Putative DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGB7_LEIBR

TriTrypDb:

LbrM.28.0790 , LBRM2903_280013400

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGB7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016491	oxidoreductase activity	2	11
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051213	dioxygenase activity	3	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0140658	ATP-dependent chromatin remodeler activity	3	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	455	459	PF00656	0.268
CLV_C14_Caspase3-7	648	652	PF00656	0.400
CLV_C14_Caspase3-7	658	662	PF00656	0.474
CLV_C14_Caspase3-7	685	689	PF00656	0.512
CLV_NRD_NRD_1	185	187	PF00675	0.269
CLV_NRD_NRD_1	239	241	PF00675	0.238
CLV_NRD_NRD_1	338	340	PF00675	0.226
CLV_NRD_NRD_1	62	64	PF00675	0.316
CLV_NRD_NRD_1	644	646	PF00675	0.418
CLV_PCSK_KEX2_1	138	140	PF00082	0.237
CLV_PCSK_KEX2_1	149	151	PF00082	0.249
CLV_PCSK_KEX2_1	239	241	PF00082	0.239
CLV_PCSK_KEX2_1	251	253	PF00082	0.218
CLV_PCSK_KEX2_1	338	340	PF00082	0.226
CLV_PCSK_KEX2_1	62	64	PF00082	0.237
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.237
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.237
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.226
CLV_PCSK_SKI1_1	124	128	PF00082	0.253
CLV_PCSK_SKI1_1	138	142	PF00082	0.208
CLV_PCSK_SKI1_1	186	190	PF00082	0.246
CLV_PCSK_SKI1_1	252	256	PF00082	0.226
CLV_PCSK_SKI1_1	349	353	PF00082	0.237
CLV_PCSK_SKI1_1	383	387	PF00082	0.250
CLV_PCSK_SKI1_1	507	511	PF00082	0.383
CLV_PCSK_SKI1_1	575	579	PF00082	0.229
CLV_PCSK_SKI1_1	581	585	PF00082	0.222
CLV_PCSK_SKI1_1	62	66	PF00082	0.269
CLV_PCSK_SKI1_1	655	659	PF00082	0.459
CLV_PCSK_SKI1_1	70	74	PF00082	0.207
DEG_APCC_DBOX_1	348	356	PF00400	0.448
DEG_APCC_DBOX_1	506	514	PF00400	0.360
DEG_MDM2_SWIB_1	246	254	PF02201	0.426
DEG_Nend_UBRbox_3	1	3	PF02207	0.304
DEG_SPOP_SBC_1	687	691	PF00917	0.474
DOC_ANK_TNKS_1	62	69	PF00023	0.437
DOC_CDC14_PxL_1	301	309	PF14671	0.437
DOC_CYCLIN_RxL_1	133	146	PF00134	0.530
DOC_CYCLIN_yClb1_LxF_4	296	302	PF00134	0.437
DOC_MAPK_gen_1	158	166	PF00069	0.437
DOC_MAPK_gen_1	181	190	PF00069	0.432
DOC_MAPK_HePTP_8	578	590	PF00069	0.426
DOC_MAPK_MEF2A_6	183	192	PF00069	0.467
DOC_MAPK_MEF2A_6	36	45	PF00069	0.437
DOC_MAPK_MEF2A_6	581	590	PF00069	0.426
DOC_PP1_RVXF_1	122	129	PF00149	0.426
DOC_PP1_RVXF_1	137	144	PF00149	0.426
DOC_PP1_RVXF_1	522	529	PF00149	0.426
DOC_SPAK_OSR1_1	628	632	PF12202	0.390
DOC_USP7_MATH_1	659	663	PF00917	0.557
DOC_USP7_MATH_1	66	70	PF00917	0.519
DOC_USP7_MATH_1	687	691	PF00917	0.720
DOC_USP7_MATH_1	704	708	PF00917	0.494
DOC_USP7_MATH_1	728	732	PF00917	0.468
DOC_USP7_MATH_1	85	89	PF00917	0.333
DOC_USP7_UBL2_3	183	187	PF12436	0.500
DOC_USP7_UBL2_3	354	358	PF12436	0.499
DOC_WW_Pin1_4	283	288	PF00397	0.426
DOC_WW_Pin1_4	431	436	PF00397	0.341
