIR_Gen_1	96	105	PF02991	0.272
LIG_LIR_Nem_3	160	166	PF02991	0.367
LIG_LIR_Nem_3	221	226	PF02991	0.256
LIG_LIR_Nem_3	228	232	PF02991	0.249
LIG_LIR_Nem_3	290	295	PF02991	0.286
LIG_LIR_Nem_3	305	311	PF02991	0.322
LIG_LIR_Nem_3	347	353	PF02991	0.312
LIG_LIR_Nem_3	364	370	PF02991	0.370
LIG_LIR_Nem_3	375	380	PF02991	0.254
LIG_LIR_Nem_3	412	418	PF02991	0.303
LIG_LIR_Nem_3	424	429	PF02991	0.378
LIG_LIR_Nem_3	430	435	PF02991	0.400
LIG_LIR_Nem_3	480	485	PF02991	0.439
LIG_LIR_Nem_3	496	500	PF02991	0.302
LIG_LIR_Nem_3	570	575	PF02991	0.524
LIG_LIR_Nem_3	74	79	PF02991	0.387
LIG_LIR_Nem_3	86	92	PF02991	0.313
LIG_LIR_Nem_3	96	102	PF02991	0.260
LIG_NRBOX	606	612	PF00104	0.536
LIG_PAM2_1	404	416	PF00658	0.328
LIG_Pex14_2	373	377	PF04695	0.303
LIG_Pex14_2	413	417	PF04695	0.279
LIG_Pex14_2	462	466	PF04695	0.311
LIG_REV1ctd_RIR_1	600	608	PF16727	0.566
LIG_RPA_C_Fungi	174	186	PF08784	0.208
LIG_SH2_CRK	163	167	PF00017	0.412
LIG_SH2_CRK	351	355	PF00017	0.430
LIG_SH2_CRK	482	486	PF00017	0.539
LIG_SH2_NCK_1	163	167	PF00017	0.352
LIG_SH2_NCK_1	308	312	PF00017	0.496
LIG_SH2_SRC	422	425	PF00017	0.435
LIG_SH2_STAP1	335	339	PF00017	0.571
LIG_SH2_STAP1	558	562	PF00017	0.347
LIG_SH2_STAT5	105	108	PF00017	0.376
LIG_SH2_STAT5	163	166	PF00017	0.379
LIG_SH2_STAT5	187	190	PF00017	0.403
LIG_SH2_STAT5	273	276	PF00017	0.462
LIG_SH2_STAT5	308	311	PF00017	0.411
LIG_SH2_STAT5	314	317	PF00017	0.318
LIG_SH2_STAT5	381	384	PF00017	0.481
LIG_SH2_STAT5	43	46	PF00017	0.463
LIG_SH2_STAT5	482	485	PF00017	0.543
LIG_SH2_STAT5	589	592	PF00017	0.490
LIG_SH3_3	119	125	PF00018	0.394
LIG_SH3_3	12	18	PF00018	0.331
LIG_SH3_3	517	523	PF00018	0.348
LIG_SH3_3	612	618	PF00018	0.418
LIG_Sin3_3	329	336	PF02671	0.404
LIG_Sin3_3	543	550	PF02671	0.322
LIG_SUMO_SIM_par_1	258	264	PF11976	0.309
LIG_SUMO_SIM_par_1	515	521	PF11976	0.499
LIG_SUMO_SIM_par_1	573	580	PF11976	0.357
LIG_SUMO_SIM_par_1	581	587	PF11976	0.313
LIG_UBA3_1	257	266	PF00899	0.454
LIG_UBA3_1	376	383	PF00899	0.434
LIG_WRC_WIRS_1	494	499	PF05994	0.410
MOD_CK1_1	20	26	PF00069	0.487
MOD_CK1_1	397	403	PF00069	0.376
MOD_CK1_1	510	516	PF00069	0.489
MOD_CK1_1	576	582	PF00069	0.423
MOD_CK1_1	584	590	PF00069	0.461
MOD_CK2_1	218	224	PF00069	0.229
MOD_CK2_1	281	287	PF00069	0.481
MOD_CK2_1	357	363	PF00069	0.417
MOD_CK2_1	372	378	PF00069	0.251
MOD_CK2_1	467	473	PF00069	0.520
MOD_GlcNHglycan	179	182	PF01048	0.355
MOD_GlcNHglycan	233	238	PF01048	0.323
MOD_GlcNHglycan	329	332	PF01048	0.249
MOD_GlcNHglycan	359	362	PF01048	0.416
MOD_GlcNHglycan	389	392	PF01048	0.614
MOD_GlcNHglycan	406	409	PF01048	0.357
MOD_GlcNHglycan	473	478	PF01048	0.604
MOD_GlcNHglycan	537	540	PF01048	0.398
