Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGB5_LEIBR

TriTrypDb:

LbrM.28.0770 , LBRM2903_280013200

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.637
CLV_NRD_NRD_1	100	102	PF00675	0.636
CLV_NRD_NRD_1	205	207	PF00675	0.549
CLV_NRD_NRD_1	231	233	PF00675	0.676
CLV_NRD_NRD_1	37	39	PF00675	0.550
CLV_NRD_NRD_1	388	390	PF00675	0.693
CLV_PCSK_KEX2_1	138	140	PF00082	0.472
CLV_PCSK_KEX2_1	204	206	PF00082	0.560
CLV_PCSK_KEX2_1	388	390	PF00082	0.693
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.472
CLV_PCSK_PC7_1	200	206	PF00082	0.678
CLV_PCSK_SKI1_1	104	108	PF00082	0.629
CLV_PCSK_SKI1_1	221	225	PF00082	0.472
CLV_PCSK_SKI1_1	233	237	PF00082	0.620
CLV_PCSK_SKI1_1	270	274	PF00082	0.548
CLV_PCSK_SKI1_1	305	309	PF00082	0.645
CLV_PCSK_SKI1_1	330	334	PF00082	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.546
DOC_CYCLIN_RxL_1	101	111	PF00134	0.647
DOC_MAPK_gen_1	101	108	PF00069	0.627
DOC_MAPK_gen_1	215	224	PF00069	0.567
DOC_MAPK_JIP1_4	102	108	PF00069	0.695
DOC_PP2B_LxvP_1	377	380	PF13499	0.654
DOC_USP7_MATH_1	262	266	PF00917	0.552
DOC_USP7_MATH_1	315	319	PF00917	0.497
DOC_USP7_UBL2_3	326	330	PF12436	0.558
DOC_WW_Pin1_4	144	149	PF00397	0.643
DOC_WW_Pin1_4	357	362	PF00397	0.565
LIG_14-3-3_CanoR_1	104	109	PF00244	0.649
LIG_14-3-3_CanoR_1	159	168	PF00244	0.516
LIG_14-3-3_CanoR_1	215	220	PF00244	0.594
LIG_14-3-3_CanoR_1	225	229	PF00244	0.480
LIG_14-3-3_CanoR_1	270	275	PF00244	0.451
LIG_14-3-3_CanoR_1	277	283	PF00244	0.682
LIG_14-3-3_CanoR_1	317	323	PF00244	0.524
LIG_FHA_1	11	17	PF00498	0.546
LIG_FHA_1	271	277	PF00498	0.560
LIG_FHA_1	372	378	PF00498	0.707
LIG_FHA_1	70	76	PF00498	0.643
LIG_FHA_2	159	165	PF00498	0.530
LIG_FHA_2	225	231	PF00498	0.670
LIG_FHA_2	250	256	PF00498	0.535
LIG_FHA_2	290	296	PF00498	0.613
LIG_FHA_2	358	364	PF00498	0.617
LIG_LIR_Apic_2	345	349	PF02991	0.641
LIG_LIR_Apic_2	370	376	PF02991	0.697
LIG_LIR_Gen_1	162	173	PF02991	0.544
LIG_LIR_Gen_1	193	203	PF02991	0.553
LIG_LIR_Gen_1	53	64	PF02991	0.545
LIG_LIR_Nem_3	162	168	PF02991	0.614
LIG_LIR_Nem_3	193	198	PF02991	0.564
LIG_LIR_Nem_3	207	213	PF02991	0.533
LIG_LIR_Nem_3	53	59	PF02991	0.543
LIG_Pex14_1	306	310	PF04695	0.524
LIG_PTB_Apo_2	275	282	PF02174	0.649
LIG_PTB_Apo_2	340	347	PF02174	0.565
LIG_PTB_Phospho_1	275	281	PF10480	0.648
LIG_PTB_Phospho_1	340	346	PF10480	0.563
LIG_SH2_CRK	56	60	PF00017	0.582
LIG_SH2_GRB2like	56	59	PF00017	0.591
LIG_SH2_NCK_1	195	199	PF00017	0.567
LIG_SH2_NCK_1	259	263	PF00017	0.594
LIG_SH2_NCK_1	310	314	PF00017	0.431
LIG_SH2_NCK_1	359	363	PF00017	0.634
LIG_SH2_NCK_1	56	60	PF00017	0.538
LIG_SH2_SRC	259	262	PF00017	0.480
LIG_SH2_STAP1	310	314	PF00017	0.433
LIG_SH2_STAP1	369	373	PF00017	0.644
LIG_SH2_STAT3	30	33	PF00017	0.662