DOC_WW_Pin1_4	715	720	PF00397	0.687
LIG_14-3-3_CanoR_1	186	191	PF00244	0.529
LIG_14-3-3_CanoR_1	233	238	PF00244	0.364
LIG_14-3-3_CanoR_1	262	272	PF00244	0.426
LIG_14-3-3_CanoR_1	280	288	PF00244	0.426
LIG_14-3-3_CanoR_1	566	576	PF00244	0.431
LIG_14-3-3_CanoR_1	70	75	PF00244	0.446
LIG_14-3-3_CanoR_1	80	84	PF00244	0.417
LIG_Actin_WH2_2	325	340	PF00022	0.426
LIG_Actin_WH2_2	391	408	PF00022	0.527
LIG_AP2alpha_2	600	602	PF02296	0.426
LIG_BRCT_BRCA1_1	440	444	PF00533	0.181
LIG_BRCT_BRCA1_1	477	481	PF00533	0.423
LIG_BRCT_BRCA1_2	477	483	PF00533	0.383
LIG_deltaCOP1_diTrp_1	123	132	PF00928	0.416
LIG_FHA_1	1	7	PF00498	0.455
LIG_FHA_1	102	108	PF00498	0.525
LIG_FHA_1	160	166	PF00498	0.426
LIG_FHA_1	187	193	PF00498	0.486
LIG_FHA_1	313	319	PF00498	0.364
LIG_FHA_1	357	363	PF00498	0.451
LIG_FHA_1	487	493	PF00498	0.313
LIG_FHA_1	553	559	PF00498	0.439
LIG_FHA_1	625	631	PF00498	0.341
LIG_FHA_2	15	21	PF00498	0.364
LIG_FHA_2	201	207	PF00498	0.434
LIG_FHA_2	211	217	PF00498	0.420
LIG_FHA_2	656	662	PF00498	0.501
LIG_LIR_Apic_2	600	605	PF02991	0.426
LIG_LIR_Gen_1	123	132	PF02991	0.416
LIG_LIR_Gen_1	151	160	PF02991	0.437
LIG_LIR_Gen_1	206	215	PF02991	0.426
LIG_LIR_Gen_1	372	380	PF02991	0.438
LIG_LIR_Gen_1	393	402	PF02991	0.451
LIG_LIR_Gen_1	474	481	PF02991	0.478
LIG_LIR_Gen_1	529	538	PF02991	0.426
LIG_LIR_LC3C_4	162	165	PF02991	0.451
LIG_LIR_Nem_3	114	118	PF02991	0.428
LIG_LIR_Nem_3	123	128	PF02991	0.407
LIG_LIR_Nem_3	151	155	PF02991	0.437
LIG_LIR_Nem_3	206	211	PF02991	0.426
LIG_LIR_Nem_3	213	218	PF02991	0.426
LIG_LIR_Nem_3	266	272	PF02991	0.426
LIG_LIR_Nem_3	372	378	PF02991	0.427
LIG_LIR_Nem_3	393	399	PF02991	0.451
LIG_LIR_Nem_3	474	480	PF02991	0.480
LIG_LIR_Nem_3	529	534	PF02991	0.426
LIG_NRBOX	294	300	PF00104	0.492
LIG_PDZ_Class_1	731	736	PF00595	0.697
LIG_Pex14_2	128	132	PF04695	0.433
LIG_Pex14_2	246	250	PF04695	0.437
LIG_Pex14_2	477	481	PF04695	0.491
LIG_PTB_Apo_2	494	501	PF02174	0.426
LIG_SH2_CRK	115	119	PF00017	0.500
LIG_SH2_CRK	215	219	PF00017	0.448
LIG_SH2_CRK	375	379	PF00017	0.426
LIG_SH2_NCK_1	545	549	PF00017	0.500
LIG_SH2_SRC	191	194	PF00017	0.469
LIG_SH2_STAP1	55	59	PF00017	0.500
LIG_SH2_STAT3	55	58	PF00017	0.500
LIG_SH2_STAT5	191	194	PF00017	0.469
LIG_SH2_STAT5	625	628	PF00017	0.369
LIG_SH2_STAT5	638	641	PF00017	0.306
LIG_SH2_STAT5	680	683	PF00017	0.571
LIG_SH3_3	161	167	PF00018	0.426
LIG_SH3_3	302	308	PF00018	0.448
LIG_SH3_3	350	356	PF00018	0.426
LIG_SH3_3	595	601	PF00018	0.437
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.426
LIG_SUMO_SIM_par_1	536	541	PF11976	0.409
LIG_SUMO_SIM_par_1	595	600	PF11976	0.426
LIG_TRAF2_1	271	274	PF00917	0.525
LIG_TRAF2_1	606	609	PF00917	0.426
LIG_UBA3_1	245	251	PF00899	0.525
LIG_UBA3_1	674	679	PF00899	0.612
LIG_WRC_WIRS_1	205	210	PF05994	0.500
LIG_WRC_WIRS_1	531	536	PF05994	0.426
