Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGB8_LEIBR

TriTrypDb:

LbrM.28.0800 , LBRM2903_280013500

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.510
CLV_NRD_NRD_1	228	230	PF00675	0.591
CLV_NRD_NRD_1	367	369	PF00675	0.559
CLV_NRD_NRD_1	476	478	PF00675	0.574
CLV_NRD_NRD_1	89	91	PF00675	0.511
CLV_PCSK_KEX2_1	167	169	PF00082	0.673
CLV_PCSK_KEX2_1	228	230	PF00082	0.525
CLV_PCSK_KEX2_1	367	369	PF00082	0.549
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.673
CLV_PCSK_SKI1_1	112	116	PF00082	0.500
CLV_PCSK_SKI1_1	162	166	PF00082	0.651
CLV_PCSK_SKI1_1	185	189	PF00082	0.646
CLV_PCSK_SKI1_1	205	209	PF00082	0.490
CLV_PCSK_SKI1_1	98	102	PF00082	0.355
DEG_APCC_DBOX_1	333	341	PF00400	0.580
DOC_CYCLIN_RxL_1	109	117	PF00134	0.500
DOC_CYCLIN_RxL_1	202	212	PF00134	0.283
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.619
DOC_PP1_RVXF_1	110	116	PF00149	0.500
DOC_PP1_RVXF_1	183	190	PF00149	0.284
DOC_PP1_RVXF_1	221	228	PF00149	0.447
DOC_PP2B_LxvP_1	100	103	PF13499	0.392
DOC_PP4_FxxP_1	35	38	PF00568	0.641
DOC_USP7_MATH_1	139	143	PF00917	0.483
DOC_USP7_MATH_1	155	159	PF00917	0.318
DOC_USP7_MATH_1	343	347	PF00917	0.537
DOC_USP7_MATH_1	55	59	PF00917	0.681
DOC_USP7_UBL2_3	40	44	PF12436	0.549
DOC_WW_Pin1_4	180	185	PF00397	0.287
LIG_14-3-3_CanoR_1	193	199	PF00244	0.260
LIG_14-3-3_CanoR_1	351	355	PF00244	0.639
LIG_14-3-3_CanoR_1	383	389	PF00244	0.681
LIG_APCC_ABBA_1	422	427	PF00400	0.831
LIG_BIR_III_4	443	447	PF00653	0.583
LIG_BRCT_BRCA1_1	123	127	PF00533	0.419
LIG_BRCT_BRCA1_1	223	227	PF00533	0.447
LIG_Clathr_ClatBox_1	56	60	PF01394	0.682
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.407
LIG_FHA_1	124	130	PF00498	0.462
LIG_FHA_1	139	145	PF00498	0.296
LIG_FHA_1	437	443	PF00498	0.729
LIG_FHA_1	48	54	PF00498	0.756
LIG_FHA_1	77	83	PF00498	0.646
LIG_FHA_2	210	216	PF00498	0.389
LIG_FHA_2	404	410	PF00498	0.737
LIG_FHA_2	418	424	PF00498	0.680
LIG_GBD_Chelix_1	106	114	PF00786	0.500
LIG_LIR_Apic_2	33	38	PF02991	0.638
LIG_LIR_Gen_1	25	34	PF02991	0.554
LIG_LIR_Gen_1	386	397	PF02991	0.697
LIG_LIR_Gen_1	431	442	PF02991	0.721
LIG_LIR_Gen_1	58	64	PF02991	0.556
LIG_LIR_Nem_3	25	29	PF02991	0.556
LIG_LIR_Nem_3	265	270	PF02991	0.416
LIG_LIR_Nem_3	271	277	PF02991	0.417
LIG_LIR_Nem_3	301	307	PF02991	0.359
LIG_LIR_Nem_3	313	319	PF02991	0.555
LIG_LIR_Nem_3	358	364	PF02991	0.725
LIG_LIR_Nem_3	386	392	PF02991	0.736
LIG_LIR_Nem_3	58	62	PF02991	0.552
LIG_MYND_1	99	103	PF01753	0.555
LIG_NRBOX	105	111	PF00104	0.500
LIG_Pex14_2	263	267	PF04695	0.391
LIG_PTB_Apo_2	29	36	PF02174	0.581
LIG_REV1ctd_RIR_1	264	272	PF16727	0.436
LIG_SH2_CRK	389	393	PF00017	0.770
LIG_SH2_NCK_1	389	393	PF00017	0.609
LIG_SH2_STAT3	20	23	PF00017	0.694
LIG_SH2_STAT5	34	37	PF00017	0.552
LIG_SH2_STAT5	348	351	PF00017	0.640
LIG_SH2_STAT5	453	456	PF00017	0.676
LIG_SH3_3	12	18	PF00018	0.577
LIG_SH3_4	37	44	PF00018	0.680
LIG_TRAF2_1	212	215	PF00917	0.428
