Sas10 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sas10/Utp3/C1D family/Sas10 C-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGB3_LEIBR

TriTrypDb:

LbrM.28.0750 , LBRM2903_280013000

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HGB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGB3

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.503
CLV_C14_Caspase3-7	128	132	PF00656	0.476
CLV_C14_Caspase3-7	15	19	PF00656	0.687
CLV_C14_Caspase3-7	27	31	PF00656	0.680
CLV_C14_Caspase3-7	50	54	PF00656	0.614
CLV_NRD_NRD_1	117	119	PF00675	0.546
CLV_NRD_NRD_1	12	14	PF00675	0.604
CLV_NRD_NRD_1	189	191	PF00675	0.234
CLV_NRD_NRD_1	228	230	PF00675	0.336
CLV_NRD_NRD_1	302	304	PF00675	0.454
CLV_NRD_NRD_1	380	382	PF00675	0.528
CLV_NRD_NRD_1	44	46	PF00675	0.567
CLV_NRD_NRD_1	460	462	PF00675	0.525
CLV_NRD_NRD_1	472	474	PF00675	0.471
CLV_NRD_NRD_1	481	483	PF00675	0.230
CLV_NRD_NRD_1	501	503	PF00675	0.183
CLV_NRD_NRD_1	51	53	PF00675	0.590
CLV_NRD_NRD_1	510	512	PF00675	0.334
CLV_NRD_NRD_1	95	97	PF00675	0.472
CLV_PCSK_FUR_1	300	304	PF00082	0.601
CLV_PCSK_KEX2_1	10	12	PF00082	0.609
CLV_PCSK_KEX2_1	117	119	PF00082	0.548
CLV_PCSK_KEX2_1	123	125	PF00082	0.612
CLV_PCSK_KEX2_1	228	230	PF00082	0.176
CLV_PCSK_KEX2_1	302	304	PF00082	0.561
CLV_PCSK_KEX2_1	379	381	PF00082	0.509
CLV_PCSK_KEX2_1	44	46	PF00082	0.499
CLV_PCSK_KEX2_1	472	474	PF00082	0.540
CLV_PCSK_KEX2_1	481	483	PF00082	0.235
CLV_PCSK_KEX2_1	51	53	PF00082	0.513
CLV_PCSK_KEX2_1	510	512	PF00082	0.314
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.609
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.606
CLV_PCSK_PC7_1	47	53	PF00082	0.550
CLV_PCSK_PC7_1	506	512	PF00082	0.314
CLV_PCSK_PC7_1	6	12	PF00082	0.493
CLV_PCSK_SKI1_1	124	128	PF00082	0.518
CLV_PCSK_SKI1_1	292	296	PF00082	0.563
CLV_PCSK_SKI1_1	307	311	PF00082	0.558
CLV_PCSK_SKI1_1	47	51	PF00082	0.636
CLV_PCSK_SKI1_1	492	496	PF00082	0.281
CLV_Separin_Metazoa	376	380	PF03568	0.623
DEG_APCC_DBOX_1	123	131	PF00400	0.417
DEG_APCC_DBOX_1	242	250	PF00400	0.431
DEG_APCC_DBOX_1	302	310	PF00400	0.469
DOC_CYCLIN_yClb5_NLxxxL_5	197	203	PF00134	0.456
DOC_MAPK_gen_1	510	519	PF00069	0.314
DOC_PP4_FxxP_1	288	291	PF00568	0.449
DOC_USP7_MATH_1	107	111	PF00917	0.537
DOC_USP7_MATH_1	112	116	PF00917	0.414
DOC_USP7_MATH_1	279	283	PF00917	0.651
DOC_USP7_MATH_1	403	407	PF00917	0.784
DOC_USP7_UBL2_3	10	14	PF12436	0.598
DOC_USP7_UBL2_3	483	487	PF12436	0.281
DOC_USP7_UBL2_3	93	97	PF12436	0.538