LIG_SH2_STAT5	149	152	PF00017	0.455
LIG_SH2_STAT5	165	168	PF00017	0.529
LIG_SH2_STAT5	340	343	PF00017	0.506
LIG_SH2_STAT5	359	362	PF00017	0.482
LIG_SH2_STAT5	369	372	PF00017	0.536
LIG_SH2_STAT5	373	376	PF00017	0.533
LIG_SH2_STAT5	56	59	PF00017	0.546
LIG_SH3_3	15	21	PF00018	0.585
LIG_SH3_3	38	44	PF00018	0.545
LIG_TYR_ITIM	54	59	PF00017	0.540
LIG_WW_3	16	20	PF00397	0.585
MOD_CK1_1	97	103	PF00069	0.672
MOD_CK2_1	223	229	PF00069	0.635
MOD_CK2_1	241	247	PF00069	0.467
MOD_CK2_1	249	255	PF00069	0.586
MOD_CK2_1	357	363	PF00069	0.623
MOD_GlcNHglycan	172	176	PF01048	0.546
MOD_GlcNHglycan	243	246	PF01048	0.523
MOD_GlcNHglycan	311	314	PF01048	0.579
MOD_GlcNHglycan	6	9	PF01048	0.546
MOD_GlcNHglycan	85	89	PF01048	0.512
MOD_GlcNHglycan	96	99	PF01048	0.485
MOD_GSK3_1	104	111	PF00069	0.559
MOD_GSK3_1	224	231	PF00069	0.572
MOD_GSK3_1	262	269	PF00069	0.466
MOD_GSK3_1	305	312	PF00069	0.592
MOD_GSK3_1	367	374	PF00069	0.763
MOD_GSK3_1	379	386	PF00069	0.684
MOD_GSK3_1	46	53	PF00069	0.571
MOD_N-GLC_1	270	275	PF02516	0.543
MOD_N-GLC_1	75	80	PF02516	0.607
MOD_NEK2_1	108	113	PF00069	0.568
MOD_NEK2_1	223	228	PF00069	0.498
MOD_NEK2_1	249	254	PF00069	0.627
MOD_NEK2_1	276	281	PF00069	0.718
MOD_NEK2_1	289	294	PF00069	0.560
MOD_NEK2_1	4	9	PF00069	0.566
MOD_NEK2_1	54	59	PF00069	0.616
MOD_NEK2_1	75	80	PF00069	0.560
MOD_PIKK_1	281	287	PF00454	0.555
MOD_PIKK_1	289	295	PF00454	0.486
MOD_PIKK_1	75	81	PF00454	0.589
MOD_PKA_2	158	164	PF00069	0.522
MOD_PKA_2	224	230	PF00069	0.600
MOD_PKA_2	276	282	PF00069	0.680
MOD_PKA_2	316	322	PF00069	0.528
MOD_PKB_1	204	212	PF00069	0.672
MOD_Plk_1	206	212	PF00069	0.668
MOD_Plk_1	262	268	PF00069	0.603
MOD_Plk_1	270	276	PF00069	0.636
MOD_Plk_1	45	51	PF00069	0.559
MOD_Plk_1	75	81	PF00069	0.612
MOD_Plk_2-3	316	322	PF00069	0.544
MOD_Plk_4	368	374	PF00069	0.691
MOD_Plk_4	379	385	PF00069	0.700
MOD_ProDKin_1	144	150	PF00069	0.648
MOD_ProDKin_1	357	363	PF00069	0.562
MOD_SUMO_for_1	137	140	PF00179	0.518
MOD_SUMO_rev_2	174	184	PF00179	0.436
TRG_AP2beta_CARGO_1	207	217	PF09066	0.574
TRG_ENDOCYTIC_2	165	168	PF00928	0.563
TRG_ENDOCYTIC_2	195	198	PF00928	0.564
TRG_ENDOCYTIC_2	369	372	PF00928	0.582
TRG_ENDOCYTIC_2	56	59	PF00928	0.541
TRG_ER_diArg_1	203	206	PF00400	0.551
TRG_NLS_MonoCore_2	100	105	PF00514	0.686
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT5	Leptomonas seymouri	65%	91%
A0A0S4JAK0	Bodo saltans	29%	100%
A0A1X0NYG9	Trypanosomatidae	50%	92%
A0A3Q8IEQ6	Leishmania donovani	84%	99%
A0A3R7KQJ1	Trypanosoma rangeli	49%	91%
A4I3E9	Leishmania infantum	85%	99%
D0A7Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	94%
E9AZN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q8J5	Leishmania major	85%	100%
V5BQC0	Trypanosoma cruzi	48%	90%