LIG_TRAF2_1	456	459	PF00917	0.752
LIG_WRC_WIRS_1	263	268	PF05994	0.427
LIG_WRC_WIRS_1	299	304	PF05994	0.300
LIG_WRC_WIRS_1	56	61	PF05994	0.496
MOD_CDK_SPK_2	180	185	PF00069	0.287
MOD_CK1_1	123	129	PF00069	0.379
MOD_CK1_1	166	172	PF00069	0.329
MOD_CK1_1	209	215	PF00069	0.357
MOD_CK1_1	233	239	PF00069	0.430
MOD_CK1_1	374	380	PF00069	0.726
MOD_CK1_1	4	10	PF00069	0.776
MOD_CK1_1	417	423	PF00069	0.845
MOD_CK2_1	209	215	PF00069	0.390
MOD_CK2_1	307	313	PF00069	0.604
MOD_CK2_1	353	359	PF00069	0.701
MOD_CK2_1	403	409	PF00069	0.724
MOD_CK2_1	417	423	PF00069	0.636
MOD_CK2_1	453	459	PF00069	0.662
MOD_GlcNHglycan	147	151	PF01048	0.586
MOD_GlcNHglycan	168	171	PF01048	0.632
MOD_GlcNHglycan	236	239	PF01048	0.644
MOD_GlcNHglycan	286	289	PF01048	0.577
MOD_GlcNHglycan	307	310	PF01048	0.488
MOD_GlcNHglycan	361	364	PF01048	0.465
MOD_GlcNHglycan	372	376	PF01048	0.453
MOD_GlcNHglycan	455	458	PF01048	0.532
MOD_GlcNHglycan	6	9	PF01048	0.486
MOD_GlcNHglycan	64	67	PF01048	0.501
MOD_GSK3_1	166	173	PF00069	0.438
MOD_GSK3_1	230	237	PF00069	0.436
MOD_GSK3_1	284	291	PF00069	0.398
MOD_GSK3_1	307	314	PF00069	0.607
MOD_GSK3_1	323	330	PF00069	0.525
MOD_GSK3_1	350	357	PF00069	0.680
MOD_GSK3_1	370	377	PF00069	0.714
MOD_GSK3_1	403	410	PF00069	0.680
MOD_N-GLC_1	221	226	PF02516	0.459
MOD_N-GLC_1	284	289	PF02516	0.665
MOD_N-GLC_2	194	196	PF02516	0.478
MOD_NEK2_1	129	134	PF00069	0.343
MOD_NEK2_1	146	151	PF00069	0.325
MOD_NEK2_1	156	161	PF00069	0.419
MOD_NEK2_1	199	204	PF00069	0.390
MOD_NEK2_1	284	289	PF00069	0.449
MOD_NEK2_2	245	250	PF00069	0.345
MOD_PIKK_1	215	221	PF00454	0.444
MOD_PIKK_1	471	477	PF00454	0.596
MOD_PKA_1	370	376	PF00069	0.769
MOD_PKA_2	139	145	PF00069	0.422
MOD_PKA_2	305	311	PF00069	0.687
MOD_PKA_2	350	356	PF00069	0.687
MOD_PKA_2	382	388	PF00069	0.677
MOD_PKB_1	368	376	PF00069	0.764
MOD_Plk_1	156	162	PF00069	0.493
MOD_Plk_1	221	227	PF00069	0.373
MOD_Plk_1	371	377	PF00069	0.753
MOD_Plk_1	435	441	PF00069	0.789
MOD_Plk_1	76	82	PF00069	0.659
MOD_Plk_2-3	336	342	PF00069	0.704
MOD_Plk_4	194	200	PF00069	0.434
MOD_Plk_4	262	268	PF00069	0.393
MOD_Plk_4	311	317	PF00069	0.576
MOD_Plk_4	350	356	PF00069	0.606
MOD_Plk_4	436	442	PF00069	0.773
MOD_ProDKin_1	180	186	PF00069	0.285
MOD_SUMO_rev_2	324	331	PF00179	0.695
MOD_SUMO_rev_2	474	480	PF00179	0.604
TRG_DiLeu_BaEn_1	77	82	PF01217	0.591
TRG_DiLeu_BaEn_1	97	102	PF01217	0.612
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.626
TRG_ENDOCYTIC_2	316	319	PF00928	0.611
TRG_ENDOCYTIC_2	389	392	PF00928	0.775
TRG_ER_diArg_1	227	229	PF00400	0.353
TRG_ER_diArg_1	366	368	PF00400	0.759
TRG_ER_diLys_1	478	481	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PES7	Leptomonas seymouri	37%	100%
A0A1X0NYH6	Trypanosomatidae	24%	85%
A0A3Q8ID12	Leishmania donovani	74%	100%
A4I3F2	Leishmania infantum	74%	100%
E9AZN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q8J2	Leishmania major	76%	100%