Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGB4_LEIBR

TriTrypDb:

LbrM.28.0760 , LBRM2903_280013100

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGB4

PDB structure(s): 7aih_Au , 7am2_Au , 7ane_Au

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.576
CLV_NRD_NRD_1	27	29	PF00675	0.638
CLV_NRD_NRD_1	9	11	PF00675	0.603
CLV_PCSK_KEX2_1	125	127	PF00082	0.577
CLV_PCSK_KEX2_1	137	139	PF00082	0.518
CLV_PCSK_KEX2_1	27	29	PF00082	0.661
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.612
CLV_PCSK_PC7_1	23	29	PF00082	0.651
CLV_PCSK_SKI1_1	10	14	PF00082	0.745
CLV_PCSK_SKI1_1	116	120	PF00082	0.515
CLV_PCSK_SKI1_1	43	47	PF00082	0.639
DEG_Nend_Nbox_1	1	3	PF02207	0.570
DOC_CKS1_1	112	117	PF01111	0.514
DOC_MAPK_gen_1	100	110	PF00069	0.558
DOC_MAPK_gen_1	137	145	PF00069	0.588
DOC_PP1_RVXF_1	114	120	PF00149	0.522
DOC_PP4_FxxP_1	50	53	PF00568	0.671
DOC_USP7_MATH_1	51	55	PF00917	0.582
DOC_USP7_UBL2_3	63	67	PF12436	0.631
DOC_WW_Pin1_4	111	116	PF00397	0.521
DOC_WW_Pin1_4	76	81	PF00397	0.563
LIG_14-3-3_CanoR_1	27	37	PF00244	0.637
LIG_14-3-3_CanoR_1	4	8	PF00244	0.605
LIG_deltaCOP1_diTrp_1	147	151	PF00928	0.540
LIG_EVH1_1	16	20	PF00568	0.592
LIG_FHA_1	112	118	PF00498	0.510
LIG_FHA_1	3	9	PF00498	0.560
LIG_IBAR_NPY_1	35	37	PF08397	0.650
LIG_LIR_Apic_2	48	53	PF02991	0.600
LIG_LIR_Nem_3	147	152	PF02991	0.524
LIG_LIR_Nem_3	84	88	PF02991	0.565
LIG_MAD2	93	101	PF02301	0.561
LIG_PCNA_PIPBox_1	142	151	PF02747	0.438
LIG_PCNA_yPIPBox_3	137	149	PF02747	0.446
LIG_PDZ_Wminus1_1	183	185	PF00595	0.550
LIG_Pex14_1	56	60	PF04695	0.485
LIG_PTB_Apo_2	44	51	PF02174	0.604
LIG_SH2_CRK	152	156	PF00017	0.532
LIG_SH2_STAP1	129	133	PF00017	0.703
LIG_SH2_STAP1	25	29	PF00017	0.687
LIG_SH2_STAT5	64	67	PF00017	0.525
LIG_SH3_1	106	112	PF00018	0.542
LIG_SH3_3	106	112	PF00018	0.542
LIG_SH3_3	14	20	PF00018	0.598
LIG_SH3_3	170	176	PF00018	0.547
LIG_SH3_3	74	80	PF00018	0.574
LIG_WW_3	18	22	PF00397	0.685
MOD_CDK_SPK_2	111	116	PF00069	0.521
MOD_CK1_1	31	37	PF00069	0.687
MOD_GSK3_1	27	34	PF00069	0.634
MOD_GSK3_1	51	58	PF00069	0.488
MOD_NEK2_1	2	7	PF00069	0.622
MOD_NEK2_1	41	46	PF00069	0.599
MOD_PKA_1	27	33	PF00069	0.623
MOD_PKA_2	102	108	PF00069	0.571
MOD_PKA_2	27	33	PF00069	0.646
MOD_PKA_2	3	9	PF00069	0.557
MOD_PKA_2	51	57	PF00069	0.499
MOD_Plk_4	3	9	PF00069	0.670
MOD_Plk_4	51	57	PF00069	0.499
MOD_ProDKin_1	111	117	PF00069	0.516
MOD_ProDKin_1	76	82	PF00069	0.570
TRG_ENDOCYTIC_2	152	155	PF00928	0.534
TRG_ENDOCYTIC_2	37	40	PF00928	0.606
TRG_ENDOCYTIC_2	85	88	PF00928	0.532
TRG_ER_diArg_1	137	139	PF00400	0.655
TRG_ER_diArg_1	158	161	PF00400	0.532
TRG_ER_diArg_1	20	23	PF00400	0.630
TRG_ER_diArg_1	27	29	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Y9	Leptomonas seymouri	89%	100%
A0A0S4J812	Bodo saltans	72%	100%
A0A1X0NYE8	Trypanosomatidae	76%	100%
A0A3R7RRY1	Trypanosoma rangeli	77%	100%
A0A3S7X1D1	Leishmania donovani	97%	100%
A4I3E8	Leishmania infantum	97%	100%
D0A7Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AZN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q8J6	Leishmania major	96%	100%