MOD_CK1_1	221	227	PF00069	0.566
MOD_CK1_1	412	418	PF00069	0.622
MOD_CK1_1	430	436	PF00069	0.162
MOD_CK1_1	529	535	PF00069	0.436
MOD_CK1_1	715	721	PF00069	0.772
MOD_CK1_1	99	105	PF00069	0.400
MOD_CK2_1	14	20	PF00069	0.364
MOD_CK2_1	173	179	PF00069	0.426
MOD_CK2_1	198	204	PF00069	0.426
MOD_CK2_1	365	371	PF00069	0.426
MOD_CK2_1	706	712	PF00069	0.772
MOD_GlcNHglycan	133	136	PF01048	0.164
MOD_GlcNHglycan	220	223	PF01048	0.237
MOD_GlcNHglycan	383	386	PF01048	0.292
MOD_GlcNHglycan	661	664	PF01048	0.491
MOD_GlcNHglycan	708	711	PF01048	0.735
MOD_GSK3_1	107	114	PF00069	0.472
MOD_GSK3_1	173	180	PF00069	0.448
MOD_GSK3_1	182	189	PF00069	0.468
MOD_GSK3_1	194	201	PF00069	0.439
MOD_GSK3_1	210	217	PF00069	0.370
MOD_GSK3_1	324	331	PF00069	0.525
MOD_GSK3_1	365	372	PF00069	0.428
MOD_GSK3_1	381	388	PF00069	0.437
MOD_GSK3_1	427	434	PF00069	0.301
MOD_GSK3_1	467	474	PF00069	0.392
MOD_GSK3_1	481	488	PF00069	0.436
MOD_GSK3_1	526	533	PF00069	0.426
MOD_GSK3_1	552	559	PF00069	0.426
MOD_GSK3_1	577	584	PF00069	0.436
MOD_GSK3_1	655	662	PF00069	0.475
MOD_GSK3_1	66	73	PF00069	0.551
MOD_GSK3_1	713	720	PF00069	0.673
MOD_GSK3_1	95	102	PF00069	0.513
MOD_N-GLC_1	588	593	PF02516	0.226
MOD_N-GLC_1	712	717	PF02516	0.674
MOD_N-GLC_1	85	90	PF02516	0.237
MOD_NEK2_1	107	112	PF00069	0.511
MOD_NEK2_1	210	215	PF00069	0.426
MOD_NEK2_1	218	223	PF00069	0.426
MOD_NEK2_1	324	329	PF00069	0.525
MOD_NEK2_1	34	39	PF00069	0.437
MOD_NEK2_1	374	379	PF00069	0.439
MOD_NEK2_1	481	486	PF00069	0.526
MOD_NEK2_1	500	505	PF00069	0.185
MOD_NEK2_1	556	561	PF00069	0.447
MOD_NEK2_1	588	593	PF00069	0.437
MOD_PIKK_1	14	20	PF00454	0.366
MOD_PIKK_1	263	269	PF00454	0.426
MOD_PIKK_1	412	418	PF00454	0.600
MOD_PIKK_1	486	492	PF00454	0.540
MOD_PIKK_1	526	532	PF00454	0.525
MOD_PIKK_1	688	694	PF00454	0.488
MOD_PIKK_1	99	105	PF00454	0.364
MOD_PKA_1	186	192	PF00069	0.486
MOD_PKA_1	482	488	PF00069	0.333
MOD_PKA_2	369	375	PF00069	0.482
MOD_PKA_2	79	85	PF00069	0.451
MOD_Plk_1	19	25	PF00069	0.437
MOD_Plk_1	85	91	PF00069	0.451
MOD_Plk_1	95	101	PF00069	0.447
MOD_Plk_2-3	204	210	PF00069	0.525
MOD_Plk_4	374	380	PF00069	0.465
MOD_Plk_4	409	415	PF00069	0.500
MOD_Plk_4	476	482	PF00069	0.426
MOD_Plk_4	530	536	PF00069	0.426
MOD_Plk_4	96	102	PF00069	0.480
MOD_ProDKin_1	283	289	PF00069	0.426
MOD_ProDKin_1	431	437	PF00069	0.341
MOD_ProDKin_1	715	721	PF00069	0.689
MOD_SUMO_for_1	357	360	PF00179	0.426
MOD_SUMO_rev_2	176	182	PF00179	0.426
TRG_DiLeu_BaEn_1	159	164	PF01217	0.451
TRG_DiLeu_BaEn_1	67	72	PF01217	0.500
TRG_DiLeu_BaEn_2	205	211	PF01217	0.426
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.542
TRG_DiLeu_LyEn_5	67	72	PF01217	0.385
TRG_ENDOCYTIC_2	115	118	PF00928	0.500
TRG_ENDOCYTIC_2	215	218	PF00928	0.448
TRG_ENDOCYTIC_2	375	378	PF00928	0.426
TRG_ER_diArg_1	337	339	PF00400	0.426