DOC_WW_Pin1_4	156	161	PF00397	0.401
DOC_WW_Pin1_4	287	292	PF00397	0.449
LIG_14-3-3_CanoR_1	190	199	PF00244	0.373
LIG_14-3-3_CanoR_1	267	274	PF00244	0.675
LIG_14-3-3_CanoR_1	461	467	PF00244	0.425
LIG_14-3-3_CanoR_1	96	104	PF00244	0.510
LIG_Actin_WH2_2	319	337	PF00022	0.389
LIG_APCC_ABBA_1	242	247	PF00400	0.431
LIG_BIR_III_2	131	135	PF00653	0.554
LIG_BRCT_BRCA1_1	289	293	PF00533	0.442
LIG_BRCT_BRCA1_1	523	527	PF00533	0.411
LIG_eIF4E_1	258	264	PF01652	0.392
LIG_FHA_1	216	222	PF00498	0.431
LIG_FHA_1	383	389	PF00498	0.497
LIG_FHA_2	145	151	PF00498	0.469
LIG_FHA_2	48	54	PF00498	0.721
LIG_FHA_2	97	103	PF00498	0.545
LIG_LIR_Gen_1	140	149	PF02991	0.449
LIG_LIR_Gen_1	218	226	PF02991	0.431
LIG_LIR_Gen_1	354	364	PF02991	0.538
LIG_LIR_Gen_1	412	421	PF02991	0.507
LIG_LIR_Gen_1	441	450	PF02991	0.515
LIG_LIR_Gen_1	57	67	PF02991	0.605
LIG_LIR_Nem_3	140	146	PF02991	0.460
LIG_LIR_Nem_3	218	223	PF02991	0.431
LIG_LIR_Nem_3	354	360	PF02991	0.530
LIG_LIR_Nem_3	441	447	PF02991	0.518
LIG_LIR_Nem_3	532	538	PF02991	0.281
LIG_LIR_Nem_3	57	63	PF02991	0.616
LIG_NRBOX	161	167	PF00104	0.503
LIG_NRBOX	259	265	PF00104	0.300
LIG_PCNA_yPIPBox_3	255	264	PF02747	0.382
LIG_PDZ_Class_1	546	551	PF00595	0.411
LIG_REV1ctd_RIR_1	354	363	PF16727	0.629
LIG_SH2_STAP1	188	192	PF00017	0.550
LIG_SH2_STAP1	444	448	PF00017	0.502
LIG_SH2_STAT5	213	216	PF00017	0.431
LIG_SH2_STAT5	220	223	PF00017	0.431
LIG_SH2_STAT5	245	248	PF00017	0.431
LIG_SH2_STAT5	34	37	PF00017	0.627
LIG_SUMO_SIM_anti_2	150	156	PF11976	0.479
LIG_SUMO_SIM_anti_2	366	376	PF11976	0.636
LIG_SUMO_SIM_anti_2	83	92	PF11976	0.521
LIG_TRAF2_1	251	254	PF00917	0.370
LIG_TRAF2_1	348	351	PF00917	0.691
LIG_TRAF2_1	474	477	PF00917	0.653
LIG_TRAF2_1	99	102	PF00917	0.582
LIG_UBA3_1	162	170	PF00899	0.300
LIG_UBA3_1	374	383	PF00899	0.585
LIG_WRC_WIRS_1	199	204	PF05994	0.535
MOD_CDK_SPK_2	287	292	PF00069	0.449
MOD_CK1_1	265	271	PF00069	0.542
MOD_CK1_1	358	364	PF00069	0.466
MOD_CK1_1	396	402	PF00069	0.511
MOD_CK2_1	144	150	PF00069	0.428
MOD_CK2_1	198	204	PF00069	0.570
MOD_CK2_1	345	351	PF00069	0.698
MOD_CK2_1	370	376	PF00069	0.524
MOD_CK2_1	96	102	PF00069	0.587
MOD_Cter_Amidation	226	229	PF01082	0.242
MOD_Cter_Amidation	45	48	PF01082	0.495
MOD_Cter_Amidation	484	487	PF01082	0.421
MOD_Cter_Amidation	7	10	PF01082	0.707
MOD_GlcNHglycan	192	195	PF01048	0.287
MOD_GlcNHglycan	264	267	PF01048	0.474
MOD_GlcNHglycan	281	284	PF01048	0.583
MOD_GlcNHglycan	30	34	PF01048	0.536
MOD_GlcNHglycan	331	334	PF01048	0.504