MOD_GlcNHglycan	558	561	PF01048	0.272
MOD_GlcNHglycan	579	582	PF01048	0.407
MOD_GlcNHglycan	586	589	PF01048	0.401
MOD_GSK3_1	126	133	PF00069	0.350
MOD_GSK3_1	175	182	PF00069	0.392
MOD_GSK3_1	218	225	PF00069	0.295
MOD_GSK3_1	241	248	PF00069	0.562
MOD_GSK3_1	302	309	PF00069	0.554
MOD_GSK3_1	357	364	PF00069	0.321
MOD_GSK3_1	499	506	PF00069	0.498
MOD_GSK3_1	552	559	PF00069	0.394
MOD_GSK3_1	573	580	PF00069	0.390
MOD_N-GLC_1	245	250	PF02516	0.286
MOD_N-GLC_1	71	76	PF02516	0.393
MOD_N-GLC_2	66	68	PF02516	0.392
MOD_NEK2_1	120	125	PF00069	0.331
MOD_NEK2_1	222	227	PF00069	0.355
MOD_NEK2_1	4	9	PF00069	0.343
MOD_NEK2_1	42	47	PF00069	0.458
MOD_NEK2_1	466	471	PF00069	0.467
MOD_NEK2_1	533	538	PF00069	0.346
MOD_NEK2_1	554	559	PF00069	0.376
MOD_NEK2_1	562	567	PF00069	0.402
MOD_NEK2_1	59	64	PF00069	0.229
MOD_NEK2_1	624	629	PF00069	0.501
MOD_NEK2_2	372	377	PF00069	0.363
MOD_PIKK_1	499	505	PF00454	0.300
MOD_PIKK_1	518	524	PF00454	0.458
MOD_PIKK_1	91	97	PF00454	0.448
MOD_PK_1	179	185	PF00069	0.387
MOD_PKA_2	203	209	PF00069	0.368
MOD_PKA_2	387	393	PF00069	0.384
MOD_Plk_1	161	167	PF00069	0.436
MOD_Plk_1	605	611	PF00069	0.448
MOD_Plk_4	179	185	PF00069	0.377
MOD_Plk_4	218	224	PF00069	0.412
MOD_Plk_4	253	259	PF00069	0.359
MOD_Plk_4	273	279	PF00069	0.464
MOD_Plk_4	287	293	PF00069	0.352
MOD_Plk_4	372	378	PF00069	0.345
MOD_Plk_4	513	519	PF00069	0.546
MOD_Plk_4	573	579	PF00069	0.403
MOD_Plk_4	59	65	PF00069	0.221
MOD_Plk_4	606	612	PF00069	0.433
MOD_ProDKin_1	126	132	PF00069	0.306
MOD_ProDKin_1	339	345	PF00069	0.297
TRG_DiLeu_BaEn_1	140	145	PF01217	0.292
TRG_DiLeu_BaEn_1	431	436	PF01217	0.363
TRG_DiLeu_BaEn_1	606	611	PF01217	0.398
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.202
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.353
TRG_ENDOCYTIC_2	155	158	PF00928	0.511
TRG_ENDOCYTIC_2	163	166	PF00928	0.341
TRG_ENDOCYTIC_2	229	232	PF00928	0.233
TRG_ENDOCYTIC_2	292	295	PF00928	0.383
TRG_ENDOCYTIC_2	308	311	PF00928	0.309
TRG_ENDOCYTIC_2	350	353	PF00928	0.331
TRG_ENDOCYTIC_2	482	485	PF00928	0.583
TRG_ENDOCYTIC_2	76	79	PF00928	0.452
TRG_ER_diArg_1	117	119	PF00400	0.267
TRG_ER_diArg_1	271	273	PF00400	0.417
TRG_ER_diArg_1	89	91	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.221
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM74	Leptomonas seymouri	54%	100%
A0A1X0NYU6	Trypanosomatidae	28%	100%
A0A3S7X1C5	Leishmania donovani	79%	100%
A4I3F4	Leishmania infantum	78%	100%
D0A7Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AZP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q8J0	Leishmania major	78%	100%
V5BQB3	Trypanosoma cruzi	27%	100%