TRG_ER_diArg_1	62	64	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.226
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM03	Leptomonas seymouri	78%	100%
A0A0N1PE28	Leptomonas seymouri	22%	73%
A0A0P0WGX7	Oryza sativa subsp. japonica	26%	75%
A0A0S4IWJ2	Bodo saltans	26%	74%
A0A0S4JCY2	Bodo saltans	55%	100%
A0A1X0NZ31	Trypanosomatidae	70%	98%
A0A1X0P4C3	Trypanosomatidae	29%	74%
A0A3R7MBR3	Trypanosoma rangeli	28%	75%
A0A3R7N379	Trypanosoma rangeli	23%	66%
A0A3S5H7I9	Leishmania donovani	90%	100%
A0A422N365	Trypanosoma rangeli	72%	98%
A0A451EJ80	Leishmania donovani	23%	80%
A4HEA7	Leishmania braziliensis	24%	76%
A4HRE5	Leishmania infantum	23%	95%
A4I3F1	Leishmania infantum	91%	100%
B0R061	Danio rerio	24%	76%
B4MX21	Drosophila willistoni	23%	94%
C9ZKA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	78%
D0A5K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	75%
D0A7Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	97%
D3Z9Z9	Rattus norvegicus	26%	72%
E1B7X9	Bos taurus	26%	72%
E7F1C4	Danio rerio	25%	77%
E9AJB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	79%
E9AZN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4J9M5	Arabidopsis thaliana	24%	67%
G5EDG2	Caenorhabditis elegans	26%	74%
O10302	Orgyia pseudotsugata multicapsid polyhedrosis virus	25%	100%
O13762	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	82%
O42861	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	80%
O55764	Invertebrate iridescent virus 6	24%	100%
O60177	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	71%
P34739	Drosophila melanogaster	28%	69%
P41447	Autographa californica nuclear polyhedrosis virus	25%	100%
P54509	Bacillus subtilis (strain 168)	22%	100%
P79051	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	85%
Q04692	Mus musculus	25%	72%
Q0PCS3	Arabidopsis thaliana	23%	81%
Q10332	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	89%
Q14527	Homo sapiens	25%	73%
Q4Q8J3	Leishmania major	90%	100%
Q5ACX1	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	68%
Q5FWR0	Xenopus tropicalis	28%	73%
Q60848	Mus musculus	26%	90%
Q6C2R8	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	72%
Q6CJM4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	66%
Q6PCN7	Mus musculus	25%	73%
Q6PFE3	Mus musculus	23%	83%
Q753V5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	68%
Q8W103	Arabidopsis thaliana	27%	68%
Q94BR5	Arabidopsis thaliana	26%	75%
Q95216	Oryctolagus cuniculus	27%	73%
Q9DG67	Gallus gallus	23%	80%
Q9FF61	Arabidopsis thaliana	27%	84%
Q9FNI6	Arabidopsis thaliana	27%	72%
Q9H4L7	Homo sapiens	26%	72%
Q9LHE4	Arabidopsis thaliana	27%	70%
Q9NRZ9	Homo sapiens	25%	88%
Q9VL72	Drosophila melanogaster	25%	87%
Q9ZUL5	Arabidopsis thaliana	26%	96%
V5B5G3	Trypanosoma cruzi	24%	100%
V5BKT9	Trypanosoma cruzi	70%	100%