MOD_GlcNHglycan	341	344	PF01048	0.569
MOD_GlcNHglycan	5	9	PF01048	0.490
MOD_GSK3_1	198	205	PF00069	0.558
MOD_GSK3_1	262	269	PF00069	0.488
MOD_GSK3_1	321	328	PF00069	0.536
MOD_GSK3_1	334	341	PF00069	0.489
MOD_GSK3_1	387	394	PF00069	0.695
MOD_GSK3_1	519	526	PF00069	0.411
MOD_N-GLC_1	334	339	PF02516	0.599
MOD_NEK2_1	202	207	PF00069	0.447
MOD_NEK2_1	209	214	PF00069	0.435
MOD_NEK2_1	215	220	PF00069	0.431
MOD_NEK2_1	256	261	PF00069	0.390
MOD_NEK2_1	334	339	PF00069	0.601
MOD_PIKK_1	519	525	PF00454	0.360
MOD_PK_1	462	468	PF00069	0.361
MOD_PKA_1	190	196	PF00069	0.373
MOD_PKA_1	329	335	PF00069	0.619
MOD_PKA_1	47	53	PF00069	0.724
MOD_PKA_1	96	102	PF00069	0.544
MOD_PKA_2	266	272	PF00069	0.688
MOD_PKA_2	358	364	PF00069	0.750
MOD_PKA_2	392	398	PF00069	0.767
MOD_PKB_1	391	399	PF00069	0.593
MOD_PKB_1	45	53	PF00069	0.490
MOD_Plk_1	29	35	PF00069	0.513
MOD_Plk_1	319	325	PF00069	0.382
MOD_Plk_2-3	345	351	PF00069	0.590
MOD_Plk_2-3	370	376	PF00069	0.646
MOD_Plk_4	168	174	PF00069	0.541
MOD_Plk_4	198	204	PF00069	0.506
MOD_Plk_4	215	221	PF00069	0.366
MOD_Plk_4	370	376	PF00069	0.556
MOD_Plk_4	462	468	PF00069	0.626
MOD_ProDKin_1	156	162	PF00069	0.392
MOD_ProDKin_1	287	293	PF00069	0.446
MOD_SUMO_for_1	155	158	PF00179	0.451
MOD_SUMO_for_1	223	226	PF00179	0.431
MOD_SUMO_for_1	529	532	PF00179	0.331
MOD_SUMO_rev_2	185	193	PF00179	0.526
MOD_SUMO_rev_2	201	207	PF00179	0.508
MOD_SUMO_rev_2	247	256	PF00179	0.499
TRG_DiLeu_BaEn_1	158	163	PF01217	0.404
TRG_DiLeu_BaEn_1	370	375	PF01217	0.612
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.386
TRG_ENDOCYTIC_2	220	223	PF00928	0.431
TRG_ENDOCYTIC_2	444	447	PF00928	0.539
TRG_ER_diArg_1	228	230	PF00400	0.376
TRG_ER_diArg_1	378	381	PF00400	0.546
TRG_ER_diArg_1	44	47	PF00400	0.491
TRG_ER_diArg_1	472	474	PF00400	0.689
TRG_ER_diArg_1	496	499	PF00400	0.347
TRG_NLS_MonoExtC_3	8	13	PF00514	0.607
TRG_NLS_MonoExtC_3	95	101	PF00514	0.593
TRG_NLS_MonoExtN_4	6	13	PF00514	0.598
TRG_NLS_MonoExtN_4	93	100	PF00514	0.585
TRG_PTS1	548	551	PF00515	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH2	Leptomonas seymouri	71%	100%
A0A0S4JBP1	Bodo saltans	38%	100%
A0A1X0NYI2	Trypanosomatidae	49%	100%
A0A3S7X1D4	Leishmania donovani	85%	98%
A0A422P1Q1	Trypanosoma rangeli	51%	100%
A4I3E7	Leishmania infantum	85%	98%
D0A800	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AZN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4Q8J7	Leishmania major	84%	100%
V5BG83	Trypanosoma cruzi	50%	100%